Involvement of the checkpoint protein Mec1p in silencing of gene expression at telomeres in Saccharomyces cerevisiae

Molecular and Cellular Biology

Volumn 20, Issue 7, 2000, Pages 2378-2384

  Craven, Rolf J ^a   Petes, Thomas D ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; DNA DAMAGE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE INSERTION; GENE MUTATION; GENE OVEREXPRESSION; GENE SILENCING; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; TELOMERE; TRANSCRIPTION REGULATION;

CELL CYCLE PROTEINS; ENZYME INHIBITORS; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; GENE SILENCING; GENETIC COMPLEMENTATION TEST; MUTATION; PROTEIN KINASES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TELOMERE;

SACCHAROMYCES CEREVISIAE;

EID: 0034100565     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.7.2378-2384.2000     Document Type: Article

References (43)

1. Allen, J. B., Z. Zhou, W. Siede, E. C. Friedberg, and S. J. Elledge. 1994. The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast. Genes Dev. 8:2416-2428.
2. Aparicio, O. M., B. L. Billington, and D. E. Gottschling. 1991. Modifiers of position effect are shared between telomeric and silent mating-type loci of S. cerevisiae. Cell 66:1279-1287.
3. Aparicio, O. M., and D. E. Gottschling. 1994. Overcoming telomeric silencing: a trans-activator competes to establish gene expression in a cell cycle-dependent way. Genes Dev. 8:1133-1146.
4. Boulton, S. J., and S. P. Jackson. 1998. Components of the Ku-dependent non-homologous end joining pathway are involved in telomeric length maintenance and telomeric silencing. EMBO J. 17:1819-1828.
5. Chapman, C. R., S. T. Evans, A. M. Carr, and T. Enoch. 1999. Requirement of sequences outside the conserved kinase domain of fission yeast Rad3p for checkpoint control. Mol. Biol. Cell 10:3223-3238.
6. Christianson, T. W., R. S. Sikorski, M. Dante, J. H. Shero, and P. Hieter. 1992. Multifunctional yeast high-copy-number shuttle vectors. Gene 110: 119-122.
7. Corda, Y., V. Schramke, M. P. Longhese, T. Smokvina, V. Paciotti, V. Brevet, E. Gilson, and V. Geli. 1999. Interactions between Set1p and checkpoint protein Mec3p in DNA repair and telomere functions. Nat. Genet. 21: 204-208.
8. Craven, R. J., and T. D. Petes. 1999. Dependence of the regulation of telomere length on the type of subtelomeric repeat in the yeast Saccharomyces cerevisiae. Genetics 152:1531-1541.
9. Dahlen, M., T. Olsson, B. Kanter-Smoler, A. Ramne, and P. Sunnerhagen. 1998. Regulation of telomere length by checkpoint genes in Schizosaccharomyces pombe. Mol. Biol. Cell 9:611-621.
10. Desany, B. A., A. A. Alcasabas, J. B. Bachant, and S. J. Elledge. 1998. Recovery from DNA replication stress is the essential function of the S-phase checkpoint pathway. Genes Dev. 12:2956-2970.
11. Elledge, S. J. 1996. Cell cycle checkpoints: preventing an identity crisis. Science 274:1664-1672.
12. Emili, A. 1998. MEC1-dependent phosphorylation of Rad9p in response to DNA damage. Mol. Cell 2:183-189.
13. Gardner, R., C. W. Putnam, and T. Weinert. 1999. RAD53, DUN1, and PDS1 define two parallel G2/M checkpoint pathways in budding yeast. EMBO J. 18:3173-3185.
14. Gottschling, D. E., O. M. Aparicio, B. L. Billington, and V. A. Zakian. 1990. Position effect at S. cerevisiae telomeres: reversible repression of Pol II transcription. Cell 63:751-762.
15. Guthrie, C., and G. R. Fink (ed.). 1991. Guide to yeast genetics and molecular biology. Academic Press, San Diego, Calif.
16. Hardy, C. F. J., L. Sussel, and D. Shore. 1992. A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation. Genes Dev. 6:801-814.
17. Hecht, A., T. Laroche, S. Strahl-Bosinger, S. M. Gasser, and M. Grunstein. 1995. Histone H3 and H4 N-termini interact with SIR3 and SIR4 proteins: a molecular model for the formation of heterochromatin in yeast. Cell 80: 583-592.
