Regulation of apolipoprotein E secretion in rat primary hippocampal astrocyte cultures

Neuroscience

Volumn 105, Issue 3, 2001, Pages 651-661

  Cedazo Minguez A ^a   Hamker, U ^b   Meske, V ^b   Veh, R W ^b   Hellweg, R ^c   Jacobi, C ^b   Albert, F ^b   Cowburn, R F ^a   Ohm, T G ^b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

Alzheimer's disease; cAMP; Nerve growth factor; Protein kinase C

Indexed keywords

ACETYLCHOLINE; ADENYLATE CYCLASE; ALPHA 1 ADRENERGIC RECEPTOR STIMULATING AGENT; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; APOLIPOPROTEIN E; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; BUCLADESINE; CARBACHOL; CLONIDINE; ISOPRENALINE; MESSENGER RNA; MUSCARINIC AGENT; NERVE GROWTH FACTOR; NORADRENALIN; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHOLIPASE C; PROTEIN KINASE C; PROTEIN KINASE C ACTIVATOR; RETINOIC ACID; SEROTONIN;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; ASTROCYTE; CELL CULTURE; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVATION; GENE EXPRESSION; HIPPOCAMPUS; NERVE GROWTH; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ALZHEIMER DISEASE; ANIMALS; ANIMALS, NEWBORN; APOLIPOPROTEINS E; ASTROCYTES; BUCLADESINE; CARBACHOL; CELL SURVIVAL; CELLS, CULTURED; CLONIDINE; CYCLIC AMP; DRUG INTERACTIONS; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; ISOPROTERENOL; NERVE GROWTH FACTOR; NOREPINEPHRINE; PROTEIN KINASE C; RATS; RATS, WISTAR; RNA, MESSENGER; SEROTONIN; TETRADECANOYLPHORBOL ACETATE; TRETINOIN;

EID: 0035881730     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(01)00224-X     Document Type: Article

References (87)

