Further evidence that 5-HT-induced relaxation of pig pulmonary artery is mediated by endothelial 5-HT(2B) receptors

British Journal of Pharmacology

Volumn 130, Issue 3, 2000, Pages 692-698

  Glusa, E ^a   Pertz, H H ^b  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

5 HT; 5 HT(2B) receptor; BW 723C86; Endothelium dependent relaxation; Pig pulmonary artery; SB 204741

Indexed keywords

1 (1 METHYL 5 INDOLYL) 3 (3 METHYL 5 ISOTHIAZOLYL)UREA; 1 ISOPROPYL 6 METHYLERGOLINE 8 CARBOXYLIC ACID 2 HYDROXY 1 METHYLPROPYL ESTER; 1 [5 (2 THIENYLMETHOXY) 3 INDOLYL] 2 PROPANAMINE; 1,2,3,5 TETRAHYDRO 5 METHYL 1 (3 PYRIDYLCARBAMOYL)PYRROLO[2,3 F]INDOLE; AMITRIPTYLINE; AMOXAPINE; CHLORPROMAZINE; CHLORPROTHIXENE; FLUPHENAZINE; KETANSERIN; LOXAPINE; MESULERGINE; METERGOLINE; METHYSERGIDE; METITEPINE; MIANSERIN; PERPHENAZINE; PIZOTIFEN; PROSTAGLANDIN F2 ALPHA; RAUWOLSCINE; RITANSERIN; SEROTONIN; SEROTONIN 2B RECEPTOR; SPIPERONE; THIORIDAZINE; UNCLASSIFIED DRUG; YOHIMBINE;

ANIMAL TISSUE; ARTERY DILATATION; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG RECEPTOR BINDING; NONHUMAN; PRIORITY JOURNAL; PULMONARY ARTERY; SWINE;

EID: 0034068805     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703341     Document Type: Article

References (38)

1. ARUNLAKSHANA, O, & SCHILD, H.O. (1959). Some quantitative uses of drug antagonists. Br. J. Pharmacol. Chemother., 14, 48-58.
2. 2B) contractile receptor in the rat stomach fundus. J. Med. Chem., 39, 2773-2780.
3. 2B receptors. Behav. Brain Res., 73, 149 152.
4. 2 receptor subtypes: a family re-united? Trends Pharmacol. Sci., 16, 105-110.
5. 2B) in rat stomach fundus longitudinal muscle. Br. J. Pharmacol., 112, 323-331.
6. 2C receptors. Br. J. Pharmacol., 115, 622-628.
7. 7 receptor ligand, blocks serotonin-induced relaxation in canine coronary artery. J. Pharmacol. Exp. Ther., 277, 1560-1566.
8. 2B-like receptors mediate endothelium-dependent relaxation of rat jugular vein. Br. J. Pharmacol., 112, 477P.
9. 2B receptors of endothelium-dependent relaxation in rat jugular vein. Br. J. Pharmacol., 114, 400-404.
10. FURCHGOTT, R.F. (1972). The classification of adrenoceptors (adrenergic receptors). An evaluation from the standpoint of receptor theory. In Catecholamines, Handbook of Experimental Pharmacology, Vol. 33. eds. Blaschko, H. & Muscholl, E. pp. 283-335. Berlin, Heidelberg. New York: Springer.
11. 1C-like receptors. Naunyn-Schmiedeberg's Arch. Pharmacol., 347, 471-477.
12. GLUSA, E. & ROOS, A. (1996). Endothelial 5-HT receptors mediate relaxation of porcine pulmonary arteries in response to ergotamine and dihydroergotamine. Br. J. Pharmacol., 119, 330-334.
13. GRAYSON, K.L. & GUPTA, P. (1995). Preliminary characterization of an endothelial 5-HT receptor which mediates relaxation in a preparation of dog isolated vena cava. Br. J. Pharmacol., 116, 409P.
14. 1D subtype. Br. J. Pharmacol., 106, 703-709.
15. 1D receptor subtypes. Trends Pharmacol. Sci., 17, 103-105.
16. HOYER, D. (1989). 5-Hydroxytryptamine receptors and effector coupling mechanism in peripheral tissues. In The Peripheral Actions of 5-Hydroxytryptamine. ed. Fozard, J.R. 72-99. Oxford, New York, Tokyo: University Press.
17. HOYER, D., CLARKE, D.E., FOZARD, J.R., HARTIG, P.R., MARTIN, G.R., MYLECHARANE, E.J., SAXENA, P.R. & HUMPHREY, P.P.A. (1994). VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol. Rev., 46, 157-203.
18. 2B receptor agonist, causes hyperphagia and reduced grooming in rats. Neuropharmacology, 36, 233-239.
19. 6 serotonin receptor. J. Neurochem., 66, 46-57.
20. 7 receptors mediating direct relaxation in Cynomolgus monkey isolated jugular vein. Br. J. Pharmacol., 117, 926-930.
21. MARTIN, G.R. (1994). Vascular receptors for 5-hydroxytryptamine: distribution, function and classification. Pharmacol. Ther., 62, 283-324.
22. MARTIN, G.R., BROWNING, C. & GILES, H. (1993). Further characterization of an atypical 5-HT receptor mediating endothelium-dependent vasorelaxation. Br. J. Pharmacol., 110, 137P.
23. 7 receptors? Br. J. Pharmacol., 114, 383P.
24. MONSMA, F.J., SHEN, Y., WARD, R.P., HAMBLIN, M.W. & SIBLEY, D.R. (1993). Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. Mol. Pharmacol., 43, 320-327.
25. MORECROFT, I. & MACLEAN, M.R. (1998). 5-Hydroxytryptamine receptors mediating vasoconstriction and vasodilation in perinatal and adult rabbit small pulmonary arteries. Br. J. Pharmacol., 125, 69-78.
26. 2B receptors. Naunyn-Schmiedeberg's Arch. Pharmacol., 357, R30.
27. ROTH, B.L., GRAIGO, S.C., CHOUDHARY, M.S., ULUER, A., MONSMA, F.J., SHEN, Y., MELTZER, H.J. & SIBLEY, D.R. (1994). Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors. J. Pharmacol. Exp. Ther., 268, 1403-1410.
28. 1-like receptors: a time to bid goodbye. Trends Pharmacol. Sci., 19, 311-316.
29. SAXENA, P.R. & VILLALÓN, C.M. (1990). Cardiovascular effects of serotonin agonists and antagonists. J. Cardiovasc. Pharmacol., 15 (Suppl. 7), S17-S34.
30. 2B receptors: an early step in the generation of migraine headache? Eur. J. Neurosci., 8, 959-967.
31. 1D receptor subtype. J. Pharmacol. Exp. Ther., 252, 387-394.
32. 7 serotonin receptor subtype. J. Biol. Chem., 268, 18200-18204.
33. SUMNER, M.J. (1991). Characterization of the 5-HT receptor mediating endothelium-dependent relaxation in porcine vena cava. Br. J. Pharmacol, 102, 938-942.
34. 7 receptor subtype. Br. J. Pharmacol., 118, 1421-1428.
35. 7 receptor mediating smooth muscle relaxation in canine cerebral arteries. Br. J. Pharmacol., 127, 609-616.
36. 2B receptor. NeuroReport, 7, 1457-1460.
37. ULMER, C., SCHMUCK, K., KALKMAN, H.O. & LÜBBERT, H. (1995). Expression of serotonin receptor mRNAs in blood vessels. FEES Lett., 370, 215-221.
38. 2B receptor: evidence for species differences. J. Pharmacol. Exp. Ther., 276, 720-727.