Imidazoline antihypertensive drugs: A critical review on their mechanism of action

Pharmacology and Therapeutics

Volumn 93, Issue 1, 2002, Pages 1-35

  Szabo, Bela ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

2 Adrenoceptor; Blood pressure; Imidazoline receptor; Presynaptic receptor; Rostral ventrolateral medulla; Sympathetic nervous system

Indexed keywords

1,3,4,5',6,6',7,12B OCTAHYDRO 1',3' DIMETHYL 2H SPIRO[BENZO[B]FURO[2,3 A]QUINOLIZINE 2,4' PYRIMIDINE] 2' ONE; 2 (2 METHOXY 1,4 BENZODIOXAN 2 YL) 2 IMIDAZOLINE; 2 ENDOAMINO 3 EXO ISOPROPYLBICYCLO[2.2.1]HEPTANE; 6 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 1H 3 BENZAZEPINE; [5 (2 METHYLPHENOXYMETHYL) 1,3 OXAZOLIN 2 YL]AMINE; AGN 192403; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; AZEPEXOLE; BRIMONIDINE; CLONIDINE; CORBADRINE; EFAROXAN; GUANABENZ; GUANFACINE; HEPTANE; IDAZOXAN; IMIDAZOLINE; IMIDAZOLINE I1 RECEPTOR; IMIDAZOLINE RECEPTOR; MEDETOMIDINE; MOXONIDINE; NEUROTRANSMITTER; OXAZOLINE DERIVATIVE; RADIOLIGAND; RAUWOLSCINE; RILMENIDINE; TALIPEXOLE; UNCLASSIFIED DRUG; YOHIMBINE;

BINDING SITE; BRAIN STEM; CARDIOVASCULAR SYSTEM; CENTRAL NERVOUS SYSTEM; DRUG ANALYSIS; DRUG CLASSIFICATION; DRUG EFFECT; DRUG MECHANISM; HUMAN; HYPOTHESIS; INHIBITION KINETICS; MEDULLA OBLONGATA; NEUROTRANSMITTER RELEASE; NONHUMAN; PRESYNAPTIC INHIBITION; PRIORITY JOURNAL; REVIEW; SOLITARY TRACT NUCLEUS; SPINAL CORD; SYMPATHETIC NERVE CELL; SYMPATHETIC TONE;

ANIMALS; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; CLONIDINE; HUMANS; HYPERTENSION; IMIDAZOLES; MEDULLA OBLONGATA; RECEPTORS, ADRENERGIC, ALPHA-2; RECEPTORS, PRESYNAPTIC; SYMPATHETIC NERVOUS SYSTEM;

EID: 0036128399     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0163-7258(01)00170-X     Document Type: Review

References (262)

