Anxiolytic-like actions of BW 723C86 in the rat Vogel conflict test are 5-HT(2B) receptor mediated

Neuropharmacology

Volumn 37, Issue 12, 1998, Pages 1603-1610

  Kennett, G A ^a,b   Trail, B ^a   Bright, F ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b Cerebrus ^*  (United Kingdom)

Author keywords

5 HT2B; Anxiety; BW 723C86; SB 206553; SB 215505

Indexed keywords

1 [5 (2 THIENYLMETHOXY) 3 INDOLYL] 2 PROPANAMINE; 1,2,3,5 TETRAHYDRO 5 METHYL 1 (3 PYRIDYLCARBAMOYL)PYRROLO[2,3 F]INDOLE; 6 CHLORO 5 METHYL 1 [[2 [(2 METHYL 3 PYRIDYL)OXY] 5 PYRIDYL]CARBAMOYL]INDOLINE; ALPRAZOLAM; BUSPIRONE; CHLORDIAZEPOXIDE; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; SB 215505; SEROTONIN 2B RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY NEUROSIS; ARTICLE; CONFLICT; CONTROLLED STUDY; HUMAN; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PUNISHMENT; RAT; SUBCUTANEOUS DRUG ADMINISTRATION; TRANQUILIZING ACTIVITY;

AMINOPYRIDINES; ANIMALS; ANTI-ANXIETY AGENTS; CHLORDIAZEPOXIDE; CONDITIONING, OPERANT; CONFLICT (PSYCHOLOGY); DOSE-RESPONSE RELATIONSHIP, DRUG; INDOLES; MALE; PIPERAZINES; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT2B; RECEPTOR, SEROTONIN, 5-HT2C; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; THIOPHENES;

EID: 0032403133     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(98)00115-4     Document Type: Article

References (28)

1. 2 receptor subtypes, a family reunited? Trends in Pharmacological Science. 16:1995;105-110.
2. 2B receptor in mouse gut cardiovascular system and brain. FEBS Letters. 391:1996;45-51.
3. 1B receptors in the anticonflict effect of mCPP in rats. Journal of Neural Transmission. 87:1992;87-96.
4. Deakin J.F.W., Graeff F.G. 5-HT and mechanisms of defence. Journal of Psychopharmacology. 5:1991;305-315.
5. 2B receptor protein in the rat central nervous system. Neuroscience. 76:1997;323-329.
6. Duxon M.S., Kennett G.A., Lightowler S., Blackburn T.P., Fone K.C.F. Activation of 5-HT2B receptors in the medial amydala causes anxiolysis in the social interaction test in the rat. Neuropharmacology. 36:1997;601-608.
7. 2B receptor mRNA in rat brain. British Journal of Pharmacology. 114:1995;369P.
8. 1A receptor antagonist. Behavioural Brain Research. 73:1996;337-353.
9. Foquet M., Hoyer D., Pardoe L.A., Parekh A., Kluxen F.W., Kalkman H.O., Stuhmer W., Lubbert H. Cloning and functional characterization of the rat stomach fundus serotonin receptor. EMBO Journal. 11:1992;3481-3487.
10. Griebel G. 5-Hydroxytryptamine-interacting drugs in animal models of anxiety disorders: more than 30 years of research. Pharmacology and Therapeutics. 65:1995;319-395.
11. 1C receptors and their therapeutic relevance. Current Opinions in investigative Drugs. 2:1993;317-362.
12. 2B receptor agonist, BW 723C86, on three rat models of anxiety. British Journal of Pharmacology. 117:1996;1443-1448.
13. 2B receptor antagonist with anxiolytic-like properties. British Journal of Pharmacology. 117:1996;427-434.
14. 2B receptor agonist causes hyperphagia and reduced grooming in rats. Neuropharmacology. 36:1997;233-239.
15. 2C receptor antagonist. Neuropharmacology. 36:1997;609-620.
16. 2B receptor antagonist in rats, British Journal of Pharmacology (in press).
17. 2F) from rat stomach fundus. Molecular Pharmacology. 42:1992;549-557.
18. 2-like receptor: expression in brain, heart and intestine. FEBS Letters. 312:1992;203-207.
19. Moller C., Bing O., Heilig M. C-fos expression in the amygdala: In vivo antisense modulation and role in anxiety. Cellular and Molecular Neurobiology. 14:1994;415-423.
20. 1A selective ligand: comparison with buspirone 8-OH-DPAT and diazepam. British Journal of Pharmacology. 99:1990;343-349.
21. Pesolt C., Treit D. The neuroanatomical specificity of the anxiolytic effects of intra-septal infusions of midazolam. Brain Research. 710:1996;161-168.
22. 2C receptors. Molecular Brain Research. 23:1994;163-178.
23. Scott S.K., Young A.W., Calder A.J., Hellawell D.J., Aggleton, Johnson M. Impaired auditory recognition of fear and anger following bilateral amygdala lesions. Nature. 385:1997;254-257.
24. Shibata S., Yamashita K., Yamamoto E., Ozaki T., Ueki S. Effects of benzodiazepine and GABA antagonists on anticonflict effects of antianxiety drugs injected into the rat amygdala in a water-lick suppression test. Psychopharmacology. 98:1989;38-44.
25. 2B serotonin receptor. FEBS Letters. 342:1994;85-90.
26. Treit D., Pesold C. Septal lesions inhibit fear reactions in two animal model of anxiolytic drug action. Physiology and Behavior. 47:1990;365-371.
27. Vogel J.R., Beer B., Clody D.E. A simple and reliable conflict procedure for testing antianxiety agents. Psychopharmacology. 100:1971;138-140.
28. Yadin E., Thomas E., Grishkat H.L., Strickland C.E. The role of the lateral septum in anxiolysis. Physiology and Behaviour. 53:1993;1077-1083.