메뉴 건너뛰기




Volumn 7, Issue 5, 1997, Pages 388-409

Serotonin 5-HT2 receptor antagonists: Potential in the treatment of psychiatric disorders

Author keywords

[No Author keywords available]

Indexed keywords

1 (1 METHYL 5 INDOLYL) 3 (3 METHYL 5 ISOTHIAZOLYL)UREA; 4 IODO 2,5 DIMETHOXYAMPHETAMINE; 5 METHOXYTRYPTAMINE; ALPHA (2,3 DIMETHOXYPHENYL) 1 [2 (4 FLUOROPHENYL)ETHYL] 4 PIPERIDINEMETHANOL; ALPHA METHYLSEROTONIN; DOPAMINE 2 RECEPTOR BLOCKING AGENT; KETANSERIN; MIRTAZAPINE; NEFAZODONE; RISPERIDONE; RITANSERIN; SEROTONIN AGONIST; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR; SPIPERONE; UNCLASSIFIED DRUG;

EID: 0030966838     PISSN: 11727047     EISSN: None     Source Type: Journal    
DOI: 10.2165/00023210-199707050-00006     Document Type: Review
Times cited : (29)

References (225)
  • 1
    • 0028897149 scopus 로고
    • 5-HT receptors: Past, present and future
    • Peroutka SJ. 5-HT receptors: past, present and future. Trends Neurosci 1995; 18: 68-9
    • (1995) Trends Neurosci , vol.18 , pp. 68-69
    • Peroutka, S.J.1
  • 3
    • 0028245619 scopus 로고
    • Molecular biology of 5-HT receptors
    • Boess FG, Martin IL. Molecular biology of 5-HT receptors. Neuropharmacology 1994; 33: 275-317
    • (1994) Neuropharmacology , vol.33 , pp. 275-317
    • Boess, F.G.1    Martin, I.L.2
  • 4
    • 0028342977 scopus 로고
    • Receptors for 5-hydroxytryptamine: Current perspectives on classification and nomenclature
    • Martin GR, Humphrey PPA. Receptors for 5-hydroxytryptamine: current perspectives on classification and nomenclature. Neuropharmacology 1994; 33: 261-73
    • (1994) Neuropharmacology , vol.33 , pp. 261-273
    • Martin, G.R.1    Humphrey, P.P.A.2
  • 5
    • 0026563370 scopus 로고
    • 2 and stomach fundusa serotonin receptor genes
    • 2 and stomach fundusa serotonin receptor genes. Neuroreport 1992; 3: 345-8
    • (1992) Neuroreport , vol.3 , pp. 345-348
    • Foguet, M.1    Nguyen, H.2    Le, H.3
  • 6
    • 0022444356 scopus 로고
    • Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine
    • Bradley PB, Engel G, Feniuk W, et al. Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine. Neuropharmacology 1986; 25: 563-76
    • (1986) Neuropharmacology , vol.25 , pp. 563-576
    • Bradley, P.B.1    Engel, G.2    Feniuk, W.3
  • 7
    • 0022401097 scopus 로고
    • Quantitative autoradiographic mapping of serotonin receptors in the rat brain. II. Serotonin-2 receptors
    • Pazos A, Cortes R, Palacios JM. Quantitative autoradiographic mapping of serotonin receptors in the rat brain. II. Serotonin-2 receptors. Brain Res 1985; 346: 231-49
    • (1985) Brain Res , vol.346 , pp. 231-249
    • Pazos, A.1    Cortes, R.2    Palacios, J.M.3
  • 8
    • 0023274497 scopus 로고
    • Serotonin receptors in the human brain. IV. Autoradiographic mapping of serotonin-2 receptors
    • Pazos A, Probst A, Palacios JM. Serotonin receptors in the human brain. IV. Autoradiographic mapping of serotonin-2 receptors. Neuroscience 1987; 21: 123-39
    • (1987) Neuroscience , vol.21 , pp. 123-139
    • Pazos, A.1    Probst, A.2    Palacios, J.M.3
  • 10
    • 0023630323 scopus 로고
    • 2 receptors throughout the rat central nervous system using quantitative autoradiography
    • 2 receptors throughout the rat central nervous system using quantitative autoradiography. Brain Res 1987; 421: 263-79
    • (1987) Brain Res , vol.421 , pp. 263-279
    • Fischette, C.T.1    Nock, B.2    Renner, K.3
  • 12
    • 0025148024 scopus 로고
    • Inhibition of spontaneous and evoked unit activity in the rat medial prefrontal cortex by mesencephalic raphe nuclei
    • Mantz J, Godbout R, Tassin JP, et al. Inhibition of spontaneous and evoked unit activity in the rat medial prefrontal cortex by mesencephalic raphe nuclei. Brain Res 1990; 524: 22-30
    • (1990) Brain Res , vol.524 , pp. 22-30
    • Mantz, J.1    Godbout, R.2    Tassin, J.P.3
  • 14
    • 0023822131 scopus 로고
    • 2 antagonists and minaprine block the 5-HT-induced inhibition of dopamine release from rat brain striatal slices
    • 2 antagonists and minaprine block the 5-HT-induced inhibition of dopamine release from rat brain striatal slices. Eur J Pharmacol 1988; 153: 89-95
    • (1988) Eur J Pharmacol , vol.153 , pp. 89-95
    • Muramatsu, M.1    Tomaki-Ohashi, J.2    Usuki, C.3
  • 15
    • 0023880018 scopus 로고
    • Serotonin-2 receptor-mediated regulation of release of acetylcholine by minaprine in cholinergic nerve terminals of hippocampus of rat
    • Muramatsu M, Tomaki-Ohashi J, Usuki C, et al. Serotonin-2 receptor-mediated regulation of release of acetylcholine by minaprine in cholinergic nerve terminals of hippocampus of rat. Neuropharmacology 1988; 27: 603-9
    • (1988) Neuropharmacology , vol.27 , pp. 603-609
    • Muramatsu, M.1    Tomaki-Ohashi, J.2    Usuki, C.3
  • 18
    • 0019313763 scopus 로고
    • Pharmacological profile of a model for central serotonin receptor activation
    • Matthews WD, Smith CD. Pharmacological profile of a model for central serotonin receptor activation. Life Sci 1980; 26: 1397-403
    • (1980) Life Sci , vol.26 , pp. 1397-1403
    • Matthews, W.D.1    Smith, C.D.2
  • 19
    • 0026706347 scopus 로고
    • Cloning and functional expression of the rat stomach fundus serotonin receptor
    • Foguet M, Hoyer D, Pardo LA, et al. Cloning and functional expression of the rat stomach fundus serotonin receptor. EMBO J 1992; 11: 3481-7
    • (1992) EMBO J , vol.11 , pp. 3481-3487
    • Foguet, M.1    Hoyer, D.2    Pardo, L.A.3
  • 22
    • 0021894691 scopus 로고
    • Role of 5-HT2 receptors in serotonin-induced contractions of nonvascular smooth muscle
    • Cohen ML, Schenck KW, Colbert W, et al. Role of 5-HT2 receptors in serotonin-induced contractions of nonvascular smooth muscle. J Pharmacol ExpTher 1985; 232: 770-4
    • (1985) J Pharmacol ExpTher , vol.232 , pp. 770-774
    • Cohen, M.L.1    Schenck, K.W.2    Colbert, W.3
  • 24
    • 0021686458 scopus 로고
    • The binding of serotonergic ligands to the porcine choroid plexus: Characterisation of a new type of serotonin recognition site
    • Pazos A, Hoyer D, Palacios JM. The binding of serotonergic ligands to the porcine choroid plexus: characterisation of a new type of serotonin recognition site. Eur J Pharmacol 1984; 106: 539-46
    • (1984) Eur J Pharmacol , vol.106 , pp. 539-546
    • Pazos, A.1    Hoyer, D.2    Palacios, J.M.3
  • 26
    • 0025336772 scopus 로고
    • 1C receptor mRNA in the rodent brain examined by in situ hybridisation histocheimstry. Comparison with receptor binding distribution
    • 1C receptor mRNA in the rodent brain examined by in situ hybridisation histocheimstry. Comparison with receptor binding distribution. Neuroscience 1990; 35: 577-91
    • (1990) Neuroscience , vol.35 , pp. 577-591
    • Mengod, G.1    Nguyen, H.2    Le, H.3
  • 28
    • 0024507731 scopus 로고
    • Molecular biology of 5-HT receptors
    • Hartig PR. Molecular biology of 5-HT receptors. Trends Pharmacol Sci 1989; 10: 64-9
    • (1989) Trends Pharmacol Sci , vol.10 , pp. 64-69
    • Hartig, P.R.1
  • 31
    • 0025827064 scopus 로고
    • 1C receptors mediate mCPP-induced hypophagia
    • 1C receptors mediate mCPP-induced hypophagia. Br J Pharmacol 1991; 103: 2016-20
    • (1991) Br J Pharmacol , vol.103 , pp. 2016-2020
    • Kennet, G.A.1    Curzon, G.2
  • 32
    • 0001941232 scopus 로고
    • 1C receptor agonism as an initiating event in migraine
    • Olesen J, Saxena PR, editors. New York: Raven Press Ltd.
