Cadherin and catenin alterations in human cancer

Genes Chromosomes and Cancer

Volumn 34, Issue 3, 2002, Pages 255-268

  Hajra, Karen M ^a   Fearon, Eric R ^a,b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CADHERIN; CATENIN; WNT PROTEIN;

CANCER CELL; CELL DIFFERENTIATION; COMPLEX FORMATION; EPITHELIUM CELL; EXTRACELLULAR MATRIX; GENE MUTATION; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; REVIEW; SOMATIC MUTATION; TRANSCRIPTION REGULATION;

BETA CATENIN; CADHERINS; CYTOSKELETAL PROTEINS; GERM-LINE MUTATION; HUMANS; MUTATION; NEOPLASMS; TRANS-ACTIVATORS;

EID: 0036108620     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/gcc.10083     Document Type: Review

References (129)

1. The human plakoglobin gene localizes on chromosome 17q21 and is subjected to loss of heterozygosity in breast and ovarian cancers
2. Inhibition of RhoA by p120 catenin
3. Regulated binding of PTP1B-like phosphatase to N-cadherin: Control of cadherin-mediated adhesion by dephosphorylation of β-catenin
4. Catenins, wnt signaling and cancer
5. The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells
6. E-cadherin gene mutations provide clues to diffuse type gastric carcinomas
7. Dissecting tumor cell invasion: Epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion
8. Loss of epithelial cell differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/β-catenin complex in cells transformed with a temperature-sensitive v-SRC gene
9. Functional interaction of β-catenin with the transcription factor LEF-1
10. E-cadherin is inactivated in a majority of invasive human lobular breast cancers by truncation mutations throughout its extracellular domain
11. Mutations of the human E-cadherin (CDH1) gene
12. β-catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer
13. Receptor protein tyrosine phosphatase PTPμ associates with cadherins and catenins in vivo
14. The small GTPases Rho and Rac are required for the establishment of cadherin-dependent cell-cell contacts
15. 2+-dependent cell-cell adhesion
16. Expression of wild-type α-catenin protein in cells with a mutant α-catenin gene restores both growth regulation and tumor suppressor activities
17. Complex cadherin expression in human prostate cancer cells
18. Transcriptional regulation of the human E-cadherin gene in human prostate cancer cell lines
19. β- and γ-catenin mutations, but not E-cadherin inactivation, underlie T-cell factor/lymphoid enhancer factor transcriptional deregulation in gastric and pancreatic cancer
20. The transcription factor Snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression
21. Mechanisms of inactivation of E-cadherin in breast carcinoma: Modification of the two-hit hypothesis of tumor suppressor gene
22. The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion
23. A general theory of carcinogenesis
24. The metalloproteinase matrilysin is a target of β-catenin transactivation in intestinal tumors
25. The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor
26. The expression of p120ctn protein in breast cancer is independent of α- and β-catenin and E-cadherin
27. PDGF, CSF-1, and EGF induce tyrosine phosphorylation of p120, a pp60src transformation-associated substrate
28. Chromosome 5 suppresses tumorigenicity of PC3 prostate cancer cells: Correlation with reexpression of α-catenin and restoration of E-cadherin function
29. BRCA1 and E-cadherin promoter hypermethylation and gene inactivation in cancer: Association or mechanism?
30. Association of human protein-tyrosine phosphatase kappa with members of the armadillo family
31. Cdc42 and Rac1 regulate the interaction of IQGAP1 with β-catenin
32. Identification of germ-line E-cadherin mutations in gastric cancer families of European origin
33. Role of E boxes in the repression of E-cadherin expression
34. Changes in cadherin-catenin complexes in the progression of human bladder carcinoma
35. E-cadherin suppresses cellular transformation by inhibiting β-catenin signaling in an adhesion-independent manner
36. E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas
37. Distinct patterns of E-cadherin CpG island methylation in papillary, follicular, Hurthle's cell, and poorly differentiated human thyroid carcinoma
38. Evidence for a function of CtBP in epithelial gene regulation and anoikis