1. Risk for Alzheimer's disease correlates with transcriptional activity of the APOE gene
2. Allelic polymorphisms in the transcriptional regulatory region of apolipoprotein E gene
3. Increase in glia-derived nerve growth factor following destruction of hippocampal neurons
4. Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition
5. Calcium current in cortical astrocytes: Induction by cAMP and neurotransmitters and permissive effect of serum factors
6. Transcriptional and post-transcriptional control of apolipoprotein E gene expression in differentiating human monocytes
7. Altered apolipoprotein E secretion in cytokine treated human astrocyte cultures
8. Trans-repressor BEF-1 phosphorylation, a potential control mechanism for human ApoE gene regulation
9. Human inmunodeficiency virus protein gp120 interferes with β adrenergic receptor-mediated protein phosphorylation in cultured rat astrocytes
10. Association of apolipoprotein E genotype with brain levels of apolipoprotein E and apolipoprotein J (clusterin) in Alzheimer's disease
11. Apolipoprotein E associated with astrocytic glia of the central nervous system and with non-myelinating glia of the peripheral nervous system
12. A role for apolipoprotein E, apolipoprotein A-I, and low density lipoprotein receptors in cholesterol transport during regeneration and remyelinization of the rat sciatic nerve
13. Protein synthesis in astrocytes: 'Spontaneus' and cyclic AMP-induced differentiation
14. A polymorphism in the regulatory region of APOE associated with risk for Alzheimer's dementia
15. Direct activation of calcium-activated phospholipid dependent protein kinase by tumor-promoting phorbol esters
16. G protein-coupled receptors: Heterologous regulation of homologous desensitization and its implications
17. The role of APOE polymorphisms in late-onset dementias
18. Adenylyl cyclase activity in postmortem human brain: Evidence of altered G protein mediation in Alzheimer's disease
19. Disrupted beta 1-adrenoceptor-G protein coupling in the temporal cortex of patients with Alzheimer's disease
20. Induction of nerve growth factor gene expression by 12-O-tetradecanoyl phorbol 13-acetate
21. Regulation of apolipoprotein E secretion by high density lipoprotein 3 in mouse macrophages
22. Posttranscriptional regulation of apolipoprotein E expression by phorbolester
23. α1 adrenergic receptor coupling with phospholipase C is negatively regulated by protein kinase C in primary cultures of hypothalamic neurons and glial cells
24. Apolipoprotein E is a kinetic but not thermodynamic inhibitor of amyloid formation: Implications for the pathogenesis and treatment of Alzheimer's disease
25. Regulation of cyclic AMP accumulation by peptide hormone receptors in immunocytochemically defined astroglial cells
26. Synthesis/secretion of nerve growth factor is associated with cell growth in cultured mouse astroglial cells
27. Regulation of nerve growth factor secretion and mRNA expression by bacterial lipopolysaccharide in primary cultures of rat astrocytes
28. Transcription factor AP-2 regulates human apolipoprotein E gene expression in astrocytoma cells
29. The phorbol ester TPA potentiates cholera-toxin and isoproterenol-stimulated cyclic AMP-synthesis in primary astrocyte cultures
30. Astrocytes are the major source of nerve growth factor upregulation following traumatic brain injury in the rat
31. Two distal downstream enhancers direct expression of the human apolipoprotein E gene to astrocytes in the brain
32. 5-Hydroxytryptamine stimulates the formation of inositol phosphate in astrocytes from different regions of the brain
33. Interaction between cAMP and inositol phosphate transduction systems in astrocytes in primary culture
34. Senile dementia of the Lewy body type has an apolipoprotein E epsilon 4 allele frequency intermediate between controls and Alzheimer's disease
35. Lipoproteins and lipid transport
36. NGF level in the rat sciatic nerve is decreased after long-term consumption of ethanol
37. Nerve growth factor synthesis in cultured rat iris: Modulation by endogenous transmitter substances
38. An improved rapid and highly sensitive enzyme immunoassay for nerve growth factor
39. The time course of nerve growth factor content in different neuropsychiatric diseases: A unifying hypothesis
40. Identification of 5-hydroxytrytamine receptors positively coupled to adenylyl cyclase in rat cultured astrocytes
41. Expression of apolipoprotein E during nerve degeneration and regeneration
42. Transcription factor AP-2 mediates induction by two different signal-transduction pathways: Protein kinase C and cAMP
43. Interactions between second messenger pathways influence NGF synthesis in mouse primary astrocytes
44. Isoform-specific effect of apolipoprotein E on cell survival and β-amyloid induced toxicity in rat hippocampal pyramidal neuronal cultures
45. Determination of nucleic acid sequence homologies and relative concentrations by a dot hybridization procedure
46. Receptors on astrocytes: What possible functions?
47. A new polymorphism in the APOE promoter associated with risk of developing Alzheimer's disease
48. Rapid and sensitive colorimetric method for visualizing biotin-labeled DNA probes hybridized to DNA or RNA immobilized on nitrocellulose: Bio-blots
49. Physiology of the neurotrophins
50. Effects of hormones on apolipoprotein E secretion in cultured rat hepatocytes
51. Lipoprotein lipase reduces secretion of apolipoprotein E from macrophages
52. Apolipoprotein E: Cholesterol transport protein with expanding role in cell biology
53. Differential involvement of protein kinase C isozymes in Alzheimer's disease
54. Ca2+-dependent and Ca2+-independent protein kinase C changes in the brain of patients with Alzheimer's disease
55. The effects of beta/A4-amyloid and its fragments on calcium homeostasis, glial fibrillary acidic protein and S100beta staining, morphology and survival of cultured hippocampal astrocytes
56. Apolipoprotein E gene expression in astrocytes: Developmental pattern and regulation
57. Influence of the apolipoprotein E genotype on amyloid deposition and neurofibrillary tangle formation in Alzheimer's disease
58. Expression of apolipoprotein E mRNA in rat microglia
59. A multiplicity of muscarinic mechanism: Enough signaling pathways to take your breath away
60. Activation of nerve growth factor synthesis in primary glial cells by phorbol 12-myristate 13-acetate: Role of protein kinase C
61. Release of nerve growth factor by human glial cells in culture
62. Reduced basal and stimulated (isoprenaline, Gpp(NH)p, forskolin) adenylate cyclase activity in Alzheimer's disease correlated with histopathological changes
63. Apolipoprotein polymorphism influences not only cerebral senile plaque load but also Alzheimer-type neurofibrillary tangle formation
64. Apolipoprotein E isoforms and the development of low and high Braak stages of Alzheimer's disease-related lesions
65. Decrease in adenylate cyclase activity antecedes neurofibrillary tangle formation
66. Expression of apolipoprotein E by mouse astrocytes and its modulation by interferon-gamma
67. Opposite regulation of adenylyl cyclase by protein kinase C in astrocyte and microglia cultures
68. Activation of muscarinic and of α1 adrenergic receptors on astrocytes results in the accumulation of inositol phosphate
69. Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins
70. Haptenylation of antibodies during affinity purification: A novel and convenient procedure to obtain labeled antibodies for quantification and double labeling
71. Astrocytic apolipoprotein E mRNA and GFAP mRNA in hippocampus after entorhrinal cortex lesioning
72. Apolipoprotein E, synaptic plasticity and Alzheimer's Disease
73. Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions
74. Cloning and regulation of messenger RNA for mouse apolipoprotein E
75. Extraction, purification and analysis of messenger RNA from eukarotic cells
76. Adenylyl cyclase activity in Alzheimer's disease brain: Stimulatory and inhibitory signal transduction pathways are differently affected
77. Astroglial adrenergic receptors
78. Neurotrophic factors in Alzheimer's and Parkinson's disease brain
79. Apolipoprotein E gene and sporadic frontal lobe dementia
80. Astrocytes and microglia respond to estrogen with increased apoE mRNA in vivo and in vitro
81. Apolipoprotein E: High-avidity binding to β-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer's disease
82. Hypothesis: Microtubule instability and paired helical filament formation in the Alzheimer's disease brain are related to apolipoprotein E genotype
83. Effects of neurotransmitters in glial cells
84. Attenuated protein kinase C activity and translocation in Alzheimer's disease brain
85. The role of apolipoprotein E in the nervous system
86. Effect of 8-bromo-cAMP and dexamethasone on glutamate metabolism in rat astrocytes