    • 1C receptor agonism as an initiating event in migraine. In: Olesen J, Saxena PR, editors. 5-Hydroxytryptamine mechanisms in primary headaches. New York: Raven Press Ltd., 1992: 200-12
    • (1992) 5-Hydroxytryptamine Mechanisms in Primary Headaches , pp. 200-212
    • Fozard, J.R.1
  • 33
    • 0026353340 scopus 로고
    • m-Chlorophenylpiperazine as a probe of serotonin function
    • Kahn RS, Wetzler S. m-Chlorophenylpiperazine as a probe of serotonin function. Biol Psychiatry 1991; 30: 1139-66
    • (1991) Biol Psychiatry , vol.30 , pp. 1139-1166
    • Kahn, R.S.1    Wetzler, S.2
  • 35
    • 0029888880 scopus 로고    scopus 로고
    • The pharmacologic profile of mirtazapine
    • De Boor T. The pharmacologic profile of mirtazapine. J Clin Psychiatry 1996; 57 Suppl. 4: 19-25
    • (1996) J Clin Psychiatry , vol.57 , Issue.4 SUPPL. , pp. 19-25
    • De Boor, T.1
  • 36
    • 0029112656 scopus 로고
    • Pharmacology and neurochemistry of nefazodone, a novel antidepressant drug
    • Taylor DP, Carter RB, Eison AS, et al. Pharmacology and neurochemistry of nefazodone, a novel antidepressant drug. J Clin Psychiatry 1995; 56 Suppl. 6: 3-11
    • (1995) J Clin Psychiatry , vol.56 , Issue.6 SUPPL. , pp. 3-11
    • Taylor, D.P.1    Carter, R.B.2    Eison, A.S.3
  • 37
    • 0020383814 scopus 로고
    • Buspirone and diazepam in anxiety: A controlled study
    • Rickels K, Weisman K, Norstad N, et al. Buspirone and diazepam in anxiety: a controlled study. J Clin Psychiatry 1982; 43: 81-6
    • (1982) J Clin Psychiatry , vol.43 , pp. 81-86
    • Rickels, K.1    Weisman, K.2    Norstad, N.3
  • 38
    • 0027749595 scopus 로고
    • A doubleblind, placebo-controlled study comparing the efficacy, safety of ipsapirone versus lorazepam in patients with generalized anxiety disorder. A prospective multicenter trial
    • Cutler NR, Sramek JJ, Heppel Hesselink JM, et al. A doubleblind, placebo-controlled study comparing the efficacy, safety of ipsapirone versus lorazepam in patients with generalized anxiety disorder. A prospective multicenter trial. J Clin Psychopharmacol 1993; 13: 429-37
    • (1993) J Clin Psychopharmacol , vol.13 , pp. 429-437
    • Cutler, N.R.1    Sramek, J.J.2    Heppel Hesselink, J.M.3
  • 39
    • 0028986825 scopus 로고
    • 5-Hydroxytryptamine-interacting drugs in animal models of anxiety disorders: More than 30 years of research
    • Griebel G. 5-Hydroxytryptamine-interacting drugs in animal models of anxiety disorders: more than 30 years of research. Pharmacol Ther 1995; 66: 319-95
    • (1995) Pharmacol Ther , vol.66 , pp. 319-395
    • Griebel, G.1
  • 40
    • 0027208571 scopus 로고
    • 5-HT receptors as targets for the development of novel anxiolytic drugs: Models, mechanisms and future directions
    • Barrett JE, Vanover KE. 5-HT receptors as targets for the development of novel anxiolytic drugs: models, mechanisms and future directions. Psychopharmacology 1993; 112: 1-12
    • (1993) Psychopharmacology , vol.112 , pp. 1-12
    • Barrett, J.E.1    Vanover, K.E.2
  • 41
    • 0023546208 scopus 로고
    • Animal models of anxiety: The effect of compounds that modify serotonergic function
    • Chopin P, Briley M. Animal models of anxiety: the effect of compounds that modify serotonergic function. Trends Pharmacol Sci 1987; 8: 383-8
    • (1987) Trends Pharmacol Sci , vol.8 , pp. 383-388
    • Chopin, P.1    Briley, M.2
  • 43
    • 0027056458 scopus 로고
    • Anxiogenic-like effects of fluprazine and eltoprazine in the mouse elevated plusmaze: Profile comparisons with 8-OH-DPAT, CGS 12066B, TFMPP and mCPP
    • Rodgers RJ, Cole JC, Cobain MR, et al. Anxiogenic-like effects of fluprazine and eltoprazine in the mouse elevated plusmaze: profile comparisons with 8-OH-DPAT, CGS 12066B, TFMPP and mCPP. Behav Pharmacol 1992; 3: 621-34
    • (1992) Behav Pharmacol , vol.3 , pp. 621-634
    • Rodgers, R.J.1    Cole, J.C.2    Cobain, M.R.3
  • 45
    • 0024417605 scopus 로고
    • Exploratory hypoactivity induced by m-trifluoromethylpiperazine (TFMPP) and m-chlorophenylpiperazine (mCPP)
    • Klodzinska A, Jaros T, Chojnacka-Wojcik E, et al. Exploratory hypoactivity induced by m-trifluoromethylpiperazine (TFMPP) and m-chlorophenylpiperazine (mCPP). J Neural Transm 1989; 1: 207-18
    • (1989) J Neural Transm , vol.1 , pp. 207-218
    • Klodzinska, A.1    Jaros, T.2    Chojnacka-Wojcik, E.3
  • 46
    • 0020462583 scopus 로고
    • Lack of central 5-hydroxytryptamine influence on the anticonflict activity of diazepam
    • Kilts CD, Commissaris RL, Cordon JJ, et al. Lack of central 5-hydroxytryptamine influence on the anticonflict activity of diazepam. Psychopharmacology 1982; 78: 156-64
    • (1982) Psychopharmacology , vol.78 , pp. 156-164
    • Kilts, C.D.1    Commissaris, R.L.2    Cordon, J.J.3
  • 47
    • 0026593712 scopus 로고
    • 1A receptors on the exploratory activity of rats in the elevated plus-maze
    • 1A receptors on the exploratory activity of rats in the elevated plus-maze. Psychopharmacology 1992; 107: 135-9
    • (1992) Psychopharmacology , vol.107 , pp. 135-139
    • Motta, V.1    Maisonnette, S.2    Morato, S.3
  • 49
    • 0024549545 scopus 로고
    • Effects of 1-(m-chlorophenyl)piperazine and 1-(m- trifluoromethylphenyl)piperazine on locomotor activity
    • Lucki I, Ward HR, Frazer A. Effects of 1-(m-chlorophenyl)piperazine and 1-(m- trifluoromethylphenyl)piperazine on locomotor activity. J Pharmacol Exp Ther 1989; 249: 155-64
    • (1989) J Pharmacol Exp Ther , vol.249 , pp. 155-164
    • Lucki, I.1    Ward, H.R.2    Frazer, A.3
  • 50
    • 0026612095 scopus 로고
    • 1C receptor antagonists have anxiolytic-like actions in the rat social interaction model
    • 1C receptor antagonists have anxiolytic-like actions in the rat social interaction model. Psychopharmacology 1992; 107: 374-84
    • (1992) Psychopharmacology , vol.107 , pp. 374-384
    • Kennett, G.A.1
  • 51
    • 0000262957 scopus 로고
    • Comparison of effects of buspirone and gepirone with benzodiazepines and antagonists of dopamine and serotonin receptors on punished behavior in rats
    • Witkin JM, Perez LA. Comparison of effects of buspirone and gepirone with benzodiazepines and antagonists of dopamine and serotonin receptors on punished behavior in rats. Behav Pharmacol 1989-1990; 1: 247-54
    • (1989) Behav Pharmacol , vol.1 , pp. 247-254
    • Witkin, J.M.1    Perez, L.A.2
  • 52
    • 8244226491 scopus 로고
    • A comparison of the anticonflict activity of serotonin agonists and antagonists in rats
    • Amrick CL, Bennett DA. A comparison of the anticonflict activity of serotonin agonists and antagonists in rats [abstract]. Soc Neurosci Abstr 1986; 12: 907
    • (1986) Soc Neurosci Abstr , vol.12 , pp. 907
    • Amrick, C.L.1    Bennett, D.A.2
  • 53
    • 0022374863 scopus 로고
    • Validation of open closed arm entries in an elevated plus-maze as a measure of anxiety in rats
    • Pellow S, Chopin P, File SE, et al. Validation of open closed arm entries in an elevated plus-maze as a measure of anxiety in rats. J Neurosci Methods 1985; 14: 149-67
    • (1985) J Neurosci Methods , vol.14 , pp. 149-167
    • Pellow, S.1    Chopin, P.2    File, S.E.3
  • 54
    • 0026659331 scopus 로고
    • 2 receptor downregulation results in anxiolytic effects in the elevated plus-maze test
    • 2 receptor downregulation results in anxiolytic effects in the elevated plus-maze test. Drug Dev Res 1992; 25: 287-97
    • (1992) Drug Dev Res , vol.25 , pp. 287-297
    • Benjamin, D.1    Saiff, E.I.2    Nevins, T.3
  • 55
    • 0343414879 scopus 로고
    • Effects of compounds acting at CNS 5-hydroxytryptamine systems on anxiety in the rat
    • File SE, Johnston AL, Pellow S. Effects of compounds acting at CNS 5-hydroxytryptamine systems on anxiety in the rat [abstract]. Br J Pharmacol 1987; 90 Suppl.: 265P
    • (1987) Br J Pharmacol , vol.90 , Issue.SUPPL.
    • File, S.E.1    Johnston, A.L.2    Pellow, S.3
  • 56
    • 0026563307 scopus 로고
    • Comparison of acute and chronic treatment of various serotonergic agents with those of diazepam and idazoxan in the elevated X-maze
    • Wright IK, Heaton M, Upton N, et al. Comparison of acute and chronic treatment of various serotonergic agents with those of diazepam and idazoxan in the elevated X-maze. Psychopharmacology 1992; 107: 405-14
    • (1992) Psychopharmacology , vol.107 , pp. 405-414
    • Wright, I.K.1    Heaton, M.2    Upton, N.3
  • 57
  • 58
    • 4243636372 scopus 로고
    • A primate model for the assessment of anxiolytic drug action
    • Costall B, Domeney AM, Gerrard PA, et al. A primate model for the assessment of anxiolytic drug action [abstract]. Br J Pharmacol 1988; 95 Suppl.: 475P
    • (1988) Br J Pharmacol , vol.95 , Issue.SUPPL.
