E-cadherin and its associated protein catenins, cancer invasion and metastasis

British Journal of Surgery

Volumn 83, Issue 4, 1996, Pages 437-446

  Jiang, W G ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CATENIN; CELL ADHESION MOLECULE; UVOMORULIN;

CANCER INVASION; CELL ADHESION; CYTOSKELETON; GENE EXPRESSION REGULATION; HUMAN; METASTASIS; PRIORITY JOURNAL; REVIEW;

CADHERINS; CELL ADHESION; CYTOSKELETAL PROTEINS; HUMANS; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS;

EID: 0029876430     PISSN: 00071323     EISSN: None     Source Type: Journal    
DOI: 10.1002/bjs.1800830404     Document Type: Review

References (138)

1. Liotta LA, Stracke ML. Tumor invasion and metastases: biochemical mechanisms. Cancer Treat Res 1988; 40: 223-38.
2. Hart IR, Goode NT, Wilson RE. Molecular aspects of the metastatic cascade. Biochim Biophys Acta 1989; 989: 65-84.
3. Jiang WG, Puntis MCA, Hallett MB. Molecular and cellular basis of cancer invasion and metastasis: implications for treatment. Br J Surg 1994; 81: 1576-90.
4. Liotta LA. Biochemical mechanisms of tumor invasion and metastases. Clin Physiol Biochem 1987; 5: 190-9.
5. Rimm DL, Morrow JS. Molecular cloning of human E-cadherin suggests a novel subdivision of the cadherin superfamily. Biochem Biophys Res Commun 1994; 200: 1754-61.
6. Suzuki S, Sano K, Tanihara H. Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue. Cell Regul 1991; 2: 261-70.
7. Napolitano EW, Venstrom K, Wheeler EF, Reichardt LF. Molecular cloning and characterization of B-cadherin, a novel chick cadherin. J Cell Biol 1991; 113: 893-905.
8. Ginsberg D, DeSimone D, Geiger B. Expression of a novel cadherin (EP-cadherin) in unfertilized eggs and early Xenopus embryos. Development 1991; 111: 315-25.
9. Matsunami H, Miyatani S, Inoue T et al. Cell binding specificity of mouse R-cadherin and chromosomal mapping of the gene. J Cell Sci 1993; 106: 401-9.
10. Ranscht B, Dours-Zimmermann MT. T-cadherin, a novel cadherin cell adhesion molecule in the nervous system lacks the conserved cytoplasmic region. Neuron 1991; 7: 391-402.
11. Okazaki M, Takeshita S, Kawai S et al. Molecular cloning and characterization of OB-cadherin, a new member of cadherin family expressed in osteoblasts. J Biol Chem 1994; 269: 12 092-8.
12. Xiang YY, Tanaka M, Suzuki M et al. Isolation of complementary DNA encoding K-cadherin, a novel rat cadherin preferentially expressed in fetal kidney and kidney carcinoma. Cancer Res 1994; 54: 3034-41.
13. Bornemann A, Schmalbruch H. Immunocytochemistry of M-cadherin in mature and regenerating rat muscle. Anal Rec 1994; 239: 119-25.
14. Puttagunta S, Mathur M, Cowin P. Structure of DSG1, the bovine desmosomal cadherin gene encoding the pemphigus foliaceus antigen. Evidence of polymorphism. J Biol Chem 1994; 269: 1949-55.
15. Schafer S, Koch PJ, Franke WW. Identification of the ubiquitous human desmoglein, Dsg2, and the expression catalogue of the desmoglein subfamily of desmosomal cadherins. Exp Cell Res 1994; 211: 391-9.
16. 2+-dependent cell adhesion molecule expressed in liver and intestine. J Cell Biol 1994; 125: 1353-69.
17. Sano K, Tanihara H, Heimark RL et al. Protocadherins: a large family of cadherin-related molecules in central nervous system. EMBO J 1993; 12: 2249-56.
18. Iwamoto T, Taniguchi M, Asai N, Ohkusa K, Nakashima I, Takahashi M. cDNA cloning of mouse ret proto-oncogene and its sequence similarity to the cadherin superfamily. Oncogene 1993; 8: 1087-91.
19. Kuma K, Iwabe N, Miyata T. Motifs of cadherin- and fibronectin type III-related sequences and evolution of the receptor-type-protein tyrosine kinases: sequence similarity between proto-oncogene ret and cadherin family. Mol Biol Evol 1993; 10: 539-51.
