Ku-deficient yeast strains exhibit alternative states of silencing competence

EMBO Reports

Volumn 2, Issue 3, 2001, Pages 203-210

  Maillet, Laurent ^a,b   Gaden, Florence ^a,c   Brevet, Vanessa ^a   Fourel, Geneviève ^a   Martin, Sophie G ^d,e   Dubrana, Karine ^d   Gasser, Susan M ^d   Gilson, Eric ^a  

^a UNIVERSITÉ DE LYON   (France)

^b UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^c UNIVERSITÉ LYON 1   (France)

^d SWISS INST FOR EXP CANCER RESEARCH   (Switzerland)

^e WELLCOME CRC INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; REGULATOR PROTEIN;

ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; GENE CLUSTER; GENE LOCATION; GENE LOCUS; GENE SILENCING; GENETIC REGULATION; MITOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; SACCHAROMYCES CEREVISIAE; TELOMERE; YEAST;

ANTIGENS, NUCLEAR; DNA HELICASES; DNA-BINDING PROTEINS; FUNGAL PROTEINS; GENE SILENCING; GENES, FUNGAL; NUCLEAR PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SILENT INFORMATION REGULATOR PROTEINS, SACCHAROMYCES CEREVISIAE; TELOMERE; TRANS-ACTIVATORS;

SACCHAROMYCES CEREVISIAE;

EID: 0035071794     PISSN: 1469221X     EISSN: None     Source Type: Journal    
DOI: 10.1093/embo-reports/kve044     Document Type: Article

References (30)

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4. Re-modelling of nuclear architecture in quiescent and senescent human fibroblasts
5. Dynamic repositioning of genes in the nucleus of lymphocytes preparing for cell division
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7. The boundaries of the silenced HMR domain in Saccharomyces cerevisiae
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10. Nuclear organization and transcriptional silencing in yeast
11. The clustering of telomeres and colocalization with Rap1, Sir3, and Sir4 proteins in wild type S. cerevisiae
12. Position effect at S. cerevisiae telomeres: Reversible repression of Pol II transcription
13. Yeast Ku as a regulator of chromosomal DNA end structure
14. Histone H3 and H4 N termini interact with the silent information regulators Sir3 and Sir4 in vitro: A molecular model for the formation of heterochromatin in yeast
15. Mitotic stability of yeast chromosomes: A colony color assay that measures nondisjunction and chromosome loss
16. Redistribution of silencing protein from telomeres to the nucleolus is associated with extension in life span in S. cerevisiae
17. Mutation of yeast Ku genes disrupts the subnuclear organization of telomeres
18. The dynamics of yeast telomeres and silencing proteins through the cell cycle
19. Evidence for silencing compartments within the yeast nucleus: A role for telomere proximity and Sir-protein concentration in silencer-mediated repression
20. Silencing of genes at nontelomeric sites in yeast is controlled by sequestration of silencing factors at telomeres by Rap1 protein
21. Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast
22. DNA damage triggers disruption of telomeric silencing and Mec1p-dependent relocation of Sir3p
23. MEC1-dependent redistribution of the Sir3 silencing protein from telomeres to DNA double-strand breaks
24. Yeast Ku protein plays a direct role in telomeric silencing and counteracts inhibition by rif proteins
25. Telomere maintenance is dependent on activities required for end repair of double-strand breaks
26. SIR3 and SIR4 proteins are required for the positioning and integrity of yeast telomeres
27. The DNA-binding protein Hdf1p (a putative Ku homologue) is required for maintaining normal telomere length in S. cerevisiae
28. Limitations of silencing at native yeast telomeres
29. SIR2 and SIR4 interactions differ in core and extended telomeric heterochromatin in yeast
30. New heterologous modules for classical or PCR-based gene disruptions in Saccharomyces cerevisiae