Adenosine A(2B) receptors

Pharmacological Reviews

Volumn 49, Issue 4, 1997, Pages 381-402

  Feoktistov, Igor ^a   Biaggioni, Italo ^a  

^a VANDERBILT UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,3 DIPROPYL 8 (4 SULFOPHENYL)XANTHINE; 2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 4 [2 [7 AMINO 2 (2 FURYL) 1,2,4 TRIAZOLO[2,3 A][1,3,5]TRIAZIN 5 YLAMINO]ETHYL]PHENOL; 5 AMINO 2 (2 FURYL) 7 (2 PHENYLETHYL)PYRAZOLO[4,3 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; 6 N CYCLOPENTYLADENOSINE; 8 (3,4 DIMETHOXYSTYRYL) 7 METHYL 1,3 DIPROPYLXANTHINE; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; 9 METHYL 6 N (2 NORBORNYL)ADENINE; ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE A2A RECEPTOR; ADENOSINE A2B RECEPTOR; ADENOSINE RECEPTOR BLOCKING AGENT; ADENOSINE RECEPTOR STIMULATING AGENT; ENPROFYLLINE; FLAVINE MONONUCLEOTIDE; GUANINE NUCLEOTIDE BINDING PROTEIN; PHENYLISOPROPYLADENOSINE; THEOPHYLLINE; ADENOSINE RECEPTOR;

ASTHMA; BLOOD VESSEL TONE; CELL GROWTH; DRUG SELECTIVITY; DRUG TARGETING; HEART MUSCLE CONTRACTILITY; HUMAN; INHALATIONAL DRUG ADMINISTRATION; INTESTINE CONTRACTION; INTRAVENOUS DRUG ADMINISTRATION; MAST CELL; NEUROSECRETION; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECEPTOR DENSITY; RECEPTOR DOWN REGULATION; REVIEW; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; ANIMAL; CELL DIVISION; CLASSIFICATION; DRUG EFFECT; DRUG POTENTIATION; HEART; HEART CONTRACTION; INTESTINE; METABOLISM; MOLECULAR GENETICS; NON-PROGRAMMATIC; PHYSIOLOGY; SEQUENCE HOMOLOGY; SYNAPTIC TRANSMISSION;

NON-PROGRAMMATIC;

AMINO ACID SEQUENCE; ANIMALS; ASTHMA; CELL DIVISION; HEART; INTESTINES; MAST CELLS; MOLECULAR SEQUENCE DATA; MYOCARDIAL CONTRACTION; RECEPTOR, ADENOSINE A2B; RECEPTORS, PURINERGIC P1; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; SYNAPTIC TRANSMISSION;

EID: 0031283107     PISSN: 00316997     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (219)

1. AATSINKI, J. T., PIETILA, E. M., LAKKAKORPI, J. T., AND RAJANIEMI, H. J.: Expression of the LH/CG receptor gene in rat ovarian tissue is regulated by an extensive alternative splicing of the primary transcript. Mol. Cell. Endocrinol. 84: 127-135, 1992.
2. 2B4 cells. Br. J. Pharmacol. 119: 1286-1290, 1996.
3. ALI, S., MUSTAFA, S. J., AND METZGER, W. J.: Adenosine-induced bronchoconstriction and contraction of airway smooth muscle from allergic rabbits with late-phase airway obstruction: evidence for an inducible adenosine A1 receptor. J. Pharmacol. Exp. Ther. 94: 1328-1334, 1994a.
4. ALI, S., MUSTAFA, S. J., AND METZGER, W. J.: Adenosine receptor-mediated bronchoconstriction and bronchial hyperresponsiveness in allergic rabbit model. Am. J. Physiol. 94: L271-L277, 1994b.
5. ALTIOK, N., BALMFORTH, A. J., AND FREDHOLM, B. B.: Adenosine receptor-induced cAMP changes in D384 astrocytoma cells and the effect of bradykinin thereon. Acta Physiol. Scand. 144: 55-63, 1992.
6. ALTIOK, N., AND FREDHOLM, B. B.: Bradykinin inhibits cyclic AMP accumulation in D384 human astrocytoma cells via a calcium-dependent inhibition of adenylyl cyclase. Cell. Signalling 5: 279-288, 1993.
7. 13, a G protein alpha subunit specifically expressed in hematopoietic cells. Proc. Natl. Acad. Sci. USA 88: 5587-5591, 1991.
8. ARAI, A., AND LYNCH, G.: Factors regulating the magnitude of long-term potentiation induced by theta pattern stimulation. Brain Res. 598: 173-184, 1992.
9. 3 adenosine receptors mediate degranulation of canine BR mastocytoma cells. (Abstract) Drug Dev. Res. 37: 147, 1996.
10. BALWIERCZAK, J. L., SHARIF, R., KRULAN, C. M., FIELD, F. P., WEISS, G. B., AND MILLER, M. J.: Comparative effects of a selective adonosine A2 receptor agonist, CGS 21680, and nitroprasside in vascular smooth muscle. Eur. J. Pharmacol. 196: 117-123, 1991.
11. BARRACO, R. A., EL-RIDI, M. R., ERGENE, E., AND PHILLIS, J. W.: Adenosine receptor subtypes in the brainstem mediate distinct cardiovascular response patterns. Brain Res. Bull. 26: 59-84, 1991.
12. BELARDINELLI, L., LINDEN, J., AND BERNE, R. M.: The cardiac effects of adenosine. Prog. Cardiovasc. Dis. 32: 73-97, 1988.
