Antagonists that differentiate between α2A- and α2D-adrenoceptors

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 353, Issue 3, 1996, Pages 245-249

  Trendelenburg, Anne Ulrike ^a   Wahl, Christian Andreas ^a   Starke, Klaus ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Benoxathian; Efaroxan; MK 912; Noradrenaline release; RX 821002; 2 autoreceptors; 2A adrenoceptors; 2D adrenoceptors

Indexed keywords

1,3,4,5',6,6',7,12B OCTAHYDRO 1',3' DIMETHYL 2H SPIRO[BENZO[B]FURO[2,3 A]QUINOLIZINE 2,4' PYRIMIDINE] 2' ONE; 2 (2 METHOXY 1,4 BENZODIOXAN 2 YL) 2 IMIDAZOLINE; ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; ALPHA 2A ADRENERGIC RECEPTOR; ALPHA 2D ADRENERGIC RECEPTOR; AUTORECEPTOR; BENOXATHIAN; BRIMONIDINE; DESIPRAMINE; EFAROXAN; NORADRENALIN; RADIOISOTOPE;

ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN SLICE; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG ANTAGONISM; ELECTROSTIMULATION; FEMALE; GUINEA PIG; MALE; NONHUMAN; NORADRENALIN RELEASE; RABBIT; RECEPTOR AFFINITY;

ADRENERGIC ALPHA-AGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; AUTORECEPTORS; BENZOFURANS; CEREBRAL CORTEX; DIOXANES; ELECTRIC STIMULATION; FEMALE; GUINEA PIGS; IDAZOXAN; IMIDAZOLES; ISOTOPE LABELING; MALE; NOREPINEPHRINE; OXATHIINS; QUINOLIZINES; QUINOXALINES; RABBITS; RECEPTORS, ADRENERGIC, ALPHA-2; STRUCTURE-ACTIVITY RELATIONSHIP; TRITIUM;

EID: 0029670461     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00168625     Document Type: Article

References (27)

1. Arunlakshana O, Schild HO (1959) Some quantitative use of drug antagonists. Br J Pharmacol 14:48-58
2. Bylund DB, Eikenberg DC, Hieble JP, Langer SZ, Lefkowitz RJ, Minneman KP, Molinoff PB, Ruffolo RR, Trendelenburg U (1994) International Union of Pharmacology nomenclature of adrenoceptors. Pharmacol Rev 46:121-136
3. 2-agonist for the characterisation of α-adrenoceptor subtypes. Eur J Pharmacol 72:413-415
4. Chapleo CB, Myers PL, Butler RCM, Davis JA, Doxey JC, Higgins SD, Myers M, Roach AG, Smith CFC, Stillings MR, Welbourn AP (1984) α-adrenoreceptor reagents. 2. Effects of modification of the 1,4-benzodioxan ring system on α-adrenoreceptor activity. J Med Chem 27:570-576
5. 3H]idazoxan-labelled non-adrenergic sites in rabbit white fat cells. Eur J Pharmacol 188:261-272
6. 2-autoreceptors in rabbit and rat brain cortex in the absence of autoinhibition. Naunyn-Schmiedeberg's Arch Pharmacol 340:639-647
7. 2-autoreceptors in rat submaxillary gland and heart atrium. Br J Pharmacol 107:246-255
8. 2-C10 homolog responsible for an interspecies variation in antagonist binding. Mol Pharmacol 42:16-27
9. 2-Adrenoceptors: more subtypes but fewer functional differences. Trends Pharmacol Sci 15:119-123
10. 1-adrenoceptors. J Med Chem 27:1535-1536
11. 2B-adrenoceptor subtypes. Br J Pharmacol 98:890-897
12. Motulsky HJ, Ransnas LA (1987) Fitting curves to data using nonlinear regression: a practical and nonmathematical review. FASEB J 1:365-374
13. 3H]RX821002 binding to alpha-2 adrenergic receptor subtypes. J Pharmacol Exp Ther 268:1362-1367
14. O'Rourke MF, Iversen LJ, Lomasney JW, Bylund DB (1994b) Species orthologs of the alpha-2A adrenergic receptor: the pharmacological properties of the bovine and rat receptors differ from the human and porcine receptors. J Pharmacol Exp Ther 271: 735-740
15. alpha-2A adrenergic receptors and other populations of alpha-2 adrenergic subtypes. J Pharmacol Exp Ther 270: 946-957
16. 2-adrenoceptors. Life Sci 44:459-467
17. 2-adrenoceptor subtypes. Ann Rev Pharmacol Toxicol 32:243-279
18. Singer EA (1988) Transmitter release from brain slices elicited by single pulses: a powerful method to study presynaptic mechanisms. Trends Pharmacol Sci 9:274-276
19. 2-adrenoceptor mediating prejunctional inhibition of cardioacceleration in the pithed rat heart. Br J Pharmacol 115:316-320
20. Starke K, Göthert M, Kilbinger H (1989) Modulation of neurotransmitter release by presynaptic autoreceptors. Physiol Rev 69:864-989
21. 2-adrenoceptors: subtype determination. Pharmacol Commun 6:99-108
22. 2-adrenoreceptor antagonists. J Med Chem 28:1054-1062
23. 2A in the rabbit. Naunyn-Schmiedeberg's Arch Pharmacol 348:35-45
24. 2D-autoreceptors in guinea-pig atria and brain. Naunyn-Schmiedeberg's Arch Pharmacol 352:49-57
25. 2-adrenoceptor. Br J Pharmacol 106:986-995
26. 2C-adrenoceptors and non-adrenergic imidazoline sites in the guinea pig. Pharmacol Toxicol 76:353-364
27. Waud DR (1976) Analysis of dose-response relationships. In: Narahashi T, Bianchi CP (eds) Advances in general and cellular pharmacology, vol 1, Plenum, New York, London, pp 145-178