BW 723C86, a 5-HT(2B) receptor agonist, causes hyperphagia and reduced grooming in rats

Neuropharmacology

Volumn 36, Issue 2, 1997, Pages 233-239

  Kennett, G A ^a   Ainsworth, K ^a   Trail, B ^a   Blackburn, T P ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

5 HT(2B) receptors; 5 HT(2C) receptors; behaviour; BW 723C86; feeding

Indexed keywords

(3 CHLOROPHENYL)PIPERAZINE; 1 [5 (2 THIENYLMETHOXY) 3 INDOLYL] 2 PROPANAMINE; 1,2,3,5 TETRAHYDRO 5 METHYL 1 (3 PYRIDYLCARBAMOYL)PYRROLO[2,3 F]INDOLE; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; SEROTONIN 1A ANTAGONIST; SEROTONIN 1C RECEPTOR; SEROTONIN 2B RECEPTOR; SEROTONIN 2B RECEPTOR ANTAGONIST; SEROTONIN 2C ANTAGONIST; SEROTONIN AGONIST; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG ANTAGONISM; FEEDING BEHAVIOR; FOOD INTAKE; GROOMING; HYPERPHAGIA; HYPERTHERMIA; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; LOCOMOTION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; OROFACIAL DYSKINESIA; PENIS ERECTION; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; EATING; GROOMING; HUMANS; HYPERPHAGIA; INDOLES; INJECTIONS, INTRAVENTRICULAR; INJECTIONS, SUBCUTANEOUS; MALE; PIPERAZINES; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; THIOPHENES;

EID: 0030965463     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(96)00171-2     Document Type: Article

References (29)

1. 1 receptor subtype coupled to the inhibition of adenylate cyclase. Proc. natn. Acad. Sci. U.S.A. 90:1993;408-412.
2. 2B receptors. Behav. Brain Res. 73:1996;149-152.
3. 2 receptor subtypes, a family reunited? Trends Pharmacol. Sci. 16:1995;105-110.
4. 2B) in the rat stomach fundus longitudinal muscle. Br. J. Pharmacol. 112:1994;323-331.
5. 1C receptors in drug-induced penile erections in rats. Psychopharmacology. 101:1990;57-61.
6. Blundell J. Pharmacological approaches to appetite suppression. Trends Pharmacol. Sci. 12:1991;147-157.
7. Dourish C.T., Hutson P.H., Curzon G. Parachlorophenylalanine prevents feeding induced by the serotonin agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT). Psychopharmacology. 89:1986;467-471.
8. 2B receptor protein in the rat brain. Br. J. Pharmacol. 115:1995;105P.
9. 2B receptor: molecular cloning, identification of a splice variant and localization of mRNA in smooth muscle and neurons of the guinea pig and rat intestines. Am. Soc. Neurosci. Abstr., 312.13.
10. 2B receptor mRNA in rat brain. Br. J. Pharmacol. 114:1995;369P.
11. Fletcher A., Forster E.A., Bill D.J., Brown G., Cliffe I.A., Hartley J.E., Jones D.E., McLenachan A., Stanhope K.J., Critchley D.J.P., Childs K.J., Middlefell V.C., Lanfumey L., Corradetti R., Laporte A.M., Gozlan H., Hamon M., Dourish C.T. Electrophysiological, biochemical, neurohormonal and behavioural studies with WAY-100635, a potent, selective and silent 5-HT1A receptor antagonist. Behav. Brain Res. 73:1996;337-353.
12. Foquet M., Hoyer D., Pardoe L.A., Parekh A., Kluxen F.W., Kalkman H.O., Stuhmer W., Lubbert H. Cloning and functional characterization of the rat stomach fundus serotonin receptor. EMBO J. 11:1992;3481-3487.
13. 2B receptor agonist, BW 723C86, on three rat models of anxiety. Br. J. Pharmacol. 117:1996;1443-1448.
14. 1B receptors. Psychopharmacology. 96:1988;93-100.
15. 2B receptor antagonist, after chronic treatment. Br. J. Pharmacol. 114:1995;370P.
16. 2C/2B receptor antagonist with anxiolytic-like properties. Br. J. Pharmacol. 117:1996;427-434.
17. 2B receptors in the control of anxiety. In: Serotonin in the Central Nervous System and Periphery (Takada A. and Curzon G., Eds), pp. 113-120. Excerpta Medica International Congress Series 1088. Elsevier Amsterdam.
18. 2C/2B receptor antagonist. Br. J. Pharmacol. 111:1995;797-802.
19. 2F) from rat stomach fundus. Molec. Pharmacol. 42:1992;549-557.
20. 2-like receptor: expression in brain, heart and intestine. FEBS Lett. 312:1992;203-207.
21. Monsma F.J., Shen Y., Ward R.P., Hamblin M.W., Sibley D.R. Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. Molec. Pharmacol. 43:1993;320-327.
22. Paxinos G. and Watson C. (1986) The Rat Brain in Stereotaxic Coordinates. Academic Press, New York.
23. 2C receptors. Molec. Brain Res. 23:1994;163-178.
24. 2B serotonin receptor. FEBS Lett. 342:1994;85-90.
25. Stewart B.R., Jenner P., Marsden C.D. Induction of purposeless chewing behaviour in rats by 5-HT agonist drugs. Eur. J. Pharmacol. 162:1989;101-107.
26. 2B receptor. Neuroreport. 7:1996;1457-1460.
27. 7 receptors in guinea-pig brain. Br. J. Pharmacol. 115:1995;107-116.
28. 4 receptor with high affinity for the antipsychotic clozapine. Nature. 350:1991;610-614.
29. Wozniak K.M., Aulakh C.S., Hill J.L., Murphy D.L. Hyperthermia induced by m-CPP in the rat and its modification by antidepressant treatments. Psychopharmacology. 97:1989;269-274.