메뉴 건너뛰기




Volumn 405, Issue 6788, 2000, Pages 847-856

Searching for genetic determinants in the new millennium

Author keywords

[No Author keywords available]

Indexed keywords

DNA SEQUENCE; FAMILIAL DISEASE; GENETIC DISORDER; GENETIC HETEROGENEITY; GENETIC LINKAGE; GENETIC MODEL; HISTORY; HUMAN; INHERITANCE; METHODOLOGY; MOLECULAR CLONING; NONHUMAN; POPULATION GENETICS; PRIORITY JOURNAL; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 0034660559     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35015718     Document Type: Review
Times cited : (1591)

References (47)
  • 2
    • 0343847019 scopus 로고
    • Some practical considerations in testing for genetic linkage in sib data
    • Penrose, L. S. Some practical considerations in testing for genetic linkage in sib data. Ohio J. Sci. 39, 291-296 (1939).
    • (1939) Ohio J. Sci. , vol.39 , pp. 291-296
    • Penrose, L.S.1
  • 3
    • 84965339061 scopus 로고
    • ABO blood groups and secretor character in duodenal ulcer
    • Clarke, C. A. et al. ABO blood groups and secretor character in duodenal ulcer. Br. Med. J. 2, 725-73 (1956).
    • (1956) Br. Med. J. , vol.2 , pp. 725-773
    • Clarke, C.A.1
  • 4
    • 0030669122 scopus 로고    scopus 로고
    • Use of siblings as controls in case-control association studies
    • Curtis, D. Use of siblings as controls in case-control association studies. Am. J. Hum. Genet. 61, 319-333 (1997).
    • (1997) Am. J. Hum. Genet. , vol.61 , pp. 319-333
    • Curtis, D.1
  • 5
    • 0031912715 scopus 로고    scopus 로고
    • A sibship based test for linkage in the presence of association: The sib transmission/disequilibrium test
    • Spielman, R. S. & Ewens, W. J. A sibship based test for linkage in the presence of association: the sib transmission/disequilibrium test. Am. J. Hum. Genet. 62, 450-458 (1998).
    • (1998) Am. J. Hum. Genet. , vol.62 , pp. 450-458
    • Spielman, R.S.1    Ewens, W.J.2
  • 6
    • 0031949273 scopus 로고    scopus 로고
    • Genetic association mapping based on discordant sib pairs: The discordant-alleles test
    • Boehnke, M. & Langefeld, C. D. Genetic association mapping based on discordant sib pairs: the discordant-alleles test. Am. J. Hum. Genet. 62, 950-961 (1998).
    • (1998) Am. J. Hum. Genet. , vol.62 , pp. 950-961
    • Boehnke, M.1    Langefeld, C.D.2
  • 7
    • 0032427048 scopus 로고    scopus 로고
    • The relative poser of family-based and case-control designs for association studies of complex human diseases. I. DNA pooling
    • Risch, N. & Teng, J. The relative poser of family-based and case-control designs for association studies of complex human diseases. I. DNA pooling. Genome Res. 8, 1273-1288 (1998).
    • (1998) Genome Res. , vol.8 , pp. 1273-1288
    • Risch, N.1    Teng, J.2
  • 8
    • 0032231911 scopus 로고    scopus 로고
    • Use of parents, sibs and unrelated controls for detection of associations between genetic markers and disease
    • Schaid, D. J. & Rowland, C. Use of parents, sibs and unrelated controls for detection of associations between genetic markers and disease. Am. J. Hum. Genet. 63, 1492-1506 (1998).
    • (1998) Am. J. Hum. Genet. , vol.63 , pp. 1492-1506
    • Schaid, D.J.1    Rowland, C.2
  • 9
    • 0019302053 scopus 로고
    • Construction of a genetic linkage map in man using restriction fragment length polymorphisms
    • Botstein, D., White, R. L., Skolnick, M. & Davis, R. W. Construction of a genetic linkage map in man using restriction fragment length polymorphisms. Am. J. Hum. Genet. 32, 314-331 (1980).
    • (1980) Am. J. Hum. Genet. , vol.32 , pp. 314-331
    • Botstein, D.1    White, R.L.2    Skolnick, M.3    Davis, R.W.4
  • 10
    • 0024582686 scopus 로고
    • Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction
    • Weber, J. L. & May, P. E. Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction. Am. J. Hum. Genet. 44, 388-396 (1989).
    • (1989) Am. J. Hum. Genet. , vol.44 , pp. 388-396
    • Weber, J.L.1    May, P.E.2
  • 11
