메뉴 건너뛰기




Volumn 106, Issue 4, 2000, Pages 533-539

Gastrin is a target of the β-catenin/TCF-4 growth-signaling pathway in a model of intestinal polyposis

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; GASTRIN;

EID: 0033856281     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI9476     Document Type: Article
Times cited : (178)

References (45)
  • 1
    • 0027394231 scopus 로고
    • The APC gene product in normal and tumor cells
    • Smith, K.J., et al. 1993. The APC gene product in normal and tumor cells. Proc. Natl. Acad. Sci. USA. 90:2846-2850.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 2846-2850
    • Smith, K.J.1
  • 2
    • 0030592517 scopus 로고    scopus 로고
    • Lessons from hereditary colorectal cancer
    • Kinzler, K.W., and Vogelstein, B. 1996. Lessons from hereditary colorectal cancer. Cell. 87:159-170.
    • (1996) Cell. , vol.87 , pp. 159-170
    • Kinzler, K.W.1    Vogelstein, B.2
  • 3
    • 0030949463 scopus 로고    scopus 로고
    • Activation of β-catenin-Tcf signaling in colon cancers by mutations in β-catenin or APC
    • Morin, P.J., et al. 1997. Activation of β-catenin-Tcf signaling in colon cancers by mutations in β-catenin or APC. Science. 275:1787-1790.
    • (1997) Science , vol.275 , pp. 1787-1790
    • Morin, P.J.1
  • 4
    • 0030975671 scopus 로고    scopus 로고
    • Constitutive transcriptional activation by a β-catenin-Tcf complex in APC-/-colon carcinoma
    • Korinek, V., et al. 1997. Constitutive transcriptional activation by a β-catenin-Tcf complex in APC-/-colon carcinoma. Science. 275:1784-1787.
    • (1997) Science , vol.275 , pp. 1784-1787
    • Korinek, V.1
  • 5
    • 0001003110 scopus 로고    scopus 로고
    • XTcf-3 transcription factor mediates β-catenin-induced axis formation in Xenopus embryos
    • Molenaar, M., et al. 1996. XTcf-3 transcription factor mediates β-catenin-induced axis formation in Xenopus embryos. Cell. 86:391-399.
    • (1996) Cell. , vol.86 , pp. 391-399
    • Molenaar, M.1
  • 6
    • 0029781509 scopus 로고    scopus 로고
    • Functional interaction of β-catenin with the transcription factor LEF-1
    • Behrens, J., et al. 1996. Functional interaction of β-catenin with the transcription factor LEF-1. Nature. 382:638-642.
    • (1996) Nature , vol.382 , pp. 638-642
    • Behrens, J.1
  • 7
    • 0031848068 scopus 로고    scopus 로고
    • Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4
    • Korinek, V., et al. 1999. Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4. Nat. Genet. 19:379-383.
    • (1999) Nat. Genet. , vol.19 , pp. 379-383
    • Korinek, V.1
  • 8
    • 0032483439 scopus 로고    scopus 로고
    • Identification of c-myc as a target of the APC pathway
    • He, T.C., et al. 1998. Identification of c-myc as a target of the APC pathway. Science. 281:1509-1512.
    • (1998) Science , vol.281 , pp. 1509-1512
    • He, T.C.1
  • 9
    • 0033119801 scopus 로고    scopus 로고
    • β-catenin regulates expression of cyclin D1 in colon carcinoma cells
    • Tetsu, O., and McCormick, F. 1999. β-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature. 398:422-426.
    • (1999) Nature , vol.398 , pp. 422-426
    • Tetsu, O.1    McCormick, F.2
  • 10
    • 0033615352 scopus 로고    scopus 로고
    • PPARδ is an APC regulated target of nonsteroidal anti-inflammatory drugs
    • He, T.C., Chan, T.A., Vogelstein, B., and Kinzler, K.W. 1999. PPARδ is an APC regulated target of nonsteroidal anti-inflammatory drugs. Cell. 99:335-345.
