Role of imidazoline receptors in the cardiovascular actions of moxonidine, rilmenidine and clonidine in conscious rabbits

Journal of Pharmacology and Experimental Therapeutics

Volumn 276, Issue 2, 1996, Pages 411-420

  Chan, Candy K S ^a   Sannajust, Frederic ^a,b   Head, Geoffrey A ^a  

^a BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^b UNIVERSITÉ DE TOURS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; ANTIHYPERTENSIVE AGENT; CLONIDINE; DRUG RECEPTOR; IMIDAZOLE DERIVATIVE; IMIDAZOLINE RECEPTORS; MOXONIDINE; OXAZOLE DERIVATIVE; RILMENIDINE;

ANIMAL; ARTICLE; BLOOD PRESSURE; DOSE RESPONSE; DRUG EFFECT; FEMALE; HEART RATE; MALE; PHYSIOLOGY; RABBIT;

ANIMALS; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; CLONIDINE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HEART RATE; IMIDAZOLES; MALE; OXAZOLES; RABBITS; RECEPTORS, ADRENERGIC, ALPHA-2; RECEPTORS, DRUG;

EID: 0030075244     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (61)

1. 2-receptor selectivity and specificity of the antihypertensive agent moxonidine. Arzneim.-Forsch. Drug Res. 38: 1435-1442, 1988.
2. ARMAH, B. I., HOFFERBER, E. AND STENZEL, W.: General pharmacology of the novel centrally acting antihypertensive agent moxonidine. Arzneim.-Forsch. Drug Res. 38: 1426-1434, 1988.
3. BADOER, E., HEAD, G. A., ABERDEEN, J. A. AND KORNER, P. I.: Localization of the main noradrenergic neuron groups in the pons and medulla of the rabbit and the importance of cathodal lesions for prolonged survival. J. Neurosci. Methods 19: 11-27, 1987.
4. BADOER, E , HEAD, G. A. AND KORNER, P. I.: Effects of intracisternal and intravenous α-methyldopa and clonidine on haemodynamics and baroreceptor-heart rate reflex properties in conscious rabbits. J. Cardiovasc. Pharmacol. 5: 760-767, 1983.
5. BOUSQUET, P , FELDMAN, J. AND SCHWARTZ, J.: Central cardiovascular effects of alpha adrenergic drugs: Differences between catecholamines and imidazolines. J. Pharmacol. Exp. Ther. 230: 232-236, 1984.
6. BOUSQUET, P. AND GUERTZENSTEIN, P. G.: Localization of the central cardiovascular action of clonidine. Br. J. Pharmacol. 49: 573-579, 1973.
7. BRICCA, G , DONTENWILL, M., MOLINES, A., FELDMAN, J., BELCOURT, A. AND BOUSQUET, P.: The imidazoline-preferring receptor: Binding studies in bovine, rat and human brainstem. Eur. J. Pharmacol. 162: 1-9, 1989a.
8. BRICCA, G., DONTENWILL, M., MOLINES, A., FELDMAN, J., TIBIBICA, E., BELCOURT, A. AND BOUSQUET, P.: Rilmenidine selectivity for imidazoline receptors in human brain. Eur. J. Pharmacol. 163: 373-377, 1989b.
9. 3H]clonidine to identify imidazoline receptors in the rabbit brainstem Br. J. Pharmacol. 110: 1537-1543, 1993.
10. 2 adrenergic receptors and non-stereoselective sites in human and rabbit brain cortex membranes. Biochem. Pharmacol. 38: 455-463, 1989.
11. COUPRY, I., LIMON, I., TESSON, F., LACHAUD, V., GARGALIDISMOUDANOS, C. AND PARINI, A.: The imidazoline-guanidinium receptive site: A subtype of imidazoline receptors. Therapie 47: 519-524, 1992.
12. 2-adrenoceptors in the human central nervous system. Neuroscience 59: 589-598, 1994.
13. 1-imidazoline sites. J. Pharmacol. Exp. Ther. 264: 172-182, 1993.
14. ERNSBERGER, P., GUILIANO, R., WILLETTE, R. N. AND REIS, D J.: Role of imidazole receptors in the vasodepressor response to clonidine analogs in the rostral ventrolateral medulla. J. Pharmacol. Exp. Ther. 253: 408-418, 1990.
15. 1-imidazoline agonist. Cardiovasc. Drug Ther. 8: 27-41, 1994.
16. 2-adrenoceptors in the ventrolateral medulla. Eur. J. Pharmacol. 134: 1-13, 1987
17. 1-imidazoline receptors. J. Cardiovasc. Pharmacol. 20: S1-S10, 1992.
