Receptor subtype and density determine the coupling repertoire of the 5-HT2 receptor subfamily

Life Sciences

Volumn 59, Issue 13, 1996, Pages 1081-1095

  Lucaites, Virginia L ^a   Nelson, David L ^a   Wainscott, David B ^a   Baez, Melvyn ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

5 HT2; Adenylyl cyclase; G protein; Pertussis toxin; Receptor density

Indexed keywords

4 IODO 2,5 DIMETHOXYAMPHETAMINE; ADENYLATE CYCLASE; COMPLEMENTARY DNA; CYCLIC AMP; FORSKOLIN; GUANINE NUCLEOTIDE BINDING PROTEIN; INOSITOL 1,4,5 TRISPHOSPHATE; KETANSERIN; MESULERGINE; PERTUSSIS TOXIN; PHOSPHOLIPASE C; RADIOLIGAND; RECEPTOR SUBTYPE; SEROTONIN; SEROTONIN 1C RECEPTOR; SEROTONIN 2 RECEPTOR; SEROTONIN 2A RECEPTOR; SEROTONIN 2B RECEPTOR; SPIPERONE;

ANIMAL CELL; ARTICLE; CELL LINE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ANTAGONISM; GENE EXPRESSION; GENETIC TRANSFECTION; NONHUMAN; PHOSPHOINOSITIDE METABOLISM; RECEPTOR DENSITY; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0030599038     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/0024-3205(96)00423-7     Document Type: Article

References (32)

1. 1 J.D. KURSAR, D.L. NELSON, D.B. WAINSCOTT, M.L. COHEN and M. BAEZ, Mol. Pharmacol. 42 549-557 (1992)
2. 2 D.B. WAINSCOTT, M.L. COHEN, K.W. SCHENCK, J.E AUDIA, J.S. NISSEN, M. BAEZ, J.D. KURSAR, V.L. LUCAITES and D.L. NELSON, Mol. Pharmacol. 43 419-426 (1993).
3. 3 A. FARGIN, J.R. RAYMOND, J.W. REGAN, S. COTECCHIA, R.J. LEFKOWITZ and M.G. CARON, J. Biol. Chem. 264 14848-14852 (1989).
4. 4 L. YU, H. NGUYEN, H. LE, L.J. BLOEM, C. A. KOZAK, B.J. HOFFMAN, T.P. SNUTCH, H.A. LESTER, N. DAVIDSON and H. LUBBERT, Mol. Brain Res. 11 143-149 (1991).
5. 5. A.G. SALTZMAN, B. MORSE, M.M. WHITMAN, Y. IVANSHCHENKO, M. JAYE and S. FELDER, Biochem. Biophys. Res. Comm. 181 1469-1478 (1991).
6. 6. J. LIU, Y. CHEN, C.A. KOZAK and L. YU, Genomics. 11 231-234 (1991).
7. 7. B.W. GRINNELL, D.T. BERG, J. WALLS and B. YAN, Bio/tech. 5 1189-1192 (1987).
8. 8. M. WIGLER, A. PELLICER, S. SILVERSTEIN, R. AXEL, G. URLAUB and L. CHASIN, Proc. Natl. Acad. Sci. USA. 76 1373-1376 (1979).
9. 9. B.A. WHITE and F.C. BANCROFT, J. Biol. Chem. 257 8569-8572 (1982).
10. 10. M.J. BERRIDGE, R.M.C. DAWSON, C.P. DOWNES, J.P. HESLOP and R.F. IRVINE, J. Biochem. 212 473-482 (1983).
11. 11. D.D. SCHOEPP and B.G. JOHNSON, J. Neurochem. 53 1865-1870 (1989).
12. 12. M.M BRADFORD, Anal. Biochem. 7 248-254 (1976).
13. 13. C.M. STOSCHECK, Anal. Biochem. 184 111-116 (1990).
14. 14. A.G. GILMAN, Proc. Nat. Aca. Sci. USA. 67 305-310 (1970).
15. 15. S. SWILLENS, Trends Pharmacol. Sci. 13 430-434 (1992).
16. 16. R.A. LYON, K.H. DAVIS and M. TITELER, Mol. Pharmacol. 31 194-199 (1987).
17. 17 M.W. QUICK, M.I. SIMON, N. DAVIDSON, H.A. LESTER and A.A. ARAGAY, J. Biol. Chem. 269 30164-30172 (1994).
18. 18 M.A. GARNOVSKAYA, C.G. NEBIGIL, J.M. ARTHUR, R.F. SPURNEY and J.R. RAYMOND, Mol. Pharmacol. 48 230-237 (1995).
19. 19. C. DELPORTE, P. POLOCZEK, P. DE NEEF, P. VERTONGEN, E. CICCARELLI, M. SVOBODA, A. HERCHUELZ, J. WINAND AND P. ROBBERECHT. Mol. Cell. Endocrinol. 107 71-76 (1995).
20. 20. L. JOURNOT, D. SPENGLER, C. PANTALONI, A. DUMUIS, M. SEBBEN and J. BOCKAERT. Semin. Cell Biol. 5 263-272 (1994).
21. 21. S.J. HILL and D.A. KENDALL, Cell. Signal. 1 135-149 (1989).
22. 22 J.M. ZGOMBICK, L.A. BORDEN, T.L. COCHRAN, S.A. KUCHAREWICZ, R.A. WEINSHANK and T.A. BRANDCHEK, Mol. Pharmacol. 44 575-582 (1993).
23. 23 R.R. FRANKE, T.P. SAKMAR, R.M. GRAHAM and H.G. KHORANA, J. Biol. Chem. 267 14767-14774 (1992).
24. 24. K. OHYAMA, Y. YAMANO, S. CHAKI, T. KONDO and T. INAGAMI, Biochem. Biophys. Res. Comm. 189 677-683 (1992).
25. 25 A. FARGIN, K. YAMAMOTO, S. COTECCHIA, P.K. GOLDSMITH, A.M. SPIEGEL, E.G. LAPETINA, M.G. CARON and R.J. LEFKOWITZ, Cellular Signalling. 3 547-557 (1991).
26. 26 E.G. PERALTA, A. ASHKENAZI, J.W. WINSLOW, J. RAMACHANDRAN and D.J. CAPON, Nature. 334 434-437 (1988).
27. 27 K.A. BERG, W.P. CLARKE, C. SAILSTAD, A. SALTZMAN and S. MAAYANI, Mol. Pharmacol. 46 477-484 (1994).
28. 28 J.R. ARDEN, O. NAGATA, M.S. SHOCKLEY, M. PHILIP, J. LAMEH and W. SADEE, Biochem. Biophys. Res. Comm. 188 1111-1115 (1992).
29. 29 S. LEONHARDT, E. GOROSPE, B.J. HOFFMAN and M. TEITLER, Mol. Pharmacol. 42 328-335 (1992).
30. 30. K.A. YAGALOFF and P.R. HARTIG, J. Neurosci. 5 3178-3183 (1985).
31. 31 K.A. YAGALOFF, L. GUILLERMINA, T. VAN DYKE, A.J. LEVINE and P.R. HARTIG, Brain Res. 385 389-394 (1986).
32. 32. J.M. PALACIOS, R. MARKSTEIN and A. PAZOS, Brain Res. 380 151-154 (1986).