13. 3H]SCH 58261 to coronary artery membranes. Circ. Res. 79: 1153-1160, 1996.
14. BIAGGIONI, I.: Contrasting excitatory and inhibitory effects of adenosine in blood pressure regulation. Hypertension 20: 457-465, 1992.
15. BJÖRCK, T., GUSTAFSSON, L. E., AND DAHLÉN, S. E.: Isolated bronchi from asthmatics are hypcrresponsive to adenosine, which apparently acts indirectly by liberation of leukotrienes and histamine. Am. Rev. Respir Dis. 145: 1087-1091, 1992.
16. 2 receptors in bovine retinal pigment epithelial membranes. Exp. Eye Res. 56: 595-599, 1993.
17. BOYLE, D. L., SAJJADI, F. G., AND FIRESTEIN, G. S.: Inhibition of synoviocyte collagennse gene expression by adenosine receptor stimulation. Arthritis Rheum. 39: 923-930, 1996.
18. 2b adenosine receptor in NIH 3T3 fibroblasts. Biochem. Pharmacol. 47: 801-814, 1994.
19. BRUNS, R. F.: Adenosine antagonism by purines, pteridines and benzopteridines in human fibroblasts. Biochem. Pharmacol. 30: 325-333, 1981.
20. 1-selective adenosine antagonist 8-cyclopentyl-l,3-dipropylxanthine to rat brain membranes. Naunyn-Schmiedeberg's Arch. Pharmacol. 335: 59-63, 1987.
21. 3H]NECA in rat striatal membranes. Mol. Pharmacol. 29: 331-346, 1986.
22. BURNSTOCK, G.: A basis for distinguishing two types of purinergic receptors. In Cell Membrane Receptors for Drugs and Hormones: A Multidisciplinary Approach, ed. by R. W. Straub and L. Bolis, pp. 107-118, Raven Press, New York, 1978.
23. 2b subtype. J. Neurochem. 59: 425-431, 1992.
24. 2n receptors on soma and central terminals of rat vagal afferent neurons. Brain Res. 94: 137-144, 1994.
25. CHERN, Y., LAI, H. L., FONG, J. C., AND LIANG, Y.: Multiple mechanisms for desensitization of A2a adenosine receptor-mediated cAMP elevation in rat pheochromocytoma PC12 cells. Mol. Pharmacol. 44: 950-958, 1993.
26. CHIANG, P. H., WU, S. N., TSAI, E. M., WU, C. C., SHEN. M. R., AND HUANG, C. H.: Adenosine modulation of neurotransmission in penile erection. Br. J. Clin. Pharmacol. 38: 357-362, 1994.
27. CHURCH, M. K., AND HOLGATE, S. T.: Adenosine and asthma. Trends Pharmacol. Sci. 7: 49-50, 1986.
28. CHURCH, M. K., HUGHES, P. J., AND VARDEY, C. J.: Studies on the receptor mediating cyclic AMP-independcnt enhancement by adenosine by IgE-dependent mediator release from rat mast cells. Br. J. Pharmacol. 87: 233-242, 1986.
29. CUSHLEY, M. J., TATTERSFIELD, A. E., AND HOLGATE, S. T.: Adenosine-induced bronchoconstriction in asthma. Am. Rev. Respir. Dis. 129: 380-384, 1984.
30. DALY, J. W., The nature of receptors regulating the formation of cyclic AMP in brain tissue. Life Sci. 18: 1349-1358, 1976.
31. DALY, J. W., BUTTS-LAMB. P., AND PADGETT, W.: Subclasses of adenosins receptors in the central nervous system: interaction with caffeine und related methylxanthines. Cell. Mol. Neurobiol. 3: 69-80, 1983.
32. DALZIEL, H. H., AND WESTFALL, D. P.: Receptors for adenine nucleotidos and nucleosides: subclassification, distribution, and molecular characterization. Pharmacol. Rev. 46: 449-466, 1994.
33. 2 receptors? Pharmacol. Ther, 71: 325-335, 1996.
34. DELL, K. R., AND WILLIAMS, L. T.: A novel form of fibroblast growth factor receptor 2: alternative splicing of the third immunuglobulin-like domain confers ligand binding specificity. J. Biol. Chem. 267: 21225-21229, 1992.
35. DE MENDONCA, A., AND RIBEIRO, J. A.: Endogenous adenosine modulates long-term potentiation in the hippocampus. Neuroscience 62: 385 -390, 1994.
36. 3H]SCH 58261. J. Pharmacol. Exp. Ther. 278: 1209 -1214, 1996.
37. DlXON, K. D., GUBITZ, A. K., SlRINATHSINGHJI, D. J. S., RICHARDSON, P. J., AND FREEMAN, T. C.: Tissue distribution of adenosine receptor mRNAs in the rat. Br. J. Pharmacol. 118: 1461-1468, 1996.
38. 2 receptor function in rat ventricular myocytes. Cardiovasc. Res. 34: 337-347, 1997.
39. DRAGUNOW, M., AND FAULL, R. L. M.: Neuroprotectivc effects of adenosine. Trends Pharmacol. Sci. 9: 193-194, 1988.
40. DRAKE, I., ROUTLEDGE, P. A., AND RICHARDS, R.: Bronchospasm induced by intravenous adenosine. Hum. & Exp. Toxicol. 13: 263-265, 1994.
