The genetics of exceptional human longevity

Journal of the American Geriatrics Society

Volumn 50, Issue 2, 2002, Pages 359-368

  Perls, Thomas ^a,d   Kunkel, Louis M ^b   Puca, Annibale A ^c  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c Centagenix   (United States)

^d BOSTON MEDICAL CENTER   (United States)

Author keywords

Aging; Centenarian; Evolution; Genetics; Longevity; Oldest old

Indexed keywords

AGING; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENETICS; HEALTH BEHAVIOR; HUMAN; LONGEVITY; MOLECULAR GENETICS; REVIEW;

AGED; AGED, 80 AND OVER; ANIMALS; DROSOPHILA; EVOLUTION; FEMALE; HUMANS; LONGEVITY; MALE; PHENOTYPE;

EID: 0036166256     PISSN: 00028614     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1532-5415.2002.49283.x     Document Type: Review

References (146)

1. Extraordinary longevity in the Soviet Union: Fact or artifact?
2. Statement regarding the purported longevous peoples of Vilcabamba
3. Longevity and age exaggeration in Vilcabamba, Ecuador
4. Longevity in Abkhazia: A reevaluation
5. The oldest human
6. On the nature of the function expressive of the law of human mortality, and on a new mode of determining the value of life contingencies
7. Slowing of mortality rates at older ages in large medfly cohorts
8. Mortality rates in a genetically heterogeneous population of Caenorhabditis elegans
9. Increased life-span of age-1 mutant in Caenorhabditis elegans and lower Gompertz rate of aging
10. The impact of heterogeneity in individual frailty on the dynamics of mortality
11. Heterogeneity's ruses: Some surprising effects of selection on population dynamics
12. Kindred lifetimes: Frailty models in population genetics
13. Biodemographic trajectories of longevity
14. Genetic associations with human longevity at the APOE and ACE loci
15. Reduced apolipoprotein epsilon 4 allele frequency in the oldest old. Alzheimer's patients and cognitively normal individuals
16. Estimation of apolipoprotein E genotype-specific relative mortality risks from the distribution of genotypes in centenarians and middle-aged men: Apolipoprotein E gene is a "frailty gene," not a "longevity gene."
17. DNA multiallelic systems reveal gene/longevity associations not detected by diallelic systems. The APOB locus
18. Influence of major histocompatibility complex region genes on human longevity among Okinawan-Japanese centenarians and nonagenarians
19. Centenarians: The older you get, the healthier you've been
20. Aging, health risks, and cumulative disability
21. The oldest old
22. Body composition, body fat distribution and resting metabolic rate in healthy centenarians
23. La transmission familiale de la longévité à Arthez d'Asson, (1686-1899)
24. Middle aged mothers live longer
25. Siblings of centenarians live longer
26. Extreme longevity in two families. A report of multiple centenarians within single generations
27. Exceptional familial clustering for extreme longevity in humans
28. Plasma lipid apolipoprotein and Lp(a) levels in elderly normolipidemic women: Relationships with coronary heart disease and longevity
29. Lipoprotein(a) and lipoprotein profile in healthy centenarians: A reappraisal of vascular risk factors
30. Offspring of centenarians have a favorable lipid profile
31. Thyrod and other organ-specific autoantibodies in healthy centenarians
32. Decline in CD28(+) T cells in centenarians and in long term T cell cultures: A possible cause for both in vivo and in vitro immunosenescence
33. The immunology of exceptional individuals: The lesson of centenarians
34. Hypercoaguability in centenarians: The paradox of successful aging
35. Gene polymorphisms predicting high plasma levels of coagulation and fibrinolysis proteins: A study in centenarians
36. Unraveling the mystery of cognitive changes in old age: Correlation of neuropsychological evaluation with neuropathological findings in the extreme old
37. Cognitive functional status of age-confirmed centenarians in a population-based study
38. Cognitive functioning in centenarians: A coordinated analysis of results from three countries
39. Dementia is not inevitable: A population-based study of Danish centenarians
40. Cause of death in the extreme aged-a pathologic survey of 5106 elderly persons 80 years old and over
41. Mental aging and its medico-social background in the very old Japanese
42. Validity of reported age and centenarian prevalence in New England
43. AKEntAnnos. The Sardinia study of Extreme Longevity
44. The emergence and proliferation of centenarians
45. Survival after the age of 80 in the United States, Sweden, France, England, and Japan
46. Determinants of longevity: Genetic, environmental and medical factors
47. The demography of centenarians in England and Wales
48. The remarkable improvements in survival at older ages
49. Biodemographic trajectories of longevity
50. In search of Methuselah: Estimating the upper limits of human longevity
51. The future of human longevity: A demographer's perspective
52. Longevity is moderately heritable in a sample of Danish twins born 1870-1880
53. Untangling genetic influences on smoking, body mass index and longevity: A multivariate study of 2464 Danish twins followed for 28 years
54. The effect of genetic factors for longevity: A comparison of identical and fraternal twins in the Swedish Twin Registry
55. The heritability of human longevity: A population-based study of 2872 Danish twin pairs born 1870-1900