20. Shapiro L, Fannon AM, Kwong PD et al. Structural basis of cell-cell adhesion by cadherins. Nature 1995; 374: 327-37.
21. Berx G, Staes K, van Hengel J et al. Cloning and characterization of the human invasion suppressor gene E-cadherin (CDH1). Genomics 1995; 26: 281-9.
22. Kraus C, Liehr T, Hulsken J et al. Localization of the human β-catenin gene (CTNNB1) to 3p21: a region implicated in tumour development. Genomics 1994; 23: 272-4.
23. McPherson JD, Morton RA, Ewing CM et al. Assignment of the human alpha-catenin gene (CTNNA1) to chromosome 5q21-q22. Genomics 1994; 19: 188-90.
24. cas associates with E-cadherin complexes. Mol Cell Biol 1994; 14: 8333-42.
25. Shibamoto S, Hayakawa M, Taceuchi K et al. Association of p 120, a tyrosine kinase substrate, with E-cadherin/catenin complexes. J Cell Biol 1995; 128: 949-57.
26. Aghib DF, McCrea PD. The E-cadherin complex contains the src substrate p120. Exp Cell Res 1995; 218: 359-69.
27. Aberle H, Butz S, Stappert J, Weissig H, Kemler R, Hoschuetzky H. Assembly of the cadherin-catenin complex in vitro with recombinant proteins. J Cell Sci 1994; 107: 3655-63.
28. Hinck L, Nathke IS, Papkoff J, Nelson WJ. Dynamics of cadherin/catenin complex formation: novel protein interactions and pathways of complex assembly. J Cell Biol 1994; 125: 1327-40.
29. Chen WC, Obrink C. Cell-cell contacts mediated by E-cadherin (uvomorulin) restrict invasive behavior of L-cells. J Cell Biol 1991; 114: 319-27.
30. Nagafuchi A, Shirayoshi Y, Okazaki K, Yasuda K, Takeichi M. Transformation of cell adhesion properties by exogenously introduced E-cadherin cDNA. Nature 1987; 329: 341-3.
31. Matsuyoshi N, Hamaguchi M, Taniguchi S, Nagafuchi A, Tsukita S, Takeichi M. Cadherin mediated cell-cell adhesion is perturbed by v-src tyrosine phosphorylation in metastatic fibroblasts. J Cell Biol 1992; 118: 703-14.
32. Shibamoto S, Hayakawa M, Takeuchi K et al. Tyrosine phosphorylation of beta-catenin and plakoglobin enhanced by hepatocyte growth factor and epidermal growth factor in human carcinoma cells. Cell Adhesion and Communication 1994; 1: 295-305.
33. Nagafuchi A, Ishihara S, Tsukita S. The roles of catenins in the cadherin-mediated cell adhesion: functional analysis of E-cadherin-alpha catenin fusion molecules. J Cell Biol 1994; 127: 235-45.
34. Shiozaki H, Kadowaki T, Doki Y et al. Effect of epidermal growth factor on cadherin-mediated adhesion in a human oesophageal cancer cell line. Br J Cancer 1995; 71: 250-8.
35. Behrens J, Vakaet L, Friis R et al. Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-SRC gene. J Cell Biol 1993; 120: 757-66.
36. Kawanishi J, Kato J, Sasaki K, Fujii S, Watanabe N, Niitsu Y. Loss of E-cadherin-dependent cell-cell adhesion due to mutation of the beta-catenin gene in a human cancer cell line. HSC-39. Mol Cell Biol 1995; 15: 1175-81.
37. Navarro P, Lozano E, Cano A. Expression of E- or P-cadherin is not sufficient to modify the morphology and the tumorigenic behavior of murine spindle carcinoma cells. Possible involvement of plakoglobin. J Cell Sci 1993; 105: 923-34.
38. Lampugnani MG, Corada M, Caveda L et al. The molecular organization of endothelial cell to cell junctions: differential association of plakoglobin, beta-catenin, and alpha-catenin with vascular endothelial cadherin (VE-cadherin). J Cell Biol 1995; 129: 203-17.
39. Ozawa M, Ringwald M, Kemler R. Uvomorulin-catenin complex formation is regulated by a specific domain in the cytoplasmic region of the cell adhesion molecule. Proc Natl Acad Sci U S A 1990; 87: 4246-50.