41. DRURY, A. W., AND SZENT-GYÖRGYI, A.: The physiological activity of adenosine compounds with a special reference to their action upon the mammalian heart. J. Physiol. 68: 213-237, 1929.
42. DUBEY, R. K., GILLESPIE, D. G., Ml, Z., SUZUKI, F., AND JACKSON, E. K.: Smooth muscle cell-derived adenosine inhibits cell growth. Hypertension 27: 766-773, 1996a.
43. 2b receptor. Hypertension 27: 786-793, 1996b.
44. 1 receptors inhibit adenylate cyclase activity and neurotransmitter release and hyperpolarize pyramidal neurons in rat hippocampus. J. Pharmacol. Exp. Thcr. 249: 31-37, 1989.
45. EAGLE, K. A., AND BOUCHER. C. A.: Intravenous dipyridamole infusion causes severe bronchospasm in asthmatic patients. (Editorial) Chest 95: 258-289, 1989.
46. ELFMAN, L., LINDGREN, E., WALUM, E., AND FREDHOLM, B. B.: Adenosine analogues stimulate cyclic AMP-accumulation in cultured neuroblastoma and gliomA cells. Acta Pharmacol. Toxicol. 55: 297-302, 1984.
47. FALCONE, J. C., KUO, L., AND MEININGER, G. A.: Endothelial cell calcium increase during flow-induced dilation in isolated arterioles. Am. J. Physiol. 264: H653-H659, 1993.
48. FARMER, S. G., CANNING. B. J., AND WILKINS, D. E.: Adenosine receptor-mediated contraction and relaxation of guinea-pig isolated tracheal smooth muscle: effects of adenosine antagonists. Br. J. Pharmacol. 95: 371-378, 1988.
49. 2 receptors. Mol. Pharmacol. 43: 909-914, 1993.
50. 2b receptors evoke interleukin-8 secretion in human mast cells: an enprofylline-sensitive mechanism with implications for asthma. J. Clin. Invest. 96: 1979-1986, 1995.
51. FEOKTISTOV, I., AND BIAGGIONI, I.: Role of adenosine in asthma. Drug Dev. Res. 39: 333-336, 1996.
52. 2B adenosine receptor subtypes. Biochem. Pharmacol., in press, 1997.
53. FEOKTISTOV, I., BREYER, R. M., AND BIAGGIONI, I.: Prostanoid receptor with a novel pharmacolgical profile in human erythroleukemia cells. Biochem. Pharmacol. 54: 917-926, 1997.
54. 1 receptors via a cholera toxin-sensitive mechanism in human erythroleukemia cells. Mol. Pharmacol. 45: 1160-1167, 1994.
55. 2b receptors in human lung mast cells as a target for antiasthmatic methylxanthines. (Abstract) FASEB J. 10: A1232, 1996.
56. 2b receptors mediate an increase in interleukin (IL)-6 mRNA and IL-6 protein synthesis in human astroglioma cells. J. Neurochem. 66: 1426-1431, 1996a.
57. 2A receptors. Glia 18: 152-160, 1996b.
58. FREDHOLM, B. B.: Purinoceptors in the nervous system. Pharmacol. Toxicol. 76: 228-239, 1995.
59. FREDHOLM, B. B., ABBRACCHIO, M. P., BURNSTOCK, G., DALY, J. W., HARDEN, T. K., JACOBSON, K. A., LEFF, P., AND WILLIAMS, M.: Nomenclature and classification of purinoceptors. Pharmacol. Rev. 46: 143-156, 1994.
60. FREDHOLM, B. B., ABBRACCHIO, M. P., BURNRTOCK, G., DUBYAK, G. R., HARDEN, T. K., JACOBSON, K. A., SCHWABE, U., AND WILLIAMS, M.: Towards a revised nomenclature for P1 and P2 receptors. Trends Pharmucol. Sci, 18: 79-82, 1997.
61. FREDHOLM, B. B., ARSLAN, G., KULL, B., KONTNY, E., AND SVENNINGSSON, P.: Adenosine (P1) receptor signaling. Drug Dev. Res. 39: 262-268, 1996a.
62. FREDHOLM, B. B., BURNSTOCK. G., HARDEN, T. K., AND SPEDDING, M.: Receptor nomenclature. Drug Dev. Res. 39: 461-466, 1996b.
63. FREDHOLM, B. B., LINDGREN, E., LINDSTRÖM, K., AND NORSTEDT, C.: Alpha-adrenoreceptor stimulation, but not muscarinic stimulation, increases cyclic AMP accumulation in brain slices due to protein kinase C mediated enhancement of adenosine receptor effects, Acta Physiol. Scand. 131: 543-551, 1987.
64. FREDHOLM, B. B., AND PERSSON, C. G.: Xanthine derivatives as adenosine receptor antagonists. Eur. J. Pharmacol. 81: 673-676, 1982.
65. FREDHOLM, B. B., AND SANDBERG, G.: Inhibition by xanthine derivatives of adenosine receptor-stimulated cyclic adenosine 3′-5′-munophosphate accumulation in rat and guinea-pig thymocytes. Br. J. Pharmacol. 80: 639-644, 1983,
66. 2A receptors mediate the inhibitory effect of adenusine on formyl-Met-Leu-Phe-stimulated respiratory burst in neutruphil leucocytes. Naunyn-Schmiedeberg's Arch. Pharmacol. 354: 262-267, 1996c.
