Imidazoline-binding domains on monoamine oxidase B and subpopulations of enzyme

Journal of Pharmacology and Experimental Therapeutics

Volumn 292, Issue 3, 2000, Pages 1135-1145

  Raddatz, Rita ^d   Savic, Sandra L ^d   Bakthavachalam, Venkatesalu ^a   Lesnick, John ^b   Jasper, Jeffrey R ^b   McGrath, Christopher R ^a   Parini, Angelo ^c   Lanier, Stephen M ^d  

^a Research Biochemicals International   (United States)

^b ROCHE BIOSCIENCE   (United States)

^c INSERM   (France)

^d MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; IMIDAZOLINE;

ARTICLE; DRUG PROTEIN BINDING; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME STRUCTURE; IMMUNOBLOTTING; PHOTOAFFINITY LABELING; PRIORITY JOURNAL; PROTEIN DOMAIN;

BINDING SITES; HUMANS; IDAZOXAN; IMIDAZOLES; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; PICOLINIC ACIDS;

EID: 0034059925     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Atlas D (1994) Identifying clonidine-displacing substance. Science (Wash DC) 266: 462-464.
2. Bach AW, Lan NC, Johnson DL, Abell CW, Bembenek ME, Kwan SW, Seeburg PH and Shih JC (1988) cDNA cloning of human liver monoamine oxidase A and B: Molecular basis of differences in enzymatic properties. Proc Natl Acad Sci USA 85:4934-4938.
3. Carpéné C, Collon P, Remaury A, Cordi A, Hudson A, Nutt D and Lafontan M (1995) Inhibition of amine oxidase activity by derivatives that recognize imidazoline I2 sites. J Pharmacol Exp Ther 272:681-688.
4. 3H-Ro 19-6327: A reversible ligand and affinity labelling probe for monoamine oxidase B. Eur J Pharmacol 162:457-465.
5. Cesura AM, Gottowik J, Lahm HW, Lang G, Imhof R, Malherbe P, Ràthlisberger U and DaPrada M (1996) Investigation on the structure of the active site of monoamine oxidase B by affinity labeling with the selective inhibitor lazabemide and by site-directed mutagenesis. Eur J Biochem 236:96-1002.
6. 50) of an enzymatic reaction. Biochem Pharmacol 22:3099-3108.
7. Eglen RM, Hudson AL, Kendall DA, Nutt DJ, Morgan NG, Wilson VG and Dillon MP (1998) 'Seeing through a glass darkly': Casting light on imidazoline 'I' sites. Trends Pharmacol Sci 19:381-390.
8. Fellman JH, Roth ES and Mollica RF (1969) A radiochemical method for monoamine oxidase assay. Anal Biochem 30:339-345.
9. Fowler JS, Volkow ND, Wang GJ, Pappas N, Logan J, Macgregor R, Alexoff D, Shea C, Schlyer D, Wolf AP, Warner D, Zezulkova I and Cilento R (1996a) Inhibition of monoamine oxidase B in the brains of smokers. Nature (Lond) 379:733-736.
10. Fowler JS, Volkow ND, Wang GJ, Pappas N, Logan J, Shea C, Alexoff D, Macgregor RR, Schlyer DJ, Zezulkova I and Wolf AP (1996b) Brain monoamine oxidase A inhibition in cigarette smokers. Proc Natl Acad Sci USA 93:14065-14069.
11. Gottowik J, Malherbe P, Lang G, DaPrada M and Cesura M (1995) Structure/ function relationships of mitochondrial monoamine oxidase A and B chimeric forms. Eur J Biochem 230:934-942.
12. Ivkovic B, Bakthavachalam V, Zhang W, Parmi A, Diz D, Bosch S, Neumeyer JL and Lanier SM (1994) Development of a high affinity radioiodinated ligand for identification of imidazoline/guanidinium receptive sites (IGRS): Intratissue distribution of IGRS in forebrain, kidney and liver. Mol Pharmacol 46:15-23.
13. 35]GTP-gamma-S binding. Biochem Pharmacol 55:1035-1043.
14. Keller HH, Kettler R, Keller G and Da Prada M (1987) Short-acting novel MAO inhibitors: In vitro evidence for the reversibility of MAO inhibition by moclobenamide and Ro 16-6491. Naunyn-Schmiedeberg's Arch Pharmacol 335:12-20.
