Contributions of Na+ flux and the anoxic depolarization to adenosine 5'-triphosphate levels in hypoxic/hypoglycemic rat hippocampal slices

Neuroscience

Volumn 83, Issue 3, 1998, Pages 717-722

  Fowler, J C ^a   Li, Y ^a  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER SCHOOL OF MEDICINE   (United States)

Author keywords

ATP; Hippocampus; Hypoglycemia; Hypoxia; Ischemia; Tetrodotoxin

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM ION; COBALT; DANTROLENE; DIZOCILPINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; SODIUM ION; TETRODOTOXIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN ELECTROPHYSIOLOGY; BRAIN HYPOXIA; BRAIN ISCHEMIA; BRAIN SLICE; DEPOLARIZATION; HIPPOCAMPUS; HYPOGLYCEMIA; ION CURRENT; MALE; NONHUMAN; PRIORITY JOURNAL;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANOXIA; ELECTROPHYSIOLOGY; HIPPOCAMPUS; HYPOGLYCEMIA; MALE; RATS; RATS, SPRAGUE-DAWLEY; SODIUM; TETRODOTOXIN;

EID: 0032484506     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(97)00460-0     Document Type: Article

References (27)

1. 1. Akaike N. and Takahashi K. (1992) Tetrodotoxin-sensitive calcium-conducting channels in the rat hippocampal CA1 region. J. Physiol., Lond. 450, 529-546.
2. 2. Balestrino M. (1995) Pathophysiology of anoxic depolarization: new findings and a working hypothesis. J. Neurosci. Meth. 59, 99-103.
3. 3. Boening J. A., Kass I. S., Cottrell J. E. and Chambers G. (1989) The effect of blocking sodium influx on anoxic damage in the rat hippocampal slice. Neuroscience 33, 263-268.
4. 4. Dux E., Schubert P. and Kreutzberg G. W. (1992) Ultrastructural localization of calcium in ischemic hippocampal slices: the influence of adenosine and theophylline. J. cerebr. Blood Flow Metab. 12, 520-524.
5. 2+ concentration in response to oxygen-glucose deprivation in rat hippocampal slices. Neurosci. Lett. 168, 155-158.
6. 6. Fowler J. C. (1990) Adenosine antagonists alter the synaptic response to in vitro ischemia in the rat hippocampus. Brain Res. 509, 331-334.
7. 7. Fowler J. C. (1993) Purine release and inhibition of synaptic transmission during hypoxia and hypoglycemia in rat hippocampal slices. Neurosci. Lett. 157, 83-86.
8. 8. Fredholm B. B. and Lloyd H. G. (1990) Sources of adenosine released from hippocampal slices following electrical and hypoxic/hypoglycemic stimulation. Ann. N. Y. Acad. Sci. 603, 497-499.
9. 9. Gerber U. and Gahwiler B. H. (1991) Cobalt blocks postsynaptic response induced by neurotransmitters in the hippocampus in vitro. Neurosci. Lett. 134, 53-56.
10. 10. Hansen A. J. (1985) Effects of anoxia on ion distribution in the brain. Physiol. Rev. 65, 101-148.
11. 11. Kass I. S., Abramowicz A. E., Cottrell J. E. and Chambers G. (1992) The barbiturate thiopental reduces ATP levels during anoxia but improves electrophysiological recovery and ionic homeostasis in the rat hippocampal slice. Neuroscience 49, 537-543.
12. 12. Kass I. S., Chambers G. and Cottrell J. E. (1989) The N-methyl-D-aspartate antagonists aminophosphonovaleric acid and MK-801 reduce anoxic damage to dentate granule and CA1 pyramidal cells in the rat hippocampal slice. Expl Neurol. 103, 116-122.
13. 13. Kass I. S., Cottrell J. E. and Chamber G. (1988) Magnesium and cobalt, not nimodipine, protect neurons against anoxic damage in the rat hippocampal slice. Anesthesiology 69, 710-715.
14. 14. Kass I. S. and Lipton P. (1986) Calcium and long-term transmission damage following anoxia in dentate gyrus and CA1 regions of the rat hippocampal slice. J. Physiol., Lond. 378, 313-334.
15. 15. Kass I. S. and Lipton P. (1982) Mechanisms involved in irreversible anoxic damage to the in vitro rat hippocampal slice. J. Physiol., Lond. 332, 459-472.
16. 16. Kass I. S. and Lipton P. (1989) Protection of hippocampal slices from young rats against anoxic transmission damage is due to better maintenance of ATP. J. Physiol., Lond. 413, 1-11.
17. 17. Latini S., Corsi C., Pedata F. and Pepeu G. (1995) The source of brain adenosine outflow during ischemia and electrical stimulation. Neurochem. Int. 27, 239-244.
18. 18. Lipton P. and Whittingham T. S. (1982) Reduced ATP concentration as a basis for synaptic transmission failure during hypoxia in the in vitro guinea-pig hippocampus. J. Physiol., Lond. 325, 51-65.
19. 19. Lobner D. and Lipton P. (1993) Intracellular calcium levels and calcium fluxes in the CA1 region of the rat hippocampal slice during in vitro ischemia: relationship to electrophysiological cell damage. J. Neurosci. 13, 4861-4871.
20. 2+ and energy levels during in vitro ischemia in the gerbil hippocampal slice. J. Neurochem. 62, 626-634.
21. 2+ elevation induced by in vitro ischemia-like condition in hippocampal slices. Brain Res. 601, 103-110.
22. 22. Papas S., Crépel V. and Ben-Ari Y. (1993) The NMDA receptor contributes to anoxic aglycemic induced irreversible inhibition of synaptic transmission. Brain Res. 607, 54-60.
23. 23. Pedata F., Latini S., Pugliese A. M. and Pepeu G. (1993) Investigations into the adenosine outflow from hippocampal slices evoked by ischemia-like conditions. J. Neurochem. 61, 284-289.
24. 24. Taylor C. P. and Dudek E. (1984) Synchronization without active chemical synapses during hippocampal after discharge. J. Neurophysiol. 52, 143-155.
25. 25. Weber M. L. and Taylor C. P. (1994) Damage from oxygen and glucose deprivation in hippocampal slices is prevented by tetrodotoxin, lidocaine and phenytoin without blockade of action potentials. Brain Res. 664, 167-177.
26. 26. Whittingham T. S., Lust W. D. and Passonneau J. V. (1984) An in vitro model of ischemia: metabolic and electrical alterations in the hippocampal slice. J. Neurosci. 4, 793-802.
27. 27. Young J. N., Aitken P. G. and Somjen G. G. (1991) Calcium, magnesium, and long-term recovery from hypoxia in hippocampal tissue slices. Brain Res. 548, 343-345.