67. FURCHGOTT, R. F.: The role of endothelium in the responses of vascular smooth muscle to drugs. Ann. Rev. Pharmueol Toxicol 24: 175-197, 1984.
68. 3-selectivc adenosine agonists. J. Med. Chem. 37: 636-646, 1994.
69. GERGEN, P. J., MULLALLY, D. I., AND EVANS, R., III.: National survey of prevalence of asthma among children in the United States. 1976 to 1980. Pediatrics 81: 1-7, 1988.
70. 1 MK-2 smooth muscle cells. Mol. Pharmacol. 40: 149-155, 1991.
71. 2 adenosine receptors in guinea pig trachea. Life Sci. 41: 1215-1224, 1987.
72. 2b receptor in the rat pineal gland. Eur. J. Pharmacol. 225: 359-360, 1992.
73. 2 dopamine receptor isoforms. Nature (Lond) 342: 923-926, 1989.
74. 2 adenosine receptors inhibits the ingestion of photoreceptor outer segments by retinal pigment epithelium. Invest. Ophthalmol. Visual Sci. 35: 819-825, 1994.
75. HANCOCK, U. L., AND COUPAR, I. M.: Functional characterization of the adenosine receptor mediating inhibition of intestinal secretion, Br. J. Pharmacol. 114: 152-156, 1995.
76. 2B subtype. (Abstract) Br. J. Pharmacol. 102: 198P, 1991.
77. HAYNES, J. J., OBIKAO, B., THOMPSON, W. J., AND DOWNEY, J.: Adenosine-induced vasodilation: receptor characterization in pulmonary circulation. Am. J. Physiol. 268: H1862-H1868, 1995.
78. HEADRICK, J. P., AND BERNE, R. M.: Endothelium-dependent and -independent relaxations to adenosine in guinea pig aorta. Am. J. Physiol. 259: H62-H67, 1990.
79. 2 adenosine receptors from rat striatum and rat pheochromocytoma PC12 cells: characterization with radioligand binding and by activation of adenylate cyclase. Mol. Pharmacol. 41: 352-359, 1992.
80. HOLLlNGSWORTH, E. B., SEARS, E. B., AND DALY, J. W.: An activator of protein kinase C (phorbol-12-myristate-13-acetate) augments 2-chloradenosine-elicited accumulation of cyclic AMP in guinea pig cerebral cortical particulate preparations. FEBS Lett. 184: 339-342, 1985.
81. HÖSLI, E., AND HÖSLI, L. : Autoradiographic studies on the uptake of adenosine and on binding of adenosine analogues in neurons and astrocytes of cultured rat cerebellum and spinal cord. Neuroscience 24: 621-628, 1988.
82. HOURANI, S. M., NICHOLAS, J., LEE, B. S., HALFHIDE, E. J., AND KITCHEN, I.: Characterization and ontogeny of P1-purinoceptors on rat vas deferens. Br. J. Pharmacol. 108: 754-758, 1993.
83. 8 directly activates cardiac calcium channels in lipid bilayers. Am. J. Physiol. 255: H722-H728, 1988.
84. 2 receptor-cAMP system in human aortic endothelial cells. Biochem. Biophys. Res. Commun. 199: 905-910, 1994.
85. 3-adenoaine and ATP receptors. (Abstract) Drug Dev. Res. 37: 112, 1996.
86. JACOBSON, K. A., AND SUZUKI, F.: Recent developments in selective agonists and antagonistS acting at purine and pyrimidine receptors. Drug Dev. Res. 39: 289-300, 1996.
87. JACOBSON. K. A., VAN GALEN, P. J. M., AND WILLIAMS, M.: Perspective: adenosine receptors - pharmacology, structure-activity relationships and therapeutic potential. J. Med. Chem. 35: 407-422, 1992.
88. 3 adenosine receptor antagonists. (Abstract) Drug Dev. Res. 37: 131, 1996.
89. 2b adenosine receptor gene (ADORA2B) and its pseudogene. Genomics 27: 374-376, 1995.
90. 2 adenosine receptor agonist directly labels A2 receptors in rat brain. J. Pharmacol. Exp. Ther. 251: 888-893, 1989.
91. 3 adenosine receptor antagonists. J. Med. Chem. 39: 4667-4675, 1998.
92. 3 adenosine receptor antagonists. J. Med. Chem. 39: 2293-2301, 1996.
93. KENAKIN, T, P., BOND, R. A., AND BONNER, T. I.: Definition of pharmacological receptors. Pharmacol. Rev. 44: 351-361, 1992.
94. 2 receptors in the induction of long-term potentiation in the CA1 region of rat hippocampus. Brain Res. 756: 184-190, 1997.
95. KILIC, S., SALIH, M., ANAFARTA, K., BALTACI, S., AND KOSAR, A.: Adenosine: a new agent in the diagnosis of impotence. Int. J. Impot. Res. 6: 191-198, 1994.
96. 1 adenosine receptors in brain from different species by radioligand binding and photoaffinity labeling Naunyn-Schmiedeberg's Arch. Pharmacol. 343: 196-201, 1991.
97. KONTNY, E., KVANTA, A., AND FREDHOLM, B. B.: Activation of protein kinase C and elevation of cAMP interact synergistically to raise c-Fos, c-June and AP-1 activity in Jurkat cells. Eur. J. Pharmncol. 227: 333-338, 1992.
98. KVANTA, A., AND FREDHOLM, B. B.: Synergistic effects between protein kinase C and cAMP on activator protein-1 activity and differentiation of PC-12 phnochromocytoma cells. J. Mol. Neurosci. 4: 205-214, 1994.
