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Volumn 19, Issue 7, 1999, Pages 2464-2473

A test of the cytosolic apolipoprotein E hypothesis fails to detect the escape of apolipoprotein E from the endocytic pathway into the cytosol and shows that direct expression of apolipoprotein E in the cytosol is cytotoxic

Author keywords

Alzheimer's disease; apoE; Cytosolic; Cytotoxic; Endocytosis; Microtubules; Nuclear localization assay; Tau

Indexed keywords

APOLIPOPROTEIN E;

EID: 0033119820     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.19-07-02464.1999     Document Type: Article
Times cited : (31)

References (55)
  • 1
    • 0028850374 scopus 로고
    • Stable expression and secretion of apolipoprotein E3 and E4 in mouse neuroblastoma cells produces differential effects on neurite outgrowth
    • Bellosta S, Nathan BP, Orth M, Dong L-M, Mahley RW, Pitas RE (1995) Stable expression and secretion of apolipoprotein E3 and E4 in mouse neuroblastoma cells produces differential effects on neurite outgrowth. J Biol Chem 270:27063-27071.
    • (1995) J Biol Chem , vol.270 , pp. 27063-27071
    • Bellosta, S.1    Nathan, B.P.2    Orth, M.3    Dong, L.-M.4    Mahley, R.W.5    Pitas, R.E.6
  • 3
    • 0000854861 scopus 로고
    • Growth of a rat neuroblastoma cell line in serum-free supplemented medium
    • Bottenstein JE, Sato GH (1979) Growth of a rat neuroblastoma cell line in serum-free supplemented medium. Proc Natl Acad Sci USA 76:514-517.
    • (1979) Proc Natl Acad Sci USA , vol.76 , pp. 514-517
    • Bottenstein, J.E.1    Sato, G.H.2
  • 4
    • 0022350033 scopus 로고
    • Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system
    • Boyles JK, Pitas RE, Wilson E, Mahley RW, Taylor JM (1985) Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system. J Clin Invest 76:1501-1513.
    • (1985) J Clin Invest , vol.76 , pp. 1501-1513
    • Boyles, J.K.1    Pitas, R.E.2    Wilson, E.3    Mahley, R.W.4    Taylor, J.M.5
  • 5
    • 0025149375 scopus 로고
    • Accumulation of apolipoproteins in the regenerating and remyelinating mammalian peripheral nerve. Identification of apolipoprotein D, apolipoprotein A-IV, apolipoprotein E, and apolipoprotein A-I
    • Boyles JK, Notterpek LM, Anderson LJ (1990) Accumulation of apolipoproteins in the regenerating and remyelinating mammalian peripheral nerve. Identification of apolipoprotein D, apolipoprotein A-IV, apolipoprotein E, and apolipoprotein A-I. J Biol Chem 265:17805-17815.
    • (1990) J Biol Chem , vol.265 , pp. 17805-17815
    • Boyles, J.K.1    Notterpek, L.M.2    Anderson, L.J.3
  • 6
    • 0023392945 scopus 로고
    • High-efficiency transformation of mammalian cells by plasma DNA
    • Chen C, Okayama H (1987) High-efficiency transformation of mammalian cells by plasma DNA. Mol Cell Biol 7:2745-2752.
    • (1987) Mol Cell Biol , vol.7 , pp. 2745-2752
    • Chen, C.1    Okayama, H.2
  • 7
    • 0023033135 scopus 로고
    • Induction of rat E and chicken A-1 apolipoproteins and mRNAs during optic nerve degeneration
    • Dawson PA, Schechter N, Williams DL (1986) Induction of rat E and chicken A-1 apolipoproteins and mRNAs during optic nerve degeneration. J Biol Chem 261:5681-5684.
    • (1986) J Biol Chem , vol.261 , pp. 5681-5684
    • Dawson, P.A.1    Schechter, N.2    Williams, D.L.3
  • 8
    • 0032512634 scopus 로고    scopus 로고
    • A minimally-lipidated form of cell-derived apolipoprotein E exhibits isoform-specific stimulation of neurite outgrowth in the absence of exogenous lipids or lipoproteins
    • DeMattos RB, Curtiss LK, Williams DL (1998) A minimally-lipidated form of cell-derived apolipoprotein E exhibits isoform-specific stimulation of neurite outgrowth in the absence of exogenous lipids or lipoproteins. J Biol Chem 273:4206-4212.