    • 0024514081 scopus 로고
    • A hypervariable microsatellite revealed by in vitro amplification of a dinucleotide repeat within the cardiac muscle actin gene
    • Litt, M. & Luty, J. A. A hypervariable microsatellite revealed by in vitro amplification of a dinucleotide repeat within the cardiac muscle actin gene. Am. J. Hum. Genet. 44, 397-401 (1989).
    • (1989) Am. J. Hum. Genet. , vol.44 , pp. 397-401
    • Litt, M.1    Luty, J.A.2
  • 13
    • 0043048571 scopus 로고
    • Sequential tests for the detection of linkage
    • Morton, M. E. Sequential tests for the detection of linkage. Am. J. Hum. Genet. 7, 277-318 (1955).
    • (1955) Am. J. Hum. Genet. , vol.7 , pp. 277-318
    • Morton, M.E.1
  • 15
    • 17344372511 scopus 로고    scopus 로고
    • A second-generation screen of the human genome for susceptibility to insulin-dependent diabetes mellitus
    • Concannon, P. et al. A second-generation screen of the human genome for susceptibility to insulin-dependent diabetes mellitus. Nature Genet. 19, 292 (1998).
    • (1998) Nature Genet. , vol.19 , pp. 292
    • Concannon, P.1
  • 16
    • 0029001682 scopus 로고    scopus 로고
    • Extreme discordant sib pairs for mapping quantitative trait loci in humans
    • Risch, N. & Zhang, H. Extreme discordant sib pairs for mapping quantitative trait loci in humans. Science 268, 1584-1589 (1998).
    • (1998) Science , vol.268 , pp. 1584-1589
    • Risch, N.1    Zhang, H.2
  • 17
    • 0028102233 scopus 로고
    • Locating human quantitative trait loci: Guidelines for the selection of sibling pairs for genotyping
    • Eaves, L. & Meyer, J. Locating human quantitative trait loci: guidelines for the selection of sibling pairs for genotyping. Behav. Genet. 24, 443-455 (1994).
    • (1994) Behav. Genet. , vol.24 , pp. 443-455
    • Eaves, L.1    Meyer, J.2
  • 18
    • 0031946381 scopus 로고    scopus 로고
    • Mapping genes though the use of linkage disequilibrium generated by genetic drift: "Drift mapping" in small populations with no demographic-expansion
    • Terwilliger, J. D., Zollner, S., Laan, M. & Paabo, S. Mapping genes though the use of linkage disequilibrium generated by genetic drift: "drift mapping" in small populations with no demographic-expansion. Hum. Hered. 48, 138-154 (1998).
    • (1998) Hum. Hered. , vol.48 , pp. 138-154
    • Terwilliger, J.D.1    Zollner, S.2    Laan, M.3    Paabo, S.4
  • 19
    • 0029741063 scopus 로고    scopus 로고
    • The future of genetic studies of complex human diseases
    • Risch, N. & Merikangas, K. The future of genetic studies of complex human diseases. Science 273, 1516-1517 (1996).
    • (1996) Science , vol.273 , pp. 1516-1517
    • Risch, N.1    Merikangas, K.2
  • 20
    • 0030688004 scopus 로고    scopus 로고
    • Variations on a theme: Cataloging human DNA sequence variation
    • Collins, F. S., Guyer, M. S. & Chakravarti, A. Variations on a theme: cataloging human DNA sequence variation. Science 278, 1580-1581 (1997).
    • (1997) Science , vol.278 , pp. 1580-1581
    • Collins, F.S.1    Guyer, M.S.2    Chakravarti, A.3
  • 21
    • 0033039497 scopus 로고    scopus 로고
    • Prospects for whole-genome linkage disequilibrium mapping of common disease genes
    • Kruglak, I., Prospects for whole-genome linkage disequilibrium mapping of common disease genes. Nature Genet. 22, 139-144 (1998).
    • (1998) Nature Genet. , vol.22 , pp. 139-144
    • Kruglak, I.1
  • 22
    • 0030667521 scopus 로고    scopus 로고
    • Demographic history and linkage disequilibrium in human populations
    • Laan, M. & Paabo, S. Demographic history and linkage disequilibrium in human populations. Nature Genet. 17, 435-4381, (1997).
    • (1997) Nature Genet. , vol.17 , pp. 435-4381
    • Laan, M.1    Paabo, S.2
  • 24
    • 0032707163 scopus 로고    scopus 로고
    • Population choice in mapping genes for complex diseases
    • Wright, A. F., Carothers, A. D. & Pirastu, M. Population choice in mapping genes for complex diseases. Nature Genet. 23, 397-404 (1999).