99. KVANTA, A., GERWINS, P., JONDAL, M., AND FREDHOLM, B. B.: Stimulation of T-cells OKT3 antibodies increases forskolin binding and cyclic AMP accumulation. Cell Signalling 2: 461-470, 1990.
100. KVANTA, A., KONTNY, E., JONDAL, M., OKRET, S., AND FREDHOLM, B. B.: Mitogen stimulation of T-cells increases c-Fos and c-Jun protein levels, AP-1 binding and AP-1 transcriptional activity. Cell Signalling 4: 275-286, 1992.
101. KVANTA, A., NORSTEDT, C., JONDAL, M., AND FREDHOLM, B. B.: Activation of protein kinase C via the T-receptors potentiates cyclic AMP responses in T-cells. Naunyn-Schmiedeberg's Arch. Phurmacol. 340: 715-717, 1989.
102. 2a receptor. Nature (Lond.) 388: 674-678, 1997.
103. 2 receptor. J. Pharmacol. Exp. Ther. 257: 1013-1019, 1991.
104. LlANG, B. T., AND HALZIWANGER, B.: Adenosine A2a and A2b receptors in cultured fetal chick heart cells: high- and low-affinity coupling to stimulation of myocyle contractility and cAMP accumulation. Circ. Res. 76: 242-251, 1995.
105. 2a receptor in the intact cardiac cell. J. Biol. Chem. 271: 18678-18685, 1996.
106. 1 adenosine receptor. EMBO J. 10: 1677-1682, 1991.
107. 1 adenosine receptors. FASEB J. 5: 2668-2676, 1991.
108. 3 receptors: pharmacological properties, species differences and receptor functions. Trends Pharmacol. Sci 15: 298-306, 1994.
109. 3 adenosine receptor with widespread tissue distribution. Mol. Pharmacol. 44: 524-532, 1993.
110. 3H]-CGS 21680 in the rat brain. Naunyn-Schmiedeberg's Arch. Pharmacol. 354: 539-541, 1996.
111. LONDOS, C., COOPER, D. M. F., AND WOLFF, J.: Subclasses of external adenosine receptors. Proc. Natl. Acad. Sci. USA 77: 2551-2554, 1980.
112. 2 receptor agonist CGS21680 on in vitro electrophysiology, cAMP formation and dopamine release in rat hippocampus and striatum. J. Pharmacol. Exp. Ther. 252: 1134-1141, 1990.
113. MADARA, J. L., PATAPOFF, T. W., GILLECE-CASTRO, B., COLGAN, S. P., PARKOS, C. A., DELP, C., AND MRSNY, R. J.: 5′-adenosine monophosphate is the neutrophil-derived paracrine factor that elicits chloride secretion from T84 intestinal epithelial cell monolayers. J. Clin. Invest. 91: 2320-2325, 1993.
114. MAEKAWA, K., SAITO, D., OBAYASHI, N., UCHIDA, S., AND HARAOKA, S.: Role of endothelium-derived nitric oxide and adenosine in functional myocardial hyperemia. Am. J. Physiol. 267: H166-H173, 1994.
115. 2 receptor with physiological constitutive activity. Biochem. Biophys. Res, Commun. 173: 1169-1178, 1990.
116. MANN, J. S., AND HOLGATE, S. T.: Specific antagonism of adenosine-induced bronchoconstriction is asthma by oral theophylline. Br. J. Clin. Pharmacol 19: 685-692, 1985.
117. MARQUARDT, D. L., PARKER, C. W., AND SULLLIVAN, T. J.: Potcntiation of mast cell mediator release by adenosine, J. Immunol. 120: 871-878, 1978.
118. MARQUARDT, D. L., AND ALKER, L. L.: Modulation of mast cell responses to adenosine by agents that alter protein kinase C activity. Biochem. Pharmacol. 39: 1929-1934, 1990.
119. MARQUARDT, D. L., AND WALKER, L. L.: Inhibition of protein kinase A fails to alter mast cell adenosine responsiveness. Agents Actions 43: 7-12, 1994.
120. MARQUARDT, D. L., WALKER, L. L., AND HEINEMANN, S.: Cloning of two adenosine receptor subtypes from mouse bone marrow-derived mast cells. J. Immunol. 152: 4508-4515, 1994.
121. 2b receptors in the guinea pjg aorta. Eur. J. Pharmacol. 216: 235-242, 1992.
122. 6-cyclopentyladenosine. J. Pharmacol. Exp. Ther. 270: 893-899, 1994.
123. 2 adenosine receptors in the aorta and the coronary vessels from the guinea pig. J. Pharmacol. Exp. Ther. 265: 248-253, 1993.
124. 1 receptor subtype. Mol. Pharmacol. 31: 247-252, 1987.
125. 2+ influx and activates a protein phosphatase in bovine adrenal chromaffin cells. J. Neurochem. 64: 77-84, 1995.
126. 16 as a universal G protein adapter: implications for agonist screening strategies. Trends Pharmacol. Sci. 17: 235-237, 1996.
127. 2+ current in hippocampal CA3 neurons. Neuron 10: 327-334, 1993.
128. MOSER, G. H., SCHRADER, J., AND DEUSSEN, A.: Turnover of adenosine in plasma of human and dog blood. Am. J. Physiol. 256: C799-C806, 1989.