    • (1998) J Biol Chem , vol.273 , pp. 4206-4212
    • DeMattos, R.B.1    Curtiss, L.K.2    Williams, D.L.3
  • 9
    • 0025949412 scopus 로고
    • Nuclear targeting sequences - A consensus?
    • Dingwall C, Laskey RA (1991) Nuclear targeting sequences - a consensus? Trends Biochem Sci 16:478-481.
    • (1991) Trends Biochem Sci , vol.16 , pp. 478-481
    • Dingwall, C.1    Laskey, R.A.2
  • 10
    • 0004982358 scopus 로고
    • Apolipoprotein E mRNA is abundant in the brain and adrenal, as well as in the liver and is present in other peripheral tissues of rats and marmosets
    • Elshourbagy NA, Liao WS, Mahley RW, Taylor JM (1985) Apolipoprotein E mRNA is abundant in the brain and adrenal, as well as in the liver and is present in other peripheral tissues of rats and marmosets. Proc Natl Acad Sci USA 82:203-207.
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 203-207
    • Elshourbagy, N.A.1    Liao, W.S.2    Mahley, R.W.3    Taylor, J.M.4
  • 14
    • 0028822219 scopus 로고
    • Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line
    • Holtzman DM, Pitas RE, Kilbridge J, Nathan B, Mahley RW, Bu G, Schwartz AL (1995) Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line. Proc Natl Acad Sci USA 92:9480-9484.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 9480-9484
    • Holtzman, D.M.1    Pitas, R.E.2    Kilbridge, J.3    Nathan, B.4    Mahley, R.W.5    Bu, G.6    Schwartz, A.L.7
  • 15
    • 0028884566 scopus 로고
    • Interaction of apolipoprotein E with laminin increases neuronal adhesion and alters neurite morphology
    • Huang DY, Weisgraber KH, Strittmatter WJ, Matthew WD (1995) Interaction of apolipoprotein E with laminin increases neuronal adhesion and alters neurite morphology. Exp Neurol 136:251-257.
    • (1995) Exp Neurol , vol.136 , pp. 251-257
    • Huang, D.Y.1    Weisgraber, K.H.2    Strittmatter, W.J.3    Matthew, W.D.4
  • 18
    • 0018800929 scopus 로고
    • Binding of arginine-rich (E) apoprotein after recombination with phospholipid vesicles to the low density lipoprotein receptors of fibroblasts
    • Innerarity TL, Pitas RE, Mahley RW (1979) Binding of arginine-rich (E) apoprotein after recombination with phospholipid vesicles to the low density lipoprotein receptors of fibroblasts. J Biol Chem 254:4186-4190.
    • (1979) J Biol Chem , vol.254 , pp. 4186-4190
    • Innerarity, T.L.1    Pitas, R.E.2    Mahley, R.W.3
  • 19
    • 0032577695 scopus 로고    scopus 로고
    • Differential cellular accumulation/retention of apolipoprotein E mediated by cell surface heparan sulfate proteoglycans
    • Ji Z, Pitas RE, Mahley RW (1998) Differential cellular accumulation/retention of apolipoprotein E mediated by cell surface heparan sulfate proteoglycans. J Biol Chem 273:13452-13460.
    • (1998) J Biol Chem , vol.273 , pp. 13452-13460
    • Ji, Z.1    Pitas, R.E.2    Mahley, R.W.3
  • 20
    • 0022556073 scopus 로고
    • Density gradient ultracentrifugation of serum lipoproteins in a swinging bucket rotor
    • Kelly JL, Kruski AW (1986) Density gradient ultracentrifugation of serum lipoproteins in a swinging bucket rotor. Methods Enzymol 128:170-181.
