Cardiovascular effects of central administration of clonidine in conscious cats

Brain Research

Volumn 761, Issue 2, 1997, Pages 283-289

  Ally, Ahmmed ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEW ENGLAND   (United States)

Author keywords

2 Adrenoceptor; Arterial blood pressure; H2 histamine like receptor; Heart rate; Imidazoline receptor; Intracerebroventricular; Ventrolateral medulla

Indexed keywords

CIMETIDINE; CLONIDINE; EFAROXAN; HISTAMINE H2 RECEPTOR; IMIDAZOLE; YOHIMBINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTERIAL PRESSURE; ARTICLE; CARDIOVASCULAR FUNCTION; CAT; CONSCIOUSNESS; DATA ANALYSIS; FEMALE; HEART RATE; NONHUMAN; PRIORITY JOURNAL; RENOVASCULAR HYPERTENSION;

ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; ANTIHYPERTENSIVE AGENTS; BEHAVIOR, ANIMAL; BENZOFURANS; BLOOD PRESSURE; CARDIOVASCULAR SYSTEM; CATS; CIMETIDINE; CLONIDINE; COLORING AGENTS; CONSCIOUSNESS; DOSE-RESPONSE RELATIONSHIP, DRUG; EVANS BLUE; FEMALE; HEART RATE; HISTAMINE H2 ANTAGONISTS; IMIDAZOLES; INJECTIONS, INTRAVENTRICULAR; YOHIMBINE;

EID: 0030835531     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)00353-3     Document Type: Article

References (44)

