Membrane localization and guanine nucleotide sensitivity of medullary I1-imidazoline binding sites

Neurochemistry International

Volumn 30, Issue 1, 1997, Pages 17-23

  Ernsberger, Paul ^a,b   Shen, I Hsuan ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 CHLORO 2 (2 IMIDAZOLIN 2 YLAMINO)ISOINDOLINE; ADENOSINE TRIPHOSPHATE; ADRENALIN; CLONIDINE; GUANINE NUCLEOTIDE; IDAZOXAN; IMIDAZOLINE RECEPTOR; MEMBRANE PROTEIN; MYELIN;

ANIMAL TISSUE; ARTICLE; BINDING SITE; BRAIN MITOCHONDRION; CATTLE; CELL MEMBRANE; CONTROLLED STUDY; GLIA; ISOTOPE LABELING; MEDULLA OBLONGATA; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RECEPTOR BINDING; SUCROSE DENSITY GRADIENT CENTRIFUGATION;

AFFINITY LABELS; ANIMALS; BINDING SITES; CATTLE; CELL FRACTIONATION; CELL MEMBRANE; CLONIDINE; GUANINE NUCLEOTIDES; GUANYLYL IMIDODIPHOSPHATE; IDAZOXAN; MEDULLA OBLONGATA; RECEPTORS, DRUG; TRITIUM;

EID: 0031026350     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-0186(96)00033-2     Document Type: Article

References (42)