    • (1986) Methods Enzymol , vol.128 , pp. 170-181
    • Kelly, J.L.1    Kruski, A.W.2
  • 22
    • 0040177065 scopus 로고
    • Low density lipoprotein receptor-related protein mediates uptake of cholesteryl esters derived from apoprotein E-enriched lipoproteins
    • Kowal RC, Herz J, Goldstein JL, Esser V, Brown MS (1989) Low density lipoprotein receptor-related protein mediates uptake of cholesteryl esters derived from apoprotein E-enriched lipoproteins. Proc Natl Acad Sci USA 86:5810-5814.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 5810-5814
    • Kowal, R.C.1    Herz, J.2    Goldstein, J.L.3    Esser, V.4    Brown, M.S.5
  • 23
    • 0025302165 scopus 로고
    • Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein
    • Kowal RC, Herz J, Weisgraber KH, Mahley RW, Brown MS, Goldstein JL (1990) Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein. J Biol Chem 265:10771-10779.
    • (1990) J Biol Chem , vol.265 , pp. 10771-10779
    • Kowal, R.C.1    Herz, J.2    Weisgraber, K.H.3    Mahley, R.W.4    Brown, M.S.5    Goldstein, J.L.6
  • 24
    • 0022552131 scopus 로고
    • Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes
    • Kozak M (1986) Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. Cell 44:283-292.
    • (1986) Cell , vol.44 , pp. 283-292
    • Kozak, M.1
  • 27
    • 0029989760 scopus 로고    scopus 로고
    • The intracellular fate of apolipoprotein E is tau- dependent and apoE allele-specific
    • Lovestone S, Anderton BH, Hartley C, Jensen TG, Jorgensen AL (1996) The intracellular fate of apolipoprotein E is tau- dependent and apoE allele-specific. NeuroReport 7:1005-1008.
    • (1996) NeuroReport , vol.7 , pp. 1005-1008
    • Lovestone, S.1    Anderton, B.H.2    Hartley, C.3    Jensen, T.G.4    Jorgensen, A.L.5
  • 29
    • 0029995278 scopus 로고    scopus 로고
    • Neurons of the human frontal cortex display apolipoprotein E immunoreactivity: Implications for Alzheimer's disease
    • Metzger RE, LaDu MJ, Pan JB, Getz GS, Frail DE, Falduto MT (1996) Neurons of the human frontal cortex display apolipoprotein E immunoreactivity: implications for Alzheimer's disease. J Neuropathol Exp Neurol 55:372-380.
    • (1996) J Neuropathol Exp Neurol , vol.55 , pp. 372-380
    • Metzger, R.E.1    LaDu, M.J.2    Pan, J.B.3    Getz, G.S.4    Frail, D.E.5    Falduto, M.T.6
  • 30
    • 0025908356 scopus 로고
    • The consortium to establish a registry for Alzheimer's disease (CERAD). II. Standardization of the neuropathologic assessment of Alzheimer's disease
    • Mirra SS, Heyman A, McKeel D, Sumi SM, Crain BJ, Brownlee LM, Vogel FS, Hughes JP, van Belle G, Berg L (1991) The consortium to establish a registry for Alzheimer's disease (CERAD). II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 41:479-486.
    • (1991) Neurology , vol.41 , pp. 479-486
    • Mirra, S.S.1    Heyman, A.2    McKeel, D.3    Sumi, S.M.4    Crain, B.J.5    Brownlee, L.M.6    Vogel, F.S.7    Hughes, J.P.8    Van Belle, G.9    Berg, L.10
  • 31
    • 0028238344 scopus 로고
    • The relationship between low density lipoprotein-related protein/alpha 2-macroglobulin (alpha 2M) receptors and the newly described alpha 2M signaling receptor
    • Misra UK, Chu CT, Gawdi G, Pizzo SV (1994) The relationship between low density lipoprotein-related protein/alpha 2-macroglobulin (alpha 2M) receptors and the newly described alpha 2M signaling receptor. J Biol Chem 269:18303-18306.