39. E-cadherin germline mutations in familial gastric cancer
40. E-cadherin germline mutations define an inherited cancer syndrome dominated by diffuse gastric cancer
41. Extinction of E-cadherin expression in breast cancer via a dominant repression pathway acting on proximal promoter elements
42. The SLUG zinc-finger protein represses E-cadherin in breast cancer
43. p60v-src causes tyrosine phosphorylation and inactivation of the N-cadherin-catenin cell adhesion system
44. The epidermal growth factor receptor modulates the interaction of E-cadherin with the actin cytoskeleton
45. N-cadherin promotes adhesion between invasive breast cancer cells and the stroma
46. Exogenous expression of N-cadherin in breast cancer cells induces cell migration, invasion, and metastasis
47. Identification of c-MYC as a target of the APC pathway
48. PPARδ is an APC-regulated target of nonsteroidal anti-inflammatory drugs
49. Nuclear-cytoplasmic shuttling of APC regulates β-catenin subcellular localization and turnover
50. Progression of carcinoma cells is associated with alterations in chromatin structure and factor binding at the E-cadherin promoter in vivo
51. Inactivation of the E-cadherin-mediated cell adhesion system in human cancers
52. Inhibition of invasion of epithelial cells by Tiam1-Rac signaling
53. β-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor
54. β-catenin-sensitive isoforms of lymphoid enhancer factor-1 are selectively expressed in colon cancer
55. E-cadherin and APC compete for the interaction with β-catenin and the cytoskeleton
56. Expression of N-cadherin by human squamous carcinoma cells induces a scattered fibroblastic phenotype with disrupted cell-cell adhesion
57. Transcriptional defects underlie loss of E-cadherin expression in breast cancer
58. E-cadherin and its associated protein catenins, cancer invasion and metastasis
59. Regulation of cadherin-mediated cell-cell adhesion by the Rho family GTPases
60. c-erbB-2 gene product directly associates with β-catenin and plakoglobin
61. Tyrosine phosphorylation of a 120-kilodalton pp60src substrate upon epidermal growth factor and platelet-derived growth factor receptor stimulation and in polyomavirus middle-T-antigen-transformed cells
62. Loss of E-cadherin-dependent cell-cell adhesion due to mutation of the β-catenin gene in a human cancer cell line, HSC-39
63. Diffuse type gastric and lobular breast carcinoma in a familial gastric patient with an E-cadherin germline mutation
64. Hereditary cancer, oncogenes, and antioncogenes
65. Axin directly interacts with plakoglobin and regulates its stability
66. Gastrin is a target of the β-catenin/TCF-4 growth-signaling pathway in a model of intestinal polyposis
67. Neoplastic transformation of RK3E by mutant β-catenin requires deregulation of Tcf/Lef transcription but not activation of c-myc expression
68. γ-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of β-catenin
69. Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity
70. Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherin-mediated cell-cell adhesion
71. Association between a transmembrane protein tyrosine phosphatase and the cadherin-catenin complex
72. APC gene: Database of germline and somatic mutations in human tumors and cell lines
73. H-cadherin, a novel cadherin with growth inhibitory functions and diminished expression in human breast cancer
74. Adenomatous polyposis coli gene mutation alters proliferation through its β-catenin-regulatory function in aggressive fibromatosis (desmoid tumor)
75. Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating β-catenin/TCF signalling
76. Contributions of tumor and stromal matrix metalloproteinases to tumor progression, invasion and metastasis
77. Cadherin-mediated cell-cell adhesion is perturbed by v-src tyrosine phosphorylation in metastatic fibroblasts
78. β-catenin signaling and cancer
79. Reduction of E-cadherin levels and deletion of the α-catenin gene in human prostate cancer cells
80. E-cadherin gene mutations in signet ring cell carcinoma of the stomach
81. Structural basis of calcium-induced E-cadherin rigidification and dimerization
82. Expression of E-cadherin, α-catenin, β-catenin and plakoglobin in esophageal carcinomas and its prognostic significance
83. N-cadherin promotes motility in human breast cancer cells regardless of their E-cadherin expression