1. Characterization of hippocampal norepinephrine release as measured by microdialysis perfusion: Pharmacological and behavioral studies
2. 2-adrenergic receptors in gigantocellular reticular formation
3. 2-adrenoceptors in the guinea pig, rat and pig
4. 2-Adrenoceptor-mediated inhibition of bulbospinal barosensitive cells of rat rostral medulla
5. Cardiovascular effects of central administration of clonidine in conscious cats
6. Cardiovascular effects of intravenous administration of clonidine in conscious cats
7. 2A-adrenergic receptor knockout mice
8. 2-Adrenoceptor-mediated potassium currents in acutely dissociated rat locus coeruleus neurones
9. 2-adrenoceptor stimulation to the antihypertensive action of moxonidine
10. 2-receptor selectivity and specificity of the antihypertensive agent moxonidine
11. General pharmacology of the novel centrally acting antihypertensive agent moxonidine
12. Isolation and partial purification of a clonidine-displacing endogenous brain substance
13. Isolation of an endogenous clonidine-displacing substance from rat brain
14. Cardiac and systemic sympathetic activity in response to clonidine in human heart failure
15. Growth hormone secretion in response to the new centrally acting antihypertensive agent moxonidine in normal human subjects: Comparison to clonidine and GHRH
16. Interactions between imidazoline binding sites and dopamine levels in the rat nucleus accumbens
17. General pharmacologic actions of the antihypertensive agent 2,6-dichlorobenzylidene aminoguanidine acetate (WY-8678)
18. Polyclonal anti-idiotypic antibodies to idazoxan and their interaction with human brain imidazoline binding sites
19. Neuroendocrine regulation of growth hormone
20. Characterization of the alpha-2C adrenergic receptor subtype in the opossum kidney and in the OK cell line
21. Analysis of the receptor involved in the central hypotensive effect of rilmenidine and moxonidine
22. Possible involvement of central adrenaline neurons in vasomotor and respiratory control. Studies with clonidine and its interactions with piperoxane and yohimbine
23. Drugs acting on imidazoline receptors. A review of their pharmacology, their use in blood pressure control and their potential interest in cardioprotection
24. Localization of the central cardiovascular action of clonidine
25. Central cardiovascular effects of alpha adrenergic drugs: Differences between catecholamines and imidazolines
26. The imidazoline preferring receptor: Binding studies in bovine, rat and human brainstem
27. Rilmenidine selectivity for imidazoline receptors in human brain
28. Relevance of the use of [3H]-clonidine to identify imidazoline receptors in the rabbit brainstem
29. Human brain imidazoline receptors: Further characterization with [3H]clonidine
30. Evidence for a peripheral component in the sympatholytic effect of clonidine in rats
31. 2-adrenergic receptors in the antihypertensive responses evoked by central administration of clonidine analogs in conscious spontaneously hypertensive rats
32. IV. International union of pharmacology nomenclature of adrenoceptors
33. 1-adrenoceptor agonist-induced responses by rilmenidine in vascular smooth muscle
34. 2-adrenoceptor agonists medetomidine and ST-91 in anesthetized sheep
35. Role of imidazoline receptors in the cardiovascular actions of moxonidine, rilmenidine and clonidine in conscious rabbits
36. Action of dexmedetomidine on rat locus coeruleus neurones: Intracellular recording in vitro
37. Effects of clonidine on sympathoexcitatory neurons in the rostral ventrolateral medulla
38. Pharmacological characteristics of spinal α-adrenoceptors in rats
39. Clonidine distribution in the rat: Temporal relationship between tissue levels and blood pressure response
40. 2 agonist, is mediated in the locus coeruleus in rats
41. Identification and characterization of imidazoline-binding sites from calf striatum
42. The subretrofacial vasomotor nucleus: Anatomical, chemical and pharmacological properties and role in cardiovascular regulation
43. Pharmacokinetics and concentration-effect relationships of intravenous and oral clonidine
44. Centrally induced hypotension and bradycardia after administration of α-methylnoradrenaline into the area of the nucleus tractus solitarii of the rat
45. 2-adrenoceptors in the bradycardiac effects of clonidine and analogues
46. 1-adrenoceptor agonist: 2-(2-chloro-5-trifluoromethylphenylimino)imidazolidine (St 587)
47. 2-adrenoceptors affect sleep and arousal mechanisms
48. 2-adrenergic agonism counteracts the inhibitory effect of muscarinic cholinergic receptor blockade on the GH response to GH-releasing hormone
49. 2-adrenoceptors
50. Clinical pharmacology and pharmacokinetics of clonidine
51. Influence of the alpha-2 agonist oxaminozoline (S3341) on firing rate of central noradrenergic and serotonergic neurons in the rat. Comparison with clonidine
