Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer disease

Proceedings of the National Academy of Sciences of the United States of America

Volumn 92, Issue 26, 1995, Pages 12260-12264

  Poirier, Judes ^a,b   Delisle, Marie Claude ^b   Quirion, Rémi ^a,b   Aubert, Isabelle ^b   Farlow, Martin ^d   Lahiri, Debmoi ^d   Hui, Siu ^d   Bertrand, Philippe ^b   Nalbantoglu, Josephine ^a   Gilfix, Brian M ^c   Gauthier, Serge ^a  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c ROYAL VICTORIA HOSPITAL   (Canada)

^d INDIANA UNIVERSITY   (United States)

Author keywords

choline acetyltransferase; muscarinic receptor; nicotinic receptor; tacrine

Indexed keywords

APOLIPOPROTEIN E4; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; MUSCARINIC RECEPTOR; NICOTINIC RECEPTOR; TACRINE;

AGED; ALLELE; ALZHEIMER DISEASE; ARTICLE; BRAIN LEVEL; CHOLESTEROL TRANSPORT; CHOLINESTERASE INHIBITION; CLINICAL ARTICLE; CLINICAL TRIAL; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG RECEPTOR BINDING; FEMALE; GENETIC SUSCEPTIBILITY; HUMAN; MALE; PHOSPHOLIPID TRANSFER; PRIORITY JOURNAL; PROGNOSIS; RECEPTOR DENSITY; TREATMENT OUTCOME;

AGE OF ONSET; AGED; ALLELES; ALZHEIMER DISEASE; APOLIPOPROTEIN E4; APOLIPOPROTEINS E; BRAIN; CHOLINE O-ACETYLTRANSFERASE; CHOLINESTERASE INHIBITORS; DEMOGRAPHY; FEMALE; HETEROZYGOTE DETECTION; HIPPOCAMPUS; HUMANS; MALE; POLYMORPHISM, GENETIC; PREDICTIVE VALUE OF TESTS; RECEPTORS, MUSCARINIC; RECEPTORS, NICOTINIC; REFERENCE VALUES; TACRINE; TEMPORAL LOBE; TREATMENT OUTCOME;

EID: 0007691164     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.92.26.12260     Document Type: Article

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