18. FELDMAN, J., TIBIRICA, E., BRICCA, G., DONTENWILL, M., BELCOURT, A AND BOUSQUET, P.: Evidence for the involvement of imidazoline receptors in the central hypotensive effect of rilmenidine in the rabbit. Br. J. Pharmacol. 100: 600-604, 1990.
19. 2-adrenoceptors in rat brain membranes. Arzneim.-Forsch. Drug Res. 38: 1442-1448, 1988.
20. FILLASTRE, J. P., LETAC, B., GALINIER, F., LE BIHAN, G. AND SCHWARTZ, J.: A multicentre double blind comparative study of rilmenidine and clonidine in 333 hypertensive patients. Am. J. Cardiol. 61: 81d-85d, 1988
21. FINCH, L. AND HAEUSLER, G.: Further evidence for a central hypotensive action of α-methyldopa in both rat and cat. Br. J. Pharmacol. 47: 217-228, 1973.
22. GOLDBERG, M. R., SE TUNG, C., RING, M., OATES, J. A., GERKENS, J. F. AND ROBERTSON, D.: Evidence that α-methylepinephrine is an antihypertensive metabolite of α-methyldopa. Clin. Exp. Hypertens. [A] A4: 595-604, 1982.
23. GOMEZ, R. E., ERNSBERGER, P , FEINLAND, G. AND REIS, D. J.: Rilmenidine lowers arterial pressure via imidazole receptors in brainstem C1 area. Eur. J. Pharmacol. 195: 181-191, 1991.
24. 2-adrenoceptors. J. Cardiovasc. Pharmacol. 20: s16-s20, 1992.
25. 3H]idazoxan bind to different sites on rabbit forebrain and kidney membranes. Eur. J. Pharmacol. 146: 345-348, 1988.
26. 2-adrenoceptor sites? Clin. Exp. Hypertens. [A] 14: 815-835, 1992.
27. HAUSLER, G.: Central α-adrenoceptors involved in cardiovascular regulation. J. Cardiovasc. Pharmacol. 4: s72-s76, 1982.
28. 1-imidazoline agonist moxonidine administered into the rostral ventrolateral medulla J. Cardiovasc. Pharmacol. 20: s11-s15, 1992.
29. 1-imidazoline receptors in the rostral ventrolateral medulla. J. Cardiovasc. Pharmacol. 24: S1-S8, 1994.
30. HEAD, G. A. AND BURKE, S. L.; Importance of central noradrenergic and serotonergic pathways in the cardiovascular actions of rilmenidine and clonidine. J. Cardiovasc. Pharmacol. 18: 819-826, 1991.
31. HEAD, G. A., GODWIN, S. J. AND SANNAJUST, F.: Differential receptors involved in the cardiovascular effects of clonidine and rilmenidine in conscious rabbits. J. Hypertens. 11: suppl. 5, s322-s323, 1993.
32. HEAD, G. A., KORNER, P. I., LEWIS, S. L. AND BADOER, E.: Contribution of noradrenergic and serotonergic neurons to the circulatory effects of centrally acting clonidine and α-methyldopa in rabbits. J. Cardiovasc. Pharmacol. 5: 945-953, 1983.
33. HEAD, G. A. AND SANNAJUST, F.: Importance of imidazoline receptors in the cardiovascular responses to clonidine and rilmenidine in conscious rabbits. Fundam. Clin Pharmacol. 6: suppl. 1, 31s-43s, 1992.
34. 2-adrenoceptors, Br. J. Pharmacol. 110: 1635-1639, 1993.
35. 2-adrenoceptors and imidazoline binding sites: Distribution of imidazoline binding sites in rat brain. Brain Res. 514: 15-21, 1990.
36. 2-adrenoceptor-mediated pressor response to clonidine in conscious, spontaneously hypertensive rats. Jpn. J. Pharmacol. 59: 321-331, 1992.
37. KOBINGER, W. AND PILCHER, L.: Differentiation of drugs acting centrally upon the cardiovascular system by means of sympathetic and vagal responses. Clin. Exp. Hypertens. [A] 1: 229-249, 1978.
38. 2A-adrenoceptors. Eur J. Pharmacol. 167: 95-104, 1989.
39. LOUIS, W. J., CONWAY, E., SUMMERS, R, BEART, P. AND JARROTT, B.: Effects of methyldopa metabolites on amine transmitters and adrenergic receptors in rat brain. Hypertension 6: II-40-II-44, 1984.
40. 3H]RX821002 in the rat brain. Br J Pharmacol. 102: 221P, 1991.
41. 3H]RX821002 (2-methoxy idazoxan) in the human and rat brains. J. Pharmacol. Exp. Ther. 264: 1187-1197, 1993.
