Novel agonists of 5HT2c receptors. Synthesis and biological evaluation of substituted 2-(Indol-1-yl), 1-methylethylamines and 2-(Indeno[1,2- b]pyrrol-1-yl)-1-methylethylamines. Improved therapeutics for obsessive compulsive disorder

Journal of Medicinal Chemistry

Volumn 40, Issue 17, 1997, Pages 2762-2769

  Bos, M ^a   Jenck, F ^a   Martin, J R ^a   Moreau, J L ^a   Sleight, A J ^a   Wichmann, J ^a   Widmer, U ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

2 (5 FLUOROINDOL 1 YL) 1 METHYLETHYLAMINE FUMARATE; ETHYLAMINE; SEROTONIN 1C RECEPTOR; UNCLASSIFIED DRUG; LIGAND; SEROTONIN; SEROTONIN 2A RECEPTOR; SEROTONIN 2C RECEPTOR; SEROTONIN AGONIST; SEROTONIN RECEPTOR;

ANIMAL MODEL; ARTICLE; BINDING AFFINITY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; LIPOPHILICITY; NONHUMAN; OBSESSION; POSTSYNAPTIC MEMBRANE; PROTEIN DOMAIN; RECEPTOR AFFINITY; SEQUENCE HOMOLOGY; ANIMAL; CELL STRAIN 3T3; CHEMISTRY; DRUG EFFECT; FEMALE; HUMAN; MALE; METABOLISM; MOUSE; OBSESSIVE COMPULSIVE DISORDER; PENIS ERECTION; RAT; SYNTHESIS; THIRST;

3T3 CELLS; ANIMALS; ETHYLAMINES; FEMALE; HUMANS; LIGANDS; MALE; MICE; OBSESSIVE-COMPULSIVE DISORDER; PENILE ERECTION; RATS; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTOR, SEROTONIN, 5-HT2C; RECEPTORS, SEROTONIN; SEROTONIN; SEROTONIN AGONISTS; THIRST;

EID: 0030610606     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970030l     Document Type: Article

References (23)