Programming of the pancreas

Molecular and Cellular Endocrinology

Volumn 185, Issue 1-2, 2001, Pages 99-108

  Schwitzgebel, Valérie M ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

Diabetes mellitus; Langerhans; Pancreas

Indexed keywords

HELIX LOOP HELIX PROTEIN; HEPATOCYTE NUCLEAR FACTOR 3ALPHA; HEPATOCYTE NUCLEAR FACTOR 3BETA; HEPATOCYTE NUCLEAR FACTOR 6; HOMEODOMAIN PROTEIN; INSULIN PROMOTING FACTOR 1; LIM PROTEIN; NEUROGENIC DIFFERENTIATION FACTOR; NEUROGENIN 3; NKX2.2 PROTEIN; NKX6.1 PROTEIN; PROTEIN HB9; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PAX4; TRANSCRIPTION FACTOR PAX6; UNCLASSIFIED DRUG; WINGED HELIX TRANSCRIPTION FACTOR;

CONFERENCE PAPER; DEVELOPMENT; DIABETES MELLITUS; ENDODERM; GENE ACTIVATION; GENE EXPRESSION; HUMAN; MORPHOGENESIS; NONHUMAN; PANCREAS; PANCREAS ISLET; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; ANIMAL; CLASSIFICATION; EMBRYOLOGY; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; PHYSIOLOGY; REVIEW;

ANIMAL; DIABETES MELLITUS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMAN; PANCREAS; TRANSCRIPTION FACTORS;

EID: 0035924062     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0303-7207(01)00628-1     Document Type: Conference Paper

References (83)

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2. Beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes
3. Independent requirement for ISLi in formation of pancreatic mesenchyme and islet cells
4. Hybrid insulin genes reveal a developmental lineage for pancreatic endocrine cells and imply a relationship with neurons
5. HNF-3 beta is essential for node and notochord formation in mouse development
6. The formation and maintenance of the definitive endoderm lineage in the mouse: involvement of HNF3/forkhead proteins
7. Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas
8. Notch signalling controls pancreatic cell differentiation
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12. Organization and partial sequence of the hepatocyte nuclear factor-4 alpha/MODY1 gene and identification of a missense mutation, Ri 27W, in a Japanese family with MODY
13. Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas
14. A missense mutation in hepatocyte nuclear factor-4 alpha, resulting in a reduced transactivation activity, in human late-onset non-insulin-dependent diabetes mellitus
15. Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus
16. Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice
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18. Regulation of pancreas development by hedgehog signaling
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24. Liver and kidney function in Japanese patients with maturity-onset diabetes of the young
25. Transcription factor hepatocyte nuclear factor 6 regulates pancreatic endocrine cell differentiation and controls expression of the proendocrine gene ngn3
26. mRNA profiling of rat islet tumors reveals nkx 6.1 as a beta-cell-specific homeodomain transcription factor
27. Independent development of pancreatic alpha-and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation
28. Control of endodermal endocrine development by Hes-1
29. Insulin-promoter-factor 1 is required for pancreas development in mice
30. Inactivation of the winged helix transcription factor HNF3alpha affects glucose homeostasis and islet glucagon gene expression in vivo
31. Notochord to endoderm signaling is required for pancreas development
32. Activin receptor patterning of foregut organogenesis
33. Pancreas development is promoted by cyclopamine, a hedgehog signaling inhibitor
34. Isoforms of hepatocyte nuclear factor-6 differ in DNA-binding properties, contain a bifunctional homeodomain, and define the new ONECUT class of homeodomain proteins
35. Remission in models of type 1 diabetes by gene therapy using a single-chain insulin analogue
36. Mutation in the HNF-4alpha gene affects insulin secretion and triglyceride metabolism
37. Hepatocyte nuclear factor 6, a transcription factor that contains a novel type of homeodomain and a single cut domain
38. Selective agenesis of the dorsal pancreas in mice lacking homeobox gene Hlxb9
39. Hepatic function in a family with a nonsense mutation (R154X) in the hepatocyte nuclear factor-4alpha/MODY1 gene
40. A novel syndrome of diabetes mellitus, renal dysfunction and genital malformation associated with a partial deletion of the pseudo-POU domain of hepatocyte nuclear factor-1beta
41. Exclusion of the hepatocyte nuclear factor 4alpha as a candidate gene for late-onset NIDDM linked with chromosome 20q
42. Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus
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44. Studies of the genetic variability of the coding region of the hepatocyte nuclear factor-4alpha in Caucasians with maturity onset NIDDM
45. A novel Phe75fsdelT mutation in the hepatocyte nuclear factor-4alpha gene in a Danish pedigree with maturity-onset diabetes of the young
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47. Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor
48. Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice
49. Frameshift mutation, A263fsinsGG, in the hepatocyte nuclear factor-1beta gene associated with diabetes and renal dysfunction
50. PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum
51. IPF1, a homeodomain-containing transactivator of the insulin gene
52. Human insulin gene is a target gene of hepatocyte nuclear factor-1alpha (HNF-1alpha) and HNF-1beta
53. Rat endocrine pancreatic development in relation to two homeobox gene products (Pdx-1 and Nkx 6.1)
54. p300 mediates transcriptional stimulation by the basic helix-loop-helix activators of the insulin gene
55. Pancreatic beta cells express a diverse set of homeobox genes
56. Sequential expression of HNF-3 beta and HNF-3 alpha by embryonic organizing centers: the dorsal lip/node, notochord and floor plate
57. Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development
58. Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of β-cell formation in the pancreas
59. Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split
60. Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo
61. Expression of neurogenin3 reveals an islet cell precursor population in the pancreas
62. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen
63. The NeuroD1/BETA2 sequences essential for insulin gene transcription colocalize with those necessary for neurogenesis and p300/CREB binding protein binding
64. The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration
65. Developmental biology of the pancreas
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67. Pax6 is required for differentiation of glucagon-producing alpha-cells in mouse pancreas
68. Early-onset type-II diabetes mellitus (MODY4) linked to IPF1
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70. Insulin promoter factor-1 gene mutation linked to early-onset type 2 diabetes mellitus directs expression of a dominant negative isoprotein
71. Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells
72. Precursor cells of mouse endocrine pancreas coexpress insulin, glucagon and the neuronal proteins tyrosine hydroxylase and neuropeptide Y, but not pancreatic polypeptide
73. Pax-QNR/Pax-6, a paired box- and homeobox-containing gene expressed in neurons, is also expressed in pancreatic endocrine cells
74. Expression of peptide YY in all four islet cell types in the developing mouse pancreas suggests a common peptide YY-producing progenitor
75. The winged-helix transcription factor HNF-3 beta is required for notochord development in the mouse embryo
76. Early mouse endoderm is patterened by soluble factors from adjacent germ layers
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78. Monogenic diabetes mellitus in youth. The MODY syndromes
79. Hepatocyte nuclear factor 3beta is involved in pancreatic beta-cell-specific transcription of the pdx-1 gene
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81. Mutations in the hepatocyte nuclear factor-1alpha gene in maturity- onset diabetes of the young (MODY3)
82. Identification of missense mutations in the hepatocyte nuclear factor- 3beta gene in Japanese subjects with late-onset Type II diabetes mellitus