    • (1999) Cell. , vol.99 , pp. 335-345
    • He, T.C.1    Chan, T.A.2    Vogelstein, B.3    Kinzler, K.W.4
  • 11
    • 0000711111 scopus 로고    scopus 로고
    • The role of gastrin in the adenoma: Carcinoma sequence in the colon
    • Abstr.
    • Watson, S.A., Michaeli, D., Morris, R.M., McWilliams, D., and Smith, A.M. 1999. The role of gastrin in the adenoma: carcinoma sequence in the colon. Digestion. 60:600. (Abstr.)
    • (1999) Digestion , vol.60 , pp. 600
    • Watson, S.A.1    Michaeli, D.2    Morris, R.M.3    McWilliams, D.4    Smith, A.M.5
  • 12
    • 0027391418 scopus 로고
    • Identification of progastrin derived peptides in colorectal carcinoma extracts
    • Nemeth, J., Taylor, B., Pauwels, S., Varro, A., and Dockray, G.J. 1993. Identification of progastrin derived peptides in colorectal carcinoma extracts. Gut. 34:90-95.
    • (1993) Gut , vol.34 , pp. 90-95
    • Nemeth, J.1    Taylor, B.2    Pauwels, S.3    Varro, A.4    Dockray, G.J.5
  • 14
    • 0027514212 scopus 로고
    • Developmental expression of the gastrin and cholecystokinin genes in rat colon
    • Luttichau, H.R., van Solinge, W.W., Nielsen, F.C., and Rehfeld, J.F. 1993. Developmental expression of the gastrin and cholecystokinin genes in rat colon. Gastroenterology. 104:1092-1098.
    • (1993) Gastroenterology , vol.104 , pp. 1092-1098
    • Luttichau, H.R.1    Van Solinge, W.W.2    Nielsen, F.C.3    Rehfeld, J.F.4
  • 15
    • 0029861301 scopus 로고    scopus 로고
    • Processing and proliferative effects of human progastrin in transgenic mice
    • Wang, T.C., et al. 1996. Processing and proliferative effects of human progastrin in transgenic mice. J. Clin. Invest. 98:1918-1929.
    • (1996) J. Clin. Invest. , vol.98 , pp. 1918-1929
    • Wang, T.C.1
  • 16
    • 0033561308 scopus 로고    scopus 로고
    • Overexpression of glycine-extended gastrin in transgenic mice results in increased colonic proliferation
    • Koh, T.J., et al. 1999. Overexpression of glycine-extended gastrin in transgenic mice results in increased colonic proliferation. J. Clin. Invest. 103:1119-1126.
    • (1999) J. Clin. Invest. , vol.103 , pp. 1119-1126
    • Koh, T.J.1
  • 17
    • 0030848520 scopus 로고    scopus 로고
    • Gastrin deficiency results in altered gastric differentiation and decreased colonie proliferation in mice
    • Koh, T.J., et al. 1997. Gastrin deficiency results in altered gastric differentiation and decreased colonie proliferation in mice. Gastroenterology. 113:1015-1025.
    • (1997) Gastroenterology , vol.113 , pp. 1015-1025
    • Koh, T.J.1
  • 19
    • 0028012352 scopus 로고
    • Activation of gastrin transcription in pancreatic insulinoma cells by a CACC promoter element and a 70-kDa sequence-specific DNA-binding protein
    • Tillotson, L.G., Wang, T.C., and Brand, S.J. 1994. Activation of gastrin transcription in pancreatic insulinoma cells by a CACC promoter element and a 70-kDa sequence-specific DNA-binding protein. J. Biol. Chem. 269:2234-2240.