40. Dantzig AH, Hoskins JA, Tabas LB et al. Association of intestinal peptide transport with a protein related to the cadherin superfamily. Science 1994; 264: 430-3.
41. Watabe M, Nagafuchi A, Tsukita S, Takcichi M. Induction of polarized cell-cell association and retardation of growth by activation of the E-cadherin-catenin adhesion system in a dispersed carcinoma line. J Cell Biol 1994; 127: 247-56.
42. Frixen UH, Behrens J, Sachs M et al. E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells. J Cell Biol 1991; 113: 173-85.
43. Vleminckx K, Vakaet L Jr, Marcel M, Fiers W, van Roy F. Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role. Cell 1991; 66: 107-19.
44. Navarro P, Gomez M, Pizarro A, Gamallo C, Quintanilla M, Cano A. A role for the E-cadherin cell-cell adhesion molecule during tumor progression of mouse epidermal carcinogenesis. J Cell Biol 1991; 115: 517-33.
45. Fahraeus R, Chen W, Trivedi P, Klein G, Obrink B. Decreased expression of E-cadherin and increased invasive capacity in EBV-LMP-transfected human epithelial and murine adenocarcinoma cells. Int J Cancer 1992; 52: 834-8.
46. Doki Y, Shiozaki M, Tahara H et al. Correlation between E-cadherin expression and invasiveness in vitro in a human esophageal cancer cell line. Cancer Res 1993; 53: 3421-6.
47. Kinsella AR, Lepts GC, Hill CL, Jones M. Reduced E-cadherin expression correlates with increased invasiveness in colorectal carcinoma cell lines. Clin Exp Metastasis 1994; 12: 335-42.
48. Slagle BL, Zhou YZ, Birchmeier W, Scorsone KA. Deletion of the E-cadherin gene in hepatitis B virus-positive Chinese hepatocellular carcinomas. Hepatology 1993; 18: 757-62.
49. Jou TS, Stewart DB, Stappert J, Nelson WJ, Marrs JA. Genetic and biochemical dissection of protein linkages in the cadherin-catenin complex. Proc Natl Acad Sci USA 1995; 92: 5067-71.
50. Shimoyama Y, Nagafuchi A, Fujita S et al. Cadherin dysfunction in a human cancer cell line: possible involvement of loss of alpha-catenin expression in reduced cell-cell adhesiveness. Cancer Res 1992; 52: 5770-4.
51. 2+-dependent cell-cell adhesion. Cell Adhesion and Communication 1993; 1: 239-50.
52. Byers SW, Sommers CL, Hoxter B, Mercurio AM, Tozeren A. Role of E-cadherin in the response of tumor cell aggregates to lymphatic, venous and arterial flow: measurement of cell-cell adhesion strength. J Cell Sci 1995; 108: 2053-64.
53. Pignatelli M, Liu D, Nasim MM, Stamp GW, Hirano S, Takeichi M. Morphoregulatory activities of E-cadherin and beta-1 integrins in colorectal tumour cells. Br J Cancer 1992; 66: 629-34.
54. Frixen UH, Nagamine Y. Stimulation of urokinase-type plasminogen activator expression by blockage of E-cadherin-dependent cell-cell adhesion. Cancer Res 1993; 53: 3618-23.
55. Jensen PJ, Wheelock MJ. Regulation of urokinase plasminogen activator localization in keratinocytes by calcium ion and E-cadherin. Exp Cell Res 1992; 202: 190-8.
56. Shibata T, Gotoh M, Ochiai A, Hirohashi S. Association of plakogoblin with APC, a tumor suppressor gene product, and its regulation by tyrosine phosphorylation. Biochem Biophys Res Commun 1994; 203: 519-22.
57. Rubinfeld B, Souza B, Albert I et al. Association of the APC gene product with β-catenin. Science 1993; 262: 1731-4.
58. Peifer M. Cancer, catenins, and cuticle pattern: a complex connection. Science 1993; 262: 1667-8.
59. Hulsken J, Birchmeier W, Behrens J. E-cadherin and APC compete for the interaction with β-catenin and the cytoskeleton. J Cell Biol 1994; 127: 2061-9.
