Immunophilins. The next generation

Advances in Medicinal Chemistry

Volumn 5, Issue C, 2000, Pages 1-84

  Hamilton, Gregory S ^a   Thomas, Christine ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0001882904     PISSN: 10675698     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1067-5698(00)80003-6     Document Type: Article

References (299)

1. For a more comprehensive picture of this topic, the reader is referred to the following reviews. Schreiber S.L. Science 251 (1991) 283-287
2. Schreiber S.L. Angew. Chem., Intl Ed. Engl. 31 (1992) 384-400
3. Armistead D.M., and Harding M.W. Ann. Rep. Med. Chem. 28 (1993) 207-215
4. Fischer G., Bang H., and Mech C. Biomed. Biochim. Acta 43 (1984) 1101-1112
5. Fischer G., and Bang H. Biochim. Biophys. Acta 828 (1984) 39-42
6. Borel J.F. Pharmacol. Rev. 41 (1989) 259-371
7. Handschumacher R.E., Harding M.W., Rice J., Drugge R.J., and Speicher D.W. Science 226 (1984) 544-546
8. Fischer G., Wittmann-Liebold B., Lang K., Kiefhaber T., and Schmid F.X. Nature 337 (1989) 476-478
9. Takahashi N., Hayano T., and Suzuki M. Nature 337 (1989) 473-475
10. Sigal N.H., and Dumont F.J. Ann. Rev. Immunol. 10 (1992) 519-560
11. Kunz J., and Hall M.N. Trends Biochem. Sci. 18 (1993) 334-338
12. Harding M.W., Galat A., Uehling D.E., and Schreiber S.L. Science 341 (1989) 761-763
13. Siekerka J.J., Hung S.H.Y., Poe M., Lin S.C., and Sigal N.H. Nature 341 (1989) 755-757
14. Tocci M.J., Matkovich D.A., Collier K.A., Kwok P., Dumont F., Lin C.S., DeGudicibus S., Siekerka J.J., Chin J., and Hutchinson N.I. J. Immunol. 143 (1989) 718-726
15. Lin C.S., Boltz R.C., Siekerka J.J., and Sigal N.H. Cell. Immunol. 133 (1991) 269-284
16. Bierer B.E., Mattila P.S., Standaert R.F., Herzenberg L.A., Burakoff S.J., Crabtree G., and Schreiber S.L. Proc. Natl. Acad. Sci. USA 87 (1990) 9231-9235
17. Dumont F.J., Staruch M.J., Koprak S.L., Melino M.R., and Sigal N.H. J. Immunol. 144 (1990) 251-258
18. Dumont F.J., Melino M.R., Staruch M.J., Koprak S.L., Fisher P.A., and Sigal N.H. J. Immunol. 144 (1990) 1418-1424
19. Bierer B.E., Somers P.K., Wandless T.J., Burakoff S.J., and Schreiber S.L. Science 250 (1990) 556-559
20. Somers P.K., Wandless T.J., and Schreiber S.L. J. Am. Chem. Soc. 113 (1991) 8045-8056
21. Dumont F.J., Staruch M.J., Koprak S.L., Siekerka J.J., Lin C.S., Harrison R., Sewell T., Kindt V., Beattie T.R., Wyvratt M., and Sigal N.H. J. Exp. Med. 176 (1992) 751-760
22. Ocain T.D., Longhi D., Steffan R.J., Caccese R.G., and Sehgal S.N. Biochem. Biophys. Res. Commun. 192 (1993) 1340-1346
23. Sigal N.H., Dumont F., Durette P., Siekierka J.J., Peterson L., Rich D.H., Dunlap B.E., Staruch M.J., Melino M.R., Koprak S.L., Williams D., Witzel B., and Pisano J.M. J. Exp. Med. 173 (1991) 619-628
24. Liu J., Farmer Jr. J.D., Lane W.S., Friedman J., Weissman I., and Schreiber S.L. Cell 66 (1991) 807-815
25. Friedman J., and Weissman I. Cell 66 (1991) 799-806
26. Klee C.B., Crouch T.H., and Krinks M.H. Proc. Natl. Acad. Sci. USA 76 (1979) 6270-6273
27. Flanagan W.M., Corthesy B., Bram R.J., and Crabtree G.R. Nature 352 (1991) 754-755
28. Clipston N.A., and Crabtree G.R. Nature 357 (1992) 695-697
29. O'Keefe S.J., Tamura J., Kincaid R.F., Tocci M.J., and O'Neill M.A. Nature 357 (1992) 692-694
30. Kuo C.J., Chung J., Florentino D.F., Flanagan W.M., Blenis J., and Crabtree G.R. Nature 358 (1992) 70-73
31. Chung J., Kuo C.J., Crabtree G.R., and Blenis J. Cell 69 (1992) 1227-1236
32. Price D.J., Grove J.R., Calco V., Avruch J., and Bierer B.E. Science 257 (1992) 973-977
33. Jayaraman T., and Marks A.R. J. Biol. Chem. 268 (1993) 25385-25388
34. Morice W.G., Wiederrecht G., Brunn G.J., Siekerka J.J., and Abraham R.T. J. Biol. Chem. 268 (1993) 22737-22745
35. Kunz J., Henriquez R., Schneider U., Deuter-Reinhard M., Movva N.R., and Hall M.N. Cell 73 (1993) 585-596
36. Brown E.J., Albers M.W., Shin T.B., Ichikawa K., Keith C.T., Lane W.S., and Schreiber S.L. Nature 369 (1994) 756-758