    • (1999) Nature Genet. , vol.23 , pp. 397-404
    • Wright, A.F.1    Carothers, A.D.2    Pirastu, M.3
  • 25
    • 0031588662 scopus 로고    scopus 로고
    • Genetic analysis of complex diseases
    • Muller-Myhsok, B. & Abel, L. Genetic analysis of complex diseases. Science 275, 1328-1329 (1997).
    • (1997) Science , vol.275 , pp. 1328-1329
    • Muller-Myhsok, B.1    Abel, L.2
  • 26
    • 0033073397 scopus 로고    scopus 로고
    • Power of association and linkage tests when the disease alleles are unobserved
    • Tu, I.-P. & Whittemore, A. S. Power of association and linkage tests when the disease alleles are unobserved. Am. J. Hum. Genet. 64, 641-649 (1999).
    • (1999) Am. J. Hum. Genet. , vol.64 , pp. 641-649
    • Tu, I.-P.1    Whittemore, A.S.2
  • 27
    • 17344364213 scopus 로고    scopus 로고
    • DNA sequence diversity in a 9.7kb region of the human lipoprotein lipase gene
    • Nickerson, D. A et al. DNA sequence diversity in a 9.7kb region of the human lipoprotein lipase gene. Nature Genet. 19, 233-240 (1998).
    • (1998) Nature Genet. , vol.19 , pp. 233-240
    • Nickerson, D.A.1
  • 28
    • 0345350737 scopus 로고
    • Use of pooled DNA samples to detect linkage disequilibrium of polymorphic restriction fragments and human disease: Studies of the HLA class II loci
    • Arnheim, N., Strange, C. & Erlich, H. Use of pooled DNA samples to detect linkage disequilibrium of polymorphic restriction fragments and human disease: studies of the HLA class II loci. Proc. Natl Acad. Sci. USA 82, 6970-6974 (1985).
    • (1985) Proc. Natl Acad. Sci. USA , vol.82 , pp. 6970-6974
    • Arnheim, N.1    Strange, C.2    Erlich, H.3
  • 29
    • 0007966518 scopus 로고
    • Use of DNA pooling strategy to identify a human obesity syndrome locus on chromosome 15
    • Carmi, R. et al. Use of DNA pooling strategy to identify a human obesity syndrome locus on chromosome 15. Hum. Mol. Genet. 3, 1331-1335 (1995).
    • (1995) Hum. Mol. Genet. , vol.3 , pp. 1331-1335
    • Carmi, R.1
  • 30
    • 0030763566 scopus 로고    scopus 로고
    • Association mapping of disease loci by use of a pooled DNA genomic screen
    • Barcellos, L. F. et al. Association mapping of disease loci by use of a pooled DNA genomic screen. Am. J. Hum. Genet. 61, 734-747 (1997).
    • (1997) Am. J. Hum. Genet. , vol.61 , pp. 734-747
    • Barcellos, L.F.1
  • 31
    • 0032991552 scopus 로고    scopus 로고
    • Characterization of single-nucleotide polymorphisms in coding regions of human genes
    • Cargill, M. et al. Characterization of single-nucleotide polymorphisms in coding regions of human genes. Nature Genet. 22, 231-238 (1999).
    • (1999) Nature Genet. , vol.22 , pp. 231-238
    • Cargill, M.1
  • 32
    • 0032990407 scopus 로고    scopus 로고
    • Patterns of single-nucleotidc polymorphisms in candidate genes for blood-pressure homeostasis
    • Halushka, M. K. et al. Patterns of single-nucleotidc polymorphisms in candidate genes for blood-pressure homeostasis. Nature Genet. 22, 239-247 (1999).
    • (1999) Nature Genet. , vol.22 , pp. 239-247
    • Halushka, M.K.1
  • 33
    • 0023235253 scopus 로고
    • Haplotype relative risks: An easy reliable way to construct a proper control sample for risk calculations
    • Falk, C. T. & Rubinstein, P. Haplotype relative risks: an easy reliable way to construct a proper control sample for risk calculations. Ann. Hum. Genet. 51, 227-233 (1987).
    • (1987) Ann. Hum. Genet. , vol.51 , pp. 227-233
    • Falk, C.T.1    Rubinstein, P.2
  • 34
    • 0026494911 scopus 로고
    • A haplotype-based "haplotype-relative risk" approach to detecting allelic associations
    • Terwilliger, J. D. & Ott, J. A haplotype-based "haplotype-relative risk" approach to detecting allelic associations. Hum. Hered. 42, 337-346 (1992).
    • (1992) Hum. Hered. , vol.42 , pp. 337-346
    • Terwilliger, J.D.1    Ott, J.2
  • 35
    • 0027377799 scopus 로고
    • Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus (IDDM)
