Presynaptic imidazoline receptors and non-adrenoceptor [3H]-idazoxan binding sites in human cardiovascular tissues

British Journal of Pharmacology

Volumn 122, Issue 1, 1997, Pages 43-50

  Molderings, G J ^a   Likungu, J ^b   Jakschik, J ^c   Gothert M ^a  

^a UNIVERSITY OF BONN   (Germany)

^b Klin F Herz Gefaßchirurgie   (Germany)

^c Klinik und Poliklinik fur Urologie   (Germany)

Author keywords

3H idazoxan; Human atrium; Human pulmonary artery; Imidazoline binding sites; Presynaptic imidazoline receptors

Indexed keywords

1,3 BIS(2 METHYLPHENYL)GUANIDINE; 4 CHLORO 2 (2 IMIDAZOLIN 2 YLAMINO)ISOINDOLINE; AGANODINE; AGMATINE; ALPHA 2 ADRENERGIC RECEPTOR; CIRAZOLINE; CLONIDINE; CORTICOSTERONE; DESIPRAMINE; GUANIDINE DERIVATIVE; IDAZOXAN; IMIDAZOLINE RECEPTOR; NORADRENALIN; PRESYNAPTIC RECEPTOR; RAUWOLSCINE; SODIUM CHLORIDE;

ALPHA ADRENERGIC RECEPTOR BLOCKING; AORTA; ARTICLE; BINDING AFFINITY; BINDING SITE; CARDIOVASCULAR SYSTEM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; HEART RIGHT ATRIUM; HUMAN; HUMAN TISSUE; NORADRENALIN RELEASE; PRIORITY JOURNAL; PULMONARY ARTERY; RABBIT; SYMPATHETIC NERVE;

ADRENERGIC ALPHA-AGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ADULT; AGED; ANIMALS; ANTICONVULSANTS; ATRIAL FUNCTION; BINDING SITES; BINDING, COMPETITIVE; ELECTRIC STIMULATION; FEMALE; GUANIDINES; HEART ATRIA; HUMANS; IDAZOXAN; IMIDAZOLES; MALE; MIDDLE AGED; MYOCARDIUM; NOREPINEPHRINE; PULMONARY ARTERY; RABBITS; RECEPTORS, ADRENERGIC, ALPHA-2; RECEPTORS, DRUG; TRITIUM; YOHIMBINE;

EID: 0030869394     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701343     Document Type: Article

References (27)

1. BYLUND, D.B., EIKENBERG, D.C., HIEBLE, J.P., LANGER, S.Z., LEFKOWITZ, R.J., MINNEMAN, K.P., MOLINOFF, P.B. & RUFFOLO, R.R. (1994). International union of pharmacology nomenclature of adrenoceptors. Pharmacol. Rev., 46, 121-136.
2. 50) of an enzyme reaction. Biochem. Pharmacol., 22, 3099-3108.
3. 3-adrenoceptors in the ventrolateral medulla. Eur. J. Pharmacol., 134, 1-13.
4. 1-imidazoline receptors. J. Cardiovasc. Pharmacol., 20, (Suppl 4) S1-S10.
5. 2-adrenoceptors. Naunyn-Schmiedeberg's Arch. Pharmacol., 348, 372-378.
6. 2-adrenoceptors and putative imidazoline receptors on rabbit heart sympathetic nerves. Naunyn-Schmiedeberg's Arch. Pharmacol., 348, 127-133.
7. FURCHGOTT, R.F. (1972). The classification of adrenoceptors (adrenergic receptors). An evaluation from the standpoint of receptor theory. In Handbook of Experimental Pharmacology. Catecholamines. vol XXXIII. ed. Blaschko, H & Muscholl, E. pp. 283-235. Springer: Berlin, Heidelberg, New York.
8. 2-adrenoceptor-independent inhibition of noradrenaline release by imidazoline derivatives. Naunyn-Schmiedeberg's Arch. Pharmacol., 343, 271-282.
9. LI, G., REGUNATHAN, S., BARROW, C.J., ESHRAGI, J., COOPER, R. & REIS, D.J. (1994). Agmatine: an endogenous clonidine-displacing substance in the brain. Science, 263, 966-969.
10. 2-adrenoceptors in the human heart: discrimination by clonidine and moxonidine. Naunyn-Schmiedeberg's Arch. Pharmacol., 354, 689-692.
11. 2-adrenergic drugs also bind with high affinity to a nonadrenergic sites. Mol. Pharmacol., 35, 324-330.
12. 1Dα, receptors in human atrium. Naunyn-Schmiedeberg's Arch. Pharmacol., 353, 272-280.
13. 2-imidazoline binding sites. Naunyn-Schmiedeberg's Arch. Pharmacol., 351, 507-516.
14. MOLDERINGS, G.J., HENTRICH, F. & GÖTHERT, M. (1991). Pharmacological characterization of the imidazoline receptor which mediates inhibition of noradrenaline release in the rabbit pulmonary artery. Naunyn-Schmiedeberg's Arch. Pharmacol., 344, 630-638.
15. 2-imdazoline sites. Naunyn-Schmiedeberg's Arch. Pharmacol., 350, 252-251.
16. 3H]idazoxan binding sites in human right atrium. Naunyn-Schmiedeberg's Arch. Pharmacol., 354 (Suppl 1), R9.
17. 3H]idazoxan binding sites in human right atrium. J. Autonom. Pharmacol., (in press).
18. 1-imidazoline sites in bovine adrenal meduallary membranes. Naunyn-Schmiedeberg's Arch. Pharmacol., 348, 70-76.
19. PARINI, A., MOUDANOS, G., PIZZINAT, N. & LANIER, S.M. (1996). The elusive family of imidazoline binding sites. Trends Pharmacol. Sci., 17, 13-16.
20. REGUNATHAN, S. & REIS, D.J. (1996). Imidazoline receptors and their endogenous ligands. Ann. Rev. Pharmacol. Toxicol., 36, 511-544.
21. RUFFOLO, R.R. & WADDELL, J.E. (1982). Receptor interactions of Imidazolines. IX. Cirazoline is an alpha-1 adrenergic agonist and an alpha-2 adrenergic antagonist. J. Pharmacol. Exp. Ther., 22, 29-36.
22. 2C-Adrenoceptor-modulated release of noradrenaline in human right atrium. Br. J. Pharmacol., 116, 2617-2624.
23. RUMP, L.C., RIERA-KNORRENSCHILD, G., SCHWERTFEGER, E., BOHMANN, C., SPILLNER, G. & SCHOLLMEYER, P. (1995b). Dopaminergic and α-adrenergic control of neurotransmission in human right atrium. J. Cardiovasc. Pharmacol., 26, 462-470.
24. STARKE, K. (1981). α-Adrenoceptor classification. Rev. Physiol. Biochem. Pharmacol., 88, 199-236.
25. STARKE, K. (1987). Presynaptic α-autoreceptors. Rev. Physiol. Biochem. Pharmacol., 107, 73-146.
26. WEBER, E., SONDERS, M., QUARUM, M., MCLEAN, S., POU, S. & KEANA, J.F.W. (1986). 1,3-Di(2-(5-3H)tolyl)guanidine: A selective ligand that labels sigma-type receptors for psychomimetic opiates and antipsychotic drugs. Proc. Natl. Acad. Sci. U.S.A., 83, 8784-8788.
27. 3H]-idazoxan binding sites (I-receptors) occurs to interacting or interconvertible forms of receptors. Pharmacol. Toxicol., 70, 208-219.