37. Sabatini D.M., Erdjument-Bromage H., Lui M., Tempst P., and Snyder S.H. Cell 78 (1994) 35-43
38. Brown E.J., Beal P.A., Keith C.T., Chen J., Shin T.B., and Schreiber S.L. Nature 377 (1995) 441-446
39. Chou M.M., and Blenis J. Curr. Opin. Cell Biol. 7 (1995) 806-814
40. Brown E.J., and Schreiber S.L. Cell 86 (1996) 517-520
41. Beretta L., Gingras A.-C., Svitkin Y.V., Hall M., and Sonenburg N. EMBO J. 15 (1996) 658-664
42. Galat A. Eur. J. Biochem. 216 (1993) 689-707
43. Kay J.E. Biochem. J. 314 (1996) 361-385
44. Rahfield J.-U., Rucknagel K.P., Schelbert B., Ludwig B., Hacker J., Mann K., and Fischer G. FEBS Lett. 352 (1994) 180-184
45. Rudd K.E., Sofia H.J., Koonin E.V., Plunkett G., Lazar S., and Rouviere P.R. Trends Biochem. Sci. 20 (1995) 12-14
46. Standaert R.F., Galat A., Verdine G.L., and Schreiber S.L. Nature 346 (1990) 671-674
47. Albers M.W., Walsh C.T., and Schreiber S.L. J. Org. Chem. 55 (1990) 4984-4986
48. Sewell T., Lam E., Martin M., Leszyk J., Weidner J., Calaycay J., Griffith P., Williams H., Hung S., Cryan J., Sigal N., and Wiederrecht G. J. Biol. Chem. 269 (1994) 21094-21102
49. Lam E., Martin M.M., Timerman A.P., Sabers C., Fleischer S., Lukas T., Abraham R.T., O'Keefe S.J., O'Neill E.A., and Weiderrecht G. J. Biol. Chem. 270 (1995) 26511-26522
50. Jin Y.-J., Albers M.W., Lane W.S., Bierer B.E., Schreiber S.L., and Burakoff S.J. Proc. Natl. Acad. Sci. USA 88 (1991) 6677-6681
51. Jin Y.-J., Burakoff S.J., and Bierer B.E. J. Biol. Chem. 267 (1992) 10942-10945
52. Galat A., Lane W.S., Standaert R.F., and Schreiber S.L. Biochemistry 31 (1992) 2427-2434
53. Murthy J.N., Goodyear N., and Soldin S.J. Clin. Biochem. 30 (1997) 129-133
54. Peattie D.A., Harding M.W., Fleming M.A., DeCenzo M.T., Lippke J.A., Livingston D.J., and Benasutti M. Proc. Natl. Acad. Sci. USA 89 (1992) 10974-10978
55. Lebeau M.-C., Massol N., Herrick J., Faber L.E., Renoir J.-M., Radanyi C., and Baulieu E.-E. J. Biol. Chem. 267 (1992) 4281-4284
56. Yem A.W., Tommasselli A.G., Heinrikson R.L., Zurcher-Neely H., Ruff V.A., Johnson D.A., and Deibel M.R. J. Biol. Chem. 267 (1992) 2868-2871
57. Harding M.W., Handschumacher R.E., and Speicher D.W. J. Biol. Chem. 261 (1986) 8547-8555
58. Price E.R., Zydowsky L.D., Jin M., Baker C.H., McKeonand F.D., and Walsh C.T. Proc. Natl. Acad. Sci. USA 88 (1991) 1903-1907
59. Schneider H., Charara N., Schmitz R., Wehrli S., Mikol V., Zurini M.G., Quesniaux V.F., and Movva N.R. Biochemistry 33 (1994) 8218-8224
60. Connern C.P., and Halestrap A.P. Biochem. J. 284 (1992) 381-385
61. Kieffer L.J., Thalhammer T., and Handschumacher R.E. J. Biol. Chem. 267 (1992) 5503-5507
62. Anderson S.K., Gallinger S., Roder J., Frey J., Young H.A., and Ortaldo J.R. Proc. Natl. Acad. Sci. USA 90 (1993) 542-546
63. Kofron J.L., Kuzmic P., Kishore V., Bonilla-Colon E., and Rich D.H. Biochemistry 30 (1991) 6127-6134
64. Kofron J.L., Kuzmic P., Kishore P., Gemmecker G., Fesik S.W., and Rich D.H. J. Am. Chem. Soc. 114 (1992) 2670-2675
65. Lang K., Schmid F.X., and Fischer G. Nature 329 (1987) 268-270
66. Mucke M., and Schmid F.X. Biochemistry 31 (1992) 7848-7854
67. Schonbrunner E.R., Mayer S., Tropschug M., Fischer G., Takahashi N., and Schmid F.X. J. Biol. Chem. 266 (1991) 3630-3635
68. Hsu V.L., Handschumacher R.E., and Armitage I.A. J. Am. Chem. Soc. 112 (1990) 6745-6747
69. Justice R.M., Kline A.D., Sluka J.P., Roeder W.D., Rodgers G.H., Roehm N., and Mynderse J.S. Biochem. Biophys. Res. Comm. 171 (1990) 445-450
70. Harrison R.K., and Stein R.L. Biochemistry 29 (1990) 3813-3816
71. Liu J., Albers M.W., Chen C.M., Schreiber S.L., and Walsh C.T. Proc. Natl. Acad. Sci. USA 87 (1990) 2304-2308
72. Harrison R.K., and Stein R.L. Biochemistry 29 (1990) 1684-1689
73. Rosen M.K., Standaert R.F., Galat A., Nakatsuka M., and Schreiber S.L. Science 248 (1990) 863-866
74. Orozco M., Tirado-Rives J., and Jorgensen W.L. Biochemistry 32 (1993) 12864-12874
