Granule cells and cerebellar boundaries: Analysis of Unc5h3 mutant chimeras

Journal of Neuroscience

Volumn 20, Issue 11, 2000, Pages 4129-4137

  Goldowitz, Dan ^a   Hamre, Kristin M ^a   Przyborski, Stefan A ^b,c   Ackerman, Susan L ^b  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b JACKSON LABORATORY   (United States)

^c UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

Cerebellum; Mouse; Neurological mutant mice; Neuronal migration; Purkinje cells; rcm; Rostral cerebellar malformation

Indexed keywords

NETRIN;

ANIMAL CELL; ARTICLE; CELL MIGRATION; CEREBELLUM; CHIMERA; CONTROLLED STUDY; EMBRYO; FEMALE; GENE EXPRESSION; GENE MUTATION; GENE TARGETING; GENETIC ANALYSIS; GRANULE CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PURKINJE CELL; TEGMENTUM; WHITE MATTER;

EID: 0034212625     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.20-11-04129.2000     Document Type: Article

References (21)

1. Ackerman SL, Kozak LP, Przyborski SA, Rund LA, Boyer BB, Knowles BB (1997) The mouse rostral cerebellar malformation gene encodes an UNC-5-like protein. Nature 386:838-842.
2. Ben Arie N, Bellen HJ, Armstrong DL, McCall AE, Gordadze PR, Guo Q, Matzuk MM, Zoghbi HY (1997) Math1 is essential for genesis of cerebellar granule neurons. Nature 390:169-172.
3. Eisenman LM, Brothers R (1998) Rostral cerehellar malformation (rcm/ rcm): a murine mutant to study regionalization of the cerebellum. J Comp Neurol 394:106-117.
4. Friedrich G, Soriano P (1991) Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice. Genes Dev 5:1513-1523.
5. Goldowitz D (1989) Cell allocation in mammalian CNS formation: evidence from murinc interspecies aggregation chimeras. Neuron 3:705-713.
6. Goldowitz D, Mullen RJ (1982a) Granule cell as a site of gene action in the weaver mouse cerebellum: evidence from heterozygous mutant chimeras. J Neurosci 2:1474-1485.
7. Goldowitz D, Mullen RJ (1982b) Nuclear morphology of ichthyosis mutant mice as a cell marker in chimeric brain. Dev Biol 89:261-267.
8. Hu H, Rutishauser U (1996) A septum-derived chemorepulsive factor for migrating olfactory interneuron precursors. Neuron 16:933-940.
9. Lane PW, Bronson RT, Spencer CA (1992) Rostral cerebellar malformation (rcm): a new recessive mutation on chromosome 3 of the mouse. J Hered 83:315-318.
10. Lee KJ, Jessell TM (1999) The specification of dorsal cell fates in the vertebrate central nervous system. Annu Rev Neurosci 22:261-294.
11. Leonardo ED, Hinck L, Masu M, Keino Masu K, Ackerman SL, Tessier Lavigne M (1997) Vertebrate homologues of C. degans UNC-5 are candidate netrin receptors. Nature 386:833-838.
12. Livesey FJ, Hunt SP (1997) Netrin and netrin receptor expression in the embryonic mammalian nervous system suggests roles in retinal, striatal, nigral, and cerehellar development. Mol Cell Neurosci 8:417-429.
13. Miale IL, Sidman RL (1961) An autoradiographic analysis of histogenesis in the mouse cerebellum. Exp Neurol 4:277-296.
14. Oberdick J, Wallace JD, Lewin A, Smeyne RJ (1994) Transgenic expression to monitor dynamic organization of neuronal development: use of the E. coli lacZ gene product, β-galactosidase. Neuroprotocols 5:54-62.
15. Przyborski SA, Knowles BB, Ackerman SL (1998) Embryonic pheno-type of Unc5h3 mutant mice suggests chemorepulsion during the formation of the rostral cerebellar boundary. Development 125:41-50.
16. Rubenstein JL, Martinez S, Shimamura K, Puelles L (1994) The embryonic vertebrate forebrain: the prosomeric model. Science 266:578-580.
17. Serafini T, Colamarino SA, Leonardo ED, Wang H, Beddington R, Skarnes WC, Tessier-Lavigne M (1996) Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system. Cell 87:1001-1014.
18. Soriano E, Del Rio JA (1991) Simultaneous immunocytochemical visualization of bromodeoxyuridine and neural tissue antigens. J Histochem Cytochem 39:255-263.
19. Wood SA, Allen ND, Rossant J, Auerbach A, Nagy A (1993) Non-injection methods for the production of embryonic stem cell-embryo chimaeras. Nature 365:87-89.
20. Wu W, Wong K, Chen J, Jiang Z, Dupuis S, Wu JY, Rao Y (1999) Directional guidance of neuronal migration in the olfactory system by the protein Slit. Nature 400:331-336.
21. Zambrowicz BP, Imamoto A, Fiering S, Herzenberg LA, Kerr WG, Soriano P (1997) Disruption of overlapping transcripts in the ROSA beta geo 26 gene trap strain leads to widespread expression of beta-galactosidase in mouse embryos and hematopoietic cells. Proc Natl Acad Sci USA 94:3789-3794.