    • (1994) J. Biol. Chem. , vol.269 , pp. 2234-2240
    • Tillotson, L.G.1    Wang, T.C.2    Brand, S.J.3
  • 20
    • 0032801892 scopus 로고    scopus 로고
    • Neoplastic transformation of RK3E by mutant β-catenin requires deregulation of Tcf/Lef transcription but not activation of c-myc expression
    • Kolligs, F.T., Hu, G., Dang, C.V., and Fearon, E.R. 1999. Neoplastic transformation of RK3E by mutant β-catenin requires deregulation of Tcf/Lef transcription but not activation of c-myc expression. Mol. Cell. Biol. 19:5696-5706.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 5696-5706
    • Kolligs, F.T.1    Hu, G.2    Dang, C.V.3    Fearon, E.R.4
  • 21
    • 0027938331 scopus 로고
    • Loss of APC in intestinal adenomas from Min mice
    • Luongo, C., Moser, A.R., Gledhill, S., and Dove, W.F. 1994. Loss of APC in intestinal adenomas from Min mice. Cancer Res. 54:5947-5952.
    • (1994) Cancer Res. , vol.54 , pp. 5947-5952
    • Luongo, C.1    Moser, A.R.2    Gledhill, S.3    Dove, W.F.4
  • 22
    • 0028904619 scopus 로고
    • Transgenic expression of human MGMT protects against azoxymethane-induced aberrant crypt foci and G to A mutations in the K-ras oncogene of mouse colon
    • Zaidi, N.H., et al. 1995. Transgenic expression of human MGMT protects against azoxymethane-induced aberrant crypt foci and G to A mutations in the K-ras oncogene of mouse colon. Carcinogenesis. 16:451-456.
    • (1995) Carcinogenesis , vol.16 , pp. 451-456
    • Zaidi, N.H.1
  • 24
    • 0030862410 scopus 로고    scopus 로고
    • Glycine-extended gastrin acts as an autocrine growth factor in a nontransformed colon cell line
    • Hollande, F., et al. 1997. Glycine-extended gastrin acts as an autocrine growth factor in a nontransformed colon cell line. Gastroenterology. 113:1576-1588.
    • (1997) Gastroenterology , vol.113 , pp. 1576-1588
    • Hollande, F.1
  • 25
    • 0026643104 scopus 로고
    • The HMG domain of lymphoid enhancer factor1 bends DNA and facilitates assembly of functional nucleoprotein structures
    • Giese, K., Cox, J., and Grosschedl, R. 1992. The HMG domain of lymphoid enhancer factor1 bends DNA and facilitates assembly of functional nucleoprotein structures. Cell. 69:185-195.
    • (1992) Cell. , vol.69 , pp. 185-195
    • Giese, K.1    Cox, J.2    Grosschedl, R.3
  • 26
    • 0032830931 scopus 로고    scopus 로고
    • TCF transcription factors: Molecular switches in carcinogeneis
    • Roose, J., and Clevers, H. 1999. TCF transcription factors: molecular switches in carcinogeneis. Biochim. Biophys. Acta. 1424:M23-M37.
    • (1999) Biochim. Biophys. Acta , vol.1424
    • Roose, J.1    Clevers, H.2
  • 27
    • 0026019629 scopus 로고
    • Identification and cloning of TCF-1, a T lymphocyte specific transcription factor containing a sequence-specific HMG box
    • van de Wetering, M., Oosterwegael, M., Dooijies, D., and Clevers, H. 1991. Identification and cloning of TCF-1, a T lymphocyte specific transcription factor containing a sequence-specific HMG box. EMBO J. 10:123-132.
    • (1991) EMBO J. , vol.10 , pp. 123-132
    • Van De Wetering, M.1    Oosterwegael, M.2    Dooijies, D.3    Clevers, H.4
  • 28
    • 0030606299 scopus 로고    scopus 로고
    • Suppression of intestinal polyposis in APCΔ716 knockout mice by inhibition of cyclooxygenase 2
    • Oshima, M., et al. 1996. Suppression of intestinal polyposis in APCΔ716 knockout mice by inhibition of cyclooxygenase 2. Cell. 87:803-809.
    • (1996) Cell. , vol.87 , pp. 803-809
    • Oshima, M.1
  • 29
    • 0028875341 scopus 로고
    • Gastrin and glycine-extended progastrin processing intermediates induce different programs of early gene activation
    • Todisco, A., Takeuchi, Y., Seva, C., Dickinson, C.J., and Yamda, T. 1995. Gastrin and glycine-extended progastrin processing intermediates induce different programs of early gene activation. J. Biol. Chem. 270:28337-28341.
