Autophosphorylation of p110δ phosphoinositide 3-kinase: A new paradigm for the regulation of lipid kinases in vitro and in vivo

EMBO Journal

Volumn 18, Issue 5, 1999, Pages 1292-1302

  Vanhaesebroeck, Bart ^a   Higashi, Kyochiro ^a,b   Raven, Catherine ^c   Welham, Melanie ^c   Andersen, Simon ^a   Brennan, Paul ^d   Ward, Stephen G ^c   Waterfield, Michael D ^a,e  

^a LUDWIG INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^b MEIJI PHARMACEUTICAL UNIVERSITY   (Japan)

^c University of Bath   (United Kingdom)

^d IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^e UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Autophosphorylation; Lipid; Phosphoinositide 3 kinase; Phosphospecific antibodies

Indexed keywords

ANTISERUM; CD28 ANTIGEN; OKADAIC ACID; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE; PROTEIN TYROSINE KINASE; SERINE; WORTMANNIN; 2 MORPHOLINO 8 PHENYLCHROMONE; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; ANDROSTANE DERIVATIVE; CHROMONE DERIVATIVE; MORPHOLINE DERIVATIVE; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PHOSPHOPEPTIDE; PHOSPHOSERINE; RECOMBINANT PROTEIN;

ANIMAL CELL; ARTICLE; AUTOPHOSPHORYLATION; CARBOXY TERMINAL SEQUENCE; CELL LINE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME KINETICS; GENE MAPPING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; AMINO ACID SEQUENCE; BINDING SITE; DOWN REGULATION; GENETICS; LEUKEMIA CELL LINE; METABOLISM; MOLECULAR GENETICS; MUTATION; PEPTIDE MAPPING; PHOSPHORYLATION; SEQUENCE ALIGNMENT;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AMINO ACID SEQUENCE; ANDROSTADIENES; ANTIGENS, CD28; BINDING SITES; CHROMONES; DOWN-REGULATION; HUMANS; JURKAT CELLS; MOLECULAR SEQUENCE DATA; MORPHOLINES; MUTATION; PEPTIDE MAPPING; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; PHOSPHATIDYLINOSITOLS; PHOSPHOPEPTIDES; PHOSPHORYLATION; PHOSPHOSERINE; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION;

EID: 0033104502     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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