52. "Seeing through a glass darkly": Casting light on imidazoline "I" sites
53. 2-adrenergic agonists
54. Pharmacokinetics and pharmacodynamics of intraspinal dexmedetomidine in sheep
55. Clonidine diminishes c-jun gene expression in the cardiovascular sensitive areas of the rat brainstem
56. Effects of alpha2-adrenoceptor agonists on locus coeruleus firing rate and brain noradrenaline turnover in N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ)-treated rats
57. 1-imidazoline binding site is a functional receptor mediating vasodepression via the ventral medulla
58. 1-imidazoline binding sites
59. 2-adrenoceptors in the ventrolateral medulla
60. Role of imidazole receptors in the vasodepressor response to clonidine analogs in the rostral ventrolateral medulla
61. 1-imidazoline sites
62. 1 receptors in the ventrolateral medulla and their role in cardiorespiratory control
63. 1-imidazoline receptor: From binding site to therapeutic target in cardiovascular disease
64. Molecular characterization and isolation of a 45-kilodalton imidazoline receptor protein from the rat brain
65. Increased sympathetic nervous system activity and its therapeutic reduction in arterial hypertension, portal hypertension and heart failure
66. Overflow of catecholamine neurotransmitters to the circulation: Source, fate, and functions
67. 2-adrenergic and imidazoline receptor agonist, produces spinal antinociception in mice
68. Possible role of an endogenous opiate in the cardiovascular effects of central alpha adrenoceptor stimulation in spontaneously hypertensive rats
69. Evidence for the involvement of imidazoline receptors in the central hypotensive effect of rilmenidine in the rabbit
70. Identification, localization and functional analysis of imidazoline and alpha adrenergic receptors in canine prostate
71. Safety aspects of long-term antihypertensive therapy (10 years) with clonidine
72. A multicenter double-blind comparative study of rilmenidine and clonidine in 333 hypertensive patients
73. Hemodynamic and analgesic profile after intrathecal clonidine in humans
74. 2-adrenoceptors and putative imidazoline receptors on rabbit heart sympathetic nerves
75. 2-autoinhibition
76. Effects of clonidine on renal sympathetic nerve activity and norepinephrine spillover
77. Central nervous system site of action for the hypotensive effect of clonidine in the cat
78. Catecholamine receptors and signal transduction
79. Rilmenidine lowers arterial pressure via imidazole receptors in brainstem C1 area
80. 2-adrenoceptor-independent inhibition of noradrenaline release by imidazoline derivatives
81. A1 noradrenergic neurons tonically inhibit sympathoexcitatory neurons of C1 area in rat brainstem
82. The effect of clonidine on centrally and peripherally evoked submaxillary salivation
83. 1-imidazoline agonism. Sympathetic mechanisms in hypertension
84. Local influence of endogenous norepinephrine on extracellular dopamine in rat medial prefrontal cortex
85. The peripheral action of clonidine analog St-91: Involvement of atrial natriuretic factor
86. Is the hypotensive effect of clonidine and related drugs due to imidazoline binding sites?
87. 2-Adrenergic receptors rather than imidazoline binding sites mediate the sympatholytic effect of clonidine in the rostral ventrolateral medulla
88. Studies on the possible contribution of a peripheral presynaptic action of clonidine and dopamine to their vascular effects under in vivo conditions
89. Imidazole binding sites in rabbit kidney and forebrain membranes
90. Chemische konstitution und pharmakologische wirksamkeit von in 2-stellung substituierten imidazolinen
91. Electrophysiological characterization of putative C1 adrenergic neurons in the rat
92. Influence of imidazolines on catecholamine release in pithed spontaneously hypertensive rats
93. 1-imidazoline receptors in the rostral ventrolateral medulla
94. Alpha2-adrenoceptor-mediated presynaptic inhibition in bulbospinal neurons of rostral ventrolateral medulla
95. Prototypical imidazoline-1 receptor ligand moxonidine activates alpha2-adrenoceptors in bulbospinal neurons of the RVL
96. Adrenergic responses in silent and putative inhibitory pacemaker-like neurons of the rat rostral ventrolateral medulla in vitro
97. Importance of central noradrenergic and serotonergic pathways in the cardiovascular actions of rilmenidine and clonidine
98. Relative importance of medullary brain nuclei for the sympatho-inhibitory actions of rilmenidine in the anaesthetized rabbit
99. 1 Imidazoline receptors in cardiovascular regulation: The place of rilmenidine
100. Comparison of renal sympathetic baroreflex effects of rilmenidine and alpha-methylnoradrenaline in the ventrolateral medulla of the rabbit
101. 2-adrenoceptors involved in the sympatho-inhibitory actions of centrally acting antihypertensive agents
102. Evidence for the existence of imidazoline-specific binding sites in synaptosomal plasma membranes of the bovine brainstem