    • (1994) J Biol Chem , vol.269 , pp. 18303-18306
    • Misra, U.K.1    Chu, C.T.2    Gawdi, G.3    Pizzo, S.V.4
  • 34
    • 0029157112 scopus 로고
    • The inhibitory effect of apolipoprotein E4 on neurite outgrowth is associated with microtubule depolymerization
    • Nathan BP, Chang K-C, Bellosta S, Brisch E, Ge N, Mahley RW, Pitas RE (1995) The inhibitory effect of apolipoprotein E4 on neurite outgrowth is associated with microtubule depolymerization. J Biol Chem 270:19797-19799.
    • (1995) J Biol Chem , vol.270 , pp. 19797-19799
    • Nathan, B.P.1    Chang, K.-C.2    Bellosta, S.3    Brisch, E.4    Ge, N.5    Mahley, R.W.6    Pitas, R.E.7
  • 35
    • 0021923648 scopus 로고
    • Quantitation of apolipoprotein E messenger RNA in the liver and peripheral tissues of nonhuman primates
    • Newman TC, Dawson PA, Rudel LL, Williams DL (1985) Quantitation of apolipoprotein E messenger RNA in the liver and peripheral tissues of nonhuman primates. J Biol Chem 260:2452-2457.
    • (1985) J Biol Chem , vol.260 , pp. 2452-2457
    • Newman, T.C.1    Dawson, P.A.2    Rudel, L.L.3    Williams, D.L.4
  • 36
    • 0029998347 scopus 로고    scopus 로고
    • Plasma lipopolysaccharide-binding protein is found associated with a particle containing apolipoprotein A-I, phospholipid, and factor H-related proteins
    • Park CT, Wright SD (1996) Plasma lipopolysaccharide-binding protein is found associated with a particle containing apolipoprotein A-I, phospholipid, and factor H-related proteins. J Biol Chem 271:18054-18060.
    • (1996) J Biol Chem , vol.271 , pp. 18054-18060
    • Park, C.T.1    Wright, S.D.2
  • 37
    • 0023080585 scopus 로고
    • Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins
    • Pitas RE, Boyles JK, Lee SH, Foss D, Mahley RW (1987a) Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins. Biochim Biophys Acta 917:148-161.
    • (1987) Biochim Biophys Acta , vol.917 , pp. 148-161
    • Pitas, R.E.1    Boyles, J.K.2    Lee, S.H.3    Foss, D.4    Mahley, R.W.5
  • 38
  • 39
    • 0027424327 scopus 로고
    • Hepatic expression of genes regulating lipid metabolism in rabbits
    • Rea TJ, DeMattos RB, Pape ME (1993) Hepatic expression of genes regulating lipid metabolism in rabbits. J Lipid Res 34:1901-1910.
    • (1993) J Lipid Res , vol.34 , pp. 1901-1910
    • Rea, T.J.1    DeMattos, R.B.2    Pape, M.E.3
  • 40
    • 0027374047 scopus 로고
    • Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions
    • Rebeck GW, Reiter JS, Strickland DK, Hyman BT (1993) Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions. Neuron 11:575-580.
    • (1993) Neuron , vol.11 , pp. 575-580
    • Rebeck, G.W.1    Reiter, J.S.2    Strickland, D.K.3    Hyman, B.T.4
  • 41
    • 0023669094 scopus 로고
    • The effect of protein context on nuclear location signal function
    • Roberts BL, Richardson WD, Smith AE (1987) The effect of protein context on nuclear location signal function. Cell 50:465-475.
    • (1987) Cell , vol.50 , pp. 465-475
    • Roberts, B.L.1    Richardson, W.D.2    Smith, A.E.3
  • 42
    • 0030783740 scopus 로고    scopus 로고
    • Novel members of the low density lipoprotein receptor superfamily and their potential roles in lipid metabolism
    • Schneider WJ, Nimpf J, Bujo H (1997) Novel members of the low density lipoprotein receptor superfamily and their potential roles in lipid metabolism. Curr Opin Lipidol 8:315-319.
    • (1997) Curr Opin Lipidol , vol.8 , pp. 315-319
    • Schneider, W.J.1    Nimpf, J.2    Bujo, H.3
  • 43
    • 0026022910 scopus 로고
    • How proteins enter the nucleus
    • Silver PA (1991) How proteins enter the nucleus. Cell 64:489-497.