75. Fischer S., Michnik S., and Karplus M. Biochemistry 32 (1993) 13830-13837
76. Ikeda Y., Schultz W., Clardy J., and Schreiber S.L. J. Am. Chem. Soc. 116 (1994) 4143-4144
77. Ke H., Mayrose D., and Cao W. Proc. Natl. Acad. Sci. USA 90 (1993) 3324-3328
78. Kallen J., and Walkinshaw M.D. FEBS Lett. 300 (1992) 286-290
79. London R.E., Davis D.G., Vavrek R.J., Stewart J.M., and Handschumacher R.E. Biochemistry 29 (1990) 10298-10302
80. Zhao Y., and Ke H. Biochemistry 35 (1996) 7362-7368
81. Konno M., Ito M., Hayano T., and Takahashi N. J. Mol. Biol. 256 (1996) 897-908
82. Zhao Y., and Ke H. Biochemistry 35 (1996) 7356-7361
83. Kakalis L.T., and Armitage I.M. Biochemistry 33 (1994) 1495-1501
84. Zhao Y., Chen Y., Schutkowski M., Fischer G., and Ke H. Structure 5 (1997) 139-146
85. Trandinh C.C., Pao G.M., and Saier M.H. FASEB J. 6 (1992) 3410-3420
86. Nigam S.K., Jin Y.-J., Jin M.J., Bush K.T., Bierer B.E., and Burakoff S.J. Biochem. J. 294 (1993) 511-515
87. Bush K.T., Hendrickson B.A., and Nigam S.K. Biochem. J. 303 (1994) 705-708
88. Riviere S., and Menez G.A. FEBS Lett. 315 (1993) 247-251
89. Jin Y.J., and Burakoff S.J. Proc. Natl. Acad. Sci. USA 90 (1993) 7769-7773
90. Fretz H., Albers M.A., Galat A., Standaert R.F., Lane W.S., Burakoff S.J., Bierer B.E., and Schreiber S.L. J. Am. Chem. Soc. 113 (1991) 1409-1410
91. Tai P.K.-K., Albers M.A., Chang H., Faber L.E., and Schreiber S.L. Science 256 (1992) 1315-1318
92. Callebaut L., Renoir J.-M., Lebeau M.-C., Massol N., Burny R., Baulieu E.-E., and Mornon J.-P. Proc. Natl. Acad. Sci. USA 89 (1992) 6270-6274
93. Chambraud B., Rouviere-Fourmy N., Radanyl C., Hsiao K., Peattie D.A., Livingston D.J., and Baulieu E.-E. Biochem. Biophys. Res. Comm. 196 (1993) 160-166
94. Ruff V.A., Yem A.W., Munns P.L., Adams L.D., Reardon I.M., Deibel M.R., and Leach K.L. J. Biol. Chem. 267 (1992) 21285-21288
95. Czar M.J., Owens-Grillo J.K., Yem A.W., Leach K.L., Deibel M.R., Welsh M.J., and Pratt W.B. Mol. Endocrinol. 8 (1994) 1731-1741
96. Perrot-Applanat M., Cibert C., Geraud G., Renoir J.-M., and Baulieu E.-E. J. Cell Sci. 108 (1995) 2037-2051
97. Zeng B., MacDonald J.R., Bann J.G., Beck K., Gambee J.E., Boswell B.A., and Bachinger H.P. Biochem. J. 330 (1998) 109-114
98. Donnelly J.G., and Soldin S.J. Clin. Biochem. 27 (1994) 367-372
99. Etzkorn F.A., Chang Z.Y., Stolz L.A., and Walsh C.T. Biochemistry 33 (1994) 2380-2388
100. Spik G., Haendler B., Delmas O., Mariller C., Chamoux M., Maes P., Tartar A., Montreuil J., Stedman K., Kocher H.P., Keller R., Hiestand P.C., and Movva N.R. J. Biol. Chem. 266 (1991) 10735-10738
101. Allain F., Boutillon C., Mariller C., and Spik G. J. Immunol. Methods 178 (1995) 113-120
102. Friedman J., Trahey M., and Weissman I. Proc. Natl. Acad. Sci. USA 90 (1993) 6815-6819
103. Bergsma D.J., Eder C., Gross M., Kerster H., Sylvester D., Appelbaum E., Cusimano D., Livi G.P., McLaughlin M.M., Kasyan K., Porter T.G., Silverman C., Dunnington D., Hand A., Prichett W.P., Bossard M.J., Brandt M., and Levy M.A. J. Biol. Chem. 266 (1991) 23204-23214
104. Woodfield K.Y., Price N.T., and Halestrap A.P. Biochim. Biophys. Acta 1351 (1997) 27-30
105. Tanveer A., Viriji S., Andreeva L., Totty N.F., Hsuan J.J., Ward J.M., and Crompton M. Eur. J. Biochem. 238 (1996) 166-172
106. Hoffmann K., Kakalis T., Anderson K.S., Armitage I.A., and Handschumacher R.E. Eur. J. Biochem. 229 (1995) 188-193
107. Kieffer L., Seng T.W., Li W., Osterman D.G., Handschumacher R.E., and Bayney R.M. J. Biol. Chem. 268 (1993) 12303-12310
108. Ratajczak T., Carrello A., Mark P.J., Warner B.J., Simpson R.J., Moritz R.L., and House A.K. J. Biol. Chem. 268 (1993) 13187-13192
109. Lilie H., Rudolph R., and Buchner J. J. Mol. Biol. 248 (1995) 190-201
110. Freskgard P.-O., Bergenhem N., Jonsson B.-H., Svensson M., and Carlson Y. Science 258 (1992) 466-468