    • Costall, B.1    Domeney, A.M.2    Gerrard, P.A.3
  • 59
    • 0027479008 scopus 로고
    • Effects of acute and subchronic administration of ritanserin on the social behavior of mice
    • Gao B, Cutler MG. Effects of acute and subchronic administration of ritanserin on the social behavior of mice. Neuropharmacology 1993; 32: 265-72
    • (1993) Neuropharmacology , vol.32 , pp. 265-272
    • Gao, B.1    Cutler, M.G.2
  • 60
    • 0021885892 scopus 로고
    • Behavioural and 5-HT antagonist effects of ritanserin: A pure and selective antagonist of LSD discrimination in rats
    • Colpaert FC, Meert TF, Niemegeers CJE, et al. Behavioural and 5-HT antagonist effects of ritanserin: a pure and selective antagonist of LSD discrimination in rats. Psychopharmacology 1985; 86: 45-54
    • (1985) Psychopharmacology , vol.86 , pp. 45-54
    • Colpaert, F.C.1    Meert, T.F.2    Niemegeers, C.J.E.3
  • 61
    • 8244242229 scopus 로고
    • Effects of S2 antagonists in two conflict procedures that involve exploratory behaviour
    • Meert TF, Colpaert FC. Effects of S2 antagonists in two conflict procedures that involve exploratory behaviour [abstract]. Psychopharmacology 1986; 89: S23
    • (1986) Psychopharmacology , vol.89
    • Meert, T.F.1    Colpaert, F.C.2
  • 62
    • 0026678029 scopus 로고
    • The comparison of benzodiazepine derivatives and serotonergic agonists and antagonists in two animal models of anxiety
    • Stefanski R, Palejko W, Kostowski W, et al. The comparison of benzodiazepine derivatives and serotonergic agonists and antagonists in two animal models of anxiety. Neuropharmacology 1992; 31: 1251-8
    • (1992) Neuropharmacology , vol.31 , pp. 1251-1258
    • Stefanski, R.1    Palejko, W.2    Kostowski, W.3
  • 63
    • 0000136627 scopus 로고
    • Comparative studies on the anti-punishment effects of chlordiazepoxide, huspirone and ritanserin in the pigeon Geller-Seifter and Vogel conflict procedures
    • Brocco MJ, Koek W, Degryse AD, et al. Comparative studies on the anti-punishment effects of chlordiazepoxide, huspirone and ritanserin in the pigeon Geller-Seifter and Vogel conflict procedures. Behav Pharmacol 1990; 1: 403-18
    • (1990) Behav Pharmacol , vol.1 , pp. 403-418
    • Brocco, M.J.1    Koek, W.2    Degryse, A.D.3
  • 64
    • 0026647671 scopus 로고
    • 2 receptor sensitivity in generalised anxiety disorder: A pilot study with ritanserin
    • 2 receptor sensitivity in generalised anxiety disorder: a pilot study with ritanserin. Psychopharmacology 1992; 108: 387-9
    • (1992) Psychopharmacology , vol.108 , pp. 387-389
    • Da Roza Davis, J.M.1    Sharpley, A.L.2    Cowen, P.J.3
  • 65
    • 0023895447 scopus 로고
    • 1 recognition sites
    • 1 recognition sites. J Recept Res 1988; 8: 59-81
    • (1988) J Recept Res , vol.8 , pp. 59-81
    • Hoyer, D.1
  • 66
    • 0024514089 scopus 로고
    • 1-(m-Chlorophenyl)piperazine (mCPP) interactions with neurotransmitter receptors in the human brain
    • Hamik A, Peroutka SJ. 1-(m-Chlorophenyl)piperazine (mCPP) interactions with neurotransmitter receptors in the human brain. Biol Psychiatry 1989; 25: 569-75
    • (1989) Biol Psychiatry , vol.25 , pp. 569-575
    • Hamik, A.1    Peroutka, S.J.2
  • 67
    • 0023729246 scopus 로고
    • Neuroendocrine evidence for serotonin receptor supersensitivity in patients with panic disorder
    • Kahn RS, Asnis GM, Wetzler S, et al. Neuroendocrine evidence for serotonin receptor supersensitivity in patients with panic disorder. Psychopharmacology 1988; 96: 360-4
    • (1988) Psychopharmacology , vol.96 , pp. 360-364
    • Kahn, R.S.1    Asnis, G.M.2    Wetzler, S.3
  • 68
    • 0023676915 scopus 로고
    • Behavioral indications of serotonin receptor hypersensitivity in patients with panic disorder
    • Kahn RS, Wetzler S, van Praag HM, et al. Behavioral indications of serotonin receptor hypersensitivity in patients with panic disorder. Psychiatry Res 1988; 25: 101-4
    • (1988) Psychiatry Res , vol.25 , pp. 101-104
    • Kahn, R.S.1    Wetzler, S.2    Van Praag, H.M.3
  • 69
    • 0023179757 scopus 로고
    • Serotonin function in anxiety. II. Effects of the serotonin agonist mCPP in panic disorder patients and healthy subjects
    • Charney DS, Woods SW, Goodman WK, et al. Serotonin function in anxiety. II. Effects of the serotonin agonist mCPP in panic disorder patients and healthy subjects. Psychopharmacology 1987; 92: 14-24
    • (1987) Psychopharmacology , vol.92 , pp. 14-24
    • Charney, D.S.1    Woods, S.W.2    Goodman, W.K.3
  • 70
    • 0026443999 scopus 로고
    • Anger and anxiety responses to m-chlorophenylpiperazine in generalized anxiety disorder
    • Germine M, Goddard AW, Woods SW, et al. Anger and anxiety responses to m-chlorophenylpiperazine in generalized anxiety disorder. Biol Psychiatry 1992; 34: 457-61
    • (1992) Biol Psychiatry , vol.34 , pp. 457-461
    • Germine, M.1    Goddard, A.W.2    Woods, S.W.3
  • 72
    • 0023830602 scopus 로고
    • Serotonergic responsivity in obsessive-compulsive disorder: Effects of chronic clomipramine treatment
    • Zohar J, Insel TR, Zohar-Kadouch RC, et al. Serotonergic responsivity in obsessive-compulsive disorder: effects of chronic clomipramine treatment. Arch Gen Psychiatry 1988; 45: 167-72
    • (1988) Arch Gen Psychiatry , vol.45 , pp. 167-172
    • Zohar, J.1    Insel, T.R.2    Zohar-Kadouch, R.C.3
  • 73
    • 0026519130 scopus 로고
    • Serotonergic function in obsessive-compulsive disorder: Behavioral and neuroendocrine responses to oral m-chlorophenylpiperazine and fenfluramine in patients and healthy volunteers
    • Hollander E, DeCaria CM, Nitescu A, et al. Serotonergic function in obsessive-compulsive disorder: behavioral and neuroendocrine responses to oral m-chlorophenylpiperazine and fenfluramine in patients and healthy volunteers. Arch Gen Psychiatry 1992; 49: 21-8
    • (1992) Arch Gen Psychiatry , vol.49 , pp. 21-28
    • Hollander, E.1    DeCaria, C.M.2    Nitescu, A.3
  • 74
    • 0023860008 scopus 로고
    • Serotonergic function in obsessive compulsive disorder: A comparison of the effects of tryptophan and mCPP in patients and healthy subjects
    • Charney DS, Goodman WK, Price LH, et al. Serotonergic function in obsessive compulsive disorder: a comparison of the effects of tryptophan and mCPP in patients and healthy subjects. Arch Gen Psychiatry 1988; 45: 177-85
    • (1988) Arch Gen Psychiatry , vol.45 , pp. 177-185
    • Charney, D.S.1    Goodman, W.K.2    Price, L.H.3
  • 75
    • 0027458735 scopus 로고
    • A comparison of the behavioral effects of oral versus intravenous mCPP administration in OCD patients and the effect of metergoline prior to IV mCPP
    • Pigott TA, Hill JL, Grady TA, et al. A comparison of the behavioral effects of oral versus intravenous mCPP administration in OCD patients and the effect of metergoline prior to IV mCPP. Biol Psychiatry 1993; 33: 3-14
    • (1993) Biol Psychiatry , vol.33 , pp. 3-14
    • Pigott, T.A.1    Hill, J.L.2    Grady, T.A.3
  • 76
    • 0025757156 scopus 로고
    • Metergoline blocks the behavioral and neuroendocrine effects of orally administered m-chlorophenylpiperazine in patients with obsessive-compulsive disorder
    • Pigott TA, Zohar J, Hill JL, et al. Metergoline blocks the behavioral and neuroendocrine effects of orally administered m-chlorophenylpiperazine in patients with obsessive-compulsive disorder. Biol Psychiatry 1991; 29: 418-26
    • (1991) Biol Psychiatry , vol.29 , pp. 418-426
    • Pigott, T.A.1    Zohar, J.2    Hill, J.L.3
  • 77
    • 0025936170 scopus 로고
    • 2 antagonist WY-50,324 in pigeons
    • 2 antagonist WY-50,324 in pigeons. Drug Dev Res 1991; 24: 179-88
    • (1991) Drug Dev Res , vol.24 , pp. 179-188
    • Barrett, J.E.1    Zhang, L.2
  • 79
    • 0030087708 scopus 로고    scopus 로고
    • 2A/2C antagonist anxiolytics. I. Antipunishment effects in the pigeon
    • 2A/2C antagonist anxiolytics. I. Antipunishment effects in the pigeon. J Pharmacol Exp Ther 1996; 276: 388-97
    • (1996) J Pharmacol Exp Ther , vol.276 , pp. 388-397
    • Kleven, M.S.1    Koek, W.2
  • 80
    • 0022183592 scopus 로고
    • The influence of ritanserin, a serotonin antagonist, in anxiety disorders: A double-blind placebo-controlled study versus lorazepam
    • Ceulemans DLS, Hoppenbrouwers LJA, Gelders YG, et al. The influence of ritanserin, a serotonin antagonist, in anxiety disorders: a double-blind placebo-controlled study versus lorazepam. Pharmacopsychiatry 1985; 18: 303-5
    • (1985) Pharmacopsychiatry , vol.18 , pp. 303-305
    • Ceulemans, D.L.S.1    Hoppenbrouwers, L.J.A.2    Gelders, Y.G.3
  • 82
    • 8244236894 scopus 로고
    • The effect of benzodiazepine withdrawal on the therapeutic efficacy of a serotonin antagonist in anxiety disorders
    • Sep 9-14; Philadelphia
    • Ceulemans DLS, Hoppenbrouwers LJA, Gelders YG, et al. The effect of benzodiazepine withdrawal on the therapeutic efficacy of a serotonin antagonist in anxiety disorders. IVth World Congress of Biological Psychiatry: 1985 Sep 9-14; Philadelphia, 58
    • (1985) IVth World Congress of Biological Psychiatry , pp. 58
    • Ceulemans, D.L.S.1    Hoppenbrouwers, L.J.A.2    Gelders, Y.G.3
  • 83
    • 84989137816 scopus 로고
    • Ritanserin - An original thymosthenic in the treatment of generalized anxiety disorders
    • Jansen AAI, Pangalilia-Ratu Langi EA. Ritanserin - an original thymosthenic in the treatment of generalized anxiety disorders [abstract]. Psychopharmacology 1988; 96 Suppl.: S350
    • (1988) Psychopharmacology , vol.96 , Issue.SUPPL.
    • Jansen, A.A.I.1    Pangalilia-Ratu Langi, E.A.2
  • 86
    • 0025282360 scopus 로고
    • Serotonin function in panic disorder: A double blind placebo controlled study with fluvoxamine and ritanserin
    • Den Boer JA, Westenberg HGM. Serotonin function in panic disorder: a double blind placebo controlled study with fluvoxamine and ritanserin. Psychopharmacology 1990; 102: 85-94
    • (1990) Psychopharmacology , vol.102 , pp. 85-94
    • Den Boer, J.A.1    Westenberg, H.G.M.2
  • 87
    • 0000587671 scopus 로고
    • The serotonin hypothesis of major depression
    • Bloom FE, Kupfer DJ, editors. New York, Raven Press Ltd.