    • (1991) Cell , vol.64 , pp. 489-497
    • Silver, P.A.1
  • 44
    • 0010731311 scopus 로고
    • Nerve injury stimulates the secretion of apolipoprotein E by nonneuronal cells
    • Snipes GJ, McGuire CB, Norden JJ, Freeman JA (1986) Nerve injury stimulates the secretion of apolipoprotein E by nonneuronal cells. Proc Natl Acad Sci USA 83:1130-1134.
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 1130-1134
    • Snipes, G.J.1    McGuire, C.B.2    Norden, J.J.3    Freeman, J.A.4
  • 45
    • 0031079601 scopus 로고    scopus 로고
    • Astrocytes and microglia respond to estrogen with increased apoE mRNA in vivo and in vitro
    • Stone DJ, Rozovsky I, Morgan TE, Anderson CP, Hajian H, Finch CE (1997) Astrocytes and microglia respond to estrogen with increased apoE mRNA in vivo and in vitro. Exp Neurol 143:313-318.
    • (1997) Exp Neurol , vol.143 , pp. 313-318
    • Stone, D.J.1    Rozovsky, I.2    Morgan, T.E.3    Anderson, C.P.4    Hajian, H.5    Finch, C.E.6
  • 50
    • 0032080231 scopus 로고    scopus 로고
    • Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: Astrocyte-specific expression and differing biological effects of astrocyte-secreted apoE3 and apoE4 lipoproteins
    • Sun Y, Wu S, Bu G, Onifade MK, Patel SN, LaDu MJ, Fagan AM, Holtzman DM (1998) Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: astrocyte-specific expression and differing biological effects of astrocyte-secreted apoE3 and apoE4 lipoproteins. J Neurosci 18:3261-3272.
    • (1998) J Neurosci , vol.18 , pp. 3261-3272
    • Sun, Y.1    Wu, S.2    Bu, G.3    Onifade, M.K.4    Patel, S.N.5    LaDu, M.J.6    Fagan, A.M.7    Holtzman, D.M.8
  • 51
    • 0026338739 scopus 로고
    • The influence of particle size and multiple apoprotein E-receptor interactions on the endocytic targeting of β-VLDL in mouse peritoneal macrophages
    • Tabas I, Myers JN, Innerarity TL, Xu X-X, Arnold K, Boyles J, Maxfield FR (1991) The influence of particle size and multiple apoprotein E-receptor interactions on the endocytic targeting of β-VLDL in mouse peritoneal macrophages. J Cell Biol 115:1547-1560.
    • (1991) J Cell Biol , vol.115 , pp. 1547-1560
    • Tabas, I.1    Myers, J.N.2    Innerarity, T.L.3    Xu, X.-X.4    Arnold, K.5    Boyles, J.6    Maxfield, F.R.7
  • 52
    • 0028988731 scopus 로고
    • Identification of hSRP1 β as a functional receptor for nuclear localization sequences
    • Weis K, Mattaj IW, Lamond AI (1995) Identification of hSRP1 β as a functional receptor for nuclear localization sequences. Science 268:1049-1053.
    • (1995) Science , vol.268 , pp. 1049-1053
    • Weis, K.1    Mattaj, I.W.2    Lamond, A.I.3
  • 53
    • 0028303072 scopus 로고
    • Apolipoprotein E: Structure-function relationships
    • Weisgraber KH (1994) Apolipoprotein E: structure-function relationships. Adv Protein Chem 45:249-302.
    • (1994) Adv Protein Chem , vol.45 , pp. 249-302
    • Weisgraber, K.H.1
  • 54
    • 0021920599 scopus 로고
    • Apolipoprotein E synthesis in peripheral tissues of nonhuman primates
    • Williams DL, Dawson PA, Newman TC, Rudel LL (1985) Apolipoprotein E synthesis in peripheral tissues of nonhuman primates. J Biol Chem 260:2444-2451.
    • (1985) J Biol Chem , vol.260 , pp. 2444-2451
    • Williams, D.L.1    Dawson, P.A.2    Newman, T.C.3    Rudel, L.L.4


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