The combined role of P- and E-selectins in atherosclerosis

Journal of Clinical Investigation

Volumn 102, Issue 1, 1998, Pages 145-152

  Dong, Zhao Ming ^a   Chapman, Susan M ^a   Brown, Allison A ^a   Frenette, Paul S ^a   Hynes, Richard O ^b   Wagner, Denisa D ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Animal model for atherosclerosis; Leukocyte adhesion; Lipofuscin; Macrophage; Smooth muscle cells

Indexed keywords

ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; LOW DENSITY LIPOPROTEIN RECEPTOR; PADGEM PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROGENESIS; ATHEROGENIC DIET; ATHEROSCLEROSIS; CONTROLLED STUDY; LEUKOCYTE ADHERENCE; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

EID: 0142096796     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI3001     Document Type: Article

References (35)

1. Ross, R. 1993. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature. 362:801-809.
2. Bevilacqua, M.P., R.M. Nelson, G. Mannori, and O. Cecconi. 1994. Endothelial-leukocyte adhesion molecules in human disease. Annu. Rev. Med. 45: 361-378.
3. Carlos, T.M., and J.M. Harlan. 1994. Leukocyte-endothelial adhesion molecules. Blood. 84:2068-2101.
4. Frenette, P.S., and D.D. Wagner. 1997. Insights into selectin function from knockout mice. Thromb. Haemostasis. 78:60-64.
5. Mayadas, T.N., R.C. Johnson, H. Rayburn, R.O. Hynes, and D.D. Wagner. 1993. Leukocyte rolling and extravasation are severely compromised in P-selectin-deficient mice. Cell. 74:541-554.
6. Labow, M.A., C.R. Norton, J.M. Rumberger, K.M. Lombard-Gillooly, D.J. Shuster, J. Hubbard, R. Bertko, P.A. Knaack, R.W. Terry, M.L. Harbison et al. 1994. Characterization of E-selectin-deficient mice: demonstration of overlapping function of the endothelial selectins. Immunity. 1:709-720.
7. Frenette, P.S., T.N. Mayadas, H. Rayburn, R.O. Hynes, and D.D. Wagner. 1996. Susceptibility to infection and altered hematopoiesis in mice deficient in both P-and E-selectins. Cell. 84:563-574.
8. Bullard, D.C., E.J. Kunkel, H. Kubo, M.J. Hicks, I. Lorenzo, N.A. Doyle, C.M. Doerschuk, K. Ley, and A.L. Beaudet. 1996. Infectious susceptibility and severe deficiency of leukocyte rolling and recruitment in E-selectin and P-selectin double mutant mice. J. Exp. Med. 183:2329-2336.
9. Staite, N.D., J.M. Justen, L.M. Sly, A.L. Beaudet, and D.C. Bullard. 1996. Inhibition of delayed-type contact hypersensitivity in mice deficient in both E-selectin and P-selectin. Blood. 88:2973-2979.
10. Ishibashi, S., M.S. Brown, J.L. Goldstein, R.D. Gerard, R.E. Hammer, and J. Herz. 1993. Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery. J. Clin. Invest. 92:883-893.
11. Johnson, R.C., S.M. Chapman, Z.M. Dong, J.M. Ordovas, T.N. Mayadas, J. Herz, R.O. Hynes, E.J. Schaefer, and D.D. Wagner. 1997. Absence of P-selectin delays fatty streak formation in mice. J. Clin. Invest. 99:1037-1043.
12. Shimada, M., S. Ishibashi, T. Inaba, H. Yagyu, K. Harada, J.I. Osuga, K. Ohashi, Y. Yazaki, and N. Yamada. 1996. Suppression of diet-induced atherosclerosis in low density lipoprotein receptor knockout mice overexpressing lipoprotein lipase. Proc. Natl. Acad. Sci. USA. 93:7242-7246.
13. Qiao, J.H., P.Z. Xie, M.C. Fishbein, J. Kreuzer, T.A. Drake, L.L. Demer, and A.J. Lusis. 1994. Pathology of atheromatous lesions in inbred and genetically engineered mice: genetic determination of arterial calcification. Arterioscler. Thromb. 14:1480-1497.
14. Qiao, J.H., C.L. Welch, P.Z. Xie, M.C. Fishbein, and A.J. Lusis. 1993. Involvement of the tyrosinase gene in the deposition of cardiac lipofuscin in mice: association with aortic fatty streak development. J. Clin. Invest. 92:2386-2393.
15. Litton, M.J., B. Sander, E. Murphy, A. O'Garra, and J.S. Abrams. 1994. Early expression of cytokines in lymph nodes after treatment in vivo with Staphvlococcus enterotoxin B. J. Immunol. Methods. 175:47-58.
