Studies on the acute and chronic effects of reboxetine on extracellular noradrenaline and other monoamines in the rat brain

British Journal of Pharmacology

Volumn 128, Issue 6, 1999, Pages 1332-1338

  Sacchetti, G ^a   Bernini, M ^a   Bianchetti, A ^b   Parini, S ^a   Invernizzi, R W ^a   Samanin, R ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^b PFIZER INC   (United States)

Author keywords

5 HT; Dopamine; Dorsal hippocampus; Frontal cortex; Idazoxan; Microdialysis; Noradrenaline; Reboxetine; Striatum; 2 adrenoceptors

Indexed keywords

CLONIDINE; DOPAMINE; IDAZOXAN; MONOAMINE; NORADRENALIN; REBOXETINE; SEROTONIN;

ADAPTATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; DOSE RESPONSE; DRUG EFFECT; DRUG POTENTIATION; DRUG SELECTIVITY; FRONTAL CORTEX; HIPPOCAMPUS; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; NORADRENALIN BRAIN LEVEL; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0032712514     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702926     Document Type: Article

References (28)

1. ADELL, A. & ARTIGAS, F. (1991) Differential effects of clomipramine given locally or systemically on extracellular 5-hydroxytryptamine in raphe nuclei and frontal cortex. N. S. Arch. Pharmacol., 343, 237-244.
2. 1A receptor antagonist (S)-UH-301 augments the increase in the extracellular concentrations of 5-HT in the frontal cortex produced by both acute and chronic treatment with citalopram. N. S. Arch. Pharmacol., 353, 630-640.
3. 1A antagonists. Trends Neurosci., 19, 378-383.
4. DE MONTIGNY, C., CHAPUT, Y. & BLIER, P. (1993) Classical and novel targets for antidepressant drugs. In: J. Mendlewicz, N. Brunello, S.Z. Langer and G. Racagni, eds. New Pharmacological Approaches to the Therapy of Depressive Disorders. Karger, Basel, pp. 8-17.
5. EDWARDS, D.M.F., PELLIZZONI, C., BREUEL, H.P., BERARDI, A., CASTELLI, M.G., FRIGERIO, E., POGGESI, I., ROCCHETTI, M., DUBINI, A. & STROLIN BENEDETTI, M. (1995) Pharmacokinetics of reboxetine in healthy volunteers. Single oral doses, linearity and plasma protein binding. Biopharm. Drug Disp., 16, 443-460.
6. 2-adrenoceptor function in the brain: rapid down-regulation by sibutramine hydrochloride. Psychopharmacology, 103, 251-257.
7. 1A autoreceptors in the action of selective 5-HT reuptake inhibitors. Eur. J. Pharmacol., 260, 251-255.
8. INVERNIZZI, R., BELLI, S. & SAMANIN, R. (1991) An increase of extracellular 5-HT in the dorsal raphe masks the effect of sertraline in the frontal cortex. In: H. Rollema, B.H.C. Westerink and W.J. Drijfhout, eds, Monitoring Molecules in Neuroscience. University Centre for Pharmacy: Groningen. pp. 253-255.
9. INVERNIZZI, R., BELLI, S. & SAMANIN, R. (1992) Citalopram's ability to increase the extracellular concentrations of 5-HT in the dorsal raphe prevents the drug's effect in the frontal cortex. Brain Res., 584, 322-324.
10. 1A receptors. Eur. J. Pharmacol., 260, 243-246.
11. 1A receptors in the effects of acute and chronic fluoxetine on extracellular 5-HT in the frontal cortex. Pharmacol. Biochem. Behav., 54, 143-147.
12. 1A receptor antagonists on citalopram-induced increase in extracellular 5-HT in the frontal cortex, striatum and dorsal hippocampus. Neuropharmacology, 36, 467-473.
13. LACROIX, D., BLIER, P., CURET, O. & DE MONTIGNY, C. (1991) Effects of long-term desipramine administration on noradrenergic neurotransmission: electrophysiological studies in the rat brain. J. Pharmacol. Exp. Ther., 257, 1081-1090.
14. LINDVALL, O., & BJORKLUND, A. (1974) The organization of the ascending catecholamine neuron system in the rat brain as revealed by the glyoxylic acid fluorescence method. Acta Physiol. Scand., 412, Suppl. 1.
15. 2-adrenoceptors in the locus coeruleus are involved in the in vivo modulation of cortical noradrenaline release by the antidepressant desipramine. J. Neurochem., 71, 790-798.
16. 2-adrenoceptors subtypes. N. S. Arch. Pharmacol., 345, 410-416.
17. MCMILLEN, B.A., WARNACK, W., GERMAN, D.C. & SHORE, P.A. (1980) Effects of chronic desipramine treatment on rat brain noradrenergic responses to α-adrenergic drugs. Eur. J. Pharmacol., 61, 239-246.
18. MONTGOMERY, S.A. (1999) Predicting response: noradrenaline reuptake inhibition. Int. Clin. Psychopharmacol., 14 (suppl 1): S21-S26.
19. PAXINOS, G. & WATSON, C. (1982). The rat brain in stereotaxic coordinates. Academic Press: Sydney.
20. RIVA, M., BRUNELLO, N., ROVESCALLI, A.C., GALIMBERTI, R., CARFAGNA, N., CARMINATI, P., POZZI, O., RICCIARDI, S., RONCUCCI, R., ROSSI, A. & RACAGNI, G. (1989) Effect of reboxetine, a new antidepressant drug, on the central noradrenergic system: behavioural and biochemical studies. Journal Drug Development, 1, 243-253.
21. ROBINSON, T.E. & WHISHAW, I.Q. (1988) Normalization of extracellular dopamine in striatum following recovery from a partial unilateral 6-OHDA lesion of the substantia nigra: a microdialysis study in freely moving rats. Brain Res., 450, 209-224.
22. ROMERO, L. & ARTIGAS, F. (1997). Preferential potentiation of the effect of 5-HT uptake inhibitors by 5-HT1A receptor antagonists in the dorsal raphe pathway: role of somatodendritic autoreceptors. J. Neurochem., 68, 2593-2603.
23. RUTTER, J.J., GUNDLAH, C. & AUERBACH, S.B. (1994) Increase in extracellular 5-HT produced by uptake inhibitors is enhanced after chronic treatment with fluoxetine. Neuroscience Letters, 171, 183-186.
24. STROLIN BENEDETTI, M., FRIGERIO, E., TOCCHETTI, P., BRIANCESCHI, G., CASTELLI, M.G., PELLIZZONI, C. & DOSTERT, P. (1995) Stereoselective and species-dependent kinetics of reboxetine in mouse and rat. Chirality, 7, 285-289.
25. THOMAS, D.N. & HOLMAN, R.B. (1991) Regulation of endogenous noradrenaline release in rat hippocampus and frontal cortex: in vivo microdialysis. Br. J. Pharmacol., 102, 5P.
26. THOMAS, D.N., POST, R.M. & PERT, A. (1994) Focal and systemic cocaine differentially affect extracellular norepinephrine in the locus coeruleus, frontal cortex and hippocampus of the anaesthetized rat. Brain Res., 645, 135-142.
27. VAN VELDHUIZEN, M.J.A., FEENSTRA, M.G.P. & BOER, G.J. (1994) Regional differences in the in vivo regulation of the extracellular levels of noradrenaline and its metabolites in rat brain. Brain Res., 635, 238-248.
28. 1A binding sites on 5-HT containing neurons in the raphe dorsalis and raphe centralis nuclei of the rat brain. Neurochem. Int., 7, 1061-1072.