A missense mutation in hepatocyte nuclear factor-4α, resulting in a reduced transactivation activity, in human late-onset non-insulin-dependent diabetes mellitus

Journal of Clinical Investigation

Volumn 101, Issue 3, 1998, Pages 521-526

  Hani, El Habib ^a   Suaud, Laurence ^b   Boutin, Philippe ^a   Chèvre, Jean Claude ^a   Durand, Emmanuelle ^a   Philippi, Anne ^c   Demenais, Florence ^c   Vionnet, Nathalie ^a   Furuta, Hiroto ^d   Velho, Gilberto ^e   Bell, Graeme I ^d   Laine, Bernard ^b   Froguel, Philippe ^a,f  

^a LILLE UNIVERSITY HOSPITAL   (France)

^b INSERM   (France)

^c SAINT LOUIS HOSPITAL   (France)

^d UNIVERSITY OF CHICAGO   (United States)

^e HÔPITAL SAINT VINCENT DE PAUL   (France)

^f INSTITUT PASTEUR DE LILLE   (France)

Author keywords

Gene expression; Hepatocyte nuclear factor; Late onset non insulin dependent diabetes mellitus; MODY; Mutation

Indexed keywords

NUCLEAR FACTOR I; NUCLEAR FACTOR IV ALPHA; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; AUTOSOMAL DOMINANT DISORDER; GENE EXPRESSION REGULATION; GENE LOCUS; HUMAN; HUMAN CELL; HYPERGLYCEMIA; INSULIN RELEASE; MATURITY ONSET DIABETES MELLITUS; MISSENSE MUTATION; MULTIGENE FAMILY; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; TRANSACTIVATION;

EID: 0032006573     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI1403     Document Type: Article

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