129. MOSQUEDA-GARCIA, R., APPALSAMY, M., AND ROBERTSON, D.: Mechanisms of the central cardiovascular effects of adenosine: interaction with brain L-glutamate. (Abstract) Neuroscience 15: 1178, 1989.
130. MOSQUEDA-GARCIA, R., TSENG, C. J., APPALSAMY, M., BECK, C., AND ROBERTSON, D.: Cardiovascular excitatory effects of adenosine in the nucleus of the solitary tract. Hypertension 18: 494-502, 1991.
131. MULLANE, K.: Acadesine: the prototype adenosine regulating agent for reducing myocardial injury. Cardiovasc. Res. 27: 43-47, 1993.
132. 2 receptor desensitization. Mol. Pharmacol, 51: 991-998, 1997.
133. 3 receptor gene. FEBS Lett. 384: 243 -246, 1996.
134. 2b receptors coupled to distinct interactive signaling pathways in intestinal muscle cells. J. Pharmacol. Exp. Ther. 274: 300-306, 1995.
135. NAKANE, T., AND CHIBA, S.: Adenosine constricts the isolated and perfused monkey coronary artery. Heart Vessels 5: 71-75, 1990.
136. 2 adenosine receptor: guanine nucleotide modulation of agonist binding is enhanced by proteolysis Mol. Pharmacol. 39: 130-135, 1991.
137. NEES, S., HERZOG, V., BECKER, B. F., BOCK, M., DES ROSIERS, C., AND GERLACH, E,: The coronary endothelium: a highly active metabolic harrier for adenosine. Basic Res. Cardiol. 80: 515-529. 1985.
138. NEGLISHI, M., SUGIMOTO, Y., AND ICHIKAWA, A.: Molecular mechanisms of diverse actions of prostanoid receptors. Biochim. Biophys Act a 1259: 109-120. 1995.
139. 3 pseudogene. Biochem. Biophys. Res. Commun. 181: 16-21, 1991.
140. NICHOLLS, J., BROWNHILL, V. R., AND HOURANI, S. M. O.: Characterization of Pl-purinoceptors on rat isolated duodenum longitudinal muscle muscularis. mucosae. Br. J. Pharmacol. 117: 170-174, 1996.
141. NORSTEDT, C., AND FREDHOLM, B. B.: Phorbol-12,13-dibutirate enhances the cyclic AMP accumulation in rat hippocampal slices induced by adenosint analogues. Naunyn-Schmiedeherg's Arch. Pharmacol. 335: 136-142, 1987.
142. NORSTEDT, C., KVANTA, A., VAN DER PLOEG, I., AND FREDHOLM, B. B.: Dual effects of protein kinase C on receptor-stimulated cAMP accumulation in a human T-cell leukemia line. Eur. J. Pharmacol. 172: 51-62, 1989.
143. NYCE, J. W., AND METZGER, W. J.: DNA antisense therapy for asthma in an animal model. Nature (Lond.) 97: 721-725, 1997
144. 16 couple a wide variety of receptors to phospholipase C. J. Biol. Chem. 270: 15175-15180, 1995.
145. 2 receptors modualte extracellular dopamine levels in rat striatum. Neurosci. Lett. 212: 53-56, 1996.
146. 2a adenosine receptors. J. Biol. Chem. 272: 337-344, 1997.
147. OLSSON, R. A.: Adenosine receptors in the cardiovascular system. Drug Dev. Res. 39: 301-307, 1996.
148. OLSSON, R. A., DAVIS, C. C., AND KHOURI, E. M.: Coronary vasoactivity of adenosine covalently linked to polylysine. Life Sci. 21: 1343-1350, 1977.
149. OLSSON, R. A., AND PEARSON, J. D.: Cardiovascular purinoceptors. Pharmacol. Rev. 70: 761-845, 1990.
150. 2A receptors. Drug Dev. Res. 39: 450-460, 1996.
151. 2A receptors. Trends Pharmacol. Sci. 17: 364-372, 1096.
152. 2 adenosine receptors by two antipeptide antibody preparations. Mol. Pharmacol. 42: 391-397, 1992.
153. PALMER, T. M., AND STILES, G. L.: Adenosine receptors. Neuropharmacology 34: 683-694, 1995.
154. 2a adenosine receptor domain specifically responsible for mediating of short-term desensitization. Biochemistry 36: 832-838, 1997.
155. 1 receptors. J. Auton. Pharmacol. 1: 287-290, 1981.
156. PEACHELL, P. T., LICHTENSTEIN, L. M., AND SCHLEIMER, R. P.: Differential regulation of human basophil and lung mast cell function by adenosine. J. Pharmacol. Exp. Ther. 256: 717-726, 1991.
157. 2b-receptor-mediated cyclic AMP accumulation in primary rat astrocytes. Br. J. Pharmacol. 111: 191-198, 1994.
158. 1 receptor-mediated inhibition of cyclic AMP accumulation in type-2 but not type-1 rat astrocytes. Eur. J. Pharmacol. 306: 281-289, 1996.
159. 2a adenosine receptor gene. (Abstract) Drug Dev. Res. 31: 306, 1994.
160. PHILLIPS, G. D., NG, W. H., CHURCH, M. K., AND HOLGATE, S. T.: The response of plasma histamine to bronchoprovocation with methacholine. adenosine 5′-monophosphate, and allergen in atopic nonasthmutic subjects. Am. Rev. Respir. Dis. 90: 9-13, 1990.