111. Kiefhaber T., Quass R., Hahn U., and Schmid F.X. Biochemistry 29 (1990) 3061-3070
112. Kern G., Drakenberg T., Wilkstrom M., Forsen S., Bang H., and Fischer G. FEBS Lett. 323 (1993) 198-202
113. Kern G., Kern D., Schmid F.X., and Fischer G. FEBS Lett. 348 (1994) 145-148
114. Tropschug M., Wachter E., Mayer S., Schonbrunner E.R., and Scmid F.X. Nature 343 (1990) 674-677
115. Colley N.J., Baker E.K., Stamnes M.A., and Zuker C.S. Cell 67 (1991) 255-263
116. Ondek B., Hardy R.W., Baker E.K., Stammes M.A., Shieh B.-H., and Zuker C.S. J. Biol. Chem. 267 (1992) 16460-16466
117. Lodish H.F., and Kong N. J. Biol. Chem. 266 (1991) 14835-14838
118. Steinmann B., and Bruckner P. J. Biol. Chem. 266 (1991) 1299-1303
119. Helekar S.A., Char D., Neff S., and Patrick J. Neuron 12 (1994) 179-189
120. Davis E.C., Broekelmann T.J., Ozawa Y., and Mecham R.P. J. Cell Biol. 140 (1998) 295-303
121. Callebaut I., and Mornon J.P. FEBS Lett. 374 (1995) 211-215
122. Duina A.A., Chang H.-C.J., Marsh J.A., Lindquist S., and Gaber R.F. Science 274 (1996) 1713-1715
123. Freeman B.C., Toft D.O., and Morimoto R.I. Science 274 (1996) 1718-1720
124. Bose S., Weikl T., Bugl H., and Buchner J. Science 274 (1996) 1715-1718
125. Owens-Grillo J.K., Hoffmann K., Hutchison K.A., and Yem A.W. J. Biol. Chem. 270 (1995) 20479-20484
126. Coss M.C., Stephens R.M., Morrison D.K., Winterstein D., Smith L.M., and Simek S.L. Cell Growth Differ. 9 (1998) 41-48
127. Uittenbogaard A., Ying Y., and Smart E.J. J. Biol. Chem. 273 (1998) 6525-6532
128. Gardner P. Ann. Rev. Immun. 8 (1990) 231-252
129. Khan A.A., Steiner J.P., Klein G., Scneider M.F., and Snyder S.H. Science 257 (1992) 815-818
130. Berridge M.J., and Irvine R.F. Nature 341 (1989) 197-204
131. Ferris C.D., and Snyder S.H. Ann. Rev. Physiol. 54 (1991) 469-488
132. Furuichi T. Nature 342 (1989) 32-38
133. Cameron A.M., Steiner J.P., Sabatini D.M., Kaplin A.I., Walensky L.D., and Snyder S.H. Proc. Natl. Acad. Sci. USA 92 (1995) 1784-1788
134. Cameron A.M., Steiner J.P., Roskams A.J., Ali S.M., Ronnett G.V., and Snyder S.H. Cell 83 (1995) 463-472
135. Cameron A.M., Nucifora F.C., Fung E.T., Livingston D.J., Aldape R.A., Ross C.A., and Snyder S.H. J. Biol. Chem. 272 (1997) 27582-27588
136. Fleischer S., and Inui M. Ann. Rev. Biophys. Biophys. Chem. 18 (1989) 333-364
137. Sorrentino V., and Volpe P. Trends Pharm. Sci. 14 (1993) 98-103
138. Marks A.R., Tempst P., Hwang K.S., Taubman M.B., Inui M., Chadwick C., Fleischer S., and Nadal-Ginard B. Proc. Natl. Acad. Sci. USA 86 (1989) 8683-8687
139. Takeshima H., Nishimura S., Matsumoto T., Ishida H., Kangawa K., Minamino N., Matsuo H., Ueda M., Hanaoka M., Hirose T., et al. Nature 339 (1989) 439-445
140. Otsu K., Willard H.F., Khanna V.K., Zorzato F., Green N.M., and MacLennan D.H. J. Biol. Chem. 265 (1990) 13472-13483
141. Collins J.H. Biochem. Biophys. Res. Commun. 178 (1991) 1288-1290
142. Timerman A.P., Onoue H., Xin H.-B., Barg S., Copello J., Wiederrecht G., and Fleischer S. J. Biol. Chem. 271 (1996) 20385-20391
143. Jayraman T., Brillantes A.-M., Timerman A.P., Fleischer S., Erdjument-Bromage H., Tempst P., and Marks A.R. J. Biol. Chem. 267 (1992) 9474-9477
144. Brillantes A.-M., Ondrias K., Scott A., Kobrinsky E., Ondriasova E., Moschella M.C., Jayraman T., Landers M., Ehrlich B.E., and Marks A.R. Cell 77 (1994) 513-523
145. Timerman A.P., Wiederrecht G., Marcy A., and Fleischer S. J. Biol. Chem. 270 (1995) 2451-2459
146. Wagenknecht T., Radermacher M., Grassucci R., Berkowitz J., Xin H.-B., and Fleischer S. J. Biol. Chem. 272 (1997) 32463-32471
147. Bram R.J., and Crabtree G.R. Nature 371 (1994) 355-358
148. Halloway M.P., and Bram R.J. J. Biol. Chem. 271 (1996) 8549-8552
149. Bram R.J. Gene 174 (1996) 307-309
150. Bang H., Muller W., Hans M., Brune K., and Swandulla D. Proc. Natl. Acad. Sci. USA 92 (1995) 3435-3438
151. Sherry B., Yarlett N., Strupp A., and Cerami A. Proc. Natl. Acad. Sci. USA 89 (1992) 3511-3515
