The role of adenosine A2a receptors in regulating GABAergic synaptic transmission in striatal medium spiny neurons

Journal of Neuroscience

Volumn 16, Issue 2, 1996, Pages 605-611

  Mori, Akihisa ^a   Shindou, Tomomi ^a   Ichimura, Michio ^a   Nonaka, Hiromi ^a   Kase, Hiroshi ^a  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

Adenosine; Adenosine receptor; cAMP; CGS 21680; GABA; IPSC; IPSP; KF17837; Striatum

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 4 AMINOBUTYRIC ACID; ADENOSINE; ADENOSINE RECEPTOR; CYCLIC AMP; DRUG DERIVATIVE; PHENETHYLAMINE DERIVATIVE; 8 (3,4 DIMETHOXYSTYRYL) 7 METHYL 1,3 DIPROPYLXANTHINE; ADENOSINE A1 RECEPTOR ANTAGONIST; ADENOSINE A2 RECEPTOR; CYCLIC AMP DERIVATIVE;

ANIMAL; ARTICLE; CELL MEMBRANE POTENTIAL; CORPUS STRIATUM; DOSE RESPONSE; DRUG EFFECT; PATCH CLAMP; PHYSIOLOGY; RAT; SYNAPTIC TRANSMISSION; WISTAR RAT; ANIMAL TISSUE; CONTROLLED STUDY; INHIBITORY POSTSYNAPTIC POTENTIAL; NERVE CELL; NONHUMAN; PRIORITY JOURNAL;

ADENOSINE; ANIMALS; CORPUS STRIATUM; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; GAMMA-AMINOBUTYRIC ACID; MEMBRANE POTENTIALS; PATCH-CLAMP TECHNIQUES; PHENETHYLAMINES; RATS; RATS, WISTAR; RECEPTORS, PURINERGIC P1; SYNAPTIC TRANSMISSION;

EID: 0029670648     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.16-02-00605.1996     Document Type: Article

References (36)

1. Abbracchio MP, Flaminio C, Fredholm BB, Williams M (1993) Purinoceptor nomenclature: a status report. Drug Dev Res 28:207-213.
2. Fredholm BB, Dunwiddie TV (1988) How does adenosine inhibit transmitter release? Trends Pharmacol Sci 9:130-137.
3. Garthwaite J, Garthwaite G (1987) Cellular origins of cyclic GMP responses to excitatory amino acid receptor agonists in rat cerebellum in vitro. J Neurochem 48.29-39.
4. Gerfen CR (1992) The neostriatal mosaic: multiple levels of compartmental organization in the basal ganglia. Annu Rev Neurosci 15:285-320.
5. Graybiel AM (1990) Neurotransmitters and neuromodulators in the basal ganglia. Trends Neurosci 13:244-254.
6. Groves PM (1983) A theory of the functional organization of the neostriatum and the neostriatal control of voluntary movement. Brain Res Rev 5:109-132.
7. 2a adenosine receptors from rat striatum and rat pheochromocytoma PC12: characterization with radioligand binding and by activation of adenylate cyclase. Mol Pharmacol 41:352-359.
8. Jaeger D, Kita H, Wilson CJ (1994) Surround inhibition among projection neurons is weak or nonexistent in the rat neostriatum. J Neurophysiol 72:2555-2558.
9. 3H]CGS21680. Eur J Pharmacol 168:243-246.
10. 2 receptors in rat brain. J Pharmacol Exp Ther 251:888-893.
11. Jiang Z-G, North RA (1991) Membrane properties and synaptic responses of rat striatal neurones in vitro. J Physiol (Lond) 443:533-553.
12. 2a receptor in GABAergic synaptic transmission in the striatum (Abstr). Br J Pharmacol 114:300A.
13. Kita H (1993) GABAergic circuits of the striatum. In: Progress in brain research. Vol 99 (Arbuthnott GW, Emson PC, eds), pp 51-72. New York: Elsevier.
14. Kita T, Kita H, Kitai ST (1984) Passive electrical membrane properties of rat neostriatal neurons in an in vitro slice preparation. Brain Res 300:129-139.
15. 3H]acetylcholine release. J Neurochem 62:960-966.
16. 2a receptor-mediated modulation of striatal GABA and ACh release. Br J Pharmacol 113:43-48.
17. Lohse MJ, Klotz KN, Lindenborn-Fotinos J, Reddington M, Schwabe U, Olsson RA (1987) 8-Cyclopentyl-1,3-dipropylxanthine (DPCPX): a selective high affinity antagonist radioligand for A1 adenosine receptors. Naunyn Schmiedebergs Arch Pharmacol 336:204-210.
18. 2 receptor agonist CGS-21680 on in vitro electrophysiology, cAMP formation and dopamine release in rat hippocampus and striatum. J Pharmacol Exp Ther 252:1134-1141.
19. 2 receptors: selective location in the human basal ganglia and alterations with disease. Neuroscience 42:697-706.
20. 2a receptor modulation of electrically evoked endogenous GABA release from slices of rat globus pallidus. J Neurochem 60:2334-2337.
21. 2a receptor in GABAergic synaptic transmissions in the striatum. Neurosci Res [Suppl] 19:S52.
22. Mori A, Takahashi T, Miyashita Y, Kasai H (1994b) Two distinct glutamatergic synaptic inputs to striatal medium spiny neurones of neonatal rats and paired-pulse depression. J Physiol (Lond) 476:217-228.
23. Mori A, Takahashi T, Miyashita Y, Kasai H (1994c) Quantal properties of H-type glutamatergic synaptic input to the striatal medium spiny neurons. Brain Res 654:177-179.
24. Nicoll RA, Malenka R, Kauer JA (1990) Functional comparison of neurotransmitter receptor subtypes in mammalian central nervous system. Physiol Rev 70:513-565.
25. 2 receptor antagonist. Eur J Pharmacol 267:335-341.
26. 2 receptor antagonist, to rat brain membranes. Mol Pharmacol 46:817-822.
27. 3H]CGS-21680 as a ligand. Naunyn Schmiedebergs Arch Pharmacol 342:85-89.
28. 2 receptor (RDC8) is expressed by enkephalin but not by substance P neurons: an in situ hybridization histochemistry study. J Neurochem 57:1062-1067.
29. Schiffmann SN, Libert F, Vassart G, Dumont JE, Vanderhaeghen J-J (1990) A cloned G protein-coupled protein with a distribution restricted to striatal medium-sized neurons. Possible relationship with D1 dopamine receptor. Brain Res 519:333-337.
30. 2 receptor mRNA in the human brain. Neurosci Lett 130:177-181.
31. 2 antagonist. J Med Chem 35:2342-2345.
32. Shindou T, Watanabe S, Kamata O, Yamamoto K, Nakanishi H (1994) Calcium-dependent hyperexcitability of hippocampal CA1 pyramidal cells in an in vitro slice after ethanol withdrawal of the rats. Brain Res 656:432-436.
33. Suzuki F, Shimada J, Mizumoto H, Karasawa A, Kubo K, Nonaka H, Ishii A, Kawakita T (1992) Adenosine A1 antagonists. II. Structure-activity relationships on diuretic activities and protective effects against acute renal failure. J Med Chem 35:3066-3075.
34. 6-Bicycloalkyladenosine with unusually high potency and selectivity for adenosine A1 receptor. J Med Chem 32:8-11.
35. Van Calker D, Müller M, Hamprecht B (1979) Adenosine regulates via different types of receptors: the accumulation of cyclic AMP in cultured brain cells. J Neurochem 33:999-1005.
36. Van der Kloot W (1991) The regulation of quantal size. Prog Neurobiol 36:93-130.