Transport of clonidine across cultured brain microvessel endothelial cells

Journal of Pharmacology and Experimental Therapeutics

Volumn 282, Issue 1, 1997, Pages 81-85

  Huwyler, Jörg ^a   Fricker, Gert ^b   Török, Michael ^a   Schneider, Markus ^a   Drewe, Jürgen ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b Inst Pharmaceut and Biopharmacy   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BUFFER; CLONIDINE; IONOPHORE; OCTANOL; POTASSIUM ION; PROPRANOLOL; VALINOMYCIN;

ACTIVE TRANSPORT; ANIMAL CELL; APICAL MEMBRANE; ARTICLE; BASOLATERAL MEMBRANE; BLOOD BRAIN BARRIER; BRAIN CAPILLARY; CAPILLARY ENDOTHELIUM; CONTROLLED STUDY; DRUG PENETRATION; DRUG TRANSPORT; ENDOTHELIUM CELL; GRAY MATTER; MICHAELIS MENTEN KINETICS; NONHUMAN; PARTITION COEFFICIENT; PRIORITY JOURNAL; SWINE;

ADRENERGIC ALPHA-AGONISTS; ANIMALS; BIOLOGICAL TRANSPORT; BRAIN; CAPILLARIES; CLONIDINE; ENDOTHELIUM, VASCULAR; HYDROGEN-ION CONCENTRATION; P-GLYCOPROTEIN; SWINE;

EID: 0030868189     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. ATISOOK, K. AND MADARA, J. L.: An oligopeptide permeates intestinal tight junctions at glucose-elicited dilatations: Implications for oligopeptide absorption. Gastroenterology 100: 719-724, 1991.
2. AUDUS, K. L. AND BORCHARDT, R. T.: Characterisation of an in vitro blood-brain barrier model system for studying drug transport and metabolism. Pharm. Res. 3: 81-87, 1986.
3. BLOOR, B. C.: General pharmacology of α2-adrenoceptors. Anaesth. Pharmacol. Rev. 1: 221-232, 1993.
4. CASTRO, M. I. AND EISENACH, J. C.: Pharmacokinetics and dynamics of intravenous, intrathecal and epidural clonidine in sheep. Anesthesiology 71: 418-425, 1989.
5. DEHOUCK, M. P., JOLLIET-RIANT, P., BREE, F., FRUCHART, J. C., CECCHELLI, R. AND TILLEMENT, J. P.: Drug transfer across the blood-brain barrier: Correlation between in vitro and in vivo models. J. Neurochem. 58: 1790-1797, 1992.
6. DE KOCK, M., MARTIN, N. AND SCHOLTES, J. L.: Central effects of epidural and intravenous clonidine in patients anesthetized with enflurane/nitrous oxide: An electroencephalographic analysis. Anesthesiology 77: 457-462, 1992.
7. ENDICOTT, J. A. AND LING, V.: The biochemistry of P-glycoprotein-mediated multidrug resistance. Annu. Rev. Biochem. 58: 137-171, 1989.
8. FRELIN, C., VIGNE, P., LADOUX, A. AND LAZDUNSKY, M.: The regulation of the intracellular pH in cells from vertebrates. Eur. J. Biochem. 174: 3-14, 1988.
9. FRICKER, G. AND DREWE, J.: Enterai absorption of octreotide: Modulation of intestinal permeability by distinct carbohydrates. J. Pharmacol. Exp. Ther. 274: 826-832, 1995.
10. + exchanger. Biochem. Pharmacol. 35: 3989-3994, 1986.
11. GOLD, M. S., POTTASH, A. C., SWEENEY, D. R. AND KLEBER, H. D.: Opiate withdrawal using clonidine: A safe, effective, and rapid nonopiate treatment. JAMA 243: 343-346, 1980.
12. GOUDAS, L. C.: Clonidine. Curr. Opin. Anaesth. 8: 455-460, 1995.
13. 2 adrenoceptor agonists and anaesthesia. Br. J. Anaesth. 71: 108-118, 1993.
14. HUWYLER, J., DREWE, J., KLUSEMANN, C. AND FRICKER, G.: Evidence for P-glycoprotein-modulated penetration of morphine-6-glucuronide into brain capillary endothelium. Br. J. Pharmacol. 118: 1879-1885, 1996.
15. 2-adrenoceptor agonist, on experimental pain in humans. Anesthesiology 74: 3-8, 1991.
16. MADARA, J. L., CARLSON, S. AND ANDERSON, J. M.: ZO-1 maintains its spatial distribution but dissociates from junctional fibrils during tight junction regulation. Am. J. Physiol. 264: C1096-C1101, 1993.
17. + exchangers in cultured cells. Biochem. J. 280: 317-322, 1991.
18. REDDY, S. V. R., MADERDRUT, J. L. AND YAKSH, T. L.: Spinal cord pharmacology of adrenergic agonist-mediated antinociception. J. Pharmacol. Exp. Ther. 213: 525-533, 1980.
19. RONINSON, I. B.: The role of the MDR1 (P-glycoprotein) gene in multidrug resistance in vitro and in vivo. Biochem. Pharmacol, 43: 95-102, 1992.
20. SEELIG, A., GOTTSCHLICH, R. AND DEVANT, R. M.: A method to determine the ability of drugs to diffuse through the blood-brain barrier. Proc. Natl. Acad. Sci. USA 91: 68-72, 1994.
21. SPAULDING, T. C., VENAFRO, J. J., M. A., M. G. AND FIELDING, S.: The dissociation of the antinociceptive effect of clonidine from supraspinal structures. Neuropharmacology 18: 103-105, 1979.
22. SULLIVAN, A. F., DASHWOOD, M. R. AND DICKENSON, A. H.: Alpha-2 adrenoreceptor modulation of nociception in rat spinal cord: Location, effects, and interaction with morphine. Eur. J. Pharmacol. 138: 169-177, 1987.
23. TRYBA, M., KULKA, P. AND ZENZ, M.: Sympathetic Hyperactivity Syndromes in Ventilated Patients, pp. 529-539, Springer-Verlag, Berlin, 1993.
24. TSUJI, A., TERASAKI, T., TAKABATAKE, Y., TENDA, Y., TAMAI, I., YAMASHIMA, T., MORITANI, S. AND YAMASHITA, J.: P-glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial cells. Life Sci. 51: 1427-1437. 1992.
25. YAKSH, T. L.: Pharmacology of spinal adrenergic systems which modulate spinal nociceptive processing. Pharmacol. Biochem. Behav. 22: 845-858. 1985.
26. YAM, P. C., FORBES, A. AND Kox, W. J.: Clonidine in the treatment of alcohol withdrawal in the intensive care unit. Br. J. Anaesth. 68: 106-108. 1992.