Turning telomeres off and on

Current Opinion in Cell Biology

Volumn 13, Issue 3, 2001, Pages 281-289

  Dubrana, K ^a   Perrod, S ^a   Gasser, S M ^a  

^a SWISS INST FOR EXP CANCER RESEARCH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

TELOMERASE;

CHROMOSOME REPLICATION; CHROMOSOME SIZE; CHROMOSOME STRUCTURE; DNA DAMAGE; DNA REPLICATION; ENZYME ACTIVITY; FEEDBACK SYSTEM; GENETIC RECOMBINATION; PRIORITY JOURNAL; PROTEIN SYNTHESIS; REGULATORY MECHANISM; REVIEW; TELOMERE; YEAST;

EID: 0035371393     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(00)00210-6     Document Type: Review

References (95)

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3. The stability of broken ends of chromosomes in Zea mays
4. TRF2 protects human telomeres from end-to-end fusions
5. Positive and negative regulation of telomerase access to the telomere
6. Recombination in telomere-length maintenance
7. Telomeres and the functional architecture of the nucleus
8. Position effect at S. cerevisiae telomeres: Reversible repression of Pol II transcription
9. The clustering of telomeres and colocalization with Rap1, Sir3, and Sir4 proteins in wild-type Saccharomyces cerevisiae
10. Telomere-telomere interactions and candidate telomere binding protein(s) in mammalian sperm cells
11. Telomeres and telomerase: More than the end of the line
12. The DNA structures at the ends of eukaryotic chromosomes
13. Progressive cis-inhibition of telomerase upon telomere elongation
14. Telomerase-dependent repeat divergence at the 3′ ends of yeast telomeres
15. Telomere states and cell fates
16. TLC1: Template RNA component of Saccharomyces cerevisiae telomerase
17. Reverse transcriptase motifs in the catalytic subunit of telomerase
18. The Est3 protein is a subunit of yeast telomerase
19. Cdc13p: A single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance
20. Identification of the single-strand telomeric DNA binding domain of the Saccharomyces cerevisiae Cdc13 protein
21. The Saccharomyces telomere-binding protein Cdc13p interacts with both the catalytic subunit of DNA polymerase alpha and the telomerase-associated Est1 protein
22. Est1 and Cdc13 as comediators of telomerase access
23. Cell cycle restriction of telomere elongation
24. Telomerase-mediated telomere addition in vivo requires DNA primase and DNA polymerases alpha and delta
25. The function of DNA polymerase alpha at telomeric G tails is important for telomere homeostasis
26. Specific DNA replication mutations affect telomere length in Saccharomyces cerevisiae
27. Interaction of DNA polymerase alpha-primase with cellular replication protein A and SV40 T antigen
28. Yeast Ku as a regulator of chromosomal DNA end structure
29. Mutation of yeast Ku genes disrupts the subnuclear organization of telomeres
30. Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast
31. Cdc13 cooperates with the yeast Ku proteins and Stn1 to regulate telomerase recruitment
32. The function of a stem-loop in telomerase RNA is linked to the DNA repair protein Ku
33. Distortion of the DNA double helix by RAP1 at silencers and multiple telomeric binding sites
34. A protein-counting mechanism for telomere length regulation in yeast
35. Evidence that a complex of SIR proteins interacts with the silencer and telomere-binding protein RAP1
36. Action of a RAP1 carboxy-terminal silencing domain reveals an underlying competition between HMR and telomeres in yeast
37. Varying the number of telomere-bound proteins does not alter telomere length in tel1Δ cells
38. Dependence of the regulation of telomere length on the type of subtelomeric repeat in the yeast Saccharomyces cerevisiae
39. Telomere maintenance is dependent on activities required for end repair of double-strand breaks
40. RAD50 and RAD51 define two pathways that collaborate to maintain telomeres in the absence of telomerase
41. The Mre11p/Rad50p/Xrs2p complex and the Tel1p function in a single pathway for telomere maintenance in yeast
42. An alternative pathway for yeast telomere maintenance rescues est1-senescence
43. Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes
44. Telomerase-independent lengthening of yeast telomeres occurs by an abrupt Rad50p-dependent, Rif-inhibited recombinational process
45. Separation of transcriptional activation and silencing functions of the RAP1-encoded repressor/activator protein 1: Isolation of viable mutants affecting both silencing and telomere length