103. Adrenergic receptor signal transduction and regulation
104. 2-adrenoceptors
105. Pharmakologische wirkungen des 2-(2,6-dichlorphenylamino)-2-imidazolin-hydrochlorids, einer neuen, antihypertensiven substanz
106. Transport of clonidine across cultured brain microvessel epithelial cells
107. Imidazoline receptor proteins are regulated in platelet-precursor MEG-01 cells by agonists and antagonists
108. Characterization of a partial cDNA clone detected by imidazoline receptor-selective antisera
109. Co-detection by two imidazoline receptor protein antisera of a novel 85 kilodalton protein
110. Effects of clonidine and yohimbine on parasympathetic reflex salivation and vasodilatation in cat SMG
111. 2adrenergic receptors
112. Cardiovascular effects of clonidine in an avian species, Larus argentatus
113. 2-receptors
114. 1A receptors
115. 2-Adrenoceptor and catecholamine-insensitive binding sites for [3H]rilmenidine in membranes from rat cerebral cortex
116. 2-adrenergic and non-adrenergic I-receptor binding sites labelled by [3H]rilmenidine
117. 2-adrenoceptors and norepinephrine release in the forearm of normal humans
118. Serendipity bei der entdeckung von catapresan
119. Über den wirkungsmechanismus einer neuen antihypertensiven substanz mit imidazolinstruktur
120. Central α-adrenergic systems as targets for hypotensive drugs
121. Investigation into some imidazoline compounds, with respect to peripheral α-adrenoceptor stimulation and depression of cardiovascular centers
122. Centrally acting drugs (clonidine, methyldopa, guanfacine)
123. Cardiovascular and central nervous system effects of rilmenidine (S 3341) in rats
124. Hemodynamic and neurohormonal effects of clonidine in patients with preganglionic sympathetic lesions
125. Pharmacological characterization of the alpha2-adrenoceptors responsible for a decrease of blood pressure in the nucleus tractus solitarii of the rat
126. Pharmacological characterization of spinal alpha adrenoceptors related to blood pressure control in rats
127. Involvement of spinal alpha adrenoceptors in mediation of the hypotensive action of guanabenz in rats
128. In vivo monitoring of catecholaminergic metabolism in the C1 region of the rat medulla oblongata: A comparative study by voltammetry and intracerebral microdialysis
129. Presynaptic regulation of the release of catecholamines
130. 2-adrenoceptors
131. 2-adrenoceptor agonist
132. Agmatine: An endogenous clonidine-displacing substance in the brain
133. Clonidine and rilmenidine suppress hypotension-induced Fos expression in the lower brainstem of the conscious rabbit
134. 2-adrenergic receptors
135. 2-adrenergic receptors
136. 2-Adrenergic, but not imidazole, agonists activate NaCl cotransport in rabbit tracheal epithelial cells
137. 2-adrenoceptors in the human heart: Discrimination by clonidine and moxonidine
138. 2-adrenergic receptor subtypes b and c
139. Mechanisms of sympathetic enhancement and inhibition of parasympathetically induced salivary secretion in anaesthetized dogs
140. Autonomic nervous control of venous pressure and secretion in submandibular gland of anesthetized dogs
141. 2A-adrenergic receptor subtype
142. A comparison of the haemodynamic and behavioural effects of moxonidine and clonidine in normotensive subjects
143. Evidence for a physiological role of presynaptic α-adrenoceptors: Modulation of noradrenaline release in the pithed rabbit
144. Suppressing sympathetic activation in congestive heart failure
145. Synergistic behavioral interaction between ethanol and clonidine in rats: Role of alpha-2 adrenoceptors
146. 2-adrenoceptors in the canine saphenous vein
147. Determination of the somadendritic alpha-2-adrenoceptor subtype located in rat locus coeruleus that modulates cortical noradrenaline release in vivo
148. Influence of the rostral ventrolateral medulla on renal sympathetic baroreflex in conscious rabbits
149. Sympathoinhibitory action of rilmenidine in conscious sinoaortically denervated rats
150. The cardiovascular actions of clonidine and neuropeptide-Y in the ventrolateral medulla of the rat
151. Clonidine's central hypotensive effect
152. 2A-adrenergic receptors are primarily presynaptic heteroreceptors in the C1 area of the rat rostral ventrolateral medulla
153. Excitatory and inhibitory effects of epinephrine on neonatal rat sympathetic preganglionic neurons in vitro
154. 2A adrenoceptor to be the subtype mediating the hypnotic response to the highly selective agonist, dexmedetomidine, in the locus coeruleus of the rat
155. 2-imidazoline binding sites
156. Presynaptic imidazoline receptors mediate inhibition of noradrenaline release from sympathetic nerves in rat blood vessels
157. Pharmacological characterization of the imidazoline receptor which mediates inhibition of noradrenaline release in the rabbit pulmonary artery
158. 1-imidazoline sites in bovine adrenal medullary membranes