42. NIJKAMP, F. P. AND DE JONG, W.: Conversion of α-methyldopa to α-methylnoa-drenaline; an explanation for the central inhibitory effect of α-methyldopa on blood pressure and heart rate of rats. Neth J. Med. 17: 304-305, 1974.
43. OLLIVIER, J. P., CHRISTEN, M. O. AND SCHAFER, S. G.: Moxonidine: A second generation of centrally acting drugs. J. Cardiovasc. Pharmacol. 20: s31-s36, 1992.
44. OSTERMANN, G., BRISGAND, B., SCHMITT. J. AND FILLASTRE, J. P.: Efficacy and acceptability of rilmenidine for mild to moderate systemic hypertension. Am. J. Cardiol. 61: 76d-80d, 1988.
45. 2-adrenergic receptor. J. Biol. Chem. 264: 11874-11878, 1989.
46. PLANITZ, V.: Crossover comparison of moxonidine and clonidine in mild to moderate hypertension. Eur. J. Clin. Pharmacol. 27: 147-152, 1984.
47. PLANITZ, V.: Comparison of moxonidine and clonidine HCl in treating patients with hypertension. J. Clin. Pharmacol. 27: 46-51, 1987.
48. PRICHARD, B. N. C., SIMMONS, R., ROOKS, M. J., HAWORTH, D. A., LAWS, D. AND WONNACOTT, S.: A double-blind comparison of moxonidine and atenolol in the management of patients with mild-to-moderate hypertension. J. Cardiovasc. Pharmacol. 20: suppl. 4, s45-s49, 1992.
49. PUNNEN, S., URBANSKI, R., KRIEGER, A. J. AND SAPRU, H. N.: Ventrolateral medullary pressor area: site of hypotensive action of clonidine. Brain Res. 422: 336-346, 1987.
50. SANNAJUST, F. AND HEAD, G. A.: Rilmenidine-induced hypotension involves imidazoline-preferring receptors in conscious rabbits. J. Cardiovasc. Pharmacol. 23: 42-50, 1994.
51. 2-autoreceptors are involved in the blood pressure-lowering effect of moxonidine. J. Cardiovasc. Pharmacol. 16: 15-22, 1990.
52. SCHMITT, H.: The pharmacology of clonidine and related products. In Handbook of Experimental Pharmacology, ed. by F. Gross, vol. 39, pp. 1-299, Springer-Verlag, Berlin, 1977.
53. SPIERS, J. P., HARRON, D. W. G. AND WILSON, R.: Acute and chronic effects of rilmenidine on baroreflex function in conscious dogs. Eur. J. Pharmacol 181: 235-240, 1990.
54. 2-adrenoceptors. Naunyn-Schmiedeberg's Arch. Pharmacol. 348: 593-600, 1993.
55. TIBIRICA, E., FELDMAN, J. AND BOUSQUET, P.: Differences in the ability of yohimbine to antagonize the hypotensive effect of clonidine in normotensive and spontaneously hypertensive anaesthetized rats. J. Pharmacol. Exp. Ther. 244: 1062-1066, 1988.
56. TIBIRICA, E., FELDMAN, J. AND BOUSQUET, P.: Contribution of catecholaminergic neurons of the dorsomedial and ventrolateral medulla-oblongata to the hypotensive effect of clonidine in spontaneously hypertensive rats: in vivo voltammetric studies. J. Hypertens 10: 1327-1334, 1992.
57. TIBIRICA, E., FELDMAN, J., MERMET, C., GONON, F. AND BOUSQUET, P.: An imidazoline-specific mechanism for the hypotensive effect of clonidine. A study with yohimbine and idazoxan. J. Pharmacol. Exp. Ther. 256: 606-613, 1991a.
58. TIBIRICA, E., FELDMAN, J., MERMET, C., MONASSIER, L., GONON, F. AND BOUSQUET, P.: Selectivity of rilmenidine for the nucleus reticularis lateralis, a ventrolateral medullary structure containing imidazoline-preferring receptors. Eur. J. Pharmacol. 209: 213-221, 1991b.
59. WALLENSTEIN, S., ZUCKER, C. L. AND FLEISS, J. L.: Some statistical methods useful in circulation research. Circ. Res. 47: 1-9, 1980.
60. WIKBERG, J E. S.: High affinity binding of idazoxan to a non-catecholaminergic binding site in the central nervous system: Description of putative idazoxan-receptor. Pharmacol. Toxicol. 64:152-155, 1989.
61. 2-adrenoceptor agonist, rilmenidine, for systemic hypertension. Am. J. Cardiol. 61: 67d-71d, 1988.