Relative importance of medullary brain nuclei for the sympatho-inhibitory actions of rilmenidine in the anaesthetized rabbit

Journal of Hypertension

Volumn 16, Issue 4, 1998, Pages 503-517

  Head, Geoffrey A ^a   Burke, Sandra L ^a  

^a BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

Author keywords

Imidazoline receptor; Nucleus of the solitary tract; Rilmenidine; Rostroventrolateral medulla; Sympathetic baroreflex; methylnoradrenaline

Indexed keywords

2 (2 METHOXY 1,4 BENZODIOXAN 2 YL) 2 IMIDAZOLINE; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; CORBADRINE; EFAROXAN; IDAZOXAN; IMIDAZOLINE RECEPTOR; RILMENIDINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE; CARDIOVASCULAR EFFECT; CONCENTRATION RESPONSE; CONTROLLED STUDY; HYPOTENSION; INTRACEREBRAL DRUG ADMINISTRATION; KIDNEY; MEAN ARTERIAL PRESSURE; MEDULLA OBLONGATA; NONHUMAN; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; RABBIT; SOLITARY TRACT NUCLEUS; SYMPATHETIC TONE;

EID: 0031956389     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004872-199816040-00012     Document Type: Article

References (56)

1. van Zwieten PA. Central imidazoline (|-1) receptors as targets of centrally acting antihypertensives: moxonidine and rilmenidine. J Hypertens 1997; 15:117-125.
2. Reis DJ, Granata AR, Joh TH, Ross CA, Ruggiero DA, Park DH. Brainstem catecholamine mechanism in tonic and reflex control of blood pressure. Hypertension 1984; 6:7-15.
3. Louis WJ, Conway E, Summers R, Beart P, Jarrott B, Effects of methyldopa metabolites on amine transmitters and adrenergic receptors in rat brain. Hypertension 1984; 6 (suppl II):II40-II44.
4. de Jong W, Nijkamp FP. Centrally induced hypotension and bradycardia after administration of α-methylnoradrenaline into the area of the nucleus tractus solitarn of the rat. Br J Pharmacol 1976, 58:593-598.
5. Tibirica E, Feldman J, Mermet C, Monassier L, Gonon F, Bousquet P. Selectivity of rilmenidine for the nucleus reticularis lateralis, a ventrolateral medullary structure containing imidazoline-preferring receptors. Eur J Pharmacol 1991; 209:213-221.
6. Willette RN, Punnen S, Krieger AJ, Sapru HN. Interdependence of rostral and caudal ventrolateral medullary areas in the control of blood pressure. Brain Res 1984; 321:169-174.
7. Guyenet PG, Brown DL. Nucleus paragigantocellularis lateralis and lumbar sympathetic discharge in the rat. Am J Physiol 1986; 250:R1081-R1094.
8. Ross CA, Ruggiero DA, Park DH, Joh TH, Sved AF, Fernandez-Pardal J, et al. Tonic vasomotor control by the rostral ventrolateral medulla: effect of electrical or chemical stimulation of the area containing the C1 adrenaline neurons on arterial pressure, heart rate and plasma catecholamines and vasopressm. J Neurosci 1984; 4:474-494.
9. Bousquet P, Feldman J, Schwarz J. Central cardiovascular effects on alpha adrenergic drugs: differences between catecholamines and imidazolines. J Pharmacol Exp Ther 1984; 230:232-236.
10. Brody MJ, O'Neill TP, Porter JP. Role of central catecholaminergic systems in pathogenesis and treatment of hypertension. J Cardiovasc Pharmacol 1984; 6:S727-S741.
11. Kubo T, Misu Y. Pharmacological characterisation of the u-adrenoceptors responsible for a decrease of blood pressure in the nucleus solitarii of the rat. Naunyn Schmiedebergs Arch Pharmacol 1981; 317:120-125.
12. Schmitt H, Schmitt M, Boissier JR, Guidicelli JF. Centrally-mediated decrease in sympathetic tone induced by 2-(2,6 dichlorophenylamino)-2-imidazoline (ST.155) catapressan. Eur J Pharmacol 1967; 2:147-148.
13. Kobinger W, Walland A. Investigations into the mechanism of the hypotensive effect of 2-(2,6-dichlorophenylamino)-2-imidazoline-HCI. Eur J Pharmacol 1967; 2:155-162.
14. Timmermans PBMWM, Van Zwieten PA. Characterisation of alpha-adrenoceptors participating in the central hypotensive and sedative effects of clonidine using yohimbine, rauwolscine and corynanthine. Eur J Pharmacol 1981; 70:7-15.
15. 2 adrenoceptor agonist. J Pharmacol 1985; 16:259-278.