152. Xu Q., Leiva M.C., Dischkoff S.A., Handschumacher R.E., and Lyttle C.R. J. Biol. Chem. 267 (1992) 11968-11971
153. Endrich M.M., Grossenbacher D., Geistlach A., and Gehring H. Biol. Cell 88 (1996) 15-22
154. Billich A., Winkler G., Aschauer H., Rot A., and Peichl P. J. Exp. Med. 185 (1997) 975-980
155. Cirillo R., dePaulis A., Ciccarelli A., Triggianai M., and Marone G. Int. Arch. Allergy Appl. Immunol. 94 (1991) 76-77
156. Massague J., Attisano L., and Wrana J.L. Trends Cell Biol. 4 (1994) 172-178
157. Wrana J.L., Attisano L., Weiser R., Ventura F., and Massague J. Nature 370 (1994) 341-347
158. Wang T.W., Donahoe P.K., and Zervos A.S. Science 265 (1994) 674-676
159. Wang T., Li B.-Y., Danielson P.D., Shah P.C., Rockwell S., Lechleider R.J., Martin J., Manganaro T., and Donahoe P.K. Cell 86 (1996) 435-444
160. Yang D., Rosen M.K., and Schreiber S.L. J. Am. Chem. Soc. 115 (1993) 819-820
161. Chang M.-J., Kinnunen P., Hawkers J., Brand T., and Scneider M.D. J. Biol. Chem. 271 (1996) 22941-22944
162. Chen Y.-G., Liu F., and Massague F. EMBO J. 16 (1997) 3866-3876
163. Okadome T., Oeda E., Saitoh M., Ichijo H., Moses H.L., Miyazono K., and Kawabata M. J. Biol. Chem. 271 (1996) 21687-21690
164. Stockwell B.R., and Schreiber S.L. Chem. Biol. 5 (1998) 385-395
165. Bush K.T., Henrickson B.A., and Nigam S.K. Biochem. J. 303 (1994) 705-708
166. Partaledis J.A., and Berlin V. Proc. Natl. Acad. Sci. USA 90 (1993) 5450-5454
167. Walensky L.D., Gascard P., Fields M.E., Blackshaw S., Conboy J.G., Mohandas N., and Snyder S.H. J. Cell Biol. 141 (1998) 143-153
168. Koide M., Obata K., Iio A., Iida M., Harayama H., Yokota M., and Tuan R.S. Heart Vessels Suppl. 12 (1997) 7-9
169. Shou W., Aghdasi B., Armstrong D.L., Guo Q., Bao S., Charng M.-J., Mathews L.M., Schneider M.D., Hamilton S.L., and Matzuk M.M. Nature 391 (1998) 489-492
170. Sananes N., Baulieu E.E., and Le Goascogne C. Biol. Reprod. 58 (1998) 353-360
171. Montague J.W., Hughes F.M., and Cidlowski J.A. J. Biol. Chem. 272 (1997) 6677-6684
172. Luban J., Bossolt K.L., Franke E.K., Kalpana G.V., and Goff S.P. Cell 73 (1993) 1067-1078
173. Franke E.K., Yuan H.E.H., and Luban J. Nature 372 (1994) 359-362
174. Thali M., Bukovsky A., Kondo E., Rosenwirth B., Walsh C.T., Sodroski J., and Gottlinger H.G. Nature 372 (1994) 363-365
175. Papageorgiou C., Sanglier J.-J., and Traber R. Bioorg. Med. Chem. Lett. 6 (1996) 23-26
176. Braaten D., Franke E.K., and Luban J. J. Virol. 70 (1996) 4220-4227
177. Braaten D., Franke E.K., and Luban J. J. Virol. 70 (1996) 3551-3560
178. Gamble T.R., Vajdos F.F., Yoo S., Worthylake D.K., Houseweart M., Sundquist W.I., and Hill C.P. Cell 87 (1996) 1285-1294
179. Endrich M.M., and Gehring H. Eur. J. Biochem. 252 (1998) 441-446
180. Braun W., Kallen J., Mikol V., Walkinshaw M.D., and Wuthrich K. FASEB J. 9 (1995) 63-72
181. Sybyl reference
182. Michnick S.W., Rosen M.K., Wandless T.J., Karplus M., and Schreiber S.L. Science 252 (1991) 836-839
183. Moore J.M., Peattie D.A., Fitzgibbon M.J., and Thomson J.A. Nature 351 (1991) 248-250
184. Chothia C. Ann. Rev. Biochem. 53 (1984) 537-572
185. 405-XX. Chirgadze Y.N. Acta Crystallogr. A43 (1987)
186. Ptitsyn O.B., and Finkelstein A.V. Q. Rev. Biophys. 13 (1980) 339-386
187. Van Duyne G.D., Standaert R.F., Karplus P.A., Schreiber S.L., and Clardy J. J. Mol. Biol. 229 (1993) 105-124
188. Van Duyne G.D., Standaert R.F., Karplus P.A., Schreiber S.L., and Clardy J. Science 252 (1991) 839-842
189. Lepre C.A., Thomson J.A., and Moore J.M. FEBS Lett. 302 (1992) 89-96
190. Meadows R.P., Nettesheim D.G., Xu R.X., Olejniczak E.T., Petros A.M., Holzman T.F., Severin J., Gubbins E., Smith H., and Fesik S.W. Biochemistry 32 (1993) 754-765
191. Wilson K.P., Yamashita M.M., Sintchak M.D., Rotstein S.H., Murcko M.A., Boger J., Thomson J.A., Fitzgibbon M.J., Black J.R., and Navia M.A. Acta Cryst. D51 (1995) 511-521