84. Making head or tail of Dickkopf
85. c-erbB-2 gene product associates with catenins in human cancer cells
86. Cloning of the human α-catenin cDNA and its aberrant mRNA in a human cancer cell line
87. A truncated β-catenin disrupts the interaction between E-cadherin and α-catenin: A cause of loss of intercellular adhesiveness in human cancer cell lines
88. The interactions and role of epithelial cadherin and catenins in tumorigenicity
89. Protein-protein interactions define specificity in signal transduction
90. Wnt signaling in oncogenesis and embryogenesis: A look outside the nucleus
91. A new role for E12/E47 in the repression of E-cadherin expression and epithelial-mesenchymal transitions
92. Cadherin-11 is expressed in invasive breast cancer cell lines
93. Mutations in the APC gene and their implications for protein structure and function
94. Wnt signaling and cancer
95. More than one way to skin a catenin
96. Loss of E-cadherin expression in melanoma cells involves up-regulation of the transcriptional repressor Snail
97. Transformation-specific tyrosine phosphorylation of a novel cellular protein in chicken cells expressing oncogenic variants of the avian cellular src gene
98. Germline E-cadherin gene (CDH1) mutations predispose to familial gastric cancer and colorectal cancer
99. Mutations of the E-cadherin gene in human gynecologic cancers
100. A mutation in α-catenin disrupts adhesion in clone A cells without perturbing its actin and β-catenin binding activity
101. Synergy between tumor suppressor APC and the β-catenin-Tcf4 target Tcf1
102. The APC tumour suppressor has a nuclear export function
103. The APC protein and E-cadherin form similar but independent complexes with α-catenin, β-catenin, and plakoglobin
104. AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1
105. Tyrosine phosphorylation of β-catenin and plakoglobin enhanced by hepatocyte growth factor and epidermal growth factor in human carcinoma cells
106. Association of plakoglobin with APC, a tumor suppressor gene product, and its regulation by tyrosine phosphorylation
107. Simultaneous expression of cadherin-11 in signet-ring cell carcinoma and stromal cells of diffuse-type gastric cancer
108. Dominant negative inhibition of the association between β-catenin and c-erbB-2 by N-terminally deleted β-catenin suppresses the invasion and metastasis of cancer cells
109. Cadherin dysfunction in a human cancer cell line: Possible involvement of loss of α-catenin expression in reduced cell-cell adhesiveness
110. Effect of epidermal growth factor on cadherin-mediated adhesion in a human oesophageal cancer cell line
111. The cyclin D1 gene is a target of the β-catenin/LEF-1 pathway
112. Suppression of tumorigenicity by plakoglobin: An augmenting effect of N-cadherin
113. Regulation of cell-cell adhesion by rac and rho small G proteins in MDCK cells
114. V-src kinase shifts the cadherin-based cell adhesion from the strong to the weak state and beta catenin is not required for the shift
115. Cadherin cell adhesion receptors as a morphogenic regulator
116. E-cadherin gene promoter hypermethylation in primary human gastric carcinomas
117. β-catenin regulates expression of cyclin D1 in colon carcinoma cells
118. Cadherin switching in human prostate cancer progression
119. Mutant E-cadherin breast cancer cells do not display constitutive Wnt signaling
120. The αE-catenin gene (CTNNA1) acts as an invasion-suppressor gene in human colon cancer cells
121. Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role
122. Induction of polarized cell-cell association and retardation of growth by activation of the E-cadherin-catenin adhesion system in a dispersed carcinoma line
123. Matrilysin: An epithelial matrix metalloproteinase with potentially novel functions
124. Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin
125. Diverse mechanisms of β-catenin deregulation in ovarian endometrioid adenocarcinomas
126. Reverse correlation of E-cadherin and snail expression in oral squamous cell carcinoma cells in vitro
127. Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human cancers
128. Plakoglobin and β-catenin: Protein interactions, regulation and biological roles
129. Oncogenic Ras downregulates Rac activity, which leads to increased Rho activity and epithelial-mesenchymal transition