18. Hecht, A., S. Strahl-Bolsinger, and M. Grunstein. 1996. Spreading of transcriptional represser SIR3 from telomeric heterochromatin. Nature 383: 92-95.
19. Jackson, S. P. 1996. The recognition of DNA damage. Curr. Opin. Genet. Dev. 6:19-25.
20. Kyrion, G., K. Liu, C. Liu, and A. J. Lustig. 1993. RAP1 and telomere structure regulate telomere position effects in Saccharomyces cerevisiae. Genes Dev. 7:1146-1159.
21. Longese, M. P., M. Foiani, M. Muzi-Falconi, G. Lucchini, and P. Plevani. 1998. DNA damage checkpoint in budding yeast. EMBO J. 17:5525-5528.
22. Lustig, A. J. 1998. Mechanisms of silencing in Saccharomyces cerevisiae. Curr. Opin. Genet. Dev. 8:233-239.
23. Lydall, D., and T. Weinert. 1995. Yeast checkpoint genes in DNA damage processing: implications for repair and arrest. Science 270:1488-1492.
24. Martin, S. G., T. Laroche, N. Suka, M. Grunstein, and S. M. Gasser. 1999. Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast. Cell 97:621-633.
25. +. Genetics 152:1501-1512.
26. McAinsh, A. D., S. Scott-Drew, J. A. H. Murray, and S. P. Jackson. 1999. DNA damage triggers disruption of telomeric silencing and Mec1p-dependent relocation of Sir3p. Curr. Biol. 9:963-966.
27. McCarroll, R. M., and W. L. Fangman. 1988. Time of replication of yeast centromeres and telomeres. Cell 54:505-513.
28. Mills, K. D., D. A. Sinclair, and L. Guarente. 1999. MEC1-dependent redistribution of the Sir3 silencing protein from telomeres to DNA double-strand breaks. Cell 97:609-620.
29. Nislow, C., E. Ray, and L. Pillus. 1997. SET1, a member of the Trithorax family, functions in transcriptional silencing and diverse cellular processes. Mol. Biol. Cell 8:2421-2436.
30. Ritchie, K. B., J. C. Mallory, and T. D. Petes. 1999. Interactions of TLC1 (which encodes the RNA subunit of telomerase), TEL1, and MEC1 in regulating telomere length in the yeast Saccharomyces cerevisiae. Mol. Cell. Biol. 19:6065-6075.
31. Sanchez, Y., J. Bachant, H. Wang, F. Hu, D. Liu, M. Tetzlaff, and S. J. Elledge. 1999. Control of the DNA damage checkpoint by Chk1 and Rad53 protein kinases through distinct mechanisms. Science 286:1166-1171.
32. Sanchez, Y., B. A. Desany, W. J. Jones, Q. Liu, B. Wang, and S. J. Elledge. 1996. Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways. Science 271:357-360.
33. Sikorski, R. S., and P. Hieter. 1989. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122:19-27.
34. Singer, M. S., A. Kahana, A. J. Wolf, L. L. Meisinger, S. E. Peterson, C. Goggin, M. Mahowold, and D. E. Gottschling. 1998. Identification of high-copy disrupters of telomeric silencing in Saccharomyces cerevisiae. Genetics 150:613-632.
35. Stevenson, J. B., and D. E. Gottschling. 1999. Telomeric chromatin modulates replication timing near chromosome ends. Genes Dev. 13:146-151.
36. Thomas, B. J., and R. Rothstein. 1989. Elevated recombination rates in transcriptionally active DNA. Cell 56:619-630.
37. Vallen, E. A., and F. R. Cross. 1999. Interactions between the MEC1-dependent DNA synthesis checkpoint and G1 cyclin function in Saccharomyces cerevisiae. Genetics 151:459-471.
38. Vialard, J. E., C. S. Gilbert, C. M. Green, and N. F. Lowndes. 1998. The budding yeast Rad9 checkpoint protein is subjected to Mec1/Tel1-dependent hyperphosphorylation and interacts with Rad53 after DNA damage. EMBO J. 19:5679-5688.
39. Weinert, T. A., G. L. Kiser, and L. H. Hartwell. 1994. Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair. Genes Dev. 8:652-665.
40. Weinert, T. A. 1998. DNA damage checkpoints update: getting molecular. Curr. Opin. Genet. Dev. 8:185-193.
41. Wotton, D., and D. Shore. 1997. A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae. Genes Dev. 11:748-760.
42. Zhao, X., E. G. D. Muller, and R. Rothstein. 1998. A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools. Mol. Cell 2:329-340.
43. Zhou, Z., and S. J. Elledge. 1993. DUN1 encodes a protein kinase that controls the DNA damage response in yeast. Cell 75:1119-1127.