Suppression of tumorigenicity by plakoglobin: An augmenting effect of N-cadherin

Journal of Cell Biology

Volumn 133, Issue 1, 1996, Pages 199-209

  Simcha, Inbal ^a   Geiger, Benjamin ^a   Yehuda Levenberg, Shulamit ^a   Salomon, Daniela ^a   Ben Ze'ev, Avri ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CADHERIN; CATENIN; PLAKOGLOBIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CARCINOGENESIS; CELL JUNCTION; CELL STRAIN 3T3; COLON CANCER; CONTROLLED STUDY; DESMOSOME; DROSOPHILA; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; KIDNEY CARCINOMA; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE;

3T3 CELLS; ALPHA CATENIN; ANIMALS; BETA CATENIN; CADHERINS; CARCINOMA, RENAL CELL; CELL CYCLE; CELL LINE, TRANSFORMED; CYTOSKELETAL PROTEINS; DESMOPLAKINS; GAMMA CATENIN; HUMANS; KIDNEY NEOPLASMS; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM TRANSPLANTATION; NEOPLASMS, EXPERIMENTAL; SIMIAN VIRUS 40; TRANS-ACTIVATORS; TRANSFECTION; TUMOR CELLS, CULTURED;

ANIMALIA; ARMADILLO; MAMMALIA; MUS MUSCULUS;

EID: 0029917554     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.133.1.199     Document Type: Article

References (41)