16. Schlicker E, Armah BI, Gothert M. Central presynaptic α2-autoreceptors are involved in the blood pressure-lowering effect of moxonidine. J Cardiovasc Pharmacol 1990; 16:15-22.
17. Armah BI, Hofferber E, Stenzel W. General pharmacology of the novel centrally acting antihypertensive agent moxonidine. Arzneimittelforschung Drug Res 1988; 38:1426-1434.
18. Feldman J, Tibirica E, Bricca G, Dontenwill M, Belcourt A, Bousquet P. Evidence for the involvement of imidazoline receptors in the central hypotensive effect of rilmenidine in the rabbit. Br J Pharmacol 1990; 100:600-604.
19. Ernsberger P, Guiliano R, Willette RN, Reis DJ. Role of imidazole receptors in the vasodepressor response to clonidine analogs in the rostral ventrolateral medulla. J Pharmacol Exp Ther 1990; 253:408-418.
20. Ernsberger PR, Westbrooks KL, Christen MO, Schafer SG. A second generation of centrally acting antihypertensive agents act on putative |1-imidazoline receptors. J Cardiovasc Pharmacol 1992; 20 (suppl 4):S1-S10.
21. Haxhiu MA, Dreshaj I, Erokwu B, Schafer SG, Christen MO, Ernsberger PR. Vasodepression elicited in hypertensive rats by the selective |1-imidazoline agonist moxonidine administered into the rostral ventrolateral medulla. J Cardiovasc Pharmacol 1992; 20 (suppl 4):S11-S15.
22. Gomez RE, Ernsberger P, Feinland G, Reis DJ. Rilmenidine lowers arterial pressure via imidazole receptors in brainstem C1 area. Eur J Pharmacol 1991; 195:181-191.
23. Ernsberger P, Feinland G, Meeley MP, Reis DJ. Characterization and visualization of clonidine-sensitive imidazole sites in rat kidney which recognize clonidine-displacing substance. Am J Hypertens 1990; 3:90-97.
24. Hamilton AA, Reid JL, Yakubu MA [3H]Yohimbine and [3H]idazoxan bind to different sites on rabbit forebrain and kidney membranes. Eur J Pharmacol 1988; 146:345-348.
25. Bricca G, Dontenwill M, Molines A, Feldman J, Belcourt A, Bousquet P. Evidence for the existence of a homogeneous population of imidazoline receptors in the human brainstem. Eur J Pharmacol 1988; 150: 401-402.
26. Bricca G, Greney H, Zhang JS, Dontenwill M, Stutzmann J, Belcourt A. et al. Human brain imidazoline receptors: further characterization with [3H]clonidine. Eur J Pharmacol Mol Pharm 1994; 266:25-33.
27. De Vos H, Bricca G, Dekeyser J, Debacker JP, Bousquet P, Vauquelin G. Imidazoline receptors, non-adrenergic idazoxan binding sites and α2-adrenoceptors in the human central nervous system. Neuroscience 1994; 59:589-598.
28. Ernsberger P, Damon TH, Graff LM, Schafer SG, Christen MO. Moxonidine, a centrally acting antihypertensive agent, is a selective ligand for |1-imidazoline sites. J Pharmacol Exp Ther 1993; 264:172-182.
29. Michel MC, Ernsberger P. Keeping an eye on the I site: imidazoline-preferring receptors. Trends Pharmacol Sci 1992; 13:369-370.
30. Punnen S, Urbanski R, Krieger AJ, Sapru HN. Ventrolateral medullary pressor area: site of hypotensive action of clonidine. Brain Res 1987; 422:336-346.
31. Ernsberger P, Friedman JE, Koletsky RJ. The |1-imidazoline receptor: from binding site to therapeutic target in cardiovascular disease, J Hypertens 1997; 15 (suppl 1):S9-S23.
32. Head GA, Godwin SJ, Sannajust F. Differential receptors involved in the cardiovascular effects of clonidine and rilmenidine in conscious rabbits. J Hypertens 1993; 11 (suppl 5):S322-S323.
33. Sannajust F, Head GA. Effect of rilmenidine on the baroreflex control of renal sympathetic nerve activity. J Hypertens 1993; 11 (suppl 5):S328-S329.
34. Head GA. Baroreflexes and cardiovascular regulation in hypertension. J Cardiovasc Pharmacol 1995; 26 (suppl 2):S7-S16.
35. Li YW, Dampney RAL. Clonidine and rilmenidine suppress hypotension-induced fos expression in the lower brainstem of the conscious rabbit. Neuroscience 1995; 66:391-402.
36. Dorward PK, Riedel W, Burke SL, Gipps J, Korner PI. The renal sympathetic baroreflex in the rabbit. Arterial and cardiac baroreceptor influences, resetting and effect of anaesthesia. Circ Res 1985; 57:618-633.
37. Head GA, Korner PI, Lewis SL, Badoer E. Contribution of noradrenergic and serotonergic neurons to the circulatory effects of centrally acting clonidine and α-methyldopa in rabbits. J Cardiovasc Pharmacol 1983; 5:945-953.