56. Genetics of aging
57. What does it take to live to 100?
58. The relationship between the sibling recurrence-risk ratio and genotype relative risk
59. Why women live longer than men
60. Familial excess longevity in Utah genealogies
61. Inheritance of human longevity in Iceland
62. Genetics and the pathobiology of ageing
63. Genetic and evolutionary aspects of aging
64. Causes, effects, and constraints in the genetics of human longevity
65. Between Zeus and the salmon: Introduction
66. Single nucleotide polymorphism spectra in newborns and centenarians: Identification of genes coding for rise of mortal disease
67. Longevity and the allele of APOE: The Finnish Centenarians Study
68. Genetic and phenotypic markers among centenarians
69. Genes and longevity: Lessons from studies of centenarians
70. Genetic analysis of ageing: Role of oxidative damage and environmental stresses
71. Oxidants, oxidative stress and the biology of aging
72. Array-based gene expression profiling to study aging
73. Cell senescence in human aging: A review of the theory
74. Genetic pathways that regulate ageing in model organisms
75. Oxidative stress and advancing age: Results in healthy centenarians
76. Mitochondrial DNA inherited variants are associated with successful aging and longevity in humans
77. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
78. Molecular mechanisms of yeast longevity
79. Metabolic control and ageing
80. Genetic and environmental conditions that increase longevity in Caenorhabditis elegans decrease metabolic rate
81. Aging and resistance to oxidative damage in Caenorhabditis elegans
82. daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans
83. Determination of life-span in Caenorhabditis elegans by four clock genes
84. Signals from the reproductive system regulate the lifespan of C. elegans
85. A C. elegans mutant that lives twice as long as wild type
86. Structural and functional conservation of the Caenorhabditis elegans timing gene clk-1
87. A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility
88. An insulin-like signaling pathway affects both longevity and reproduction in Caenorhabditis elegans
89. CLK-1 controls respiration, behavior and aging in the nematode Caenorhabditis elegans
90. A cytosolic catalase is needed to extend adult lifespan in C. elegans daf-C and clk-1 mutants
91. Extended life-span and stress resistance in the Drosophila mutant methuselah
92. FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila
93. Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse
94. Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons
95. A mutant Drosophila insulin receptor homologue that extends life-span and impairs neuroendocrine function
96. Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein
97. The p66shc adaptor protein controls oxidative stress response and life span in mammals
98. A putative gene causes variability in lifespan among genotypically identical mice
99. The efficiency of genetic analysis of DNA from aged siblings to detect chromosomal regions implicated in longevity
100. A genome-wide scan for linkage to human exceptional longevity identifies a locus on chromosome 4
101. Positional cloning of the Werner's syndrome gene
102. The Werner syndrome protein is a DNA helicase
103. Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts
104. A biomarker that identifies senescent human cells in culture and in aging skin in vivo
105. Is beta-galatosidase staining a marker of senescence in vitro and in vivo?
106. How and why we age
107. Genes and ageing: Beyond good and evil in the senescent cell
108. Telomere length, aging, and somatic cell turnover
109. Telomere length, telomerase and aging
110. Structure and function of telomeres
111. Telomeres shorten during ageing of human fibroblasts
112. Telomere reduction in human colorectal carcinoma and with ageing
113. The rate of telomere sequence loss in human leukocytes varies with age
114. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts
115. Telomere length regulation
116. Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turn-over of hematopoietic stem cells and memory T cells in early childhood
117. Aging and cancer: The double-edged sword of replicative senescence
118. Telomerase and the aging cell. Implications for human health
119. Extension of life-span by introduction of telomerase into normal human cells
120. Nutrition, oxidative damage, telomere shortening and cellular senescence: Individual or connected agents of aging?
121. DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cipl in normal human fibroblasts
122. Gene expression profile of aging and its retardation by caloric restriction
123. Why do we age?
124. Is early natural menopause a biological marker of health and aging?
125. The evolution of menopause and human life span
126. The evolution of human longevity
127. Quantitative genetics of postponed ageing in Drosophila melanogaster. I. Analysis of outbred populations
128. Reproductive potential predicts longevity of female Mediterranean fruit flies
129. Human longevity at the cost of reproductive success
130. Evolutionary ecology of human life history
131. Grandmothering, menopause, and the evolution of human life histories
132. Reproductive cessation in female mammals
133. A conserved regulatory system for aging
134. Ten Years of Life. Is It a Matter of Choice?