60. De Benedetti L, Sciallero S, Gismondi V et al. Association of APC gene mutations and histological characteristics of colorectal adenomas. Cancer Res 1994; 54: 3553-6.
61. Miyaki M, Konishi M, Kikuchi-Yanoshita R et al. Characteristics of somatic mutation of the adenomatous polyposis coli gene in colorectal tumors. Cancer Res 1994; 54: 3011-20.
62. Dogan A, Wang ZD, Spencer J. E-cadherin expression in intestinal epithelium. J Clin Pathol 1995; 48: 143-6.
63. Ochiai A, Akimoto S, Kanai Y, Shibata T, Oyama T, Hirohashi S. c-erbB-2 gene product associates with catenins in human cancer cells. Biochem Biophys Res Commun 1994; 205: 73-8.
64. Brabant G, Hoang-Vu C, Cetin Y et al. E-cadherin: a differentiation marker in thyroid malignancies. Cancer Res 1993; 53: 4987-93.
65. Jiang WG, Hiscox S, Hallett MB, Scott C, Horrobin DF. Puntis MCA. Inhibition of hepatocyte growth factor-induced motility and in vitro invasion of human colon cancer cells by gamma-linolenic acid. Br J Cancer 1995; 71: 744-52.
66. Jiang WG, Hiscox S, Hallett MB, Horrobin DF, Mansel RE. Puntis MCA. Regulation of the expression of E-cadherin in human cancer cells by gamma linolenic acid. Cancer Res 1995; 55: 5043-8.
67. Oda T, Kanai Y, Shimoyama Y, Nagafuchi A, Tsukita S, Hirohashi S. Cloning of the human alpha-catenin cDNA and its aberrant mRNA in a human cancer cell line. Biochem Biophys Res Commun 1993; 193: 897-904.
68. Bongiorno PF, al-Kasspooles M, Lee SW et al. E-cadherin expression in primary and metastatic thoracic neoplasms and in Barrett's oesophagus. Br J Cancer 1995; 71: 166-72.
69. Vandewalle B, Revillion F, Doutrelant P, Granier AM, Lefebvre J. Effect of calcium on E-cadherin expression in breast tumor cells. International Journal of Oncology 1994; 4: 181-5.
70. Morton RA, Ewing CM, Nagafuchi A, Tsukita S, Isaacs WB. Reduction of E-cadherin levels and deletion of the alpha-catenin gene in human prostate cancer cells. Cancer Res 1993; 53: 3585-90.
71. Kinsella AR, Bowie GL, Field JK, Jones AS. Expression of the cell-cell adhesion molecule E-cadherin in tongue carcinoma cell lines. J Laryngol Otol 1994; 108: 957-61.
72. Van Aken J, Cuvelier CA, De Wever N, Roels J, Gao Y, Mareel MM. Immunohistochemical analysis of E-cadherin expression in human colorectal tumours. Pathol Res Pract 1993; 189: 975-8.
73. Dorudi S, Sheffield JP, Poulsom R, Northover JM, Hart IR. E-cadherin expression in colorectal cancer. An immunocytochemical and in situ hybridization study. Am J Pathol 1993; 142: 981-6.
74. Shimoyama Y, Hirohashi S. Expression of E- and P-cadherin in gastric carcinomas. Cancer Res 1991; 51: 2185-92.
75. Ochiai A, Akimoto S, Shimoyama Y et al. Frequent loss of α-catenin expression in scirrhous carcinoma with scattered cell growth. Japanese J Cancer Res 1994; 85: 266-73.
76. Yasui W, Kuniyasu H, Akama Y et al. Expression of E-cadherin, alpha- and beta-catenins in human gastric carcinomas: correlation with histology and tumor progression. Oncology Reports 1995; 2: 111-17.
77. Mayer B, Johnson JP, Leitl F et al. E-cadherin expression in primary and metastatic gastric cancer: down-regulation correlates with cellular dedifferentiation and glandular disintegration. Cancer Res 1993; 53: 1690-5.
78. Matsuura K, Kawanishi J, Fujii S et al. Altered expression of E-cadherin in gastric cancer tissues and carcinomatous fluid. Br J Cancer 1992; 66: 1122-30.
79. Becker KF, Atkinson MJ, Reich U et al. E-cadherin gene mutations provide clues to diffuse type gastric carcinomas. Cancer Res 1994; 54: 3845-52.