159. Presynaptic imidazoline receptors and non-adrenoceptor [3H]-idazoxan binding sites in human cardiovascular tissues
160. Presynaptic cannabinoid and imidazoline receptors in the human heart and their potential relationship
161. 2A-adrenoceptors
162. Effects of yohimbine on submaxillary salivation in dogs
163. Imidazolines and pancreatic hormone secretion
164. Involvement of brain catecholamines and acetylcholine in growth hormone hypersecretory states
165. 1 receptor specific agent
166. Clonidine reduces sympathetic activity but maintains baroreflex responses in normotensive humans
167. 2-adrenergic receptor subtypes in rat brain: An in situ hybridization study
168. The distribution and significance of CNS adrenoceptors examined with in situ hybridization
169. Subtype determination of soma-dendritic alpha2-autoreceptors in slices of rat locus coeruleus
170. Decarboxylase inhibition and blood pressure reduction by α-methyl-3,4-dihydroxy-DL-phenylalanine
171. The elusive family of imidazoline binding sites
172. Extraction of active clonidine-displacing substance from bovine lung and comparison with clonidine-displacing substance extracted from other tissues
173. Antinociception induced by alpha-2-adrenoceptor agonists, with special emphasis on medetomidine studies
174. Presynaptic activity at peripheral adrenergic sites and blood pressure effect of α-adrenoceptor stimulating drugs
175. Nonadrenergic imidazoline binding sites on human platelets
176. 2-adrenoceptor states plus a non-adrenergic site on human platelet plasma membranes
177. 1-imidazoline binding sites and the high affinity state of alpha-2 adrenoceptor subtypes
178. Imidazoline receptor antisera-selected (IRAS) cDNA: Cloning and characterization
179. Crossover comparison of moxonidine and clonidine in mild to moderate hypertension
180. Comparison of moxonidine and clonidine HCl in treating patients with hypertension
181. Cardiovascular effects of clonidine-like drugs in pithed rabbits
182. ATP channels is mediated by Kir6.2
183. Ventrolateral medullary pressor area: Site of hypotensive action of clonidine
184. Imidazoline-binding domains on monoamino oxidase B and subpopulations of enzyme
185. 1A receptor agonists, 8-OH-DPAT and ipsapirone, have a central hypotensive action that differs from that of clonidine in anaesthetised cats
186. Imidazoline receptors and their endogenous ligands
187. Effect of clonidine on second messenger systems in rat adrenal gland
188. Effects of clonidine and other imidazole-receptor binding agents on second messenger systems and calcium influx in bovine adrenal chromaffin cells
189. Neurons and receptors in the rostroventrolateral medulla mediating the antihypertensive actions of drugs acting at imidazoline receptors
190. Is agmatine a novel neurotransmitter in brain?
191. The insulin-secreting cell line, RINm5F, expresses an alpha-2D adrenoceptor and nonadrenergic idazoxan-binding sites
192. alpha2A adrenergic receptor and other populations of alpha-2 adrenergic subtypes
193. 2A-adrenergic receptors in catecholaminergic and other brainstem neurons in the rat
194. 2C-adrenergic receptor-like immunoreactivity in the rat central nervous system
195. Immunocytochemical localization of an imidazoline receptor protein in the central nervous system
196. Imidazoline/guanidinium binding sites and their relation to inhibition of K(ATP) channels in pancreatic β-cells
197. Studies on the acute and chronic effects of reboxetine on extracellular noradrenaline and other monoamines in the rat brain
198. 2-adrenoceptor agonist
199. Rilmenidine-induced hypotension in conscious rabbits involves imidazoline-preferring receptors
200. Sympathoinhibitory effects of rilmenidine may be mediated by sites located below the brainstem
201. Influence of anaesthesia on the cardiovascular effects of rilmenidine and clonidine in spontaneously hypertensive rats
202. Safety and tolerability of moxonidine in the treatment of hypertension
203. 2-adrenoceptor agonists?
204. The pharmacology of clonidine and related products
205. Action of alpha-adrenergic blocking drugs on the sympathetic centres and their interactions with the central sympatho-inhibitory effect of clonidine
206. Pharmacological actions of the antihypertensive agent N-amidino-2-(2,6-dichlorophenyl)acetamide hydrochloride (BS 100-141)
207. 1-imidazoline receptors to diacylglyceride accumulation in PC12 rat pheochromocytoma cells
208. 1-imidazoline receptors in PC12 cells and rostral ventrolateral medulla
209. An analysis of the α-adrenoceptor modulation of vasomotor tone at the level of lateral medullary pressor area (LMPA)
210. Pharmacological characterization of alpha adrenoceptors involved in the antinociceptive and cardiovascular effects of intrathecally administered clonidine
211. Regulation of noradrenaline release by presynaptic receptor systems
212. Presynaptic α-autoreceptors
213. 2-autoreceptors