    • Maes M, Meltzer HY. The serotonin hypothesis of major depression. In: Bloom FE, Kupfer DJ, editors. Psychopharmacology: the fourth generation of progress. New York, Raven Press Ltd., 1995: 933-44
    • (1995) Psychopharmacology: The Fourth Generation of Progress , pp. 933-944
    • Maes, M.1    Meltzer, H.Y.2
  • 88
    • 0023199181 scopus 로고
    • 5-HT receptor binding in post-mortem brain from patients with affective disorder
    • McKeith IG, Marshall EF, Ferrier IN, et al. 5-HT receptor binding in post-mortem brain from patients with affective disorder. J Affect Disord 1987; 13: 67-74
    • (1987) J Affect Disord , vol.13 , pp. 67-74
    • McKeith, I.G.1    Marshall, E.F.2    Ferrier, I.N.3
  • 89
    • 0022930193 scopus 로고
    • 2 and beta-adrenergic receptor binding in the frontal corticies of suicide victims
    • 2 and beta-adrenergic receptor binding in the frontal corticies of suicide victims. Arch Gen Psychiatry 1986; 43: 945-59
    • (1986) Arch Gen Psychiatry , vol.43 , pp. 945-959
    • Mann, J.J.1    Stanley, M.2    McBride, P.A.3
  • 92
    • 0021699781 scopus 로고
    • Neurotransmitter receptors and monoamine metabolites in the brains of patients with Alzheimer-type dementia and depression, and suicide
    • Crow TJ, Cross AJ, Cooper SJ, et al. Neurotransmitter receptors and monoamine metabolites in the brains of patients with Alzheimer-type dementia and depression, and suicide. Neuropharmacology 1984; 23: 1561-9
    • (1984) Neuropharmacology , vol.23 , pp. 1561-1569
    • Crow, T.J.1    Cross, A.J.2    Cooper, S.J.3
  • 93
    • 0028178026 scopus 로고
    • Brain 5-HT2 receptors in suicide victims: Violence of death, depression and effects of antidepressant treatment
    • Lowther S, De Paermentier F, Crompton MR, et al. Brain 5-HT2 receptors in suicide victims: violence of death, depression and effects of antidepressant treatment. Brain Res 1994; 642: 281-9
    • (1994) Brain Res , vol.642 , pp. 281-289
    • Lowther, S.1    De Paermentier, F.2    Crompton, M.R.3
  • 94
    • 0017413735 scopus 로고
    • The human blood platelet: A diagnostic and research tool for the study of biogenic amines in psychiatric and neurologic disorder
    • Stahl SM. The human blood platelet: a diagnostic and research tool for the study of biogenic amines in psychiatric and neurologic disorder. Arch Gen Psychiatry 1977; 34: 509-16
    • (1977) Arch Gen Psychiatry , vol.34 , pp. 509-516
    • Stahl, S.M.1
  • 95
    • 0023613059 scopus 로고
    • 2 receptor binding on blood platelets a peripheral marker for depression?
    • 2 receptor binding on blood platelets a peripheral marker for depression? Life Sci 1987; 41: 2485-92
    • (1987) Life Sci , vol.41 , pp. 2485-2492
    • Biegon, A.1    Weizman, A.2    Karp, L.3
  • 97
    • 0025345457 scopus 로고
    • Platelet serotonin-2 binding sites in depression and suicide
    • Pandey GN, Pandey SC, Janicak PG, et al. Platelet serotonin-2 binding sites in depression and suicide. Biol Psychiatry 1990; 28: 215-22
    • (1990) Biol Psychiatry , vol.28 , pp. 215-222
    • Pandey, G.N.1    Pandey, S.C.2    Janicak, P.G.3
  • 98
    • 0026558383 scopus 로고
    • Serotonin but not epinephrine-induced calcium mobilization of platelets is enhanced in affective disorders
    • Mikuni M, Kagaya A, Takahashi K, et al. Serotonin but not epinephrine-induced calcium mobilization of platelets is enhanced in affective disorders. Psychopharmacology 1992; 106: 311-4
    • (1992) Psychopharmacology , vol.106 , pp. 311-314
    • Mikuni, M.1    Kagaya, A.2    Takahashi, K.3
  • 99
    • 0041160622 scopus 로고
    • Receptor studies in suicidal patients
    • Racagni G, Brunello N, Fukuda T, editors. Amsterdam: Elsevier Science Publishers B. V.
    • Biegon A. Receptor studies in suicidal patients. In: Racagni G, Brunello N, Fukuda T, editors. Biological psychiatry. Vol. 1. Amsterdam: Elsevier Science Publishers B. V., 1991: 103-5
    • (1991) Biological Psychiatry , vol.1 , pp. 103-105
    • Biegon, A.1
  • 100
    • 0025309555 scopus 로고
    • 2 receptor binding on blood platelets as a state dependent marker in major affective disorder
    • 2 receptor binding on blood platelets as a state dependent marker in major affective disorder. Psychopharmacology 1990; 102: 73-5
    • (1990) Psychopharmacology , vol.102 , pp. 73-75
    • Biegon, A.1    Essar, N.2    Israeli, M.3
  • 101
    • 0019122846 scopus 로고
    • Long-term antidepressant treatment decreases spiroperidol-labelled serotonin receptor binding
    • Peroutka SJ, Snyder SH. Long-term antidepressant treatment decreases spiroperidol-labelled serotonin receptor binding. Science 1980; 210: 88-90
    • (1980) Science , vol.210 , pp. 88-90
    • Peroutka, S.J.1    Snyder, S.H.2
  • 102
    • 0019460983 scopus 로고
    • Different effect of electroconvulsive shock and antidepressant drugs on serotonin-2 receptors in rat brain
    • Kellar KJ, Caseio CS, Butler JA, et al. Different effect of electroconvulsive shock and antidepressant drugs on serotonin-2 receptors in rat brain. Eur J Pharmacol 1981; 69: 515-8
    • (1981) Eur J Pharmacol , vol.69 , pp. 515-518
    • Kellar, K.J.1    Caseio, C.S.2    Butler, J.A.3
  • 103
    • 0018828374 scopus 로고
    • Lithium effects on serotonin receptors in rat brain
    • Treiser S, Kellar KJ. Lithium effects on serotonin receptors in rat brain. Eur J Pharmacol 1980; 64: 183-5
    • (1980) Eur J Pharmacol , vol.64 , pp. 183-185
    • Treiser, S.1    Kellar, K.J.2
  • 104
    • 0022557593 scopus 로고
    • Modulation of the serotonin S-2 receptor in brain after chronic lithium
    • Wajda IJ, Banay-Schwartz M, Maigault I, et al. Modulation of the serotonin S-2 receptor in brain after chronic lithium. Neurochem Res 1986; 11: 949-57
    • (1986) Neurochem Res , vol.11 , pp. 949-957
    • Wajda, I.J.1    Banay-Schwartz, M.2    Maigault, I.3
  • 105
    • 0024458752 scopus 로고
    • Pharmacological effects of paroxetine after repeated administration to animals
    • Nelson DR, Thomas DR, Johnson AM. Pharmacological effects of paroxetine after repeated administration to animals. Acta Psychiatr Scand 1989; 80 Suppl. 350: 21-3
    • (1989) Acta Psychiatr Scand , vol.80 , Issue.350 SUPPL. , pp. 21-23
    • Nelson, D.R.1    Thomas, D.R.2    Johnson, A.M.3
  • 106
    • 0025755563 scopus 로고
    • 2-mediated behavior in the rat following noradrenergic or serotonergic denervation
    • 2-mediated behavior in the rat following noradrenergic or serotonergic denervation. J Neural Transm Gen Sect 1991; 84: 19-32
    • (1991) J Neural Transm Gen Sect , vol.84 , pp. 19-32
    • Eison, A.S.1    Yocea, F.D.2    Gianutsos, G.3
  • 107
    • 0020625373 scopus 로고
    • 3H]spiperone binding in rat frontal cortex and serotonin receptor mediated behavior
    • 3H]spiperone binding in rat frontal cortex and serotonin receptor mediated behavior. Psychopharmacology 1983; 80: 150-5
    • (1983) Psychopharmacology , vol.80 , pp. 150-155
    • Stolz, J.F.1    Marsden, C.A.2    Middlemiss, D.N.3
  • 109
    • 0022595471 scopus 로고
    • Down regulation of serotonin-S2 receptor sites in rat brain by chronic treatment with the serotonin-S2 antagonists: Ritanserin and setoperone
    • Leysen JL, Van Gompel P, Commeren W, et al. Down regulation of serotonin-S2 receptor sites in rat brain by chronic treatment with the serotonin-S2 antagonists: ritanserin and setoperone. Psychopharmacology 1986; 88: 434-44
    • (1986) Psychopharmacology , vol.88 , pp. 434-444
    • Leysen, J.L.1    Van Gompel, P.2    Commeren, W.3
  • 110
    • 0019781679 scopus 로고
    • Enhancement of responsiveness of central serotonergic system and serotonin-2 receptor density in rat frontal cortex by electroconvulsive treatment
    • Vetulani J, Lehrecht U, Pile A. Enhancement of responsiveness of central serotonergic system and serotonin-2 receptor density in rat frontal cortex by electroconvulsive treatment. Eur J Pharmacol 1981; 76: 81-5
    • (1981) Eur J Pharmacol , vol.76 , pp. 81-85
    • Vetulani, J.1    Lehrecht, U.2    Pile, A.3
  • 111
    • 0023145615 scopus 로고
    • Receptor alteration associated with serotonergic agents: An autoradiographic analysis
    • Wamsley JK, Byerley WF, McCabe RT, et al. Receptor alteration associated with serotonergic agents: an autoradiographic analysis. J Clin Psychiatry 1987; 48 Suppl.: 19-25
    • (1987) J Clin Psychiatry , vol.48 , Issue.SUPPL. , pp. 19-25
    • Wamsley, J.K.1    Byerley, W.F.2    McCabe, R.T.3
  • 112
    • 0027290988 scopus 로고
    • 2 receptors in rat brain: An autoradiographic study
    • 2 receptors in rat brain: an autoradiographic study. Synapse 1993; 14: 324-31
    • (1993) Synapse , vol.14 , pp. 324-331
    • Hrdina, P.D.1    Vu, T.B.2
  • 113
    • 0021368802 scopus 로고
    • Biochemical effects and drug levels in rats after long term treatment with the specific 5-HT uptake inhibitor, citalopram
    • Hyttel J, Overo KF, Arnt J. Biochemical effects and drug levels in rats after long term treatment with the specific 5-HT uptake inhibitor, citalopram. Psychopharmacology 1984; 83: 20-7
    • (1984) Psychopharmacology , vol.83 , pp. 20-27
    • Hyttel, J.1    Overo, K.F.2    Arnt, J.3
  • 115
    • 0024542179 scopus 로고
    • Chronic ACTH treatment: Influence on 5-HT2 receptors and behavioral supersensitivity induced by 5,7-dihydroxytryptamine lesions
    • Pranzatelli MR, Eng B. Chronic ACTH treatment: influence on 5-HT2 receptors and behavioral supersensitivity induced by 5,7-dihydroxytryptamine lesions. Peptides 1989; 10: 5-8
    • (1989) Peptides , vol.10 , pp. 5-8
    • Pranzatelli, M.R.1    Eng, B.2
  • 118
    • 0025908432 scopus 로고
    • Neuroendocrine pharmacology of serotonergic (5-HT) neurons
    • Van de Kar LD. Neuroendocrine pharmacology of serotonergic (5-HT) neurons. Annu Rev Pharmacol Toxicol 1991; 31: 289-320
    • (1991) Annu Rev Pharmacol Toxicol , vol.31 , pp. 289-320
    • Van De Kar, L.D.1
  • 119
    • 0022366545 scopus 로고
    • Neurotransmitter regulation of anterior pituitary hormones
    • Tuomisto J, Mannisto P. Neurotransmitter regulation of anterior pituitary hormones. Pharmacol Rev 1985; 37: 249-332
    • (1985) Pharmacol Rev , vol.37 , pp. 249-332
    • Tuomisto, J.1    Mannisto, P.2
  • 120
    • 0026826439 scopus 로고
    • 3 receptors in the mediation of the prolactin response to serotonin and 5-hydroxytryptophan
    • 3 receptors in the mediation of the prolactin response to serotonin and 5-hydroxytryptophan. Neuroendocrinology 1992; 55: 336-43
    • (1992) Neuroendocrinology , vol.55 , pp. 336-343
    • Jorgensen, H.1    Knigge, V.2    Warberg, J.3
  • 121
    • 0026754156 scopus 로고
    • Endocrine and receptor pharmacology of serotonergic anxiolytics, antipsychotics and antidepressants
    • Levy AD, Van de Kar LD. Endocrine and receptor pharmacology of serotonergic anxiolytics, antipsychotics and antidepressants. Life Sci 1992; 51: 83-94
    • (1992) Life Sci , vol.51 , pp. 83-94
    • Levy, A.D.1    Van De Kar, L.D.2
  • 124
    • 0025173575 scopus 로고
    • Behavioral evidence for functional interactions between 5-HT receptor subtypes in rats and mice
    • Berendsen HHG, Broekkamp CLE. Behavioral evidence for functional interactions between 5-HT receptor subtypes in rats and mice. Br J Pharmacol 1990; 101: 667-73
    • (1990) Br J Pharmacol , vol.101 , pp. 667-673
    • Berendsen, H.H.G.1    Broekkamp, C.L.E.2
  • 126
    • 0025098771 scopus 로고
    • 8-OH-DPAT and buspirone analogs inhibit the ketanserin-sensitive quipazine-induced head shake responses in rats
    • Yocca FD, Wright RN, Margraf RR, et al. 8-OH-DPAT and buspirone analogs inhibit the ketanserin-sensitive quipazine-induced head shake responses in rats. Pharmacol Biochem Behav 1990; 35: 1-4
    • (1990) Pharmacol Biochem Behav , vol.35 , pp. 1-4
    • Yocca, F.D.1    Wright, R.N.2    Margraf, R.R.3
  • 127
    • 0028222644 scopus 로고
    • Effect of pindolol on the L-5-HTP-induced increase in plasma prolaclin and cortisol concentrations in man
    • Meltzer HY, Maes M. Effect of pindolol on the L-5-HTP-induced increase in plasma prolaclin and cortisol concentrations in man. Psychopharmacology 1994; 114: 635-43
    • (1994) Psychopharmacology , vol.114 , pp. 635-643
    • Meltzer, H.Y.1    Maes, M.2
  • 128
    • 0002967429 scopus 로고
    • Novel pharmacological approaches to the treatment of depression
    • Bloom FE, Kupfer DJ, editors. New York: Raven Press Ltd.
