Novel erythromycins from a recombinant Saccharopolyspora erythraea strain NRRL 2338 pIG1: I. Fermentation, isolation and biological activity

Journal of Antibiotics

Volumn 51, Issue 11, 1998, Pages 1029-1034

  Pacey, Michael S ^a   Dirlam, John P ^b   Geldart, Roderick W ^b   Leadlay, Peter F ^c   Mcarthur, Hamish A I ^b   Mccormick, Ellen L ^b   Monday, Robert A ^a   O'Connell, Thomas N ^b   Staunton, James ^c   Winchester, Toby J ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROMYCIN DERIVATIVE; SHORT CHAIN FATTY ACID;

ANTIMICROBIAL ACTIVITY; ARTICLE; DRUG ISOLATION; FERMENTATION; NONHUMAN; PRIORITY JOURNAL; SACCHAROPOLYSPORA; STREPTOMYCES COELICOLOR;

SACCHAROPOLYSPORA ERYTHRAEA;

EID: 0013033285     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.51.1029     Document Type: Article

References (15)

1. FLYNN, E. H.; M. V. SIGAL, Jr., P. E. WILEY & K. GERZON: Erythromycin I. Properties and degradation studies. J. Am. Chem. Soc. 76: 3121-3131, 1954
2. MCGUIRE, J. M.; W. S. BONIECE, C. E. HIGGINS, M. M. HOEHN, W. M. STARK, J. WESTHEAD & R. N. WOLFE: Tylosin, a new antibiotic. I. Microbiological studies. Antibiot. Chemother. 11: 320-327, 1961
3. DJOKIC, S.; G. KOBREHEL, G. LAZAREVSKI, N. LOPOTAR, Z. TAMBURASEV, B. KAMENAR, A. NAGL & I. VICKOVIC: Erythromycin series. Part 11. Ring expansion of erythromycin A oxime by the Beckmann rearrangement. J. Chem. Soc., Perkin Trans. 1: 1881-1890, 1986
4. MORIMOTO, S.; Y. TAKAHASHI, Y. WATANABE & S. OMURA: Chemical modification of erythromycins. I. Synthesis and antibacterial activity of 6-O-methylerythromycins A. J. Antibiotics 37: 187-189, 1984
5. DUTTON, C. J.; S. P. GIBSON, A. C. GOUDIE, K. S. HOLDOM, M. S. PACEY & J. C. RUDDOCK: Novel avermectins produced by mutational biosynthesis. J. Antibiotics 44: 357-365, 1991
6. CAMPBELL, W. C. & G. W. BENZ: Ivermectin: A review of efficacy and safety. J. Vet. Pharmacol. Ther. 7: 1-16, 1984
7. TUAN, J. S.; J. S. WEBER, M. J. STAVER, J. O. LEUNG, S. DONADIO & L. KATZ: Cloning of genes involved in erythromycin biosynthesis from Saccharopolyspora erythrae using a novel actinomycete-Escherichia coli cosmid. Gene 90: 21-29, 1990
8. WEBER, J. M.; C. K. WIERMAN & C. R. HUTCHINSON: Genetic analysis of erythromycin production in Streptomyces erythreus. J. Bacteriology 164: 425-433, 1985
9. VARA, J.; M. LEWANDOWSKA-SKARBEK, Y.-G. WANG, S. DONADIO & C. R. HUTCHINSON: Cloning of genes governing the deoxysugar portion of the erythromycin biosynthesis pathway in Saccharopolyspora erythrae (Streptomyces erythreus). J. Bacteriology 171: 5872-5881, 1989
10. DONADIO, S.; M. J. STAVER, J. B. MCALPINE, S. J. SWANSON & L. KATZ: Modular organisation of genes required for polyketide biosynthesis. Science 252: 675-679, 1991
11. CORTES, J.; S. F. HAYDOCK, G. A. ROBERTS, D. J. BEVITT & P. F. LEADLAY: An unusually large multifunctional polypeptide in the erythromycin producing polyketide synthase of Saccharopolyspora erythrae. Nature 348: 176-178, 1990
12. APARICIO, J. F.; I. MOLNAR, T. SCHWECKE, A. KOENIG, S. F. HAYDOCK, E. E. LAKE, J. STAUNTON & P. F. LEADLAY: Organisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of the enzymic domains in modular polyketide synthase. Gene 169: 9-16, 1996
13. MACNEIL, D. J.; J. L. Oca, K. M. GEWAIN & T. MACNEIL: Correlation of the avermectin polyketide synthase genes to the avermectin structure. Annals N.Y. Acad. Sci. 721: 123-132, 1994
14. WILKINSON, B. J.; C. J. ROWE & P. F. LEADLAY, unpublished data
15. Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically, 3rd Edition, Villanova, PA, 1993