16. Tangirala, R.K., E.R. Rubin, and W. Palinski. 1995. Quantitation of atherosclerosis in murine models: correlation between lesions in the aortic origin and in the entire aorta, and differences in the extent of lesions between sexes in LDL receptor-deficient and apolipoprotein E-deficient mice. J. Lipid. Res. 36: 2320-2328.
17. Frenette, P.S., R.C. Johnson, R.O. Hynes, and D.D. Wagner. 1995. Platelets roll on stimulated endothelium in vivo: an interaction mediated by endothelial P-selectin. Proc. Natl. Acad. Sci. USA. 92:7450-7454.
18. Subramaniam, M., S. Saffaripour, L.V.D. Water, P.S. Frenette, T.N. Mayadas, R.O. Hynes, and D.D. Wagner. 1997. Role of endothelial selectins in wound repair. Am. J. Pathol. 150:1701-1709.
19. Berliner, J.A., M. Navab, A.M. Fogelman, J.S. Frank, L.L. Demer, P.A. Edwards, A.D. Watson, and A.J. Lusis. 1995. Atherosclerosis: basic mechanisms. Circulation. 91:2488-2496.
20. Weyrich, A.S., T.M. McIntyre, R.P. McEver, S.M. Prescott, and G.A. Zimmerman. 1995. Monocyte tethering by P-selectin regulates monocyte chemotactic protein-1 and tumor necrosis factor-α secretion, signal integration and NF-κB translocation. J. Clin. Invest. 95:2297-2303.
21. Cybulsky, M.I., and M.A. Gimbrone, Jr. 1991. Endothelial expression of a mononuclear leukocyte adhesion molecule during atherosclerosis. Science. 251:788-791.
22. Li, H., M.I. Cybulsky, M.A. Gimbrone, Jr., and P. Libby. 1993. An atherogenic diet rapidly induces VCAM-1, a cytokine-regulatable mononuclear leukocyte adhesion molecules, in rabbit aortic endothelium. Arterioscler. Thromb. 13:197-204.
23. Elices, M.J., L. Osborn, Y. Takada, C. Crouse, S. Luhowskyj, M.E. Hemler, and R.R. Lobb. 1990. VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site. Cell. 60:577-584.
24. Berlin, C., R.F. Bargatze, J.J. Campbell, U.H. von Andrian, M.C. Szabo, S.R. Hasslen, R.D. Nelson, E.L. Berg, S.L. Erlandsen, and E.C. Butcher. 1995. α4 integrins mediate lymphocyte attachment and rolling under physiologic flow. Cell. 80:413-422.
25. Alon, R., P.D. Kassner, M.W. Carr, E.B. Finger, M.E. Hemler, and T.A. Springer. 1995. The integrin VLA-4 supports tethering and rolling in flow on VCAM-1. J. Cell Biol. 128:1243-1253.
26. Giuffre, L., A.S. Cordey, N. Monai, Y. Tardy, M. Schapira, and O. Spertini. 1997. Monocyte adhesion to activated aortic endothelium: role of L-selectin and heparan sulfate proteoglycans. J. Cell Biol. 136:945-956.
27. Robinson, S.D., P.S. Frenette, H. Rayburn, M. Cummiskey, M. Ullman-Cullere, D.D. Wagner, and R.O. Hynes. 1947. The generation of double and triple-deficient selectin mice. Microcirculation. 4:64a. (Abstr.).
28. Smith, J.D., E. Trogan, M. Ginsberg, C. Grigaux, J. Tian, and M. Miyata. 1995. Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein E. Proc. Natl. Acad. Sci. USA 92:8264-8268.
29. Breslow, J.J. 1996. Mouse models of atherosclerosis. Science. 272:685-688.
30. Nageh, M.F., E.T. Sandberg, K.R. Marotti, A.H. Lin, E.P. Melchior, D.C. Bullard, and A.L. Beaudet. 1997. Deficiency of inflammatory cell adhesion molecules protects against atherosclerosis in mice. Arterioscler. Thromb. Vasc. Biol. 17:1517-1520.
31. Dong, Z.M., J.C. Gutierrez-Ramos, A. Coxon, T.N. Mayadas, and D.D. Wagner. 1997. A new class of obesity genes encodes leukocyte adhesion receptors. Proc. Natl. Acad. Sci. USA. 94:7526-7530.
32. Van der Wal, A.C., P.K. Das, and A.J. Tigges. 1992. Adhesion molecules on the endothelium and mononuclear cells in human atherosclerotic lesions. Am. J. Pathol. 141:1427-1433.
33. Johnson-Tidey, R.R., J.L. McGregor, P.R. Taylor, and R.N. Poston. 1994. Increase in the adhesion molecule P-selectin in endothelium overlying atherosclerotic plaques. Am. J. Pathol. 144:952-961.
34. Wenzel, K., S. Felix, F.X. Kleber, R. Brachold, T. Menke, S. Schattke, K.L. Schulte, C. Glaser, K. Rohde, G. Baumann, and A. Speer. 1994. E-selectin polymorphism and atherosclerosis: an association study. Hum. Mol. Genet. 3: 1935-1937.
35. Revelle, B.M., D. Scott, and P.J. Beck. 1996. Single amino acid residues in the E-and P-selectin epidermal growth factor domains can determine carbohydrate binding specificity. J. Bio Chem. 271:16160-16170.