192. Becker J.W., Rotonda J., McKeever B.M., Chan H.K., Marcy A.I., Wiederrecht G., Hermes J.D., and Springer J.P. J. Biol. Chem. 268 (1993) 11335-11339
193. Holt D.A., Luengo J.I., Yamashita D.S., Oh H.-J., Konialian A.L., Yen H.-K., Rozamus L.W., Brandt M., Bossard M.J., Levy M.A., Eggleston D.S., Liang J., Schultz L.W., Stout T.J., and Clardy J. J. Am. Chem. Soc. 115 (1993) 9925-9938
194. Armistead D.M., Badia M.C., Deininger D.D., Duffy J.P., Saunders J.O., Tung R.D., Thomson J.A., DeCenzo M.T., Futer O., Livingston D.J., Murcko M.A., Yamashita M.M., and Navia M.A. Acta Cryst. D51 (1995) 522-528
195. Dragovich P.S., Barker J.E., French J., Imbacuan M., Kalish V.J., Kissinger C.R., Knighton D.R., Lewis C.T., Moomaw E.W., Parge H.E., Pelletier L.A.K., Prins T.J., Showalter R.E., Tatlock J.H., Tucker K.D., and Villafranca J.E. J. Med. Chem. 39 (1996) 1872-1884
196. Wiederrecht G., Hung S., Chan H.K., Marcy A., Martin M., Calaycay J., Boulton D., Sigal N., Kincaid R.L., and Siekerka J.J. J. Biol. Chem. 267 (1992) 21753-21760
197. Bossard M.J., Bergsma D.J., Brandt M., Livi G.P., Eng W.-K., Johnson R.K., and Levy M.A. Biochem. J. 297 (1994) 365-372
198. DeCenzo M.T., Park S.T., Jarrett B.P., Aldape R.A., Futer O., Murcko M.A., and Livingston D.J. Protein Eng. 9 (1996) 173-180
199. Aldape R.A., Futer O., DeCenzo M.T., Jarrett B.P., Murcko M.A., and Livingston D.J. J. Biol. Chem. 267 (1992) 16029-16032
200. Griffin J.P., Kim J.L., Kim E.E., Sintchak M.D., Thomson J.A., Fitzgibbon M.J., Fleming M.A., Caron P.R., Hsiao K., and Navia M.A. Cell 82 (1995) 507-522
201. Kissinger C.R., Parge H.E., Knighton D.R., Lewis C.T., Pelletier L.A., Tempczyk A., Kalish V.J., Tucker K.D., Showalter R.E., Moomaw E.W., Gastinel L.N., Habuka N., Chen X., Maldonado F., Barker J.E., Bacquet R., and Villafranca J.E. Nature 378 (1995) 641-644
202. Choi J., Chen J., Schreiber S.L., and Clardy J. Science 273 (1996) 239-242
203. Schultz L.W., Martin P.K., Liang J., Schreiber S.L., and Clardy J. J. Am. Chem. Soc. 116 (1994) 3129-3130
204. Liang J., Hung D.T., Schreiber S.L., and Clardy J. J. Am. Chem. Soc. 118 (1996) 1231-1232
205. Craescu C.T., Rouviere N., Popescu A., Cerpolini E., Lebeau M.-C., Baulieu E.-E., and Misplelter J. Biochemistry 35 (1996) 11045-11052
206. Ke H., Zydowsky L.D., Liu J., and Walsh C.T. Proc. Natl. Acad. Sci. USA 88 (1991) 9483-9487
207. Ke H. J. Mol. Biol. 228 (1992) 539-550
208. Kallen J., Spitzfaden C., Zurini M.G.M., Wider G., Widmer H., Wuthrich K., and Walkinshaw M.D. Nature 353 (1991) 276-279
209. Weber C., Wider G., Von Freyburg B., Traber R., Braun W., Widmer H., and Wuthrich K. Biochemistry 30 (1991) 6563-6574
210. Theriault Y., Logan T.M., Meadows R., Yu L., Olejniczak E.T., Holzman T.F., Simmer R.L., and Fesik S.W. Nature 361 (1993) 88-91
211. Pfluegl G., Kallen J., Schirmer T., Jansonius J.N., Zurini M.G., and Walkinshaw M.D. Nature 361 (1993) 91-94
212. Mikol V., Kallen J., Pfluegl G., and Walkinshaw M.D. J. Mol. Biol. 234 (1993) 1119-1130
213. Spitzfaden C., Braun W., Wider G., Widmer H., and Wuthrich K. J. Biomol. NMR 4 (1994) 463-482
214. Liu J., Chen C.M., and Walsh C.T. Biochemistry 30 (1991) 23206
215. Bossard M.J., Koser P.L., Brandt M., and Bergsma D.J. Biochem Biophys. Res. Comm. 176 (1991) 1141-1148
216. Zydowsky L.D., Etzkorn F.A., Chang H.Y., Ferguson S.B., Stolz L.A., Ho S.I., and Walsh C.T. Protein Sci. 9 (1992) 1092-1099
217. Mikol V., Kallen J., and Walkinshaw M.D. Proc. Natl. Acad. Sci. USA 91 (1994) 5183-5186
218. Ke H., Zhao Y., Luo F., Weissman I., and Friedman J. Proc. Natl. Acad. Sci. USA 90 (1993) 11850-11854
219. Babine R.E., and Bender S.L. Chem. Rev. 97 (1997) 1359-1472
220. In: Veerapandian P. (Ed). Structure-Based Drug Design (1997), Marcel Dekker, New York
221. In: Charifson P.S. (Ed). Practical Application of Computer-Aided Drug Design (1997), Marcel Dekker, New York
222. Greer J., Erickson J.W., Baldwin J.J., and Varney M.D. J. Med. Chem. 37 (1994) 1035-1054