    • Murphy DL, Mitchell PB, Potter WZ. Novel pharmacological approaches to the treatment of depression. In: Bloom FE, Kupfer DJ, editors. Psychopharmacologv: the fourth generation of progress. New York: Raven Press Ltd., 1995: 1143-53
    • (1995) Psychopharmacologv: The Fourth Generation of Progress , pp. 1143-1153
    • Murphy, D.L.1    Mitchell, P.B.2    Potter, W.Z.3
  • 129
    • 0025064969 scopus 로고
    • Nefazodone: Preclinical pharmacology of a new antidepressant
    • Eison AS, Eison MS, Torrente JR, et al. Nefazodone: preclinical pharmacology of a new antidepressant. Psychopharmacol Bull 1990; 26: 311-5
    • (1990) Psychopharmacol Bull , vol.26 , pp. 311-315
    • Eison, A.S.1    Eison, M.S.2    Torrente, J.R.3
  • 130
    • 0024472651 scopus 로고
    • Selective 5-hydroxytryptamine: Antagonists have antidepressant-ike effects on differential-reinforcement-of-low-rate 72-second schedule
    • Marek GJ, Li AA, Seiden LS. Selective 5-hydroxytryptamine: antagonists have antidepressant-ike effects on differential-reinforcement-of-low-rate 72-second schedule. J Pharmacol Exp Ther 1984; 250: 52-9
    • (1984) J Pharmacol Exp Ther , vol.250 , pp. 52-59
    • Marek, G.J.1    Li, A.A.2    Seiden, L.S.3
  • 132
    • 0022447405 scopus 로고
    • Thymostenic effects of ritanserin (R55667), a centrally acting serotonin S-2 receptor blocker
    • Reyntjens AJM, Gelders YG, Hoppenbrouwers LJA, et al. Thymostenic effects of ritanserin (R55667), a centrally acting serotonin S-2 receptor blocker. Drug Dev Res 1986; 8: 205-11
    • (1986) Drug Dev Res , vol.8 , pp. 205-211
    • Reyntjens, A.J.M.1    Gelders, Y.G.2    Hoppenbrouwers, L.J.A.3
  • 133
    • 0025924406 scopus 로고
    • 2 receptor antagonism in dysthymic disorder: A double-blind placebo-controlled study with ritanserin
    • 2 receptor antagonism in dysthymic disorder: a double-blind placebo-controlled study with ritanserin. Acta Psychiatr Scand 1991; 83: 244-8
    • (1991) Acta Psychiatr Scand , vol.83 , pp. 244-248
    • Bersani, G.1    Pozzi, F.2    Marini, S.3
  • 134
    • 0027763650 scopus 로고
    • Ritanserin, imipramine, and placebo in the treatment of dysthymic disorder
    • Bakish D, Lapierre YD, Weinstein R, et al. Ritanserin, imipramine, and placebo in the treatment of dysthymic disorder. J Clin Psychopharmacol 1993; 13: 409-14
    • (1993) J Clin Psychopharmacol , vol.13 , pp. 409-414
    • Bakish, D.1    Lapierre, Y.D.2    Weinstein, R.3
  • 135
    • 0029126505 scopus 로고
    • Comparison of the tolerability of bupropion, fluoxetine, imipramine, nefazodone, paroxetine, sertraline, and venlafaxine
    • Preskorn SH. Comparison of the tolerability of bupropion, fluoxetine, imipramine, nefazodone, paroxetine, sertraline, and venlafaxine. J Clin Psychiatry 1995; 56 Suppl. 6: 12-21
    • (1995) J Clin Psychiatry , vol.56 , Issue.6 SUPPL. , pp. 12-21
    • Preskorn, S.H.1
  • 136
    • 0029143275 scopus 로고
    • Response of anxiety and agitation symptoms during nefazodone treatment of major depression
    • Fawcett J, Marcus RN, Anton SF, et al. Response of anxiety and agitation symptoms during nefazodone treatment of major depression. J Clin Psychiatry 1995; 56 Suppl. 6: 37-42
    • (1995) J Clin Psychiatry , vol.56 , Issue.6 SUPPL. , pp. 37-42
    • Fawcett, J.1    Marcus, R.N.2    Anton, S.F.3
  • 137
    • 0024465324 scopus 로고
    • A comparison of nefazodone, imipramine, and placebo in patients with moderate to severe depression
    • Feighner JP, Pambakian R, Fowler RC, et al. A comparison of nefazodone, imipramine, and placebo in patients with moderate to severe depression. Psychopharmacol Bull 1989; 25: 219-21
    • (1989) Psychopharmacol Bull , vol.25 , pp. 219-221
    • Feighner, J.P.1    Pambakian, R.2    Fowler, R.C.3
  • 138
    • 0028360665 scopus 로고
    • Nefazodone and imipramine in major depression: A placebo-controlled trial
    • Rickels K, Schweizer E, Clary C, et al. Nefazodone and imipramine in major depression: a placebo-controlled trial. Br J Psychiatry 1994; 164: 802-5
    • (1994) Br J Psychiatry , vol.164 , pp. 802-805
    • Rickels, K.1    Schweizer, E.2    Clary, C.3
  • 139
    • 0027934211 scopus 로고
    • A double-blind comparison of nefazodone, imipramine, and placebo in major depression
    • Fontaine R, Ontiveros A, Elie R, et al. A double-blind comparison of nefazodone, imipramine, and placebo in major depression. J Clin Psychiatry 1994; 55: 234-41
    • (1994) J Clin Psychiatry , vol.55 , pp. 234-241
    • Fontaine, R.1    Ontiveros, A.2    Elie, R.3
  • 140
    • 0029150014 scopus 로고
    • A double-blind, placebo-controlled trial of two dose ranges of nefazodone in the treatment of depressed outpatients
    • Mendels J, Reimherr F, Marcus RN, et al. A double-blind, placebo-controlled trial of two dose ranges of nefazodone in the treatment of depressed outpatients. J Clin Psychiatry 1995; 56 Suppl. 6: 30-6
    • (1995) J Clin Psychiatry , vol.56 , Issue.6 SUPPL. , pp. 30-36
    • Mendels, J.1    Reimherr, F.2    Marcus, R.N.3
  • 141
    • 0029885576 scopus 로고    scopus 로고
    • Adrenoceptor and serotonin receptor function: Relevance to antidepressant mechanisms of action
    • Potter WZ. Adrenoceptor and serotonin receptor function: relevance to antidepressant mechanisms of action. J Clin Psychiatry 1996; 57 Suppl. 4: 4-8
    • (1996) J Clin Psychiatry , vol.57 , Issue.4 SUPPL. , pp. 4-8
    • Potter, W.Z.1
  • 142
    • 0030011182 scopus 로고    scopus 로고
    • How do antidepressants affect serotonin receptors? The role of serotonin receptors in the therapeutic and side effect profile of the SSRIs
    • Goodwin GM, Edin FR. How do antidepressants affect serotonin receptors? The role of serotonin receptors in the therapeutic and side effect profile of the SSRIs. J Clin Psychiatry 1996; 57 Suppl. 4: 9-13
    • (1996) J Clin Psychiatry , vol.57 , Issue.4 SUPPL. , pp. 9-13
    • Goodwin, G.M.1    Edin, F.R.2
  • 143
    • 0025082572 scopus 로고
    • Mirtazapine vs. amitriptyline vs. placebo in the treatment of major depressive disorder
    • Smith WT, Glaudin V, Panagides J, et al. Mirtazapine vs. amitriptyline vs. placebo in the treatment of major depressive disorder. Psychopharmacol Bull 1990; 20: 191-6
    • (1990) Psychopharmacol Bull , vol.20 , pp. 191-196
    • Smith, W.T.1    Glaudin, V.2    Panagides, J.3
  • 144
    • 0028798939 scopus 로고
    • A double-blind comparison of ORG 3770, amitriptyline, and placebo in major depression
    • Bremner JD. A double-blind comparison of ORG 3770, amitriptyline, and placebo in major depression. J Clin Psychiatry 1995; 56: 519-25
    • (1995) J Clin Psychiatry , vol.56 , pp. 519-525
    • Bremner, J.D.1
  • 145
    • 0027437017 scopus 로고
    • Selective abnormalities of prefrontal serotonergic receptors in schizophrenia
    • Laruelle M, Abi-Dargham A, Casanova MF, et al. Selective abnormalities of prefrontal serotonergic receptors in schizophrenia. Arch Gen Psychiatry 1993; 50: 810-8
    • (1993) Arch Gen Psychiatry , vol.50 , pp. 810-818
    • Laruelle, M.1    Abi-Dargham, A.2    Casanova, M.F.3
  • 147
    • 0025921604 scopus 로고
    • 2) receptor binding in the frontal cortex of schizophrenic patients
    • 2) receptor binding in the frontal cortex of schizophrenic patients. J Neural Transm 1991; 85: 19-29
    • (1991) J Neural Transm , vol.85 , pp. 19-29
    • Arora, R.C.1    Meltzer, H.2
  • 148
    • 0019505753 scopus 로고
    • Tritiated LSD binding in frontal cortex in schizophrenia
    • Whitaker PM, Crow TJ, Ferrier IN. Tritiated LSD binding in frontal cortex in schizophrenia. Arch Gen Psychiatry 1981; 38: 278-80
    • (1981) Arch Gen Psychiatry , vol.38 , pp. 278-280
    • Whitaker, P.M.1    Crow, T.J.2    Ferrier, I.N.3
  • 149
    • 84995266694 scopus 로고
    • Neurotransmitter receptors in brain in schizophrenia
    • Owen F, Cross AJ, Crow TJ, et al. Neurotransmitter receptors in brain in schizophrenia. Acta Psychiatr Scand 1981; 63: 20-8
    • (1981) Acta Psychiatr Scand , vol.63 , pp. 20-28
    • Owen, F.1    Cross, A.J.2    Crow, T.J.3
  • 150
    • 0027279038 scopus 로고
    • Serotonin uptake sites and serotonin receptors are altered in the limbic system of schizophrenics