80. Pignatelli M, Ansari TW, Gunter P et al. Loss of membranous E-cadherin expression in pancreatic cancer: correlation with lymph node metastasis, high grade, and advanced stage. J Pathol 1994; 174: 243-8.
81. Kadowaki T, Shiozaki H, Inoue M et al. E-cadherin and alpha-catenin expression in human esophageal cancer. Cancer Res 1994; 54: 291-6.
82. Bohm M, Totzeck B, Birchmeier W, Wieland I. Differences of E-cadherin expression levels and patterns in primary and metastatic human lung cancer. Clin Exp Metastasis 1994; 12: 55-62.
83. Bringuier PP, Umbas R, Schaafsma HE, Karthaus HFM, Debruyne FMJ, Schalken JA. Decreased E-cadherin immunoreactivity correlates with poor survival in patients with bladder tumors. Cancer Res 1993; 53: 3241-5.
84. Otto T, Birchmeier W, Schmidt U et al. Inverse relation of E-cadherin and autocrine motility factor receptor expression as a prognostic factor in patients with bladder carcinomas. Cancer Res 1994; 54: 3120-3.
85. Takayama T, Shiozaki H, Inoue M et al. Expression of E-cadherin and alpha catenin molecules in human breast cancer tissues and association with clinicopathological features. International Journal of Oncology 1994; 5: 775-80.
86. Moll R, Mitze M, Frixen UH, Birchmeier W. Differential loss of E-cadherin expression in infiltrating ductal and lobular breast carcinomas. Am J Pathol 1993; 143: 1731-42.
87. Palacios J, Benito N, Pizarro A et al. Anomalous expression of P-cadherin in breast carcinoma. Correlation with E-cadherin expression and pathological features. Am J Pathol 1995; 146: 605-12.
88. Gamallo C, Palacios J, Suarez A et al. Correlation of E-cadherin expression with differentiation grade and histological type in breast carcinoma. Am J Pathol 1993; 142: 987-93.
89. Oka H, Shiozaki H, Kobayashi K et al. Expression of E-cadherin cell adhesion molecules in human breast cancer tissues and its relationship to metastasis. Cancer Res 1993; 53: 1696-701.
90. Rasbridge SA, Gillett CE, Sampson SA, Walsh FS, Millis RR. Epithelial (E-) and placental (P-) cadherin cell adhesion molecule expression in breast carcinoma. J Pathol 1993; 169: 245-50.
91. Umbas R, Isaacs WB, Bringuier PP et al. Decreased E-cadherin expression is associated with poor prognosis in patients with prostate cancer. Cancer Res 1994; 54: 3929-33.
92. Otto T, Rembrink K, Goepel M, Meyer-Schwickerath M, Rubben H. E-cadherin: a marker for differentiation and invasiveness in prostatic carcinoma. Urol Res 1993; 21: 359-62.
93. Sakuragi N, Nishiya M, Ikeda K et al. Decreased E-cadherin expression in endometrial carcinoma is associated with tumor dedifferentiation and deep myometrial invasion. Gynecol Oncol 1994; 53: 183-9.
94. Risinger JI, Berchuck A, Kohler MF, Boyd J. Mutations of the E-cadherin gene in human gynecologic cancers. Nature Genetics 1994; 7: 98-102.
95. Pizarro A, Benito N, Navarro P et al. E-cadherin expression in basal cell carcinoma. Br J Cancer 1994; 69: 157-62.
96. Veatch AL, Carson LF, Ramakrishnan S. Differential expression of the cell-cell adhesion molecule E-cadherin in ascites and solid human ovarian tumor cells. Int J Cancer 1994; 58: 393-9.
97. Sakaki T, Wato M, Kaji R, Mushimoto K, Shirasu R, Tanaka A. Correlation of E- and P-cadherin expression with differentiation grade and mode of invasion in gingival carcinoma. Pathology International 1994; 44: 280-6.
98. Mattijssen V, Peters HM, Schalkwijk L et al. E-cadherin expression in head and neck squamous-cell carcinoma is associated with clinical outcome. Int J Cancer 1993; 55: 580-5.
99. Terpe HJ, Tajrobehkar K, Gunthert U, Altmannsberger M. Expression of cell adhesion molecules alpha-2, alpha-5 and alpha-6 integrin, E-cadherin, N-CAM and CD-44 in renal cell carcinomas. An immunohistochemical study. Virchows Arch A Pathol Anat Histopathol 1993; 422: 219-24.
