Clonidine evokes vasodepressor responses via α2-adrenergic receptors in gigantocellular reticular formation

Journal of Pharmacology and Experimental Therapeutics

Volumn 289, Issue 2, 1999, Pages 688-694

  Aicher, Sue A ^a   Drake, Carrie T ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHOXYLDAZOXAN; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; CLONIDINE; GLUTAMIC ACID; PRAZOSIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BRADYCARDIA; CARDIOVASCULAR RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; DOSE RESPONSE; DRUG ANTAGONISM; GIGANTOCELLULAR RETICULAR NUCLEUS; HYPOTENSION; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; RAT; RETICULAR FORMATION; RETICULOSPINAL TRACT; VASODILATATION;

ADRENERGIC ALPHA-AGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; BLOOD PRESSURE; CLONIDINE; DEPRESSION, CHEMICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HEART RATE; HEMODYNAMIC PROCESSES; IDAZOXAN; MALE; MEDULLA OBLONGATA; MICROINJECTIONS; NEURONS; PRAZOSIN; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, ALPHA-2; RETICULAR FORMATION;

EID: 0032902556     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (38)

1. 2A-Adrenergic receptors in gigantocellular reticular formation mediate vasodepressor effects of clonidine and are located primarily at postsynaptic dendritic sites (Abstract ). Soc Neurosci Abstr 24:372.
2. Aicher SA and Reis DJ (1997) Gigantocellular vasodepressor area is tonically active and distinct from caudal ventrolateral vasodepressor area. Am J Physiol Regul Integr Comp Physiol 272:R731-R742.
3. Aicher SA, Reis DJ, Nicolae R and Milner TA (1995) Monosynaptic projections from the medullary gigantocellular reticular formation to sympathetic preganglionic neurons in the thoracic spinal cord. J Comp Neurol 363:563-580.
4. Aicher SA, Reis DJ, Ruggiero DA and Milner TA (1994) Anatomical characterization of a novel reticulospinal vasodepressor area in the rat medulla oblongata. Neuroscience 60:761-779.
5. Bousquet P, Feldman J, Bloch R and Schwartz J (1981) The nucleus reticularis lateralis: A region highly sensitive to clonidine. Eur J Pharmacol 69:389-392.
6. 2-adrenoceptors: Pharmacological and molecular biological evidence converge. Trends Pharmacol Sci 9:356-361.
7. Bylund DB, Ray-Prenger C and Murphy T (1988) Alpha-2A and alpha-2R adrenergic receptor subtypes: Antagonist binding in tissues and cell lines containing only one subtype. J Pharmacol Exp Ther 245:600-607.
8. Chan SHH and Chan JYH (1983) Correlated effects of clonidine on single-neuron activities in the gigantocellular reticular nucleus, arterial pressure and heart rate in the cat. Neurosci Lett 40:139-143.
9. Chan SHH and Koo A (1978) The participation of medullary reticular formation in clonidine-induced hypotension in rats. Neuropharmacology 17:367-373.
10. Chen Y-H and Chan SHH (1980) The involvement of gigantocellular reticular nucleus in clonidine-promoted hypotension and bradycardia in experimentally-induced hypertensive cats. Neuropharmacology 19:939-945.
11. Ernsberger P, Giuliano R, Willette RN and Reis DJ (1990) Role of imidazole receptors in the vasodepressor response to clonidine analogs in the rostral ventrolateral medulla. J Pharmacol Exp Ther 253:408-418.
12. 2A-adrenergic receptors are present in lower brainstem catecholaminergic and serotonergic neurons innervating spinal cord. Brain Res 638:285-294.
13. 2-adrenergic receptors. Mol Pharmacol 40:407-412.
14. Haya A and Guyenet PG (1998) Presynaptic effects mediated by alpha2-adrenoceptors (α2-AR) in the rat rostral ventrolateral medulla (RVL) (Abstract). Soc Neurosci Abstr 24:372.
