G protein coupling of CGS 21680 binding sites in the rat hippocampus and cortex is different from that of adenosine A1 and striatal A(2A) receptors

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 359, Issue 4, 1999, Pages 295-302

  Cunha, Rodrigo A ^a   Constantino, M Dolores ^a   Ribeiro, J Alexandre ^a  

^a UNIVERSITY OF LISBON   (Portugal)

Author keywords

Adenosine; Adenosine A(2A) receptor; Adenosine A1 receptor; Cerebral cortex; G proteins; Hippocampus

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 4 [2 [7 AMINO 2 (2 FURYL) 1,2,4 TRIAZOLO[2,3 A][1,3,5]TRIAZIN 5 YLAMINO]ETHYL]PHENOL; 5 AMINO 2 (2 FURYL) 7 (2 PHENYLETHYL)PYRAZOLO[4,3 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE; ADENOSINE A1 RECEPTOR; ADENOSINE A2A RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; PHENYLISOPROPYLADENOSINE;

ANIMAL TISSUE; ARTICLE; BINDING SITE; BRAIN CORTEX; DRUG RECEPTOR BINDING; HIPPOCAMPUS; NONHUMAN; RAT; TISSUE DISTRIBUTION;

EID: 0032947295     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00005355     Document Type: Article

References (41)

1. 1 receptor expressed in Chinese hamster ovary cells not only inhibits cAMP accumulation but also stimulates phospholipase C and arachidonate release. Mol Pharmacol 45:1036-1042
2. 1-selective adenosine antagonist 8-cyclopentyl-1,3-dipropylxanthine to rat brain membranes. Naunyn Schmiedeberg's Arch Pharmacol 335:59-63
3. 3H]acetylcholine release from different areas of the rat hippocampus. J Neurochem 63:207-214
4. 2a receptor in the rat hippocampus. Brain Res 649:208-216
5. 2a adenosine receptor binding in aged striatum, hippocampus and cortex of the rat. Neuroreport 6:1583-1588
6. 2A receptors. Naunyn Schmiedeberg's Arch Pharmacol 353:261-271
7. 2A adenosine receptor agonists CGS 21680 and HENECA in the rat hippocampus. Br J Pharmacol 122:1279-1284
8. 2 receptors and their coupling to G-proteins. Dev Brain Res 93:1-9
9. 1-receptors in rat brain, as revealed by autoradiography. Neuroscience 34:759-769
10. Fredholm BB, Abbracchio MP, Bumstock G, Daly JW, Harden TK, Jacobson KA, Leff P, Williams M (1994) Nomenclature and classification of purinoceptors. Pharmacol Rev 46:143-156
11. iα-3. J Biol Chem 266:17778-17783
12. 2+ uptake through class A calcium channels in rat hippocampal CA3 but not CA1 synaptosomes. Neurosci Lett 238:73-77
13. 2a receptor involves activation of both N- and P-type calcium channels by different G proteins and protein kinases in the same striatal nerve terminals. J Neurochem 67:374-381
14. Gudermann T, Kalkbrenner F, Schultz G (1996) Diversity and selectivity of receptor-G protein interaction. Annu Rev Pharmacol Toxicol 36:429-459
15. Gudermann T, Schöneberg T, Schultz G (1997) Functional and structural complexity of signal transduction via G-protein-coupled receptors. Annu Rev Neurosci 20:399-427
16. i proteins in dual coupling of the luteinizing hormone receptor to adenylyl cyclase and phospholipase C. J Biol Chem 271:16764-16772
17. 3H]CGS 21680 to rat brain using autoradiography. Neuropharmacology 34:393-403
18. 3H]-CGS 21680 in the rat brain. Naunyn Schmiedeberg's Arch Pharmacol 354:539-541
19. Lupica CR, Cass WA, Zahniser NR, Dunwiddie TV (1990) Effects of the selective adenosine A2 receptor agonist CGS 21680 on in vitro electrophysiology, cAMP formation and dopamine release in rat hippocampus and striatum. J Pharmacol Exp Ther 252:1134-1141
20. 125I]iodophenyl)ethylamino]adenosine. Mol Pharmacol 47:307-313
21. 2-adenosine receptor to stimulatory guanine nucleotide-binding-protein in bovine brain striatum. J Pharmacol Exp Ther 266:294-300
22. Mendonça A de, Ribeiro JA (1994) Endogenous adenosine modulates long-term potentiation in the hippocampus. Neuroscience 62:385-390
23. 2-adenosine receptor. J Receptor Res 13:961-973
24. 2 adenosine receptor: guanine nucleotide modulation of agonist binding is enhanced by proteolysis. Mol Pharmacol 39:130-135
25. 1 adenosine receptor/G protein coupling: identification of a membrane protein that stabilizes the association of the receptor/G protein complex. Mol Pharmacol 48:806-817
26. 1 adenosine receptor ligands in rat brain membranes. Neurochem Int 26:263-268
27. O'Reagan MH, Simpson RE, Perkins LM, Phillis JW (1992) Adenosine receptor agonists inhibit the release of γ-aminobutyric acid (GABA) from the ischemic rat cerebral cortex. Brain Res 582:22-26
28. 3 adenosine receptor. J Biol Chem 270:16895-16902
29. 1 adenosine receptor-adenylate cyclase system in rat adipocytes. J Biol Chem 262:841-847
30. Peterson GL (1977) A simplification of the protein assay method of Lowry et al., which is more generally applicable. Anal Biochem 83:346-356
31. 2 receptor agonist, CGS 21680, is a potent depressant of cerebral cortical neuronal activity. Brain Res 509:328-330
32. 2a adenosine receptors retain ligand binding. Mol Pharmacol 45:861-870
33. 2 receptor occupancy regulates stimulated neutrophil function via activation of a serine/threonine protein phosphatase. J Biol Chem 271:17114-17118
34. 2 receptor-mediated excitatory actions on the nervous system. Prog Neurobiol 48:167-189
35. 2A-adenosine receptor in primary human endothelial cells. J Biol Chem 272:5792-5799
36. 2A receptor agonist CGS 21680. Drug Dev Res 39:108-114
37. Simpson RE, O'Reagan MH, Perkins LM, Phillis JW (1992) Excitatory transmitter amino acid release from the ischemic rat cerebral cortex: Effects of adenosine receptor agonists and antagonists. J Neurochem 58:1683-1690
38. 1 receptor. Solubilization and characterization of a guanine nucleotide-sensitive form of the receptor. J Biol Chem 260:6728-6732
39. 2-adrenoceptor to a pertussis toxin-sensitive G protein in cardiac myocytes. Mol Pharmacol 47:322-329
40. Yamane HK, Fung BKK (1993) Covalent modifications of G-proteins. Annu Rev Pharmacol Toxicol 32:201-241
41. 2A adenosine receptor antagonist, to rat striatal membranes. Br J Pharmacol 117:1381-1386