1. 2A-adrenergic receptor-like immunoreactivity. Brain Res. 650, 181-204.
2. Bousquet, P., Feldman, J., Bloch, R. and Schwartz, J. (1984) Central cardiovascular effects of α-adrenergic drugs: differences between catecholamines and imidazolines. J. Pharmacol. Exp. Ther. 230, 232-236.
3. Bousquet, P. and Guertzenstein, P. G. (1973) Localization of the central cardiovascular action of clonidine. Br. J. Pharmacol. 49, 573-579.
4. Bricca, G., Dontenwill, M., Molines, A., Feldman, J., Belcourt, A. and Bousquet, P. (1989) The imidazoline preferring receptor: binding studies in bovine, rat and human brainstem. Eur. J. Pharmacol. 162, 1-9.
5. 2-adrenoceptors in the human central nervous system. Neuroscience 59, 589-598.
6. 1 receptors in the ventrolateral medulla and their role in cardiorespiratory control. In: Ventral Brainstem Mechanisms and Control functions (Trouth O., Millis R., Kiwell-Schone H. and Schläfke M., eds), pp. 319-358. Marcel Decker, New York.
7. 1-imidazoline sites. J. Pharmacol. Exp. Ther. 264, 172-182.
8. Ernsberger, P., Giuliano, R., Willette, R. N. and Reis, D. J. (1990a) Role of imidazole receptors in the vasodepressor response to clonidine analogs in the rostral ventrolateral medulla. J. Pharmacol. Exp. Ther. 253, 408-418.
9. 1-Imidazoline receptors: Definition, characterization, distribution and transmembrane signalling. Ann. NY Acad. Sci. 763, 22-42.
10. 1-Imidazoline receptors and brainstem autonomic control: membrane binding, autoradiographic and functional studies. FASEB J.6, A1874.
11. Ernsberger, P., Iacovitti, E. and Reis, D. J. (1990b) Astrocytes cultured from specific brain regions differ in their expression of adrenergic binding sites. Brain Res. 517, 202-208.
12. 125I-PIC): possible chemosensory role. FASEB J. 6, A716.
13. 2-adrenoceptors in the ventrolateral medulla. Eur. J. Pharmacol. 134, 1-13.
14. Ernsberger, P., Meeley, M. P. and Reis, D. J. (1989) Neuroblastoma-glioma hybrid cells contain clonidine-displacing substance. Eur. J. Pharmacol. 174, 135-138.
15. 1-imidazoline sites. Ann. NY Acad. Sci. 763, 163-168.
16. 1-Imidazoline receptors mediate arachidonic acid release from PC12 pheochromocytoma cells. FASEB J. 9, A114.
17. 1-imidazoline receptors. J. Cardiovasc. Pharmacol. 20 (Suppl. 4), S1-S10.
18. 1 sites): putative G-protein-linked receptors. FASEB J. 5, A1066.
19. Feldman, J., Tibiriça, E., Bricca, G., Dontenwill, M., Belcourt, A. and Bousquet, P. (1990) Evidence for the involvement of imidazoline receptors in the central hypotensive effect of rilmenidine in the rabbit. Br. J. Pharmacol. 100, 600-604.
20. Felsen, D., Ernsberger, P., Sutaria, P. M., Nejat, R. J., Nguyen, P., May, M., Breslin, D. S., Marion, D. N. and Vaughan, E. D. Jr. (1994) Identification, localization and functional analysis of imidazoline and α-adrenergic receptors in canine prostate. J. Pharmacol. Exp. Ther. 268, 1063-1071.
21. Gatti, P. J., Hill, K. J., Da Silva, M. T., Norman, W. P. and Gillis, R. A. (1988) Central nervous system site of action for the hypotensive effect of clonidine in the cat. J. Pharmacol Exp. Ther. 245, 373-380.
22. Glossmann, H. and Presek, P. (1979) Alpha noradrenergic receptors in brain membranes: sodium, magesium and guanyl nucleotides modulate agonist binding. Naunyn Schmiedebergs Arch. Pharmacol. 306, 67-73.
23. 1-imidazoline receptors in the rostral ventrolateral medulla. J. Cardiovasc. Pharmacol. 24 (Suppl. 1), S1-S8.
24. Jones, D. H. and Matus, A. I. (1974) Isolation of synaptic plasma membrane from brain by combined floatation-sedimentation density gradient centrifugation. Biochim. Biophys. Acta 356, 276-287.
25. 2-adrenoceptors and imidazoline binding sites: distribution of imidazoline binding sites in rat brain. Brain Res. 514, 15-21.
26. 2-adrenergic receptors in the carotid body response to isocapnic hypoxia. Respir. Physiol. 83, 353-364.
27. 2-adrenergic receptors. Life Sci. 36, 355-362.
28. McPherson, G. A. (1985) Analysis of radioligand binding experiments: a collection of computer programs for the IBM PC. J. Pharmacol. Meth. 14, 213-228.
29. Michel, M. C. and Ernsberger, P. (1992) Keep an eye on the I site: imidazoline-preferring receptors. Trends Pharmacol. Sci. 13, 369-370.
30. Munson, P. J. and Rodbard, D. (1980) LIGAND: a versatile computerized approach for characterization of ligand binding systems. Analyt. Biochem. 107, 220-239.
31. Piletz, J. E. and Sletten, K. (1993) Nonadrenergic imidazoline binding sites on human platelets. J. Pharmacol. Exp. Ther. 267, 1493-1502.
32. Punnen, S., Urbanski, R., Krieger, A. J. and Sapru, H. N. (1987) Ventrolateral medullary pressor area: site of hypotensive action of clonidine. Brain Res. 422, 336-346.
33. 2-adrenoceptors. Biochem. Pharmacol. 33, 3923-3928.
34. 1-imidazoline receptors to diacylglyceride accumulation in PC12 rat pheochromocytoma cells. Molec. Pharmacol. 49, 668-675.
35. 1-imidazoline receptor binding. FASEB J. 8, A355.
36. Smith, P. K., Krohn, R. I., Hermanson, G. T., Mallia, A. K., Gartner, F. H., Provenzano, M. D., Fujimoto, E. K., Goeke, N. M., Olson, B. J. and Klenk, D. C. (1985) Measurement of protein using bicinchoninic acid. Analyt. Biochem. 150, 76-85.
37. 2-imidazoline binding sites on monoamine oxidases. J. biol. Chem. 270, 9856 9861.
38. Tesson, F., Prip-Buus, C., Lemoine, A., Pegorier, J.-P. and Parini, A. (1991) Subcellular distribution of imidazoline guanidinium-receptive sites in human and rabbit liver. Major localization to the mitochondrial outer membrane. J. biol. Chem. 266, 155-160.
39. 2-nor-adrenergic receptor binding sites in bovine brain membranes. J. Neurochem. 34, 385-394.
40. Wikberg, J. E. S. and Uhlén, S. (1990) Further characterization of the guinea pig cerebral cortex idazoxan receptor: solubilization, distinction from the imidazole site, and demonstration of cirazoline as an idazoxan receptor-selective drug. J. Neurochem. 55, 192-203.
41. Yohannan, M. D. and Ernsberger, P. (1995) Heterogeneity of neurokinin, binding sites in porcine respiratory tract. Peptides 16, 873-882.
42. Zandberg, P., De Jong, W. and De Wied, D. (1979) Effect of catecholamine-receptor stimulating agents on blood pressure after local application in the nucleus tractus solitarii of the medulla oblongata. Eur. J. Pharmacol. 55, 43-56.