Mechanism of action of human P-glycoprotein ATPase activity: Photochemical cleavage during a catalytic transition state using orthovanadate reveals cross-talk between the two ATP sites

Journal of Biological Chemistry

Volumn 273, Issue 27, 1998, Pages 16631-16634

  Hrycyna, Christine A ^a   Ramachandra, Muralidhara ^a,c   Ambudkar, Suresh V ^a   Ko, Young Hee ^b   Pedersen, Peter L ^b   Pastan, Ira ^a   Gottesman, Michael M ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; ADENOSINE TRIPHOSPHATASE; GLYCOPROTEIN P; ORTHOVANADIC ACID;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CANCER; CARBOXY TERMINAL SEQUENCE; ENZYME MECHANISM; HYDROLYSIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; ULTRAVIOLET IRRADIATION;

EID: 0032479280     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.27.16631     Document Type: Article

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