100. Katagiri A, Watanabe R, Tomita Y. E-cadherin expression in renal cell cancer and its significance in metastasis and survival. Br J Cancer 1995; 71: 376-9.
101. Sakaki T, Wato M, Tamura I et al. Expression of E-cadherin and alpha catenin in oral cancer. J Dent Res 1995; 74: 455.
102. Moller CJ, Christgau S, Williamson MR et al. Differential expression of neural cell adhesion molecule and cadherins in pancreatic islets, glucagonomas, and insulinomas. Mol Endocrinol 1992; 6: 1332-42.
103. Nicholson LJ, Pei XF, Watt FM. Expression of E-cadherin, P-cadherin and involucrin by normal and neoplastic keratinocytes in culture. Carcinogenesis 1991; 12: 1345-9.
104. Schipper JH, Frixen UH, Behrens J, Unger A, Jahnke K, Birchmeier W. E-cadherin expression in squamous cell carcinomas of head and neck: inverse correlation with tumor dedifferentiation and lymph node metastasis. Cancer Res 1991; 51: 6328-37.
105. Gagliardi G, Kandemir O, Liu D et al. Changes in E-cadherin immunoreactivity in the adenoma-carcinoma sequence of the large bowel. Virchows Archives 1995; 426: 149-54.
106. Shiozaki H, Iihara K, Oka H et al. Immunohistochemical detection of alpha-catenin expression in human cancers. Am J Pathol 1994; 144: 667-74.
107. Matsui S, Shiozaki H, Inoue M et al. Immunohistochemical evaluation of alpha-catenin expression in human cancers. Virchows Arch 1994; 424: 375-81.
108. Becker KF, Atkinson MJ, Reich U et al. Exon skipping in the E-cadherin gene transcript in metastatic human gastric carcinomas. Human Mol Genetics 1993; 2: 803-4.
109. Inoue M, Ogawa H, Miyata M, Shiozaki H, Tanizawa O. Expression of E-cadherin in normal, benign, and malignant tissues of female genital organs. Am J Clin Pathol 1992; 98: 76-80.
110. Boyer B, Dufour S, Thiery JP. E-cadherin expression during the acidic FGF-induced dispersion of a rat bladder carcinoma cell line. Exp Cell Res 1992; 201: 347-57.
111. Katayama M, Hirai S, Yasumoto M et al. Soluble fragments of E-cadherin cell adhesion molecule increase in urinary excretion of cancer patients, potentially indicating its shedding from epithelial tumor cells. International Journal of Oncology 1994; 5: 1049-57.
112. Katayama M, Hirai S, Kamihagi K, Nakagawa K, Yasumoto M, Kato I. Soluble E-cadherin fragments increased in circulation of cancer patients. Br J Cancer 1994; 69: 580-5.
113. Banks RE, Porter WH, Whelan P, Smith PH, Selby PJ. Soluble forms of the adhesion molecule E-cadherin in urine. J Clin Pathol 1995; 48: 179-80.
114. Pignatelli M. E-cadherin: a biological marker of tumour differentiation. J Pathol 1993; 171: 81-2 (Editorial).
115. Glukhova M, Koteliansky V, Sastre X, Thiery JP. Adhesion systems in normal breast and in invasive breast carcinoma. Am J Pathol 1995; 146: 706-16.
116. MacCalman CD, Brodt P, Doublet JD et al. The loss of E-cadherin mRNA transcripts in rat prostatic tumors is accompanied by increased expression of mRNA transcripts encoding fibronectin and its receptor. Clin Exp Metastasis 1994; 12: 101-7.
117. Dorudi S, Hanby AM, Poulsom R, Northover J, Hart IR. Level of expression of E-cadherin mRNA in colorectal cancer correlates with clinical outcome. Br J Cancer 1995; 71: 614-16.
118. Umbas R, Schalken JA, Aalders TW et al. Expression of the cellular adhesion molecule E-cadherin is reduced or absent in high-grade prostate cancer. Cancer Res 1992; 52: 5104-9.
119. Revillion F, Vandewalle B, Hornez L, Lefebvre J. Influence of cAMP on E-cadherin expression and cell surface heparan sulfate proteoglycan synthesis in human breast cancer cells. Anticancer Res 1993; 13: 1625-9.