223. Pascard C. Acta. Cryst. D51 (1995) 407-417
224. Erickson J.W., and Fesik S.W. Ann. Rep. Med. Chem. 27 (1992) 271-289
225. Archer S.J., and Domaille P.J. Ann. Rep. Med. Chem. 31 (1996) 299-308
226. Holt D.A., Konialian-Beck A.L., Oh H.-J., Yen H.-K., Rozamus L.W., Krog A.J., Erhard K.F., Ortiz E., Levy M.A., Brandt M., Bossard M.J., and Luengo J.I. BioMed. Chem. Lett. 4 (1994) 315-320
227. Hamilton G.S., and Steiner J.P. Curr. Pharm. Design 3 (1997) 405-428
228. Lamb M.L., and Jorgensen W.L. J. Med. Chem. 41 (1998) 3928-3939
229. LeMaster D.M. Progress NMR Spectrosc. 26 (1994) 371-419
230. Sattler M., and Fesik S.W. J. Am. Chem. Soc. 119 (1997) 33
231. Sattler M., and Fesik S.W. J. Am. Chem. Soc. 119 (1997) 7885-7886
232. Hadjuk P.J., Olejniczak E.T., and Fesik S.W. J. Am. Chem. Soc. 119 (1997) 12257-12261
233. Shuker S.B., Hadjuk P.J., Meadows R.P., and Fesik S.W. Science 274 (1996) 1531-1534
234. Hadjuk P.J., Sheppard G., Nettesheim D.G., Olejniczak E.T., Shuker S.B., Meadows R.P., Steinman D.H., Carrera G.M., Marcotte P.A., Severin J., Walter K., Smith H., Gubbins E., Simmer R., Holzman T.F., Morgan D.W., Davidsen S.K., Summers J.B., and Fesik S.W. J. Am. Chem. Soc. 119 (1997) 5818-5827
235. Cheng J.-W., Lepre C.A., Chambers S.P., Fulghum J.R., Thomson J.A., and Moore J.M. Biochemistry 32 (1993) 9000-9010
236. Lepre C.A., Pearlman D.A., Cheng J.-W., DeCenzo M.T., Livingston D.J., and Moore J.M. Biochemistry 33 (1994) 13571-13580
237. Itoh S., DeCenzo M.T., Livingston D.J., Pearlman D.A., and Navia M.A. Bioorg. Med. Chem. Lett. 5 (1995) 1983-1988
238. Ivery M.T., and Weiler L. Bioorg. Med. Chem. 5 (1997) 217-232
239. Lepre C.A., Pearlman D.A., Futer O., Livingston D.J., and Moore J.M. J. Biomolec. NMR 8 (1996) 67-76
240. Futer O., DeCenzo M.T., Park S., Jarrett B., Aldape R., and Livingston D.J. J. Biol. Chem. 270 (1995) 18935-18940
241. Rosen M.K., Yang D., Martin P.K., and Schreiber S.L. J. Am. Chem. Soc. 115 (1993) 821-822
242. The reader is also referred to the following reviews of this topic. Snyder S.H., and Sabatini D.M. Nature Medicine 1 (1995) 32-37
243. Snyder S.H., Sabatini D.M., Lai M.M., Steiner J.P., Hamilton G.S., and Suzdak P.D. Trends. Pharm. Sci. 19 (1998) 21-26
244. in press. Hamilton G.S., and Steiner J.P. J. Med. Chem. (1999)
245. Maki N., Sekiguchi F., Nishimaki J., Miwa K., Hayano T., Takahashi N., and Suzuki M. Proc. Natl. Acad. Sci. USA 87 (1990) 5440-5443
246. Steiner J.P., Dawson T.M., Fotuhi M., Glatt C.E., Snowman A.M., Cohen N., and Snyder S.H. Nature 358 (1992) 584-587
247. Dawson T.M., Steiner J.P., Lyons W.E., Fotuhi M., Blue M., and Snyder S.H. Neuroscience 62 (1994) 569-580
248. Dawson T.M., Steiner J.P., Dawson V.L., Dinerman J.L., Uhl G.R., and Snyder S.H. Proc. Natl. Acad. Sci. USA 90 (1993) 9808-9812
249. Palmer R.M., and Higgs E.A. Pharmacol. Rev. 43 (1991) 109-142
250. Dawson T.M., and Snyder S.H. J. Neurosci. 14 (1994) 5147-5159
251. Bredt D.S., Ferris C.D., and Snyder S.H. J. Biol. Chem. 267 (1992) 10976-10981
252. Bredt D.S., and Snyder S.H. Proc. Natl. Acad. Sci. USA 86 (1989) 9030-9033
253. Choi D.W. Science 258 (1992) 241-243
254. Dawson V.L., Dawson T.M., London E.D., Bredt D.S., and Snyder S.H. Proc. Natl. Acad. Sci. USA 88 (1991) 6368-6371
255. Dawson V.L., Kizushi V.M., Huang P.L., Snyder S.H., and Dawson T.M. J. Neurosci. 16 (1996) 2479-2487
256. Sharkey J., and Butcher S.P. Nature 371 (1994) 336-339
257. Tokime T., Nozaki K., and Kikuchi H. Neurosci. Lett. 206 (1996) 81-84
258. Ide T., Morikawa E., and Kirino T. Neurosci. Lett. 204 (1996) 157-160
259. Butcher S.P., Henshall D.C., Teramura Y., Iwasaki K., and Sharkey J. J. Neurosci. 17 (1997) 6939-6946
260. Yagita Y., Kitagawa K., Matsushita K., Taguchi A., Mabuchi T., Ohtsuki T., Yanagihara T., and Matsumoto M. Life Sci. 59 (1996) 1643-1650
261. Steiner J.P., Dawson T.M., Fotuhi M., and Snyder S.H. Mol. Med. 2 (1996) 325-333