46. RAP1 and telomere structure regulate telomere position effects in Saccharomyces cerevisiae
47. Mutational analysis defines a C-terminal tail domain of RAP1 essential for telomeric silencing in Saccharomyces cerevisiae
48. A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae
49. Telomerase RNA template mutations reveal sequence-specific requirements for the activation and repression of telomerase action at telomeres
50. Interaction between Set1p and checkpoint protein Mec3p in DNA repair and telomere functions
51. Stn1, a new Saccharomyces cerevisiae protein, is implicated in telomere size regulation in association with Cdc13
52. Yeast Ku protein plays a direct role in telomeric silencing and counteracts inhibition by Rif proteins
53. Sir proteins, Rif proteins, and Cdc13p bind Saccharomyces telomeres in vivo
54. The yeast Ku heterodimer is essential for protection of the telomere against nucleolytic and recombinational activities
55. Telomere-binding and Stn1p-interacting activities are required for the essential function of Saccharomyces cerevisiae Cdc13p
56. Mammalian telomeres end in a large duplex loop
57. DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes
58. DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation
59. Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang
60. Ku is associated with the telomere in mammals
61. Ku acts in a unique way at the mammalian telomere to prevent end joining
62. Interaction of human Ku70 with TRF2
63. Subtelomeric repeat amplification is associated with growth at elevated temperature in yku70 mutants of Saccharomyces cerevisiae
64. Accumulation of single-stranded DNA and destabilization of telomeric repeats in yeast mutant strains carrying a deletion of RAD27
65. Interactions of TLC1 (which encodes the RNA subunit of telomerase), TEL1, and MEC1 in regulating telomere length in the yeast Saccharomyces cerevisiae
66. Checkpoint proteins influence telomeric silencing and length maintenance in budding yeast
67. Involvement of the checkpoint protein Mec1p in silencing of gene expression at telomeres in Saccharomyces cerevisiae
68. ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway
69. ATM-dependent phosphorylation of nibrin in response to radiation exposure
70. Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products
71. Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres
72. Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex
73. Protein kinase activity of Tel1p and Mec1p, two Saccharomyces cerevisiae proteins related to the human ATM protein kinase
74. Mechanisms of silencing in Saccharomyces cerevisiae
75. Nuclear organization and transcriptional silencing in yeast
76. Perinuclear localization of chromatin facilitates transcriptional silencing
77. Nuclear compartments and gene regulation
78. Proteins connecting the nuclear pore complex with the nuclear interior
79. Nuclear pore complexes in the organization of silent telomeric chromatin
80. A novel nuclear pore protein Nup133p with distinct roles in poly(A)+ RNA transport and nuclear pore distribution
81. Ku deficient strains exhibit alternative states of silencing competence
82. The yeast silent information regulator Sir4p anchors and partitions plasmids
83. DNA damage triggers disruption of telomeric silencing and Mec1p-dependent relocation of Sir3p
84. MEC1-dependent redistribution of the Sir3 silencing protein from telomeres to DNA double-strand breaks
85. Role of yeast SIR genes and mating type in directing DNA double-strand breaks to homologous and non-homologous repair paths
86. Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing
87. Silencing factors participate in DNA repair and recombination in Saccharomyces cerevisiae
88. Yeast cell-type regulation of DNA repair
89. Loss of a yeast telomere: Arrest, recovery, and chromosome loss
90. CDC5 and CKII control adaptation to the yeast DNA damage checkpoint
91. Saccharomyces Ku70, mre11/rad50 and RPA proteins regulate adaptation to G2/M arrest after DNA damage
92. The Est1 subunit of yeast telomerase binds the Tlc1 telomerase RNA
93. Pif1p helicase, a catalytic inhibitor of telomerase in yeast
94. Cdc13 delivers separate complexes to the telomere for end protection and replication
95. Cdc13 both positively and negatively regulates telomere replication