    • (1995) J. Biol. Chem. , vol.270 , pp. 28337-28341
    • Todisco, A.1    Takeuchi, Y.2    Seva, C.3    Dickinson, C.J.4    Yamda, T.5
  • 30
    • 0031591664 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of insulin receptor substrate-1 and activation of the PI-3-kinase pathway by glycine-extended gastrin precursors
    • Kowalski-Chauvel, A., Pradayrol, L., Vaysse, N., and Seva, C. 1997. Tyrosine phosphorylation of insulin receptor substrate-1 and activation of the PI-3-kinase pathway by glycine-extended gastrin precursors. Biochem. Biophys. Res. Commun. 236:687-692.
    • (1997) Biochem. Biophys. Res. Commun. , vol.236 , pp. 687-692
    • Kowalski-Chauvel, A.1    Pradayrol, L.2    Vaysse, N.3    Seva, C.4
  • 31
    • 0028050404 scopus 로고
    • Growth promoting effects of glycine-extended progastrin
    • Seva, C., Dickinson, C.J., and Yamada, T. 1995. Growth promoting effects of glycine-extended progastrin. Science. 265:410-412.
    • (1995) Science , vol.265 , pp. 410-412
    • Seva, C.1    Dickinson, C.J.2    Yamada, T.3
  • 32
    • 0028947441 scopus 로고
    • Novel gastrin receptor mediates mitogenic effects of gastrin and processing intermediates of gastrin in Swiss 3T3 fibroblasts
    • Singh, P., Owlia, A., Espejo, R., and Dai, B. 1995. Novel gastrin receptor mediates mitogenic effects of gastrin and processing intermediates of gastrin in Swiss 3T3 fibroblasts. J. Biol. Chem. 270:28337-28341.
    • (1995) J. Biol. Chem. , vol.270 , pp. 28337-28341
    • Singh, P.1    Owlia, A.2    Espejo, R.3    Dai, B.4
  • 33
    • 0028892972 scopus 로고
    • Binding of progastrin fragments to the 78-kDa binding protein
    • Baldwin, G.S. 1995. Binding of progastrin fragments to the 78-kDa binding protein. FEBS Lett. 359:97-100.
    • (1995) FEBS Lett. , vol.359 , pp. 97-100
    • Baldwin, G.S.1
  • 34
    • 0030798118 scopus 로고    scopus 로고
    • The human gastrin/cholecystokinin receptors: Type B and type C expression in colonic tumors and cell lines
    • Biagini, P., et al. 1997. The human gastrin/cholecystokinin receptors: type B and type C expression in colonic tumors and cell lines. Life Sci. 61:1009-1018.
    • (1997) Life Sci. , vol.61 , pp. 1009-1018
    • Biagini, P.1
  • 35
    • 0029980637 scopus 로고    scopus 로고
    • Cholecystokinin-A and cholecystokinin-B/gastrin receptor mRNA expression in the gastrointestinal tract and pancreas of the rat and man
    • Monstein, H.J., et al. 1996. Cholecystokinin-A and cholecystokinin-B/gastrin receptor mRNA expression in the gastrointestinal tract and pancreas of the rat and man. Scand. J. Gastroenterol. 31:383-390.
    • (1996) Scand. J. Gastroenterol. , vol.31 , pp. 383-390
    • Monstein, H.J.1
  • 36
    • 0026576667 scopus 로고
    • Characterization of functional receptors for gastrointestinal hormones on human colon cancer cells
    • Frucht, H., Gazdar, F., Park, J.A., Oie, H., and Jensen, R.T. 1992. Characterization of functional receptors for gastrointestinal hormones on human colon cancer cells. Cancer Res. 52:1114-1122.
