Evidence for high-affinity binding sites for the adenosine A2A receptor agonist [3H] CGS 21680 in the rat hippocampus and cerebral cortex that are different from striatal A2A receptors

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 353, Issue 3, 1996, Pages 261-271

  Cunha, Rodrigo A ^a   Johansson, Björn ^b   Constantino, M Dolores ^a   Sebastião, Ana M ^a   Fredholm, Bertil B ^b  

^a INSTITUTO GULBENKIAN DE CIÊNCIA   (Portugal)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Adenosine receptors; Cerebral cortex; CGS 21680; Hippocampus; Radioligand assay; Striatum

Indexed keywords

2 [(2 AMINOETHYLAMINO)CARBONYLETHYLPHENYLETHYLAMINO] 5 N ETHYLCARBOXAMIDOADENOSINE; 2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 2 ANILINOADENOSINE; 2 CHLOROADENOSINE; 8 (3 CHLOROSTYRYL)CAFFEINE; 8 (3,4 DIMETHOXYSTYRYL) 7 METHYL 1,3 DIPROPYLXANTHINE; 8 [4 (2 AMINOETHYLCARBAMOYL)METHOXYPHENYL] 1,3 DIPROPYLXANTHINE; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE A2A RECEPTOR; ADENOSINE A2A RECEPTOR AGONIST; ADENOSINE DEAMINASE; ADENOSINE RECEPTOR; ADENOSINE RECEPTOR BLOCKING AGENT; ADENOSINE RECEPTOR STIMULATING AGENT; CYCLOHEXYLADENOSINE; GUANYLYLIMIDODIPHOSPHATE; RADIOLIGAND; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING COMPETITION; BINDING SITE; BRAIN CORTEX; BRAIN REGION; BRAIN SYNAPTOSOME; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORPUS STRIATUM; HIPPOCAMPUS; LIGAND BINDING; MALE; NONHUMAN; RAT;

2-CHLOROADENOSINE; ADENOSINE; ANIMALS; BINDING, COMPETITIVE; CEREBRAL CORTEX; CORPUS STRIATUM; DOSE-RESPONSE RELATIONSHIP, DRUG; HIPPOCAMPUS; MALE; PHENETHYLAMINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P1; STRUCTURE-ACTIVITY RELATIONSHIP; XANTHINES;

EID: 0029670460     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00168627     Document Type: Article

References (43)