38. Dampney RAL, Goodchild AK, Tan E. Vasopressor neurons in the rostral ventrolateral medulla of the rabbit. J Auton Nerv Syst 1985; 14:239-254.
39. Dampney RAL, Goodchild AK, Robertson LG, Montgomery W. Role of ventrolateral medulla in vasomotor regulation: a correlative anatomical and physiological study. Brain Res 1982; 249:223-235.
40. Badoer E, Head GA, Aberdeen JA, Korner PL. Localization of the main noradrenergic neuron groups in the pons and medulla of the rabbit and the importance of cathodal lesions for prolonged survival. J Neurosci Methods 1987; 19:11-27.
41. Korner PI, Badoer E, Head GA. Cardiovascular role of the major noradrenergic cell groups in the rabbit: analysis based on 6-hydroxydopamine-induced transmitter release. Brain Res 1987; 435:258-272.
42. Sannajust F, Head GA. Evidence for imidazoline receptors mediating the inhibition of the renal sympathetic baroreflex produced by rilmenidine in rabbits. J Hypertens 1994; 12 (suppl 3):S188.
43. Bousquet P, Guertzenstein PG, Localization of the central cardiovascular action of clonidine. Br J Pharmacol 1973; 49:573-579.
44. Muzi M, Goff DR, Kampine JP, Roerig DL, Ebert TJ. Clonidine reduces sympathetic activity but maintains baroreflex responses in normotensive humans. Anesthesiology 1992; 77:864-871.
45. Michel MC, Brodde OE, Schnepel B, Behrendt J, Tschada R, Motulsky HJ, et al. [3H]idazoxan and some other alpha2-adrenergic drugs also bind with high affinity to a nonadrenergic site. Mol Pharmacol 1989; 35:324-330.
46. Chan CKS, Sannajust F, Head GA. Role of imidazoline receptors in the cardiovascular actions of moxonidine, rilmenidine and clonidine in conscious rabbits. J Pharmacol Exp Ther 1996; 276:411-420.
47. Sannajust F, Head GA, Rilmenidine-induced hypotension in conscious rabbits involves imidazoline-preferring receptors. J Cardiovasc Pharmacol 1994; 23:42-50.
48. Head GA. Importance of imidazoline receptors in the cardiovascular actions of centrally acting antihypertensive agents. In: Reis DJ, Bousquet P, Parini A (editors): The imidazoline receptor. Pharmacology, functions, ligands, and relevance to biology and medicine. New York: The New York Academy of Sciences; 1995. pp. 531-540.
49. Head GA, Chan CKS, Sannajust F. Role of imidazoline receptors in the central actions of rilmenidine, moxonidine, and clonidine in conscious rabbits. J Hypertens 1994; 12 (suppl 3):S100.
50. Sannajust F, Head GA, Involvement of imidazoline-preferring receptors in regulation of sympathetic tone. Am J Cardiol 1994; 74 (suppl 13):7A-19A.
51. Guyenet PG, Lynch KR, Allen AM, Rosin DL, Stornetta RL. α2-Adrenergic receptors rather than 'imidazoline' binding sites mediate the sympatholytic effect of clonidine in the rostral ventrolateral medulla: a new look at the evidence. In: Trouth O, Millis R, Kiwull-Schone H, Schlafke ME (editors): Ventral brainstem mechanisms and control functions. New York: Marcel Dekker, Inc.; 1995. pp. 281-303.
52. Stornetta RL, Huangfu D, Rosin DL, Lynch KR, Guyenet PG. Alpha-2-adrenergic receptors: immunohistochemical localization and role in mediating inhibition of adrenergic RVLM presympathetic neurons by catecholamines and clonidine. In: Reis DJ, Bousquet P, Parini A (editors): The imidazoline receptor. Pharmacology, functions, ligands, and relevance to biology and medicine. New York: The New York Academy of Sciences; 1995. pp. 541-555.
53. Allen AM, Guyenet PG. α2-Adrenoceptor-mediated inhibition of bulbospinal barosensitive cells of rat rostral medulla. Am J Physiol 1993; 265:R1065-R1075.
54. 2a-adrenergic receptor subtype. Science 1996; 273:801-803.
55. Badoer E, Head GA, Korner PI. Effects of intracisternal and intravenous α-methyldopa and clonidine on haemodynamics and baroreceptor-heart rate reflex properties in conscious rabbits. J Cardiovasc Pharmacol 1983; 5:760-767.
56. Head GA, Burke SL, Chan CKS. Site and receptors involved in the sympathoinhibitory actions of rilmenidine. J Hypertens, in press.