Transcriptional defects underlie loss of E-cadherin expression in breast cancer

Cell Growth and Differentiation

Volumn 8, Issue 7, 1997, Pages 773-778

  Ji, Xiaodong ^a   Woodard, Amy S ^c   Rimm, David L ^c   Fearon, Eric R ^a,b,d  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d Molecular Medicine and Genetics   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

UVOMORULIN;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; GENE ACTIVITY; GENE MUTATION; GENETIC TRANSCRIPTION; HUMAN; MOLECULAR CLONING; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION;

ANTIMETABOLITES, ANTINEOPLASTIC; AZACITIDINE; BREAST NEOPLASMS; CADHERINS; CLONING, MOLECULAR; DNA METHYLATION; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; PROMOTER REGIONS (GENETICS); TRANS-ACTIVATORS; TRANSCRIPTION FACTOR AP-2; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0030752437     PISSN: 10449523     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Takeichi, M. Cadherin cell adhesion receptors as a morphogenetic regulator. Science (Washington DC), 251: 1451-1455, 1991.
2. Birchmeier, M., Hulsken, J., and Behrens, J. Adherens junction proteins in tumour progression. Cancer Surv., 24: 129-140, 1995.
3. Nagafuchi, A., and Takeichi, M. Cell binding function of E-cadherin is regulated by the cytoplasmic domain. EMBO J., 7: 3679-3684, 1988.
4. Ozawa, M., Baribault, H., and Kemler, R. The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species. EMBO J., 8: 1711-1717, 1989.
5. Kintner, C. Regulation of embryonic cell adhesion by the cadherin cytoplasmic domain. Cell, 69: 225-236.
6. Hirano, S., Kimoto, N., Shimoyama, Y, Hirohashi, S., and Takeichi, M. Identification of a neural α-catenin as a key regulator of cadherin function and multicellular organization. Cell, 70: 293-301, 1992.
7. Behrens, J., Mareel, M. M., van Roy, F. M., and Birchmeier, W. Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion. J. Cell Biol., 108: 2435-2447, 1989.
8. Vleminckx, K., Vakaet, L., Jr., Mareel, M., Fiers, W., and van Roy, F. Genetic manipulation of E-cadherin expression by epithelial tumor cell reveals an invasion suppressor role. Cell, 66: 107-119, 1991.
9. Birchmeier W., Weidner, K. M., Hulsken, J., and Behrens, J. Molecular mechanisms leading to cell junction (cadherin) deficiency in invasive carcinomas. Semin. Cancer Biol., 4: 231-239, 1993.
10. Natt E., Magenis, R. E., Zimmer, J., Masouri, A., and Scherer, G. Regional assignment of the human loci for uvomorulin (UVO) and chymotrysinogen B (CTRB) with the help of two overlapping deletions on the long arm of chromosome 16. Cytogenet. Cell Genet., 50: 145-148, 1989.
11. Carter, B. S., Ewing, C. M., Ward, W. S., Treiger, B. G., Aalder, T. W., Schalken, J. A., Epstein, J. I., and Isaacs W. B. Allelic loss of chromosomes 16q and 10q in human prostate cancer. Proc. Natl. Acad. Sci. USA, 87: 8751-8755, 1991.
12. Sato, T., Saito, H., Morita, R., Loi, S., Lee, J-H., and Nakamura, Y. Allelotype of human ovarian cancer. Cancer Res., 51: 5118-5122, 1991.
13. Sato, T., Akiyama, F., Sakamoto, G., Kasumi, F., and Nakamura, Y. Accumulation of genetic alterations and progression of primary breast cancer. Cancer Res., 51: 5794-5799, 1991.
14. Becker, K. F., Atkinson, M. J., Reich, U., Becker, I., Nekarda, H., Siewert, J. R., and Hofler, H. E-cadherin gene mutations provide clues to diffuse type gastric carcinomas. Cancer Res., 54: 3845-3852, 1994.
15. Risinger, J. I., Berchuck, A., Kohler, M. F., and Boyd, J. Mutations of the E-cadherin gene in human gynecologic cancers. Nat. Genet., 7: 98-102, 1994.
16. Pierceall, W. E., Woodard, A. S., Morrow, J. S., Rimm D., and Fearon, E. R. Frequent alterations in E-cadherin and α-and β-catenin expression in human breast cancer cell lines. Oncogene, 11: 1319-1326, 1995.
17. Berx, G., Cleton-Jansen, A-M., Nollet, F., de Leeuw, W. J. F., van de Vijver, M. J., Cornelisse, C., and van Roy, F. E-cadherin is a tumour/ invasion suppressor gene mutated in human lobular breast cancers. EMBO J., 14: 6107-6115, 1995.
18. Graff, J. R., Herman, J. G., Lapidius, R. G., Chopra, H., Xu R., Jarrard, D. F., Isaacs, W. B., Pitha, P. M., Davidson, N. E., and Baylin, S. B. E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas. Cancer Res., 55: 5195-5199, 1995.
19. Hennig, G., Behrens J, Truss, M., Frisch, S., Reichmann, E., and Birchmeier, W. Progression of carcinoma cells is associated with alterations in chromatin structure and factor binding at the E-cadherin promoter in vivo. Oncogene, 11: 475-484, 1995.
20. Ringwald, M., Baribault, H., Schmidt, C., and Kemler, R. The structure of the gene coding for the mouse cell adhesion molecule uvomorulin. Nucleic Acids Res., 19: 6533-6539, 1991.
21. Bussemakers, M. J. G., Giroldi, L. A., van Bokhoven, A., and Schalken, J. A. Transcriptional regulation of the human E-cadherin gene in human prostate cancer cell lines. Biochem. Biophys. Res. Comm., 203: 1284-1290, 1994.
22. Behrens, J., Lowrick, O., Klein-Hitpass, L., and Birchmeier, W. The E-cadherin promoter: functional analysis of a G-C-rich region and an epithelial cell-specific palindromic regulatory element. Proc. Natl. Acad. Sci. USA, 86: 11495-11499, 1991.
23. Hennig, G., Lowrick, O., Birchmeier, W., and Behrens, J. Mechanisms identified in the transcriptional control of epithelial gene expression. J. Biol. Chem., 271: 595-602, 1996.
24. Bosher, J. M., Williams, T., and Hurst, H. C. The developmentally regulated transcription factor AP-2 is involved in c-erbB-2 overexpression in human mammary carcinoma. Proc. Natl. Acad. Sci. USA, 92: 744-747, 1995.
25. D'souza, B., and Taylor-Papadimitriou, J. Overexpression of ERBB2 in human mammary epithelial cells signals inhibition of transcription of the E-cadherin gene. Proc. Natl. Acad. Sci. USA, 91: 7202-7206, 1994.
26. Gossen, M., and Bujard, H. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl. Acad. Sci. USA, 89: 5547-5551, 1992.
27. Lee, L. A., Dolde, C., Barrett, J., Wu, C. S., and Dang, C. V. A link between c-Myc-mediated transcriptional repression and neoplastic transformation. J. Clin. Invest., 97: 1687-1695, 1996.