    • Joyce JN, Shane A, Lexow N, et al. Serotonin uptake sites and serotonin receptors are altered in the limbic system of schizophrenics. Neuropsychopharmacology 1993; 8: 315-36
    • (1993) Neuropsychopharmacology , vol.8 , pp. 315-336
    • Joyce, J.N.1    Shane, A.2    Lexow, N.3
  • 151
    • 0020652913 scopus 로고
    • 2 receptors and their involvement in schizophrenia and neuroleptic drug action
    • 2 receptors and their involvement in schizophrenia and neuroleptic drug action. J Neural Transm 1984; 18 Suppl.: 273-7
    • (1984) J Neural Transm , vol.18 , Issue.SUPPL. , pp. 273-277
    • Reynolds, G.P.1    Rossor, M.N.2    Ivesen, L.L.3
  • 152
    • 0026048271 scopus 로고
    • The mCPP challenge test in schizophrenia: Hormonal and behavioral responses
    • Iqbal N, Asnis GM, Wetzler S, et al. The mCPP challenge test in schizophrenia: hormonal and behavioral responses. Biol Psychiatry 1991; 30: 770-8
    • (1991) Biol Psychiatry , vol.30 , pp. 770-778
    • Iqbal, N.1    Asnis, G.M.2    Wetzler, S.3
  • 153
    • 0027296447 scopus 로고
    • m-Chlorophenylpiperazine (MCPP) effects in neuroleptic-free schizophrenic patients
    • Krystal JH, Seibyl JP, Price LH, et al. m-Chlorophenylpiperazine (MCPP) effects in neuroleptic-free schizophrenic patients. Arch Gen Psychiatry 1993; 50: 624-35
    • (1993) Arch Gen Psychiatry , vol.50 , pp. 624-635
    • Krystal, J.H.1    Seibyl, J.P.2    Price, L.H.3
  • 155
    • 0027378214 scopus 로고
    • Clozapine attenuates meta-chlorophenylpiperazine (mCPP)-induced plasma cortisol increases in schizophrenia
    • Breier A, Kirkpatrick B, Buchanan RW. Clozapine attenuates meta-chlorophenylpiperazine (mCPP)-induced plasma cortisol increases in schizophrenia. Biol Psychiatry 1993; 34: 492-4
    • (1993) Biol Psychiatry , vol.34 , pp. 492-494
    • Breier, A.1    Kirkpatrick, B.2    Buchanan, R.W.3
  • 156
    • 0027254316 scopus 로고
    • Haloperidol and clozapine treatment and their effect on m-chlorophenylpiperazine-mediated responses in schizophrenia: Implications for the mechanism of action of clozapine
    • Kahn RS, Siever L, Davidson M, et al. Haloperidol and clozapine treatment and their effect on m-chlorophenylpiperazine-mediated responses in schizophrenia: implications for the mechanism of action of clozapine. Psychopharmacology 1993; 112: S90-4
    • (1993) Psychopharmacology , vol.112
    • Kahn, R.S.1    Siever, L.2    Davidson, M.3
  • 157
    • 0001792366 scopus 로고
    • The role of serotonin in schizophrenia
    • Bloom FE, Kupfer DJ, editors. New York: Raven Press, Ltd.
    • Roth BL, Meltzer HY. The role of serotonin in schizophrenia. In: Bloom FE, Kupfer DJ, editors. Psychopharmacology: the fourth generation of progress. New York: Raven Press, Ltd., 1995: 1215-27
    • (1995) Psychopharmacology: the Fourth Generation of Progress , pp. 1215-1227
    • Roth, B.L.1    Meltzer, H.Y.2
  • 158
    • 0023215296 scopus 로고
    • Implications of normal brain development for the pathogenesis of schizophrenia
    • Weinberger DR. Implications of normal brain development for the pathogenesis of schizophrenia. Arch Gen Psychiatry 1987; 44: 660-9
    • (1987) Arch Gen Psychiatry , vol.44 , pp. 660-669
    • Weinberger, D.R.1
  • 159
    • 0028978933 scopus 로고
    • 2A receptor antagonist, MDL 100,907, increases dopamine efflux in the prefrontal cortex of the rat
    • 2A receptor antagonist, MDL 100,907, increases dopamine efflux in the prefrontal cortex of the rat. Eur J Pharmacol 1995; 273: 273-9
    • (1995) Eur J Pharmacol , vol.273 , pp. 273-279
    • Schmidt, C.J.1    Fadayel, G.M.2
  • 161
    • 0025242104 scopus 로고
    • The effect of serotonergic agents on haloperidol-induced catalepsy
    • Hicks PB. The effect of serotonergic agents on haloperidol-induced catalepsy. Life Sci 1990; 47: 1609-15
    • (1990) Life Sci , vol.47 , pp. 1609-1615
    • Hicks, P.B.1
  • 162
    • 0027527435 scopus 로고
    • Serotonergic involvement in haloperidol-induced catalepsy
    • Bethany S, Neal-Beliveau JN, Lucki J, et al. Serotonergic involvement in haloperidol-induced catalepsy. J Pharmacol Exp Ther 1993; 265: 207-17
    • (1993) J Pharmacol Exp Ther , vol.265 , pp. 207-217
    • Bethany, S.1    Neal-Beliveau, J.N.2    Lucki, J.3
  • 163
    • 0000149016 scopus 로고
    • 2-receptor antagonists can attenuate submaximal haloperidol-induced catalepsy in rats
    • 2-receptor antagonists can attenuate submaximal haloperidol-induced catalepsy in rats. Schizophr Res 1995; 15: 153-4
    • (1995) Schizophr Res , vol.15 , pp. 153-154
    • Bligh-Glover, W.1    Jaskiw, G.E.2    Vrtunski, B.3
  • 164
    • 0026610397 scopus 로고
    • 2 receptor antagonists reverse amphetamine-induced slowing of dopaminergic neurons by interfering with stimulated dopamine synthesis
    • 2 receptor antagonists reverse amphetamine-induced slowing of dopaminergic neurons by interfering with stimulated dopamine synthesis. J Pharmacol Exp Ther 1992; 260: 872-8
    • (1992) J Pharmacol Exp Ther , vol.260 , pp. 872-878
    • Sorensen, S.M.1    Humphreys, T.M.2    Taylor, V.L.3
  • 165
    • 0025214384 scopus 로고
    • Effects of amperozide, a putative antipsychotic drug, on rat midbrain dopamine neurons recorded in vivo
    • Grenhoff J, Che-Se T, Uqedo L, et al. Effects of amperozide, a putative antipsychotic drug, on rat midbrain dopamine neurons recorded in vivo. Pharmacol Toxicol 1990; 66 Suppl. 1: 29-33
    • (1990) Pharmacol Toxicol , vol.66 , Issue.1 SUPPL. , pp. 29-33
    • Grenhoff, J.1    Che-Se, T.2    Uqedo, L.3
  • 166
    • 0025183453 scopus 로고
    • 2 neurotransmission as revealed by selective antagonism of hyperactivity to tryptamine and apomorphine
    • 2 neurotransmission as revealed by selective antagonism of hyperactivity to tryptamine and apomorphine. J Pharmacol Exp Ther 1990; 254: 945-51
    • (1990) J Pharmacol Exp Ther , vol.254 , pp. 945-951
    • Awouters, F.H.L.1    Niemegeers, C.J.E.2    Megens, A.A.H.P.3
  • 167
    • 0026613672 scopus 로고
    • 2 receptors exert a state dependent regulation of dopaminergic function: Studies with MDL 100,907 and the amphetamine analogue, 3,4-methylenedioxymethamphetamine
    • 2 receptors exert a state dependent regulation of dopaminergic function: studies with MDL 100,907 and the amphetamine analogue, 3,4-methylenedioxymethamphetamine. Eur J Pharmacol 1992; 223: 65-74
    • (1992) Eur J Pharmacol , vol.223 , pp. 65-74
    • Schmidt, C.J.1    Fadayel, G.M.2    Sullivan, C.K.3
  • 168
    • 0029988896 scopus 로고    scopus 로고
    • Serotonin-dopamine interaction and its relevance to schizophrenia
    • Kapur S, Remington G. Serotonin-dopamine interaction and its relevance to schizophrenia. Am J Psychiatry 1996; 153: 466-76
    • (1996) Am J Psychiatry , vol.153 , pp. 466-476
    • Kapur, S.1    Remington, G.2
  • 170
    • 0025239750 scopus 로고
    • Acute effects of typical and atypical antipsychotic drugs on the release of dopamine from prefrontal cortex, nucleus accumbens, and striatum of the rat: An in vivo microdialysis study
    • Moghaddam B, Bunney BS. Acute effects of typical and atypical antipsychotic drugs on the release of dopamine from prefrontal cortex, nucleus accumbens, and striatum of the rat: an in vivo microdialysis study. J Neurochem 1990; 54: 1755-60
    • (1990) J Neurochem , vol.54 , pp. 1755-1760
    • Moghaddam, B.1    Bunney, B.S.2
  • 171
    • 0027972670 scopus 로고
    • Preferential activation of dopamine overflow in prefrontal cortex produced by chronic clozapine treatment
    • Youngren KD, Moghaddam B, Bunney BS, et al. Preferential activation of dopamine overflow in prefrontal cortex produced by chronic clozapine treatment. Neurosci Lett 1994; 165: 41-4
    • (1994) Neurosci Lett , vol.165 , pp. 41-44
    • Youngren, K.D.1    Moghaddam, B.2    Bunney, B.S.3
  • 172
    • 0024468417 scopus 로고
    • Clinical studies on the mechanism of action of clozapine: The dopamine-serotonin hypothesis of schizophrenia
    • Meltzer HY. Clinical studies on the mechanism of action of clozapine: the dopamine-serotonin hypothesis of schizophrenia. Psychopharmacology 1989; 99: S18-27
    • (1989) Psychopharmacology , vol.99
    • Meltzer, H.Y.1
  • 174