120. Williams CL, Hayes VY, Hummel AM, Tarara JE, Halsey TJ. Regulation of E-cadherin-mediated adhesion by muscarinic acetylcholine receptors in small cell lung carcinoma. J Cell Biol 1993; 121: 643-54.
121. 4-mediated adhesion to laminin and kalinin and E-cadherin-mediated cell-cell interaction. J Cell Biol 1994; 127: 2071-80.
122. Bracke ME, Vyncke BM, Bruyneel EA et al. Insulin-like growth factor I activates the invasion suppressor function of E-cadherin in MCF-7 human mammary carcinoma cells in vitro. Br J Cancer 1993; 68: 282-9.
123. Sorscher SM, Green MR, Feramisco JR. Enhanced E-cadherin expression in epidermal growth factor receptor expressing cells. Biochem Biophys Res Commun 1995; 206: 518-24.
124. Balsamo J, Ernst H, Zanin MKB, Hoffman S, Lilien J. The interaction of the retina cell surface N-acetyl-galactosaminylphosphotransferase with an endogenous proteoglycan ligand results in inhibition of cadherin-mediated adhesion. J Cell Biol 1995; 129: 1391-401.
125. D'Souza B, Taylor-Papadimitriou J. Overexpression of ERBB2 in human mammary epithelial cells signals inhibition of transcription of the E-cadherin gene. Proc Natl Acad Sci U S A 1994; 91: 7202-6.
126. MacCalman CD, Farookhi R, Blaschuk OW. Estradiol regulates E-cadherin mRNA levels in the surface epithelium of the mouse ovary. Clin Exp Metastasis 1994; 12: 276-82.
127. Bracke ME, Charlier C, Bruyneel EA, Labit C, Marcel MM, Castronovo V. Tamoxifen restores the E-cadherin function in human breast cancer MCF-7/6 cells and suppresses their invasive phenotype. Cancer Res 1994; 54: 4607-9.
128. Anzano MA, Byers SW, Smith JM et al. Prevention of breast cancer in the rat with 9-cis-retinoic acid as a single agent and in combination with tamoxifen. Cancer Res 1994; 54: 4614-17.
129. Fahre M, Garcia de Herreros A. Phorbol ester-induced scattering of HT-29 human intestinal cancer cells is associated with down-modulation of E-cadherin. J Cell Sci 1993; 106; 513-21.
130. Tamm I, Cardinale I, Kikuchi T, Krueger JG. E-cadherin distribution in interleukin 6-induced cell-cell separation of ductal breast carcinoma cells. Proc Natl Acad Sci USA 1994; 91: 4338-42.
131. Vandenbossche GM, De Bruyne GK, Bruyneel EA et al. Micro-encapsulation of MDCK-ras-e cells prevents loss of E-cadherin invasion-suppressor function in vitro. Int J Cancer 1994; 57: 73-80.
132. Munemitsu S, Albert I, Souza B, Rubinfeld B, Polakis P. Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein. Proc Natl Acad Sci USA 1995; 92: 3046-50.
133. Hinck L, Nelson WJ, Papkoff J. Wnt-1 modulates cell-cell adhesion in mammalian cells by stabilizing beta-catenin binding to the cell adhesion protein cadherin. J Cell Biol 1994; 124: 729-41.
134. Bussemakers MJ, Giroldi LA, van Bokhoven A, Schalken JA. Transcriptional regulation of the human E-cadherin gene promoter. Biochem Biophvs Res Commun 1994; 203: 1284-90.
135. Larue L, Ohsugi M, Hirchenhain J, Kemler R. E-cadherin null mutant embryos fail to form a trophectoderm epithelium. Proc Natl Acad Sci USA 1994; 91: 8263-7.
136. Heasman J, Crawford A, Goldstone K et al. Overexpression of cadherins and underexpression of β-catenin inhibit dorsal mesoderm induction in early Xenopus embryos. Cell 1994; 79: 791-803.
137. Terry TL, Gallin WJ. Effects of fetal calf serum and disruption of cadherin function on the formation of bile canaliculi between hepatocytes. Exp Cell Res 1994; 214: 642-53.
138. Brady-Kalnay SM, Rimm DL, Tonks NK. Receptor protein tyrosine phosphatase PTUμ associates with cadherins and catenins in vivo. J Cell Biol 1995; 130: 977-86.