Combinatorial biosynthesis in microorganisms as a route to new antimicrobial, antitumor and neuroregenerative drugs

Current Opinion in Investigational Drugs

Volumn 2, Issue 12, 2001, Pages 1681-1690

  Hutchinson, C Richard ^a   McDaniel, Robert ^a  

^a KOSAN BIOSCIENCES INC   (United States)

Author keywords

Antibiotic; Antitumor; Enzyme engineering; Epothilone; Erythromycin; FK 506; FK 520; Immunosuppressive; Ketolide; Mac rolide; Neuroregeneration; Non ribosomal peptide; Polyketide

Indexed keywords

ADRIAMYSIN; ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT; ASCOMYCIN; AZITHROMYCIN; BERYTHROMYCIN; CETHROMYCIN; CLARITHROMYCIN; DOCETAXEL; DOXORUBICIN; DRUG ANALOG; EPOTHILONE A; EPOTHILONE DERIVATIVE; ERYTHROMYCIN; ERYTHROMYCIN DERIVATIVE; IMMUNOSUPPRESSIVE AGENT; KETOLIDE; MACROLIDE; MICROBIAL PRODUCTS NOT CLASSIFIED ELSEWHERE; NATURAL PRODUCT; NEUROPROTECTIVE AGENT; PEPTIDE DERIVATIVE; POLYKETIDE SYNTHASE; RAPAMYCIN; ROXITHROMYCIN; RWJ 415663; RWJ 415667; TACROLIMUS; TELITHROMYCIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

BACTERIAL INFECTION; BIOSYNTHESIS; CANCER; CHEMICAL STRUCTURE; COMBINATORIAL CHEMISTRY; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG MECHANISM; DRUG SOLUBILITY; DRUG SYNTHESIS; ESCHERICHIA COLI; GENETIC ENGINEERING; HUMAN; MICROORGANISM; NERVE DEGENERATION; NONHUMAN; PHARMACEUTICAL ENGINEERING; PROTEIN EXPRESSION; REVIEW;

ANIMALS; ANTI-INFECTIVE AGENTS; ANTINEOPLASTIC AGENTS; BIOLOGICAL FACTORS; COMBINATORIAL CHEMISTRY TECHNIQUES; HUMANS; IMMUNOSUPPRESSIVE AGENTS; NOOTROPIC AGENTS;

EID: 0035682920     PISSN: 14724472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

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