1. 2 adenosine receptor binding subunit by photoaffinity cross-linking. Proc Natl Acad Sci USA 86:6572-6576
2. 3H]phenylxanthine. Proc Natl Acad Sci USA 77: 5547-5551
3. 3H] NECA in rat striatal membranes. Mol Pharmacol 29:331-346
4. 1-selective adenosine antagonist 8-cyclopentyl-1,3-dipropylxanthine to rat brain membranes. Naunyn-Schmiedeberg's Arch Pharmacol 335:59-63
5. 3H]CV 1808) labels a novel adenosine receptor in rat brain. J Pharmacol Exp Ther 263:552-561
6. 3H]acetylcholine release from different areas of the rat hippocampus. J Neurochem 63:207-214
7. 2a receptor in the rat hippocampus. Brain Res 649:208-216
8. 3H]CGS 21680 are different in the hippocampus and cerebral cortex and in the striatum of the rat (abstract) Drug Dev Res 31:260
9. 3H]acetylcholine from the hippocampus and cerebral cortex of the rat: role of the ecto-nucleotidases. Eur J Neurosci 6:33-42
10. 2A receptors stimulate acetylcholine release from nerve terminals of the rat hippocampus. Neurosci Lett 196:41-44
11. de Mendonça A, Ribeiro JA (1994) Endogenous adenosine modulates long-term potentiation in the hippocampus. Neuroscience 62:385-390
12. Fredholm BB, Abbracchio MP, Burnstock G, Daly JW, Harden TK, Jacobson KA, Leff P, Williams M (1994) Nomenclature and classification of purinoceptors. Pharmacol Rev 46:143-156
13. 1 receptors in brain membranes. Mol Pharmacol 21:329-335
14. 2a adenosine receptors from rat striatum and rat pheochromocytoma PC12 cells: characterization with radioligand binding and by activation of adenylate cyclase. Mol Pharmacol 41:352-359
15. 2 selective adenosine receptor agonist with preferential hypotensive activity. J Pharmacol Exp Ther 251:47-55
16. Jacobson KA, Kirk KL, Padgett WL, Daly JW (1985) Functionalized congeners of 1,3-dialkylxanthines: preparation of analogues with high affinity for adenosine receptors. J Med Chem 28:1334-1340
17. Jacobson KA, Kirk KL, Padgett WL, Daly JW (1986) A functionalized congener approach to adenosine receptor antagonists: amino acid conjugates of 1,3-dipropylxanthine. Mol Pharmacol 29:126-133
18. 2 adenosine receptors. J Mol Recognit 2:170-178
19. 2-adenosine antagonist in vitro and in vivo. FEBS Lett 323:141-144
20. 2-selective adenosine antagonists. J Med Chem 36:1333-1342
21. James S, Xuereb JH, Askalan R, Richardson PJ (1992) Adenosine receptors in post-mortem human brain. Br J Pharmacol 105:238-244
22. 3H]CGS 21680. Eur J Pharmacol 168:243-246
23. 2 receptors in rat brain. J Pharmacol Exp Ther 251:888-893
24. 3H] CGS 21680 to rat brain using autoradiography. Neuropharmacol 34:393-403
25. 2 receptors in rat striatum. Biochem Pharmacol 44:2365-2370
26. 3H] CGS 21680 to rat cortex differs from its binding to rat striatum. Eur J Pharmacol 247:103-110
27. 3H]CGS 21680 binding sites in the rat striatum and cortex. Br J Pharmacol 114:537-543
28. 2a receptors. J Pharmacol Exp Ther 272:511-518
29. 125I] iodophenyl) ethylamino]adenosine. Mol Pharmacol 42:307-313
30. Munson PJ, Rodbard P (1980) LIGAND, a versatile computerized approach for characterization of ligand-binding systems. Anal Biochem 107:220-239
31. 2 receptor antagonist, to rat brain membranes. Mol Pharmacol 46:817-822
32. 2 antagonis,. (E)-1,3-dipropyl-8-(3,4-dimethoxystyryl)-7-methylxanthine. J Med Chem 36:3731-3733
33. Okada Y, Sakurai T, Mori M (1992) Excitatory effect of adenosine on neurotransmission is due to increase of transmitter release in the hippocampal slices. Neurosci Lett 142:233-236
34. O'Reagan MH, Simpson RH, Perkins LM, Phillis JW (1992) Adenosine receptor agonists inhibit the release of γ-aminobutyric acid (GABA) from the ischemic rat cerebral cortex. Brain Res 582:22-26
35. 2 adenosine receptors by two antipeptide antibody preparations. Mol Pharmacol 42:391-397
36. 2 receptor mRNA in the human brain. Neurosci Lett 130:177-181
37. 2 adenosine receptors in the rat hippocampus. Neurosci Lett 138:41-44
38. 2 antagonists. J Med Chem 35: 2342-2345
39. Spector T (1978) Refinement of the Coomassie Blue method of protein quantification. A simple and linear spectrophotometric assay for < 0.5 to 50 μg of protein. Anal Biochem 86:142-146
40. 2-adenosine receptor subtype. Mol Endocrinol 6:384-393
41. 3H]CGS 21680 to human and rat brain: evidence for multiple affinity sites. J Neurochem 55:1763-1771
42. 2b receptor in Xenopus oocytes. Mol Pharmacol 43:277-280
43. 3 adenosine receptor. Proc Natl Acad Sci USA 89:7432-7436