15. 2-adrenoceptor. Br J Pharmacol 110:1635-1639.
16. Hieble JP and Ruffolo RR (1996) Subclassification and nomenclature of alpha 1- and alpha 2-adrenoceptors. Progr Drug Res 47:81-130.
17. Huangfu D, Goodwin WB and Guyenet P (1995) Sympatholytic effect of tricyclic antidepressants: Site and mechanism of action in anesthetized rats. Am J Physiol Regul lntegr Comp Physiol 268:R1429-R1441.
18. Jansen ASP, Nguyen XV, Karpitskiy V, Mettenleiter TC and Loewy AD (1995) Central command neurons of the sympathetic nervous system: Basis of the fight-or-flight response. Science (Wash DC) 270:644-646.
19. Kiely JM and Gordon FJ (1994) Role of rostral ventrolateral medulla in centrally mediated pressor responses. AmJ Physiol 267 (Heart Circ Physiol):H1549-H1556.
20. 2A-adrenoceptors. Eur J Pharmacol 167:95-104.
21. 2-adrenoceptors of the nucleus reticularis gigantocellularis involved in cardiovascular regulation in the rat. Brain Res 638:227-234.
22. 2-adrenoreceptors in the nucleus reticularis gigantocellularis and vagal mechanism in the cardiovascular suppressive effects of guanabenz in the rat. Neurosci Lett 63:45-50.
23. Lim HC, Chong OK and Chan SHH (1985) Participation of nucleus reticularis gigantocellularis in guanabenz-promoted hypotension, decrease in cardiac contractility and bradycardia in rats. Neuropharmacology 24:1241-1246.
24. Lim HC, Chong OK and Chan SHH (1988) Characterization of α-adrenoceptors in the nucleus reticularis gigantocellularis involved in the cardiovascular depressant effects of guanabenz in the rat. Neuropharmacology 27:243-249.
25. Lipski J, Przybylski J and Solnicka E (1976) Reduced hypotensive effect of clonidine after lesions of the nucleus tractus solitari in rats. Eur J Pharmacol 38:19-22.
26. 2a-adrenergic receptor subtype. Science (Wash DC) 273:801-803.
27. 2A-adrenergic receptors are primarily presynaptic heteroreceptors in the C1 area of the rat rostral ventrolateral medulla. Brain Res, in press.
28. Morrison SF and Reis DJ (1991) Responses of sympathetic preganglionic neurons to rostral ventrolateral medullary stimulation. Am J Physiol Regul Integr Comp Physiol 261:R1247-R1256.
29. 3H]RX821002 binding to alpha-2 adrenergic receptor subtypes. J Pharmacol Exp Ther 268:1362-1367.
30. Orer HS, Zhong S, Barman SM and Gebber GL (1996) Central catecholaminergic neurons are involved in expression of the 10-Hz rhythm in SND. Am J Physiol Regul Integr Comp Physiol 270:R333-R341.
31. Punnen S, Urbanski R, Krieger AJ and Sapru HN (1987) Ventrolateral medullary pressor area: Site of hypotensive action of clonidine. Brain Res 422:336-346.
32. Schreihofer AM and Guyenet PG (1997) Identification of C1 presympathetic neurons in rat rostral ventrolateral medulla by juxtacellular labeling in vivo. J Comp Neurol 387:524-536.
33. 2 agonists and is necessary for spinal adrenergic-opioid synergy. J Neurosci 17:7167-7165.
34. Stornetta RL, Huangfu D, Rosin DL, Lynch KR and Guyenet PG (1995) Alpha-2 adrenergic receptors: Immunohistochemical localization and role in mediating inhibition of adrenergic RVLM presympathetic neurons by catecholamines and clonidine. Ann NY Acad Sci 763:541-551.
35. Sun MK and Guyenet PG (1986) Effect of clonidine and gamma-aminobutyric acid on the discharges of medullo-spinal sympathoexcitatory neurons in the rat. Brain Res 368:1-17.
36. Swanson LW (1992) Brain Maps: Structure of the Rat Brain. Elsevier Science Publishers B.V. Amsterdam, The Netherlands.
37. 2-adrenoceptor antagonists of the central sympatho-inhibitory effect of clonidine. Br J Pharmacol 117:587-593.
38. Winer BJ (1971) Statistical Principles in Experimental Design. McGraw-Hill, New York.