161. PHILLIPS, G. D., RAFFERTY, P., BEASLEY, R., AND HOLGATE, S. T.: Effect of oral terfenadine on the bronchoconstrictor response to inhaled histamine and adenosine 5′-monophasphate in non-atopic asthma. Thorax 87: 939-945, 1987.
162. PHILLIPS, G. D., SCOTT, V. L., RICHARDS, R., AND HOLGATE, S. T.: Effect of nedroeromil sodium and sodium cromoglycate against bronchoconstriction induced by inhaled adenosine 5′-monophosphate. Eur. Respir. J. 2: 210-217, 1989.
163. PHILLIS, J. W., O'REGAN, M. H., AND PERKINS, L. M.: Effect of adenosine receptor agonist on spontaneous and K -evoked acetylcholine release from the in vivo rat cerebral cortex. Bruin Res. 605: 293-297, 1993a.
164. PHILLIS, J. W., PERKINS, L. M., AND O'REGAN, M. H.: Potassium-evoked efflux of transmitter amino acids and purines from rat cerebral cortex. Brain Res. Bull. 31: 547-552, 1993b.
165. 2b receptor from human brain. Biochem. Biophys. Res. Commun. 187: 86-93, 1992.
166. 2a adenosine receptors retain ligand binding. Mol. Pharmacol, 45: 861-870, 1994.
167. POLOSA, R., NG, W. H., CRIMI, N., VANCERI, C., HOLGATE, S, T.. CHURCH, M. K., AND MISTRETTA, A.: Relcase of mast cell-derived mediators after endobronchial adenosine challenge in asthma. Am. J. Respir, Crit, Cure Med. 151: 624-629, 1995.
168. PORZIG, H., GUTKNECHT, R., KOSTOVA, G., AND THALMEIER, K.: G proteincoupled receptors in normal human erytroid progenitor cells. NaunynSchmiedeberg's Arch. Pharmacol, 353: 11-20, 1995.
169. 2a selective adenosine receptor antagonist. Br. J. Pharmacol. 115: 1096-1102, 1995.
170. PRENTICE, D. J., AND HOURANI, S. M. O.: Activation of multiple sites by adenosine analogues in the rat isolated aorta. Br. J. Pharmacol. 118: 1509-1517, 1996.
171. 2B receptor and a xanthine-resistant site. Eur. J. Pharmacol, 323: 103-106, 1997.
172. 2b receptor. Mol. Pharmacol. 47: 1126-1132, 1995.
173. RAFFERTY, P., BEASLEY, C. R., AND HOLGATE, S. T.: The contribution of histamine to immediate bronchoconstriction provoked by inhaled allergen and adenosine-5′-monophosphate in atopic asthma. Am. Rev. Respir. Dis. 136: 369-373, 1987.
174. 3 adcnosine receptor is the unique adenosine receptor which facilitates release of allergic mediators in mast cells. J. Biol. Chem. 268: 16887-16890, 1993.
175. 3 adenosine receptors in rat basophilic leukemia (RBL-2HE) cells. J. Immunol. 154: 5437-5443, 1995.
176. 1 adenosine receptor gene: evidence for alternative splicing. J. Biol. Chem. 269: 3104-3110, 1994.
177. 2b-adenosine receptor. Mol. Endocrinol. 6: 1598-1604, 1992.
178. ROBEVA, A. S., WOODARD, R. L., JIN, X., GAO, Z., BHATTACHARYA, S., TAYLOR, H. E., ROSIN, D. L., AND LINDEN. J.: Molecular characterization of recombinant human adenosine receptors, Drug Dev, Res. 39: 243-252, 1996.
179. ROMAND, F. D., MACDONALD, S. G., AND DOBSON, J. G., JR.: Adenosine receptor coupling to adenylate cyclase of rat ventricular myocyte membrane. Am. J. Physiol. 257: H1088-H1095, 1989.
180. RUBANYI, G., AND VANHOUTTE, P. M.: Endothelium removal decreases relaxations of canine coronary arteries caused by β-adrenergic agonists and udenosine. J. Cardiovasc. Pharmacol. 7: 139-144, 1985.
181. 2b subtype) and P2-purinoceptors to the control of vascular tone in the rule isolate mesenteric arterial bed. Br. J. Pharmacol. 115: 648-652, 1995.
182. 3 adenosine receptor. Proc. Natl. Acad. Sci. USA 90: 10365-10369, 1993.
183. SATTIN, A., AND RALL, T. W.: The effect of adenosine and adenine nucleotides on the adenosine 3′,5′-phosphate content of guinea pig cerebral cortex slices. Mol. Pharmacol. 6: 13-23, 1970.
184. a protein couples P2-purinergic stimulation to cardiac Ca channels without cyclic AMP production. J. Gen. Physiol. 100: 675-701, 1992.
185. SCHWARTZ, L. B.: Tryptase, a mediator of humun mast cells. J. Allergy Clin. Immunol. 86: 594-598, 1990.
186. 2 receptor-mediated excitatory actions on the nervous system. Prog. Neurobiol. 48: 167-189, 1996.
187. SOLLEVI, A., LAGERKRANSER, M., IRESTKDT, L., GORDON, E., AND LINDQUIST, C.: Controlled hypotension with adenosine in cerebral aneurysm surgery. Anesthesiology 61: 400-405, 1984.
188. 2- adenosine receptor subtype. Mol. Endocrinol. 6: 384-393, 1992.
189. 2-adenosine receptors on ventricular cardiomyocytes. J. Mol. Cell. Cardiol, 25: 655-659, 1993.
