The biosynthetic gene cluster for the microtubule-stabilizing agents epothilones A and B from Sorangium cellulosum So ce90

Chemistry and Biology

Volumn 7, Issue 2, 2000, Pages 97-109

  Molnar I ^a   Schupp, T ^b   Ono, M ^a   Zirkle, R E ^a   Milnamow, M ^a   Nowak Thompson, B ^a   Engel, N ^b   Toupet, C ^b   Stratmann, A ^b   Cyr, D D ^a   Gorlach, J ^a   Mayo, J M ^a   Hu, A ^a   Goff, S ^a   Schmid, J ^a   Ligon, J M ^a  

^a JEALOTT S HILL RESEARCH STATION   (United Kingdom)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

C methyltransferase; Epothilones A and B; Heterocyclization domain; Modular type I peptide synthase; Nonribosomal peptide synthase

Indexed keywords

BACTERIAL GENE; BACTERIAL GENOME; BIOSYNTHESIS; CELL CYCLE; CLONING; COMBINATORIAL LIBRARY; DEPOLYMERIZATION; EPOTHILONE A; EPOTHILONE B; FERMENTATION; GENE CLUSTER; GENE DISRUPTION; GENE SEQUENCING; MICROTUBULE; OPEN READING FRAME; POLYKETIDE SYNTHASE; SOLUBILITY;

BACTERIA (MICROORGANISMS); POLYANGIUM CELLULOSUM; PROKARYOTA; SORANGIUM; SORANGIUM CELLULOSUM;

EID: 0034141305     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(00)00075-2     Document Type: Article

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