Inhibition of sphingolipid induced apoptosis by caspase inhibitors indicates that sphingosine acts in an earlier part of the apoptotic pathway than ceramide

FEBS Letters

Volumn 425, Issue 1, 1998, Pages 61-65

  Sweeney, Elizabeth A ^a   Inokuchi, Jin ichi ^b   Igarashi, Yasuyuki ^a  

^a Fred Hutchinson Cancer Research Center   (United States)

^b SEIKAGAKU CORPORATION   (Japan)

Author keywords

Apoptosis; Caspase; Ceramide; N,N dimethylsphingosine; Sphingosine

Indexed keywords

CERAMIDE DERIVATIVE; GRANZYME B; N,N DIMETHYLSPHINGOSINE; PROTEINASE; PROTEINASE INHIBITOR; SPHINGOLIPID; SPHINGOSINE; SPHINGOSINE DERIVATIVE;

APOPTOSIS; ARTICLE; CELL LINE; CELL STRAIN HL 60; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL;

APOPTOSIS; CERAMIDES; CYSTEINE PROTEINASE INHIBITORS; HL-60 CELLS; HUMANS; SPHINGOLIPIDS; SPHINGOSINE;

EID: 0032549509     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(98)00198-7     Document Type: Article

References (28)

1. Stellar H. Science. 267:1995;1445-1449.
2. Salvesen G.S., Dixit V.M. Cell. 91:1997;443-446.
3. Villa P., Kaufmann S.H., Earnshaw W.C. Trends Biochem. Sci. 22:1997;388-393.
4. Thornberry N.A., Rano T.A., Peterson E.P., Rasper D.M., Timkey T., Garcia-Calvo M., Houtzager V.M., Nordstrom P.A., Roy S., Vaillancourt J.P., Chapman K.T., Nicholson D.W. J. Biol. Chem. 272:1997;179107-179110.
5. Miller D.K. Sem. Immun. 9:1997;35-49.
6. Hannun Y.A., Obeid L.M. Trends Biochem. Sci. 20:1995;73-77.
7. Ohta H., Sweeney E.A., Masamune A., Hakomori S., Igarashi Y. Cancer Res. 55:1995;691-697.
8. Sweeney E.A., Shirahama T., Sakakura C., Hakomori S., Igarashi Y. Int. J. Cancer. 66:1996;358-366.
9. Jarvis W.D., Fornari F.A., Traylor R.S., Martin H.A., Kramer L.B., Erukula R.K., Bittman R., Grant S. J. Biol. Chem. 271:1996;8275-8284.
10. Cuvillier O., Pirianov G., Kleuser B., Vanek P.G., Coso O.A., Gutkind J.S., Spiegel S. Nature. 381:1996;800-803.
11. Krown K.A., Page M.T., Nguyen C., Zechner D., Gutierrrez V., Comstock K.L., Glembotski C.C., Quintana P.J.E., Sabadini R.A. J. Clin. Invest. 98:1996;2854-2865.
12. Oral H., Dorn G.W., Mann D.L. J. Biol. Chem. 272:1997;4836-4842.
13. Sakakura C., Sweeney E.A., Shirahama T., Solca F., Kohno M., Hakomori S., Fisher E.H., Igarashi Y. Int. J. Oncol. 11:1997;31-39.
14. Jarvis W.D., Fornari F.A., Auer K.L., Freemerman A.J., Szabo E., Birrer M.J., Johnson C.R., Barbour S.E., Dent P., Grant S. Mol. Pharmacol. 52:1997;935-947.
15. Okazaki T., Sawai H., Tashima M., Sawada H., Domae N. Glycoconjug. J. 12:1995;579.
16. Igarashi Y. J. Biochem. 122:1997;1080-1087.
17. Igarashi Y., Hakomori S., Toyokuni T., Dean B., Fujita S., Sugimoto M., Ogawa T., El-Ghendy K., Racker E. Biochemistry. 28:1989;6796-6800.
18. Bielawska A., Greenberg M.S., Perry D., Jayadev S., Shayman J.A., McKay C., Hannun Y.A. J. Biol. Chem. 271:1996;12646-12654.
19. Margolin N., Raybuck S.A., Wilson K.P., Chen W., Fox T., Gu Y., Livingston D.J. J. Biol. Chem. 272:1997;7223-7228.
20. Medema J.P., Scaffidi C., Kischkel F.C., Shevchenko A., Mann M., Krammer P.H., Peter M.E. EMBO J. 16:1997;2794-2804.
21. Sarin A., Wu M., Henkart P.A. J. Exp. Med. 184:1996;2445-2450.
22. Bernardo K., Hurwitz R., Zenk T., Desnick R.J., Ferlinz K., Schuchman E.H., Sandhoff K. J. Biol. Chem. 270:1995;11098-11102.
23. Chinnaiyan A.M., Dixit V.M. Sem. Immun. 9:1997;69-76.
24. Quan L.T., Caputo A., Bleackly R.C., Pickup D.J., Salvesen G.S. J. Biol. Chem. 270:1995;10377-10379.
25. Zhou Q., Snipas S., Orth K., Muzio M., Dixit V.M., Salvesen G.S. J. Biol. Chem. 272:1997;7797-7800.
26. Kojima H., Datta R. Oncol. Res. 8:1996;497-501.
27. Geley S., Hartmann B., Kofler R. FEBS Lett. 400:1997;15-18.
28. Cuvillier O., Rosenthal D.S., Smulson M.E., Spiegel S. J. Biol. Chem. 273:1998;2910-2916.