190. 3 receptors. J. Clin. Invest. 98: 1773-1779, 1996.
191. 2b adenosine receptor mediates cAMP responses to adenosine receptor agonists in humun intestinal epithelia. J. Biol. Chem. 270: 2387-2394, 1995.
192. 2A receptors in rat brain. J. Phnrmacol. Exp. Ther. 280: 1094-1101, 1997.
193. TAMAOKI, J., TAGAYA, K., CHIYOTANI. A., TAKEMURA, H., NAGAI, A., KONNO, K., ONUKI, T., AND NITTA, S.: Effect of adenosine on adrenergic neurotransmission and modulation by endothelium in canine pulmonury artery. Am. J. Physiol. 272: H1100-H1105, 1997.
194. TOFOVIC, S. P., BRANCH, K. R., OLIVER, R. D., MAGEE, W. D., AND JACKSON, E. K.: Caffeine potentiates vasodilator-induced renin release. J. Pharmacol. Exp. Ther. 256: 850-860, 1991.
195. 2b receptor subtype gene (ADORA2B) to chromosome 17p11.2-p12 by FISH and PCR screening of somatic cell hybride Genomics 25: 805-607, 1995.
196. TSENG, C. J., BIAGGIONI, I., APPALSAMY, M., AND ROBERTSON, D.: Purinergic receptors in the brainstem mediate hypotension and bradycardia. Hypertension 11: 191-197, 1988.
197. 2A adenosine receptors identify intracellular domains important for determining selective G protein coupling. (Abstract) Drug Dev. Res. 37: 110, 1996.
198. TUCKER, A. L., AND LINDEN, J.: Cloned receptors and cardiovascular responses to adenosine. Cardiovasc. Res. 27: 62-67, 1993.
199. TURNER, J. T., CAMDEN, J. M., KANSRA, S., SHELTON-JAMES, D., WU. H., AND HALENDA, S. P.: Potentiation of cyclic adenosine monophosphate production by thrombin in the human erythroleukemia cell line HEL J. Pharmacol. Exp Ther. 263: 708-716, 1992.
200. 2 adenosine receptors of human platelets. FEBS Lett. 199: 269-274, 1986.
201. 2 adenosine receptors. Eur. J. Pharmacol, 117: 25-33, 1985.
202. VAN CALKER, D., MUELLER, M., AND HAMPRECHT, B., Adenosine regulates via two different types of receptors, the accumulation of cyclic AMP in cultured brain cells. J. Neurochem. 33: 999-1005, 1979.
203. VAN DER PLOEG, I., AHLBERG, S., PARKINSON, F. E., OLSSON, R. A., AND FREDHOLM, B, B.: Functional characterization of adenosine A2 receptors in Jurkat cells and PC12 cells using adenosine receptor agonists. NaunynSchmiedeberg's. Arch. Pharmacol. 353: 250-260, 1996.
204. 3 adenosine receptor. Mol, Pharmacol. 45: 1101-1111, 1994.
205. 3 receptors. J. Med. Chem. 39: 2980-2989. 1996.
206. VERANI, M. S. MAHMARIAN, J. J., HIXSON, J. B., BOYCE, T. M., STAUDACHER, R. A.: Diagnosis of coronary artery disease by controlled coronary vasodilatation with adenosine and thallium-201 scintigraphy in patients unable to exercise. Circulation 82: 80-87, 1990.
207. VOLLMER, W. M., BUIST, A. S., AND OSBORNE, M. L.: Twenty year trends in hospital discharges for asthma among members of a health maintenance organization. J. Clin. Epidemiol 45: 999-1006, 1992.
208. WAKADE, A. R., AND WAKADE, T. D.: Inhibition of noradrenaline release by adenosine, J. physiol. 282: 35-49. 1978.
209. WALDAN, P., AND AAS, P.: Prejunctional stimulation of cholinergic nerves in rat airway smooth muscle by an adenosine analogue. Pulm. Pharmacol. 4: 114-119, 1991.
210. 2 receptor agonist. Cardiovasc. Drug Rev, 10: 26-53, 1992.
211. WEINBERGER, M., AND HENDELES, L.: Theophylline in asthma. N. Engl. J. Med. 314: 1380-1388, 1998.
212. WEISS, K. B., GERGEN, P. J., AND WAGENER, D. K.: Breathing better or wheezing worse? The changing epidemiology of asthma morbidity and mortality. Annu. Rev. Public Health 14: 491-513, 1993.
213. q class: expression in murine tissues and in stromal and hematopoietic cell lines. Proc. Natl. Acad. Sci. USA 88: 10049-10053, 1991.
214. 2a, receptor in adult rat ventricular myocyte. Am. J. Physiol. 270: H1655-H1661, 1996.
215. 2b receptor in Xenopus oocytes. Mol. Pharmacol. 43: 277-280, 1993.
216. YEN, M.-H., WU, C.-C., AND CHIOU, W.-F.: Partially endothelium-dependent vasodilator effect of adenosine in rat aorta. Hypertension 11: 514-518, 1988.
217. 3 adenosine receptor. Proc. Natl. Acad. Sci. USA 89: 7432-7436, 1992.
218. 2A adenosine receptor antagonist. J. Pharmucol. Exp. Ther. 276: 398-404, 1996a.
219. 2A adenosine receptor antagonist, to rat striatal membranes, Br, J. Pharmnrol. 117: 1381-1386, 1996b.