The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties

Molecular and General Genetics

Volumn 264, Issue 6, 2001, Pages 827-835

  Gonzalez A ^a   Remsing, L L ^b   Lombo F ^a   Fernandez M J ^a   Prado, L ^a   Brana A F ^a   Kunzel E ^b   Rohr, J ^b   Mendez C ^a   Salas, J A ^a  

^a DEPARTAMENTO DE BIOQUÍMICA Y BIOLOGÍA MOLECULAR   (Spain)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Antitumor drug; Deoxyhexoses; Glycosylation; Methylation; Polyketides

Indexed keywords

GLYCOSYLTRANSFERASE; HEXOSE; HYDROLASE; METHYLTRANSFERASE; MITHRAMYCIN; POLYKETIDE;

ARTICLE; BIOSYNTHESIS; DNA SEQUENCE; DRUG STRUCTURE; FUNGAL GENETICS; GENE CLUSTER; GENE INACTIVATION; GENE INSERTION; GLYCOSYLATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METHYLATION; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; STREPTOMYCES; STREPTOMYCES ARGILLACEUS;

CARBOHYDRATE SEQUENCE; CHROMOSOME MAPPING; CLONING, MOLECULAR; DEOXY SUGARS; GENETIC COMPLEMENTATION TEST; HEXOSES; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; MULTIGENE FAMILY; PLICAMYCIN; STREPTOMYCES;

ACTINOBACTERIA (CLASS); STREPTOMYCES; STREPTOMYCES ARGILLACEUS; UNCULTURED ACTINOMYCETE;

EID: 17744371657     PISSN: 00268925     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004380000372     Document Type: Article

References (43)

1. Identification and expression of genes involved in L-oleandrose biosynthesis and its intermediate L-olivose in the oleandomycin producer Streptomyces antibioticus
2. Basic local alignment search tool
3. Biosynthesis of the ansamycin antibiotic rifamycin: Deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699
4. The mycarose-biosynthetic genes of Streptomyces fradiae, producer of tylosin
5. Identification of Streptomyces violaceoruber Tü22 genes involved in the biosynthesis of granaticin
6. Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents
7. Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus
8. XL1-Blue: A high efficiency plasmid transforming recA Escherichia coli strain with beta-galactosidase selection
9. A comprehensive set of sequence analysis programs for the VAX
10. Mechanism of the 2-deoxygenation step in the biosynthesis of the deoxyhexose moieties of the antibiotics granaticin and oleandomycin
11. An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus
12. Identification of two genes from Streptomyces argillaceus encoding two glycosyltransferases involved in the transfer of a disaccharide during the biosynthesis of the antitumor drug mithramycin
13. Characterization of the mtmMI and mtmMII genes encoding two methyltransferases involved in the biosynthesis of the antitumor polyketide drug mithramycin
14. Analysis of seven genes from the eryAI-eryK region of the erythromycin biosynthetic gene cluster in Saccharopolyspora erythraea
15. Analysis of eryBI, eryBIII and eryBVII from the erythromycin biosynthetic gene cluster in Saccharopolyspora erythraea
16. Pathways and mechanisms in the biogenesis of novel deoxysugars by bacteria
17. Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin
18. Cloning and insertional inactivation of Streptomyces argillaceus genes involved in earliest steps of sugar biosynthesis of the antitumor polyketide mithramycin
19. The mithramycin gene cluster of Streptomyces argillaceus contains a positive regulatory gene and two repeated DNA sequences that are located at both ends of the cluster
20. The Streptomyces peucetius dpsY and dnrX genes govern early and late steps of daunorubicin and doxorubicin biosynthesis
21. Nucleotide sequences and expression of genes from Streptomyces purpurascens that cause the production of new anthracyclines in Streptomyces galilaeus
22. Cloning and chracterization of the Streptomyces peucetius dnmZUV genes encoding three enzymes required for biosynthesis of the daunorubicin precursor thymidine diphospho-L-daunosamine
23. Pathway engineering in secondary metabolite-producing actinomycetes
24. Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin
25. Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus
26. Two glycosyltransferases and a glycosidase are involved in oleandomycin modification during its biosynthesis by Streptomyces antibioticus
27. New premithramycin and mithramycin derivatives through inactivation of a methyltransferase encoding gene involved in the biosynthesis of the deoxysugar D-mycarose
28. Generation of hybrid elloramycin analogs by combinatorial biosynthesis using genes from anthracycline-type and macrolide biosynthetic pathways
29. The structure of premithramycinone and demethylpremithramycinone, early intermediates of the aureolic acid group antibiotic mithramycin
30. Targeted gene inactivation for the elucidation of deoxysugar biosynthesis in the erythromycin producer Saccharopolyspora erythraea
31. DNA sequencing with chain terminating inhibitors
32. Enhanced antibiotic production by manipulation of the Streptomyces peucetius dnrH and dnmT genes involved in doxorubicin (adriamycin) biosynthesis
33. Antitumor antibiotics of the aureolic acid group: Chromomycin A3, mithramycin A, and olivomycin A
34. Sequencing and mutagenesis of genes from the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea that are involved in L-mycarose and D-desosamine production
35. Characterization of Streptomyces nogalater genes encoding enzymes involved in glycosylation steps in nogalamycin biosynthesis
36. Genes and enzymes of deoxysugar biosyntheses
37. New pUC-derived cloning vectors with different selectable markers and DNA replication origins
38. Cloning and characterization of a gene cluster from Streptomyces cyanogenus S136 probably involved in landomycin biosynthesis
39. The structure of mithramycin reinvestigated