    • 0023783753 scopus 로고
    • Schizophrenia and the frontal lobe
    • Weinberger DR. Schizophrenia and the frontal lobe. Trends Neurosci 1988; 11: 367-70
    • (1988) Trends Neurosci , vol.11 , pp. 367-370
    • Weinberger, D.R.1
  • 175
    • 0026452427 scopus 로고
    • Negative symptoms and hypofrontality in chronic schizophrenia
    • Wolkin A, Sanfilipo M, Wolf AP, et al. Negative symptoms and hypofrontality in chronic schizophrenia. Arch Gen Psychiatry 1992; 49: 959-65
    • (1992) Arch Gen Psychiatry , vol.49 , pp. 959-965
    • Wolkin, A.1    Sanfilipo, M.2    Wolf, A.P.3
  • 176
    • 0026611392 scopus 로고
    • The regulation of subcortical dopamine systems by the prefrontal cortex: Interaction of central dopamine systems and the pathogenesis of schizophrenia
    • Deutch AT. The regulation of subcortical dopamine systems by the prefrontal cortex: interaction of central dopamine systems and the pathogenesis of schizophrenia. J Neural Transm 1992; 36 Suppl.: 61-89
    • (1992) J Neural Transm , vol.36 , Issue.SUPPL. , pp. 61-89
    • Deutch, A.T.1
  • 177
    • 0019190758 scopus 로고
    • Effect of lesion of cortical dopamine terminals on subcortical dopamine receptors in rats
    • Pycock CJ, Kerwin RW, Carter CJ. Effect of lesion of cortical dopamine terminals on subcortical dopamine receptors in rats. Nature 1980; 286: 74-7
    • (1980) Nature , vol.286 , pp. 74-77
    • Pycock, C.J.1    Kerwin, R.W.2    Carter, C.J.3
  • 178
    • 0023616461 scopus 로고
    • Lesions of dopamine neurons in the medial prefrontal cortex: Effects on self administration of amphetamine and dopamine synthesis in the brain of the rat
    • Leccese AP, Lyness WH. Lesions of dopamine neurons in the medial prefrontal cortex: effects on self administration of amphetamine and dopamine synthesis in the brain of the rat. Neuropharmacology 1987; 26: 1303-8
    • (1987) Neuropharmacology , vol.26 , pp. 1303-1308
    • Leccese, A.P.1    Lyness, W.H.2
  • 179
    • 0024239696 scopus 로고
    • Effects of mesocortical dopaminergic lesions upon subcortical dopaminergic function
    • Haroutunian V, Knott P, Davis KL. Effects of mesocortical dopaminergic lesions upon subcortical dopaminergic function. Psychopharmacol Bull 1988; 24: 341-4
    • (1988) Psychopharmacol Bull , vol.24 , pp. 341-344
    • Haroutunian, V.1    Knott, P.2    Davis, K.L.3
  • 180
    • 0025286232 scopus 로고
    • Prefrontal cortical dopamine depletion enhances the responsiveness of mesolimbic dopamine neurons to stress
    • Deutch AY, Clark WA, Roth RH. Prefrontal cortical dopamine depletion enhances the responsiveness of mesolimbic dopamine neurons to stress. Brain Res 1990; 521: 311-5
    • (1990) Brain Res , vol.521 , pp. 311-315
    • Deutch, A.Y.1    Clark, W.A.2    Roth, R.H.3
  • 181
    • 0026763542 scopus 로고
    • Effects of 6-hydroxydopamine lesions of the prefrontal cortex on tyrosine hydroxylase activity in mesolimbic and nigrostriatal dopamine systems
    • Rosin DL, Clark WA, Goldstein M, et al. Effects of 6-hydroxydopamine lesions of the prefrontal cortex on tyrosine hydroxylase activity in mesolimbic and nigrostriatal dopamine systems. Neuroscience 1992; 48: 8319
    • (1992) Neuroscience , vol.48 , pp. 8319
    • Rosin, D.L.1    Clark, W.A.2    Goldstein, M.3
  • 182
    • 0027340586 scopus 로고
    • 2 receptor antagonist MDL 100,907 as a putative atypical antipsychotic: Behavioral, electrophysiological and neurochemical studies
    • 2 receptor antagonist MDL 100,907 as a putative atypical antipsychotic: behavioral, electrophysiological and neurochemical studies. J Pharmacol Exp Ther 1993; 266: 684-91
    • (1993) J Pharmacol Exp Ther , vol.266 , pp. 684-691
    • Sorensen, S.M.1    Kehne, J.H.2    Fadayel, G.M.3
  • 183
    • 0015742027 scopus 로고
    • Dopaminergic neurons: Effect of antipsychotic drugs and amphetamine on single cell activity
    • Bunney BS, Walter JR, Roth RH, et al. Dopaminergic neurons: effect of antipsychotic drugs and amphetamine on single cell activity. J Pharmacol Exp Ther 1973; 185: 560-71
    • (1973) J Pharmacol Exp Ther , vol.185 , pp. 560-571
    • Bunney, B.S.1    Walter, J.R.2    Roth, R.H.3
  • 184
    • 0024318577 scopus 로고
    • Effects of ICI 169,369, a selective serotonin antagonist, in electrophysiological tests predictive of antipsychotic activity
    • Goldstein JM, Litwin LC, Sutton EB, et al. Effects of ICI 169,369, a selective serotonin antagonist, in electrophysiological tests predictive of antipsychotic activity. J Pharmacol Exp Ther 1989; 249: 673-80
    • (1989) J Pharmacol Exp Ther , vol.249 , pp. 673-680
    • Goldstein, J.M.1    Litwin, L.C.2    Sutton, E.B.3
  • 185
    • 0029873266 scopus 로고    scopus 로고
    • Association between schizophrenia and T102C polymorphism of the 5 hydroxytryptamine type 2a-receptor gene
    • Williams J, Spurlock G, McGuffin P, et al. Association between schizophrenia and T102C polymorphism of the 5 hydroxytryptamine type 2a-receptor gene. Lancet 1996; 347: 1294-6
    • (1996) Lancet , vol.347 , pp. 1294-1296
    • Williams, J.1    Spurlock, G.2    McGuffin, P.3
  • 186
    • 0021943587 scopus 로고
    • Effect of serotonin antagonism in schizophrenia: A pilot study with setoperone
    • Ceulemans DLS, Gelders YG, Hoppenbrouwers JA, et al. Effect of serotonin antagonism in schizophrenia: a pilot study with setoperone. Psychopharmacology 1985; 85: 329-32
    • (1985) Psychopharmacology , vol.85 , pp. 329-332
    • Ceulemans, D.L.S.1    Gelders, Y.G.2    Hoppenbrouwers, J.A.3
  • 187
    • 0027490544 scopus 로고
    • 2/1C antagonist, and negative symptoms in schizophrenia. A placebo-controlled double-blind trial
    • 2/1C antagonist, and negative symptoms in schizophrenia. A placebo-controlled double-blind trial. Br J Psychiatry 1993; 163: 451-5
    • (1993) Br J Psychiatry , vol.163 , pp. 451-455
    • Duinkerke, S.J.1    Botter, P.A.2    Jansen, A.A.I.3
  • 188
    • 0025572228 scopus 로고
    • 2 antagonist ritanserin in neuroleptic-induced parkinsonism: A double-blind comparison with orphenadrine and placebo
    • 2 antagonist ritanserin in neuroleptic-induced parkinsonism: a double-blind comparison with orphenadrine and placebo. Clin Neuropharmacol 1990; 13: 500-6
    • (1990) Clin Neuropharmacol , vol.13 , pp. 500-506
    • Bersani, G.1    Grispini, A.2    Marini, A.3
  • 190
    • 0026547969 scopus 로고
    • The effect of ritanserin on treatment-resistant neuroleptic induced akathisia: Case reports
    • Miller CH, Hummer M, Pycha K, et al. The effect of ritanserin on treatment-resistant neuroleptic induced akathisia: case reports. Prog Neuro-Psychopharmacol Biol Psychiatry 1992; 16: 247-51
    • (1992) Prog Neuro-Psychopharmacol Biol Psychiatry , vol.16 , pp. 247-251
    • Miller, C.H.1    Hummer, M.2    Pycha, K.3
  • 192
    • 0028358082 scopus 로고
    • An open clinical and biochemical study of ritanserin in acute patients with schizophrenia
    • Wiesel F, Nordstrom AL, Farde L, et al. An open clinical and biochemical study of ritanserin in acute patients with schizophrenia. Psychopharmacology 1994; 114: 31-8
    • (1994) Psychopharmacology , vol.114 , pp. 31-38
    • Wiesel, F.1    Nordstrom, A.L.2    Farde, L.3
  • 193
    • 0023812652 scopus 로고
    • Clozapine for the treatment-resistant schizophrenic: A douhle-blind comparison with chlorpromazine
    • Kane J, Honigfeld G, Singer J, et al. Clozapine for the treatment-resistant schizophrenic: a douhle-blind comparison with chlorpromazine. Arch Gen Psychiatry 1988; 45: 789-96
    • (1988) Arch Gen Psychiatry , vol.45 , pp. 789-796
    • Kane, J.1    Honigfeld, G.2    Singer, J.3
  • 194
    • 0026796022 scopus 로고
    • Treatment of the neuroleptic non-responsive schizophrenic patients
    • Meltzer HY. Treatment of the neuroleptic non-responsive schizophrenic patients. Schiz Bull 1992; 18: 515-42
    • (1992) Schiz Bull , vol.18 , pp. 515-542
    • Meltzer, H.Y.1
  • 195
    • 0024425468 scopus 로고
    • R-associated granulocytopenia: A review of the situation
    • R-associated granulocytopenia: a review of the situation. Psychopharmacology 1989; 99 Suppl.: S118-21
    • (1989) Psychopharmacology , vol.99 , Issue.SUPPL.