15. Lanier SM, Ivkovic B, Neumeyer J and Bakthavachalam V (1993) Identification of the ligand-binding subunit of the imidazoline/guanidinium receptive site (IGRS). J Biol Chem 268:16047-16051.
16. Lazo O, Contresas M and Singh I (1991) Effect of ciprofibrate on the activation and oxidation of very long chain fatty acids. Mol Cell Biochem 100:159-167.
17. Limon I, Coupry I, Lanier SM and Parini A (1992) Purification and characterization of mitochondrial imidazoline-guanidinium receptive site from rabbit kidney. J Biol Chem 267:21645-21649.
18. Lowry OH, Rosebrough NJ, Farr AL and Randall RJ (1951) Protein measurement with the folin phenol reagent. J Biol Chem 193:265-275.
19. Mourtada M, Smith SA and Morgan NG 119971 Insulin secretagogues with an imidazoline structure inhibit arginine-induced glucagon secretion from isolated rat islets of Langerhans. Biochem Biophys Res Commun 236:162-166.
20. Olmos G, Gabilondo AM, Miralles A, Escriba PV and Garcia-Sevilla JA (1993) Chronic treatment with the monoamine oxidase inhibitors clorgyline and pargy-line down-regulates non-adrenoceptor [3H]-idazoxan binding sites in the rat brain. Br J Pharmacol 108:597-603.
21. Ozaita A, Olmos G, Boronat MA, Lizcano JM, Unzeta M and Garcia Sevilla JA (1997) Inhibition of monoamine oxidase A and B activities by imidazol/(line)/guanidine drugs, nature of the interaction and distinction from I-2-imidazoline receptors in rat liver. Br J Pharmacol 121:901-912.
22. Palaty V and Cragoe EJ Jr (1989) Inhibition of monoamine oxidase by analogues of amiloride. Mol Pharmacol 36:296-301.
23. Parini A, Moudanos CG, Pizzinat N and Lanier SM (1996) The elusive family of imidazoline binding sites. Trends Pharmacol Sci 17:3-16.
24. Raddatz R, Parini A and Lanier SM (1995) Imidazoline/guanidinium binding domains on monoamine oxidases: Relationship to subtypes of imidazoline-binding proteins and tissue-specific interaction of imidazoline ligands with monoamine oxidase B. J Biol Chem 270:27961-27968.
25. Raddatz R, Parini A and Lanier SM (1997) Localization of the IBD on monoamine oxidase B. Mol Pharmacol 62:549-553.
26. Regunathan S and Reis DJ (1996) Imidazoline receptors and their endogenous ligands. Annu Rev Pharmacol Toxicol 36:511-544.
27. Reis DJ and Piletz JE (1997) The imidazoline receptor in control of blood pressure by clonidine and allied drugs. Am J Physiol 42:R1569-R1571.
28. 3H]idazoxan binding sites (I2-imidazoline sites) in the human brain: Strong correlation of I2 with monoamine oxidase-B sites. J Neurochem 61;881-889.
29. Tesson F, Limon-Boulez I, Urban P, Puype M, Vandekerckhove J, Coupry I, Pompon D and Parini A (1995) Localization of I2-imidazoline binding sites on monoamine oxidases. J Biol Chem 270:9856-9861.
30. Tesson F, Prip-Buus C, Lemoine A, Pegorier JP and Parini A (1991) Subcellular distribution of imidazoline-guanidinium-receptive sites human and rabbit liver. Major localization to the mitochondrial membrane. J Biol Chem 266:155-160.
31. Tsugeno Y, Hirashiki I, Ogata F and Ito A (1995) Regions of the molecule responsible for substrate specificity of monoamine oxidase A and B: A chimeric enzyme analysis. J Biochem 118:974-980.
32. Tsugeno Y and Ito A (1997) A key amino acid responsible for substrate selectivity of monoamine oxidase A and B. J Biol Chem 272:14033-14036.