262. Nichols R.A., Suplick G.R., and Brown J.M. J. Biol. Chem. 269 (1994) 23817-23823
263. Hirsch D.B. Curr. Biol. 3 (1993) 749-754
264. Meiri K.F., Bickerstaff L.E., and Schwob J.E. J. Cell Biol. 112 (1991) 991-1005
265. Lyons W.E., Steiner J.P., Snyder S.H., and Dawson T.M. J. Neurosci. 15 (1995) 2985-2994
266. Lyons W.E., George E.B., Dawson T.M., Steiner J.P., and Snyder S.H. Proc. Natl. Acad. Sci. USA 91 (1994) 3191-3195
267. Gold B.G. Mol. Neurobiol. 15 (1997) 285-306
268. Chang H.Y., Takei K., Sydor A.M., Born T., Rusnak F., and Jay D.G. Nature 376 (1995) 686-690
269. Gold B.G., Storm-Dickerson T., and Austin D.R. Restorative Neurol. Neurosci. 6 (1994) 287
270. Gold B.G., Storm-Dickerson T., and Austin D.R. J. Neurosci. 15 (1995) 7509-7516
271. Steiner J.P., Connolly M.A., Valentine H.L., Hamilton G.S., Dawson T.M., Hester L., and Snyder S.H. Nature Med. 3 (1997) 421-428
272. Hamilton G.S., Huang W., Connolly M.A., Ross D.T., Guo H., Valentine H.L., Suzdak P.D., and Steiner J.P. Bioorg. Med. Chem. Lett. 7 (1997) 1785-1790
273. th National American Chemical Society Meeting. Abstract MEDI (1997) 183
274. Steiner J.P., Hamilton G.S., Ross D.T., Valentine H.L., Guo H., Connolly M.A., Liang S., Ramsey C., Li J.-H., Huang W., Howorth P., Soni R., Fuller M., Sauer H., Nowotnick A., and Suzdak P.D. Proc. Natl. Acad. Sci. USA 94 (1997) 2019-2024
275. Woolf C.J., Ma Q.P., Allchorne A., and Poole S.J. J. Neurosci. 16 (1996) 2716-2723
276. Gold B.G., Zeleney-Pooley M., Wang M.S., Chaturvedi P., and Armistead D.M. Exp. Neurobiol. 147 (1997) 269-278
277. Gold B.G., Zeleney-Poole M., Wang M.-S., Chaturvedi P., Armistead D.M., and McCaffrey P.G. Soc. Neurosci. Abstr. 449 (1997) 12
278. Valentine H.L., Spicer D., Fuller M., Hamilton G.S., and Steiner J.P. Soc. Neurosci. Abstr. 185 (1998) 9
279. Liang S., Valentine H.L., Ramsey C., Soni R., Scott C., and Steiner J.P. Soc. Neurosci. Abstr. 185 (1998) 9
280. Hamilton G.S. Chem. Ind. Feb. 16 (1998) 127-132
281. Gerlach M., Riederer P., Przuntek H., and Youdim M.B. Eur. J. Pharmacol. 208 (1991) 273-286
282. Steiner J.P., Ross D.T., Valentine H.L., Liang S., Guo H., Huang W., Suzdak P.D., and Hamilton G.S. Soc. Neurosci. Abstr. 677 (1997) 6
283. In press. Steiner J.P., Ross D.T., Sauer H., Hamilton G.S., Valentine H.L., Guo H., Liang S., Spicer D., Howorth P., Chen Y., Fuller M., and Suzdak P.D. J. Neurosci. (1999)
284. Sachs G., and Jonsson G. Biochem. Pharmacol. 24 (1975) 1-8
285. Ungerstedt U., and Aburthnott G.W. Brain Res. 24 (1970) 485-493
286. Ross D.T., Guo H., Howorth P., Fuller M., Nowotnick A., Hamilton G.S., Suzdak P.D., and Steiner J.P. Soc. Neurosci. Abstr. 677 (1997) 7
287. Guo H., Spicer D.M., Howorth P., Hamilton G.S., Suzdak P.D., and Ross D.T. Soc. Neurosci. Abstr. 677 (1997) 12
288. Bartus R.T., Dean R.L., Beer B., and Lippa A.S. Science 217 (1992) 408-417
289. Sauer H., Francis J.M., Jiang H., and Steiner J.P. Soc. Neurosci. Abstr. 269 (1998) 9
290. In press. Sauer H., Francis J.M., Jiang H., and Steiner J.P. Neuroscience (1999)
291. Liang S., Valentine H.L., Ross D.T., Huang W., Suzdak P.D., Hamilton G.S., and Steiner J.P. Soc. Neurosci. Abstr. 677 (1997) 10
292. Steiner J.P., Ho T., Coccia C., Griffin J., Snyder S., and Rothstein J.D. Soc. Neurosci. Abstr. 121 (1998) 1
293. Ross D.T., Guo H., Chen Y., Howorth P., and Steiner J.P. Soc. Neurosci. Abstr. 324 (1998) 6
294. Pawson T. Nature 373 (1995) 573-580
295. Coghlan V.M., Perrino B.A., Howard M., Langeberg L.K., Hicks J.B., Gallatin W.M., and Scott J.D. Science 267 (1995) 108-111
296. Woolf C.J., Ma Q.P., Allchorne A., and Poole S.J. J. Neurosci. 16 (1996) 2716-2723
297. Wang M.S., Zeleney-Poole M., and Gold B.G. J. Pharm. Exp. Ther. 282 (1997) 1084-1093
298. Boriongan C.V., Stahl C.E., Fujisaki T., Porter L.L., and Wtanabe S. Soc. Neurosci. Abstr. 778 (1998) 16
299. Goto S., and Singer W. Cereb. Cortex 4 (1994) 636-645