    • Krupp, P.1    Barnes, P.2
  • 196
    • 0025042383 scopus 로고
    • 3 receptors in the cerebral cortex and superior cervical ganglion of the rat
    • 3 receptors in the cerebral cortex and superior cervical ganglion of the rat. Eur J Pharmacol 1990; 182: 465-72
    • (1990) Eur J Pharmacol , vol.182 , pp. 465-472
    • Watling, K.J.1    Beer, M.S.2    Stanton, J.A.3
  • 197
    • 0023853769 scopus 로고
    • 2 dopamine receptor occupancy in schizophrenic patients treated with antipsychotic drugs
    • 2 dopamine receptor occupancy in schizophrenic patients treated with antipsychotic drugs. Arch Gen Psychiatry 1988; 45: 71-6
    • (1988) Arch Gen Psychiatry , vol.45 , pp. 71-76
    • Farde, L.1    Wiesel, F.A.2    Halldin, C.3
  • 198
    • 0026427253 scopus 로고
    • 4 receptor gene with high affinity for the antipsychotic clozapine
    • 4 receptor gene with high affinity for the antipsychotic clozapine. Nature 1991; 350: 614-9
    • (1991) Nature , vol.350 , pp. 614-619
    • Van Tol, H.H.M.1    Bunzow, J.R.2    Guan, H.C.3
  • 199
    • 0019174607 scopus 로고
    • Relationship of neuropleptic drug effects at brain dopamine, serotonin, α-adrenergic, and histamine receptors to clinical potency
    • Peroutka SJ, Snyder S. Relationship of neuropleptic drug effects at brain dopamine, serotonin, α-adrenergic, and histamine receptors to clinical potency. Am J Psychiatry 1980; 137: 1518-22
    • (1980) Am J Psychiatry , vol.137 , pp. 1518-1522
    • Peroutka, S.J.1    Snyder, S.2
  • 200
    • 0021177284 scopus 로고
    • Antagonism by neuroleptics of neurotransmitter receptors of normal human brain in vitro
    • Richelson E, Nelson A. Antagonism by neuroleptics of neurotransmitter receptors of normal human brain in vitro. Eur J Pharmacol 1984; 103: 197-214
    • (1984) Eur J Pharmacol , vol.103 , pp. 197-214
    • Richelson, E.1    Nelson, A.2
  • 201
    • 0026427253 scopus 로고
    • 4 receptor gene with high affinity for the antipsychotic clozapine
    • 4 receptor gene with high affinity for the antipsychotic clozapine. Nature 1991; 350: 614-9
    • (1991) Nature , vol.350 , pp. 614-619
    • Van Toll, H.H.M.1    Bunzow, J.R.2    Guan, H.C.3
  • 202
    • 0028991822 scopus 로고
    • 2 receptor occupancy in relation to clozapine serum concentration: A PET study of schizophrenic patients
    • 2 receptor occupancy in relation to clozapine serum concentration: a PET study of schizophrenic patients. Am J Psychiatry 1995; 152: 1444-9
    • (1995) Am J Psychiatry , vol.152 , pp. 1444-1449
    • Nordström, A.L.1    Farde, L.2    Nyberg, S.3
  • 203
    • 0026718710 scopus 로고
    • 2 dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine
    • 2 dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine. Arch Gen Psychiatry 1992; 49: 538-44
    • (1992) Arch Gen Psychiatry , vol.49 , pp. 538-544
    • Farde, L.1    Nordstrom, A.L.2    Wiesel, F.A.3
  • 204
    • 0023853769 scopus 로고
    • Central D-2 dopamine receptor occupancy in schizophrenic patients treated with anti-psychotic drugs
    • Farde L, Wiesel FA, Halldin C, et al. Central D-2 dopamine receptor occupancy in schizophrenic patients treated with anti-psychotic drugs. Arch Gen Psychiatry 1988; 45: 71-6
    • (1988) Arch Gen Psychiatry , vol.45 , pp. 71-76
    • Farde, L.1    Wiesel, F.A.2    Halldin, C.3
  • 205
    • 0024430178 scopus 로고
    • 2-dopamine receptor occupancy during treatment with conventional and atypical neuroleptics
    • 2-dopamine receptor occupancy during treatment with conventional and atypical neuroleptics. Psychopharmacology 1989, 99: S28-31
    • (1989) Psychopharmacology , vol.99
    • Farde, L.1    Wiesel, L.A.2    Nordstrom, A.L.3
  • 206
  • 207
    • 0027341623 scopus 로고
    • 2 dopamine receptor occupancy in the living human brain. A PET study with risperidone
    • 2 dopamine receptor occupancy in the living human brain. A PET study with risperidone. Psychopharmacology 1993; 110: 265-72
    • (1993) Psychopharmacology , vol.110 , pp. 265-272
    • Nyberg, S.1    Farade, L.2    Eriksson, L.3
  • 208
    • 0029026941 scopus 로고
    • 2 dopamine receptor occupancy of risperidone and its relationship to extra-pyramidal symptoms: A PET study
    • 2 dopamine receptor occupancy of risperidone and its relationship to extra-pyramidal symptoms: a PET study. Life Sci 1995; 57: PL 103-7
    • (1995) Life Sci , vol.57
    • Kapur, S.1    Remington, G.2    Zipursky, R.B.3
  • 210
    • 0345609188 scopus 로고
    • 2 receptors and antipsychotic drugs studied with PET in schizophrenia: Preliminary results
    • 2 receptors and antipsychotic drugs studied with PET in schizophrenia: preliminary results [abstract]. Anales de Psiquiatria 1992; 8 Suppl. 1: 9
    • (1992) Anales de Psiquiatria , vol.8 , Issue.1 SUPPL. , pp. 9
    • Trichard, C.1    Paillere-Martinot, M.L.2    Monfort, J.C.3
  • 211
    • 0029658331 scopus 로고    scopus 로고
    • 2 antagonism and EPS benefits: Is there a causal connection?
    • 2 antagonism and EPS benefits: is there a causal connection? Psychopharmacology 1996; 124: 35-9
    • (1996) Psychopharmacology , vol.124 , pp. 35-39
    • Kapur, S.1
  • 213
  • 214
    • 0026550602 scopus 로고
    • Risperidone versus haloperidol in the treatment of chronic schizophrenic inpatients: A multicentre double-blind comparative study
    • Claus A, Bollen J, De Cuyper H, et al. Risperidone versus haloperidol in the treatment of chronic schizophrenic inpatients: a multicentre double-blind comparative study. Acta Psychiatr Scand 1992; 85: 295-305
    • (1992) Acta Psychiatr Scand , vol.85 , pp. 295-305
    • Claus, A.1    Bollen, J.2    De Cuyper, H.3
  • 215
    • 0026444131 scopus 로고
    • Risperidone in the treatment of chronic schizophrenic patients: An international double-blind parallel-group study versus haloperidol
    • Muller-Spahn R, for the International Risperidone Research Group. Risperidone in the treatment of chronic schizophrenic patients: an international double-blind parallel-group study versus haloperidol. Clin Neuropharmacol 1992; 15 Suppl. 1, Pt A: 90A-1A
    • (1992) Clin Neuropharmacol , vol.15 , Issue.1 SUPPL. AND PART A
    • Muller-Spahn, R.1
  • 216
    • 0027475985 scopus 로고
    • A Canadian multicenter placebo-controlled study of fixed doses of risperidone and haloperidol in the treatment ot chronic schizophrenic patients
    • Chouinard G, Jones B, Remington G, et al. A Canadian multicenter placebo-controlled study of fixed doses of risperidone and haloperidol in the treatment ot chronic schizophrenic patients. J Clin Psychopharmacol 1993; 13: 25-40
    • (1993) J Clin Psychopharmacol , vol.13 , pp. 25-40
    • Chouinard, G.1    Jones, B.2    Remington, G.3
  • 217
    • 0028342655 scopus 로고
    • Risperidone in the treatment of schizophrenia
    • Marder SR, Meibach RC. Risperidone in the treatment of schizophrenia. Am J Psychiatry 1994; 151: 825-35
    • (1994) Am J Psychiatry , vol.151 , pp. 825-835
    • Marder, S.R.1    Meibach, R.C.2
  • 218
    • 0027146306 scopus 로고
    • Risperidone versus perphenazine in the treatment of chronic schizophrenic patients with acute exacerbations
    • Hoyberg OJ, Fensbo C, Remvig J, et al. Risperidone versus perphenazine in the treatment of chronic schizophrenic patients with acute exacerbations. Acta Psychiatr Scand 1993; 88: 395-402
    • (1993) Acta Psychiatr Scand , vol.88 , pp. 395-402
    • Hoyberg, O.J.1    Fensbo, C.2    Remvig, J.3
  • 219
    • 0028855094 scopus 로고
    • Randomized, double-blind, controlled trial of risperidone versus clozapine in patients with chronic schizophrenia
    • Klieser E, Lehman E, Kinzler E, et al. Randomized, double-blind, controlled trial of risperidone versus clozapine in patients with chronic schizophrenia. J Clin Psychopharmacol 1995; 15 Suppl. 1: 45S-51S
    • (1995) J Clin Psychopharmacol , vol.15 , Issue.1 SUPPL.
    • Klieser, E.1    Lehman, E.2    Kinzler, E.3
  • 220
    • 0024310652 scopus 로고
    • Melperone in the treatment of schizophrenia
    • Bjerkenstedt L. Melperone in the treatment of schizophrenia. Acta Psychiatr Scand 1989; 80 Suppl. 352: 35-9
    • (1989) Acta Psychiatr Scand , vol.80 , Issue.352 SUPPL. , pp. 35-39
    • Bjerkenstedt, L.1
  • 221
    • 0002459049 scopus 로고
    • Amperozide in the treatment of schizophrenic patients: A preliminary report
    • Meltzer HY, editor. New York: Raven Press
    • Bjork A, Bergman I, Gustavsson G. Amperozide in the treatment of schizophrenic patients: a preliminary report. In: Meltzer HY, editor. Novel atypical antipsychotic drugs. New York: Raven Press, 1992: 47-58
    • (1992) Novel Atypical Antipsychotic Drugs , pp. 47-58
    • Bjork, A.1    Bergman, I.2    Gustavsson, G.3
  • 222
    • 8244253496 scopus 로고
    • Amperozide and some other atypical compounds with antipsychotic effect
    • Meltzer HY, editor. New York: Raven Press
    • Christensson EG. Amperozide and some other atypical compounds with antipsychotic effect. In: Meltzer HY, editor. Novel atypical antipsychotic drugs. New York: Raven Press, 1992: 19-32
    • (1992) Novel Atypical Antipsychotic Drugs , pp. 19-32
    • Christensson, E.G.1
  • 223
    • 0029930337 scopus 로고    scopus 로고
    • Olanzapine verses placebo: Results of a double-blind, fixed-dose olazapine trial
    • Beasley CM, Sanger T, Satterlee W, et al. Olanzapine verses placebo: results of a double-blind, fixed-dose olazapine trial. Psychopharmacology 1996; 124: 159-67
    • (1996) Psychopharmacology , vol.124 , pp. 159-167
    • Beasley, C.M.1    Sanger, T.2    Satterlee, W.3
  • 224
    • 0026699928 scopus 로고
    • Zotepine in the treatment of schizophrenic patients with prevailingly negative symptoms: A double-blind trial vs. haloperidol
    • Barnas C, Stuppack CH, Miller C, et al. Zotepine in the treatment of schizophrenic patients with prevailingly negative symptoms: a double-blind trial vs. haloperidol. Int Clin Psychopharmacol 1992; 7: 23-7
    • (1992) Int Clin Psychopharmacol , vol.7 , pp. 23-27
    • Barnas, C.1    Stuppack, C.H.2    Miller, C.3
  • 225
    • 0029916389 scopus 로고    scopus 로고
    • A randomized, controlled, doseranging trial of sertindole in patients with schizophrenia
    • Van Kammen DP, McEvoy JP, Targum SD, et al. A randomized, controlled, doseranging trial of sertindole in patients with schizophrenia. Psychopharmacology 1996; 124: 168-75
    • (1996) Psychopharmacology , vol.124 , pp. 168-175
    • Van Kammen, D.P.1    McEvoy, J.P.2    Targum, S.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.