    • Spielman, R. S. McGinnis, R. E. & Ewens, W. J. Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am. J. Hum. Genet. 52, 506-516 (1993).
    • (1993) Am. J. Hum. Genet. , vol.52 , pp. 506-516
    • Spielman, R.S.1    McGinnis, R.E.2    Ewens, W.J.3
  • 36
    • 0029064537 scopus 로고
    • Mapping disease genes: Family-based association studies
    • Thomson, G. Mapping disease genes: family-based association studies. Am. J. Hum. Genet. 57, 487-498 (1995).
    • (1995) Am. J. Hum. Genet. , vol.57 , pp. 487-498
    • Thomson, G.1
  • 37
    • 0032897131 scopus 로고    scopus 로고
    • The relative power of family-based and case-control designs for linkage disequilibrium studies of complex human diseases. II. Individual genotyping
    • Teng, J. & Risch, N. The relative power of family-based and case-control designs for linkage disequilibrium studies of complex human diseases. II. Individual genotyping. Genome Res. 9, 234-241 (1999).
    • (1999) Genome Res. , vol.9 , pp. 234-241
    • Teng, J.1    Risch, N.2
  • 38
    • 0032530165 scopus 로고    scopus 로고
    • Tests and estimates of allelic association in complex inheritance
    • Morton, N. E. & Collins, A. Tests and estimates of allelic association in complex inheritance. Proc. Natl Acad. Sci. USA 95, 11389-11393 (1998).
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 11389-11393
    • Morton, N.E.1    Collins, A.2
  • 39
    • 0033358548 scopus 로고    scopus 로고
    • Use of unlinked genetic markers to detect population stratification in association studies
    • Pritchard, J. K. & Rosenberg, N. A. Use of unlinked genetic markers to detect population stratification in association studies. Am. J. Hum. Genet. 65, 220-228 (1999).
    • (1999) Am. J. Hum. Genet. , vol.65 , pp. 220-228
    • Pritchard, J.K.1    Rosenberg, N.A.2
  • 40
    • 0032714352 scopus 로고    scopus 로고
    • Genomic control for association studies
    • Devlin, B. & Roeder, K. Genomic control for association studies. Biometrics 55, 997-1004 (1999).
    • (1999) Biometrics , vol.55 , pp. 997-1004
    • Devlin, B.1    Roeder, K.2
  • 41
    • 9344224529 scopus 로고    scopus 로고
    • A novel MHC class 1-like gene is mutated in patients with hereditary haemochromatosis
    • Feder, J. N, et al. A novel MHC class 1-like gene is mutated in patients with hereditary haemochromatosis. Nature Genet. 13, 399-408 (1996).
    • (1996) Nature Genet. , vol.13 , pp. 399-408
    • Feder, J.N.1
  • 42
    • 0030823158 scopus 로고    scopus 로고
    • Effects of age, sex and ethnicity on the association between apolipoprotein e genotype and Alzheimer's disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium
    • Farrer, L. A. et al. Effects of age, sex and ethnicity on the association between apolipoprotein E genotype and Alzheimer's disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. J. Am. Med. Assoc. 278, 1349-1356 (1997).
    • (1997) J. Am. Med. Assoc. , vol.278 , pp. 1349-1356
    • Farrer, L.A.1
  • 43
    • 0028596909 scopus 로고
    • DZB1*0602 and DQA1*0102 (DQI) are better markers than DR2 for narcolepsy in Caucasian and Black Americans
    • Mignot, E. et al. DZB1*0602 and DQA1*0102 (DQI) are better markers than DR2 for narcolepsy in Caucasian and Black Americans. Sleep 17, S60-S67 (1994).
    • (1994) Sleep , vol.17
    • Mignot, E.1
  • 46
    • 0025019555 scopus 로고
    • Linkage strategies for genetically complex traits. I. Multi-locus models
    • Risch, N. Linkage strategies for genetically complex traits. I. Multi-locus models. Am. J. Hum. Genet. 46, 222-228 (1990).
    • (1990) Am. J. Hum. Genet. , vol.46 , pp. 222-228
    • Risch, N.1
  • 47
    • 0028877463 scopus 로고
    • Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results
    • Lander, E. & Kruglak, L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nature Genet. 11, 241-247 (1995).
    • (1995) Nature Genet. , vol.11 , pp. 241-247
    • Lander, E.1    Kruglak, L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.