    • (1992) Cancer Res. , vol.52 , pp. 1114-1122
    • Frucht, H.1    Gazdar, F.2    Park, J.A.3    Oie, H.4    Jensen, R.T.5
  • 37
    • 0030815561 scopus 로고    scopus 로고
    • Differential expression of the CCK-A and CCK-B/gastrin receptor genes in human cancers of the esophagus, stomach, and colon
    • Clerc, P., et al. 1997. Differential expression of the CCK-A and CCK-B/gastrin receptor genes in human cancers of the esophagus, stomach, and colon. Int. J. Cancer. 72:931-936.
    • (1997) Int. J. Cancer , vol.72 , pp. 931-936
    • Clerc, P.1
  • 38
    • 0031855128 scopus 로고    scopus 로고
    • Expression of CCKB/gastrin receptor isoforms in gastro-intestinal tumour cells
    • Watson, S.A., et al. 1998. Expression of CCKB/gastrin receptor isoforms in gastro-intestinal tumour cells. Int. J. Cancer. 77:572-577.
    • (1998) Int. J. Cancer , vol.77 , pp. 572-577
    • Watson, S.A.1
  • 39
    • 0024581428 scopus 로고
    • Clinical significance of gastrin receptors in human colon cancers
    • Upp, J.R., Singh, P., Townsend, C.M., and Thompson, J.C. 1989. Clinical significance of gastrin receptors in human colon cancers. Cancer Res. 49:488-492.
    • (1989) Cancer Res. , vol.49 , pp. 488-492
    • Upp, J.R.1    Singh, P.2    Townsend, C.M.3    Thompson, J.C.4
  • 40
    • 0032937784 scopus 로고    scopus 로고
    • Association of k-ras mutations with p16 methylation in human colon cancer
    • Guan, R.J., Fu, Y., Holt, P.R., and Pardee, A.B. 1999. Association of k-ras mutations with p16 methylation in human colon cancer. Gastroenterology. 116:1063-1071.
    • (1999) Gastroenterology , vol.116 , pp. 1063-1071
    • Guan, R.J.1    Fu, Y.2    Holt, P.R.3    Pardee, A.B.4
  • 41
    • 0023748414 scopus 로고
    • Genetic alterations during colorectal-tumor development
    • Vogelstein, B., et al. 1988. Genetic alterations during colorectal-tumor development. N. Engl. J. Med. 319:525-532.
    • (1988) N. Engl. J. Med. , vol.319 , pp. 525-532
    • Vogelstein, B.1
  • 42
    • 0029549813 scopus 로고
    • Molecular genetics of colorectal cancer
    • Fearon, E.R. 1995. Molecular genetics of colorectal cancer. Ann. NY Acad. Sci. 768:101-109.
    • (1995) Ann. NY Acad. Sci. , vol.768 , pp. 101-109
    • Fearon, E.R.1
  • 43
    • 0032921643 scopus 로고    scopus 로고
    • JMV1 155: A novel inhibitor of glycine-extended progastrin-mediated growth of a human colon cancer in vivo
    • Lityak, J.A., et al. 1999. JMV1 155: a novel inhibitor of glycine-extended progastrin-mediated growth of a human colon cancer in vivo. Anticancer Res. 19:45-49.
    • (1999) Anticancer Res. , vol.19 , pp. 45-49
    • Lityak, J.A.1
  • 44
    • 0029813569 scopus 로고    scopus 로고
    • Gastrin gene expression is required for the proliferation and tumorigenicity of human colon cancer cells
    • Singh, P., et al. 1996. Gastrin gene expression is required for the proliferation and tumorigenicity of human colon cancer cells. Cancer Res. 56:4111-4115.
    • (1996) Cancer Res. , vol.56 , pp. 4111-4115
    • Singh, P.1
  • 45
    • 0030020865 scopus 로고    scopus 로고
    • Gastrimmune raises antibodies that neutralize amidated and glycine-extended gastrin-17 and inhibit the growth of colon cancer
    • Watson, S.A., et al. 1996. Gastrimmune raises antibodies that neutralize amidated and glycine-extended gastrin-17 and inhibit the growth of colon cancer. Cancer Res. 56:880-885.
    • (1996) Cancer Res. , vol.56 , pp. 880-885
    • Watson, S.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.