214. Presynaptic alpha2-adrenoceptors: Subtype determination
215. 2-adrenoceptors modulating noradrenaline release?
216. Adrenoceptors and their second messenger systems
217. Pharmacology of reticulospinal vasomotor neurons in cardiovascular regulation
218. Effect of clonidine and γ-aminobutyric acid on the discharges of medullo-spinal sympathoexcitatory neurons in the rat
219. GABA-mediated inhibition of pacemaker neurons of rostral ventrolateral medulla by clonidine in vitro
220. 2-adrenoceptor that blocks coupling to potassium but not calcium currents
221. Inhibition of both noradrenergic and serotonergic neurons in brain by the α-adrenergic agonist clonidine
222. The effects of moxonidine, a novel imidazoline, on plasma norepinephrine in patients with congestive heart failure
223. Mechanism of sympathoinhibition by imidazolines
224. 1 imidazoline receptors in the sympathoinhibiton produced by intracisternally administered rilmenidine and moxonidine
225. Peripheral presynaptic and central effects of clonidine, yohimbine and rauwolscine on the sympathetic nervous system in rabbits
226. Effects of inhibitors of neuronal uptake of 5-HT on sympathetic cardiovascular regulation
227. Effect of yohimbine on renal sympathetic nerve activity and renal noradrenaline spillover in anesthetized rabbits
228. 2-adrenoceptors
229. No evidence for functional imidazoline receptors on locus coeruleus neurons
230. Evidence for a direct peripheral effect of clonidine on the norepinephrine release in vivo in pithed rats
231. 2A-adrenergic receptor-like immunoreactivity in the rat central nervous system
232. 9-tetrahydrocannabinol and its relationship to pharmacological potency
233. Differences in the ability of yohimbine to antagonize the hypotensive effect of clonidine in normotensive and spontaneously hypertensive anesthetized rats
234. Correlation between the inhibitory effect on catecholaminergic ventrolateral medullary neurons and the hypotension evoked by clonidine: A voltammetric approach
235. An imidazoline-specific mechanism for the hypotensive effect of clonidine: A study with yohimbine and idazoxan
236. Selectivity of rilmenidine for the nucleus reticularis lateralis, a ventrolateral medullary structure containing imidazoline-preferring receptors
237. Contribution of catecholaminergic neurons of the dorsomedial and ventrolateral medulla oblongata to the hypotensive effect of clonidine in spontaneously hypertensive rats: In vivo voltammetric studies
238. Characterization of α-adrenoceptors participating in the central hypotensive and sedative effects of clonidine using yohimbine, rauwolscine and corynanthine
239. 2-Adrenergic receptors are not required for central anti-hypertensive action of moxonidine in mice
240. 2D-adrenoceptors
241. 2-autoreceptors: Rat vena cava, rat atria, human kidney and guinea-pig urethra
242. 2A/D-adrenoceptor-deficient mice
243. 2C-adrenoceptors and non-adrenergic imidazoline sites in the guinea pig
244. Is the sympathoinhibitory effect of rilmenidine mediated by alpha-2 adrenoceptors or imidazoline receptors?
245. 2-adrenoceptors in the cardiovascular effects of moxonidine
246. Involvement of peripheral presynaptic inhibition in the reduction of sympathetic tone by moxonidine, rilmenidine and UK 14304
247. Selectivity of some alpha adrenoceptor agonists for peripheral alpha-1 and alpha-2 adrenoceptors in the normotensive rat
248. The hypothensive activity and side effects of methyldopa, clonidine, and guanfacine
249. Central and peripheral effects of S 3341 [(N-dicyclopropylmethyl)-amino-2-oxazoline] in animal models
250. 2-adrenoceptor antagonists of the central sympatho-inhibitory effect of clonidine
251. Effect of the amino-oxazoline derivative S-3341 on pre- and postjunctional α-adrenoceptors in isolated blood vessels
252. Rilmenidine
253. The antihypertensive mechanism of clonidine in man. Evidence against a generalized reduction of sympathetic activity
254. Production and characterization of antibodies specific for the imidazoline receptor protein
255. 2-adrenergic receptor antagonist, with intravenous clonidine
256. Preliminary clinical pharmacological studies of S3341, a new hypotensive agent, and comparison with clonidine in normal males
257. 1-Imidazoline agonist moxonidine decreases sympathetic nerve activity and blood pressure in hypertensives
258. Yohimbine as a serotonergic agent: Evidence from receptor binding and drug discrimination
259. Evidence supporting the existence of presynaptic α-adrenoceptors in the regulation of endogenous noradrenaline release upon hepatic sympathetic nerve stimulation in the dog liver in vivo
260. Regulation of norepinephrine release from cardiac sympathetic fibers in the dog by presynaptic α- and β-receptors
261. Effect of catecholamine-receptor stimulating agents on blood pressure after local application in the nucleus tractus solitarii of the medulla oblongata
262. 2A-adrenoceptor transgenic mice