1. A. Ally, G.A. Hand, J.H. Mitchell, Cardiovascular responses to static exercise in conscious cats: Effects of intracerebroventricular injection of clonidine, J. Physiol. 491 (2) (1996) 519-527.
2. 2-adrenoceptor involvement in the central cardiovascular action of clonidine in the conscious renal hypertensive cat, Eur. J. Pharmacol. 82 (1982) 155-160.
3. A.L. Berman, E.G. Jones, The Thalamus and Basal Telencephalon of the Cat, University of Wisconsin Press, Madison, WI, 1982.
4. P. Bousquet, P.G. Guertzenstein, Localization of central cardiovascular action of clonidine, Br. J. Pharmacol. 49 (1973) 573-579.
5. P. Bousquet, J. Schwanz, α-Adrenergic drugs: Pharmacological tools for the study of the central vasomotor control, Biochem. Pharmacol. 33 (1983) 1459-1465.
6. P. Bousquet, J. Feldman, J. Schwartz, Central cardiovascular effects of alpha-adrenergic drugs: Differences between catecholamines and imidazolines, J. Pharmacol. Exp. Ther. 230 (1984) 232-236.
7. P. Bousquet, J. Feldman, The blood pressure effects of alpha-adrenoceptor antagonists injected in the medullary site of action of clonidine: The nucleus reticularis lateralis, Life Science 40 (1987) 1045-1050.
8. 2-adrenergic receptors, Int. Rev. Neurobiol. 24 (1983) 343-431.
9. C.E. Byrum, R. Stornetta, P.G. Guyenet, Electrophysiological properties of spinally-projecting A5 noradrenergic neurons, Brain Res. 303 (1984) 15-29.
10. C.K.S. Chan, F. Sannajust, H.A. Head, Role of imidazoline receptors in the cardiovascular actions of moxonidine, rilmenidine and clonidine in conscious rabbits, J. Pharmacol. Exp. Ther. 276 (1996) 411-420.
11. J. Ciriello, M.M. Caverson, C. Polosa, Function of the ventrolateral medulla in the control of the circulation, Br. Res. Rev. 396 (1986) 359-391.
12. F.M.A. Correa, I.A.S. Magro, V.L. Peres-Polon, CNS mediation of cardiovascular responses to the intracerebroventricular administration of catecholamines, Trends Pharmacol. Sci. 3 (1982) 330-332.
13. 3H-para-aminoclonidine, J. Hypertens. 4 (5) (1986) S109-S111.
14. 2-adrenoceptors in the ventrolateral medulla, Eur. J. Pharmacol. 134 (1987) 1-13.
15. P. Ernsberger, M.P. Meeley, D.J. Reis, An endogenous substance with clonidine-like properties: Selective binding to imidazoline sites in the ventrolateral medulla, Brain Res. 441 (1988) 309-318.
16. P. Ernsberger, R. Giuliano, R.N. Willette, D.J. Reis, Role of imidazole receptors in the vasodepressor response to clonidine analogs in the rostral ventrolateral medulla, J. Pharmacol. Exp. Ther. 253 (1990) 408-418.
17. 1-imidazoline receptors, J. Cardiovasc. Pharmacol. 20 (1992) S1-S10.
18. L. Finch, The cardiovascular effects of intraventricular clonidine and BAY 1470 in conscious hypertensive cats, Br. J. Pharmacol. 52 (1974) 333-338.
19. L. Finch, P.E. Hicks, No evidence for central histamine-receptor involvement with the hypotensive effect of clonidine in cats, Eur. J. Pharmacol. 40 (1976) 365-368.
20. 2-agonists, J. Cardiol. 7 (Suppl. 8) (1985) S38-S44.
21. A.R. Granata, Y. Numao, M. Kumada, D.J. Reis, A1 noradrenergic neurons tonically inhibit sympathoexcitatory neurons of the C1 area in rat brainstem, Brain Res. 377 (1986) 127-146.
22. 2-Adrenergic receptors rather than "Imidazoline" binding sites mediate the sympatholytic effect of clonidine in the rostral ventrolateral medulla: a new look at the evidence, in: O. Trouth, R. Millis, H. Kiwull-Schone, M. Schlafke (Eds.), Ventral Brainstem Mechanisms and Control, Marcel Dekker, NY, 1993.
23. G.A. Head, P.I. Korner, S.L. Lewis, E. Badoer, Contribution of nor-adrenergic and serotonergic neurons to the circulatory effects of centrally acting clonidine and α-methyldopa in rabbits, J. Cardiovasc. Pharmacol. 5 (1983) 945-953.
24. J.P. Hieble, D.C. Kolpak, Mediation of the hypotensive action of systemic clonidine in the rat by alpha(2)-adrenoceptors, Br. J. Pharmacol. 110 (1993) 1635-1639.
25. 2-adrenoceptors, in: D.J. Reis, P. Bousquet, A. Parini (Eds.), The Imidazoline Receptor: Pharmacology, Functions, Ligands, and Relevance to Biology and Medicine, Ann. NY Acad. Sci., 763 (1995) 8-21.
26. L. Issac, Clonidine in the central nervous system: Site and mechanism of hypotensive response, J. Cardiovasc. Pharmacol. 2 (1980) S5-S19.
27. 2-receptors in the hypotensive effect of clonidine, Nature 259 (1976) 587-588.
28. 2-receptor involvement in the hypotensive effect of clonidine in the rat, Eur. J. Pharmacol. 42 (1977) 299-302.
29. H. Karppanen, Interrelationships between clonidine and histaminergic mechanisms, Trends Pharmacol. Sci. 2 (1981) 35-37.
30. H. Kawasaki, K. Takasaki, Central alpha-2 adrenoceptor-mediated hypertensive response to clonidine in conscious, normotensive rats, J. Pharmacol. Exp. Ther. 236 (1986) 810-818.
31. W. Kobinger, Central cardiovascular actions of clonidine, in: D.S. Davies, J.L. Reid (Eds.), Central Action of Drugs in Blood Pressure Regulation, University Park Press, Baltimore, 1975, pp. 181-193.
32. W. Kobinger, Central α-adrenergic systems as targets for hypotensive drugs, Rev. Physiol., Biochem. Pharmacol. 81 (1978) 39-100.
33. G. Li, S. Regunathan, C.J. Barrow, J. Eshraghi, R. Cooper, D.J. Reis, Agmatine: An endogenous clonidine-displacing substance in the brain, Science 262 (1994) 966-969.
34. J. Marwaha, G.K. Aghajanian, Relative potencies of alpha-1 and alpha-2 antagonists in the locus coeruleus, dorsal raphe and dorsal lateral geniculate nuclei: An electrophysiological study, J. Pharmacol. Exp. Ther. 222 (1982) 287-293.
35. K. Matsukawa, L.B. Wilson, PT. Wall, J.H. Mitchell, Differential effects of clonidine on renal sympathetic nerve activity and heart rate at onset of static exercise, J. Aut. Nervous Sys. 51 (1995) 205-212.
36. J.K. Merlis, The effects of changes in the calcium content of the cerebrospinal fluid on spinal reflex activity in the dog, Am. J. Physiol. 131 (1940) 67-72.
37. A. Philippu, R. Demmler, G. Rosenberg, Effects of centrally applied drugs on the pressor responses to hypothalamic stimulation, Naunyn-Schmiedeberg's Arch. Pharmacol. 282 (1974) 389-400.
38. S. Punnen, R. Urbanski, A.J. Krieger, H.N. Sapru, Ventrolateral medullary pressor area: Site of hypotensive action of clonidine, Brain Res. 422 (1987) 36-46.
39. L. Quintin, M. Ghigone, J.-F. Pujol, The ability of the alpha 2-adrenergic agonist clonidine to suppress central noradrenergic hyperactivity secondary to hemodynamic or environmental stimuli, J. Cardiovasc. Pharmacol. 10 (1987) S128-S134.
40. C.A. Ross, D.A. Ruggiero, D.H. Park, T.H. Joh, A.F. Sved, J.F. Pardal, J.M. Saavedra, D.J. Reis, Tonic vasomotor control by the rostral ventrolateral medulla; effect of electrical or chemical stimulation of the area containing C1 adrenaline neurons on arterial pressure, heart rate and plasma catecholamines and vasopressin, J. Neurosci. 4 (1984) 474-494.
41. B. Szabo, R. Urban, K. Starke, Sympathoinhibition by rilmenidine in conscious rabbits: Involvement of alpha(2)-adrenoceptors, Naunyn-Schmiedeberg's Arch. Pharmacol. 348 (1993) 593-600.
42. M.K. Sun, P.G. Guyenet, Effect of clonidine and gamma-aminobutyric acid on the discharges of medullo-spinal sympathoexcitatory neurons in the rat, Brain Res. 368 (1986) 1-17.
43. P.B.M.W.M. Timmermans, A. Schoop, H. Kwa, P.A. VanZwiete, Characterization of α-adrenergic receptors participating in the central hypotensive and sedative effects of clonidine using yohimbine, rauwolscine and corynanthine, Eur. J. Pharmacol. 70 (1981) 7-15.
44. G. Trolin, Effects of pentobarbitone and decerebration on the clonidine-induced circulatory changes, Eur. J. Pharmacol. 34 (1975) 1-7.