1. Aberle, H., C. Bierkamp, D. Torchard, O. Serova, T. Wagener, E. Natt, J. Wirsching, C. Heidkämper, M. Montagna, H.T. Lynch, et al. 1995. The human plakoglobin gene localizes on chromosome 17q21 and is subject to loss of heterozygosity in breast and ovarian cancer. Proc. Natl. Acad. Sci USA. 92: 6384-6388.
2. Behrens, J., M.M. Mareel, F.M. Van Roy, and W. Birchmeier. 1989. Dissecting tumor cell invasion: epithelial cells acquire invasive properties after loss of uvomorulin-mediated cell-cell adhesion. J. Cell Biol. 108:2435-2447.
3. Bejsovec, A., and E. Wieschaus. 1993. Segment polarity gene interactions modulate epidermal patterning in Drosophila embryos. Development. 119:501-517.
4. Bradley, R.S., P. Cowin, and A.M. Brown. 1993. Expression of Wnt-1 in PC12 cells results in modulation of plakoglobin and E-cadherin and increased cellular adhesion. J. Cell Biol. 123:1857-1865.
5. Chomczynski, P., and N. Sacchi. 1987. Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159.
6. Cowin, P. 1994. Unraveling the cytoplasmic interactions of the cadherin superfamily. Proc. Natl. Acad. Sci. USA. 91:10759-10761.
7. Cowin, P., H.P. Kapprell, W.W. Franke, J. Tamkun, and R.O. Hynes. 1986. Plakoglobin: a protein common to different kinds of intercellular adhering junctions. Cell. 46:1063-1073.
8. Cunningham, C.C., J.B. Gorlin, D.J. Kwiatkowski, J.H. Hartwig, P.A. Janmey. R.H. Byers, and T.P. Stossel. 1992 Actin-binding protein requirement for cortical stability and efficient locomotion. Science (Wash. DC). 255:325-327.
9. Feinberg, A.P., and B. Vogelstein. 1983. A technique for radiolabellig DNA restriction endonuclease fragments to high specific activities. Anal Biochem. 137:266-267.
10. Franke, W.W., M.D. Goldschmidt, R. Zimbelmann, H.M. Mueller, D.L. Schiller, and P. Cowin. 1989. Molecular cloning and amino acid sequence of human plakoglobin, the common junctional plaque protein. Proc. Natl Acad. Sci. USA. 86:4027-4031.
11. Frixen, U.H , J. Behrens, M. Sachs, G. Eberle, B. Voss, A. Warda, D. Löchner, and W. Birchmeir. 1991. E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells. J. Cell Biol 113:173-185.
12. Funayama, N., F. Fagotto, P. McCrea, and B.M. Gumbiner. 1995. Embryonic axis induction by the armadillo repeat domain of β-catenin: evidence for intracellular signaling J. Cell Biol. 128:959-968.
13. Geiger, B., O. Ayalon, D. Ginsberg, T. Volberg, J.L Rodríguez Fernández, Y. Yarden, and A. Ben-Zeev. 1992. Cytoplasmic control of cell-adhesion. Cold Spring Harb. Symp. Quant Biol. 57:631-642.
14. 1 fibronectin receptor suppress the transformed phenotype of chinese hamster ovary cells Cell. 69:849-859.
15. Gluck, U., and A. Ben-Ze'ev. 1994. Modulation of α-actinin levels affects cell motility and confers tumorigenicity on 3T3 cells. J. Cell Sci. 107:1773-1782
16. Glück, U., D.J. Kwiatkowski, and A. Ben-Ze'ev. 1993. Suppression of tumorigenicity in Simian virus 40-transformed cells transfected with α-actinin cDNA. Proc. Natl. Acad Sci. USA. 90:383-387.
17. Hinck, L., and I. Näthke. 1994a. Dynamics of cadherin/catenin complex formation: novel protein interactions and pathways of complex assembly. J. Cell Biol. 125:1327-1340.
18. Hinck, L., W.J. Nelson, and J. Papkoff. 1994b. Wnt-1 modulates cell-cell adhesion in mammalian cells by stabilizing β-catenin binding to the cell adhesion protein cadherin. J. Cell Biol. 124:729-741
19. Hoschuetzky, H., H. Aberle, and R. Kemler. 1994. β-Catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor. J. Cell Biol. 127:1375-1380.
20. Hulsken, J., W. Birchmeier, and J. Behrens. 1994. E-cadherin and APC compete for the interaction with β-catenin and the cytoskeleton. J. Cell Biol. 127: 2061-2069.
21. Karnovsky, A., and M.W. Klymkowsky. 1995. Anterior axis duplication in Xenopus induced by the over-expression of the cadherin-binding protein plakoglobin. Proc. Natl. Acad. Sci. USA. 92:4522-4526.
22. Knudsen, K.A., and M.J Wheelock. 1992. Plakoglobin, or an 83-kD homologue distinct from β-catenin, interacts with E-cadherin and N-cadherin. J. Cell Biol. 118:671-679.
23. Laemmli, U.K. 1970 Cleavage of structural proteins during the assembly of the head of the bacteriophage T4. Nature (Lond.). 227:680-685.
24. Navarro, P., M. Gomez, A. Pizarro, C Gamallo, M. Quintanilla, and A. Cano. 1991. A role for the E-cadherin cell-cell adhesion molecule during tumor progression of mouse epidermal carcinogenesis. J. Cell Biol. 115:517-533.
25. Navarro, P., E. Lozano, and A. Cano. 1993. Expression of E- or P-cadherin is not sufficient to modify the morphology and the tumorigenic behavior of murine spindle carcinoma cells: possible involvement of plakoglobin. J. Cell Sci 105:923-934.
26. Peifer, M., and E. Wieschaus. 1990. The segment polarity gene armadillo encodes a functionally modular protein that is the Drosophila homolog of human plakoglobin. Cell. 63:1167-1176.
27. Peifer, M., C. Rauskolb, M. Williams, B. Riggleman, and E. Wieschaus. 1991. The segment polarity gene armadillo affects the wingless signaling pathway in both embryonic and adult pattern formation. Development. 111:1028-1043.
28. Peifer, M., P.D. McCrea, K.J Green, E. Wieschaus, and B.M. Gumbiner. 1992 The vertebrate adhesive junction proteins β-catenin and plakoglobin and the Drosophila segment polarity gene armadillo form a multigene family with similar properties. J. Cell Biol. 118:681-691.
29. Powell, S.M., N. Zilz, Y. Beizer-Barclay, T. Bryan, S Hamilton, S. Thibodean, B. Vogelstein, and K. Kinzler. 1992. APC mutations occur during colorectal tumorigenesis. Nature (Lond.). 359:235-237.
30. Prasad, G.L., R.A. Fulder, and H.L. Cooper. 1993. Expression of transduced tropomyosin 1 cDNA suppresses neoplastic growth of cells transformed by the ras oncogene. Proc. Natl. Acad. Sci. USA. 90:7039-7043.
31. Rodríguez Fernández, J.L., B. Geiger, D. Salomon, and A- Ben-Ze'ev. 1992a. Overexpression of vinculin suppresses cell motility in Balb/c 3T3 cells. Cell Motil Cytoskeleton. 22:127-134.
32. Rodríguez Fernández, J.L., B. Geiger, D. Salomon, I. Sabanay, M. Zöller, and A. Ben-Ze'ev. 1992b. Suppression of tumorigenicity in transformed cells after transfection with vinculin cDNA. J. Cell Biol. 119:427-438.
33. Rodríguez Fernández, J.L., B. Geiger, D. Salomon, and A. Ben-Ze'ev. 1993. Suppression of vinculin expression by antisense transfection confers changes in cell morphology, motility and anchorage-dependent growth of 3T3 cells. J. Cell Biol. 122:1285-1294.
34. Rubinfeld, B., B. Souza, I. Albert, O. Müller, S. Chamberlain, F.R. Masiarz, S. Munemitsu, and P. Polakis. 1993. Association of the APC gene product with β-catenin. Science (Wash. DC). 262:1731-1734.
35. Salomon, D., O. Ayalon, R. Patel-King, R.O. Hynes, and B. Geiger. 1992. Extrajunctional distribution of N-cadherin in cultured human endothelial cells. J Cell Sci. 102:7-17.
36. Shibata, T., M Gotoh, A. Ochiai, and S. Hirohashi. 1994. Association of plakoglobin with APC, a tumor suppressor gene product, and its regulation by tyrosine phosphorylation Biochem. Biophys. Res Commun. 203:519-522.
37. Sokol, S., J.L. Christian, R.T. Moon, and D.A. Melton. 1991. Injected Wnt RNA induces a complete body axis in Xenopus embryos. Cell 67:741-752.
38. Sommers, C.L., E.P. Gelmann, R. Kemler, P. Cowin, and S.W. Byers. 1994. Alterations in β-catenin phosphorylation and plakoglobin expression in human breast cancer cells. Cancer Res. 54:3544-3552.
39. Su, L.K., B. Vogelstein, and K W. Kinzler. 1993. Association of the APC tumor suppressor protein with catenins. Science (Wash. DC). 262:1734-1737.
40. Tsukita, S., M. Itoh, A. Nagafuchi, S. Yonemura, and S. Tsukita. 1993. Submembranous junctional plaque proteins include potential tumor suppressor molecules. J. Cell Biol. 123:1049-1053.
41. Vlemincks, K., L.J. Vakaet, M. Mareel, W. Fiers, and F. Van Roy. 1991. Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role. Cell. 66:107-119.