Cyclin dependent kinase inhibitors and replicative senescence;Inhibiteurs des kinases dépendantes des cyclines et sénescence réplicative

Pathologie Biologie

Volumn 49, Issue 10, 2001, Pages 830-839

  Gerland, L M ^a   Ffrench, M ^a   Magaud, J P ^b  

^a INSERM   (France)

^b EDOUARD HERRIOT HOSPITAL   (France)

Author keywords

CDK inhibitors (CKI); Metabolic pathways of p53 and pRb; Replicative senescence

Indexed keywords

CELL PROTEIN; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; CYCLIN DEPENDENT KINASE INHIBITOR; PROTEIN MDM2; PROTEIN P14; PROTEIN P16; PROTEIN P21; PROTEIN P53; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F; UNCLASSIFIED DRUG;

ARTICLE; CELL AGING; CELL DIVISION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; NONHUMAN; PROTEIN EXPRESSION; SENESCENCE; TELOMERE;

EID: 0035204745     PISSN: 03698114     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0369-8114(01)00249-8     Document Type: Review

References (67)

1. The serial cultivation of human diploid cell strains
2. Quantitation of the frequency of immortalisation of normal human diploid fibroblasts by SV40 large T-antigen
3. Evidence for critical telomere length in senescent human fibroblasts
4. The human telomere terminal transferase enzyme is a ribonucleoprotein that synthetizes TTAGGG repeats
5. A biomarker that identifies senescent human cells in culture and in aging skin in vivo
6. Cellular senescence in telomerase-expressing Syrian hamster embryo cells
7. Repression of c-fos transcription and an altered genetic program in senescent human fibroblasts
8. Mammalian G1 cyclins
9. Inhibitors of mammalian G1 cyclindependent kinases
10. Altered regulation of G1 cyclins in senescent human diploid fibroblasts: Accumulation of inactive cyclin E-CDK2 and cyclin D1-CDK2 complexes
11. Deregulation of cyclins D1 and E and suppression of cdk2 and cdk4 in senescent human fibroblasts
12. Complex mechanisms underlying impaired activation of CDK4 and CDK2 in replicative senescence: Roles of p16, p21 and cyclin D1
13. Failure to phosphorylate the retinoblastoma gene product in senescent human fibroblasts
14. A role for both Rb and p53 in the regulation of human cellular senescence
15. Escape from senescence in human diploid fibroblasts induced directly by mutant p53
16. Evidence that transcriptional activation by p53 plays a direct role in the induction of cellular senescence
17. Reinitiation of DNA synthesis and cell division in senescent human fibroblasts by microinjection of anti-p53 antibodies
18. Reexpression of the retinoblastoma protein in tumor cells induces senescence and telomerase inhibition
19. Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen
20. CDKN2 expression and its implications for cell immortalization and senescence
21. A cell cycle regulator potentially involved in genesis of many tumor types
22. 5′ CpG island methylation is associated with transcriptional silencing of the tumor suppressor p16/CDKN2/MST1 in human cancers
23. Role of the INK4a locus in tumor suppression and cell mortality
24. ARF
25. Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts
26. INK4a
27. A new regulatory motif in cell cycle control causing specific inhibition of cyclin D/CDK4
28. INK4a
29. INK4/MTSI tumour suppressor gene product
30. Structural basis of inihbition of CDK-cyclin complexes by INK4 inhibtors
31. INK4A fusion protein to human diploid fibroblasts
32. ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs the Rb and p53 tumor suppressor pathways
33. INK4a/MTS1 gene
34. Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
35. ARF
36. Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2
37. Mdm2 promotes the rapid degradation of p53
38. ARF with MDM2 inhibits ubiquitin ligase activity of MDM2 for tumor suppressor p53
39. Mutations in human ARF exon 2 disrupts its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53
40. Nucleolar ARF sequesters MDM2 and activates p53
41. ARF to p53 stabilization
42. ARF prevents G1 cyclindependent kinase activation by interacting with MDM2 and activating p53 in mouse fibroblasts
43. Induction of ARF tumor suppressor gene expression and cell cycle arrest by transcription factor DMP1
44. ARF, participates in a regulatory feedback loop with p53 and MDM2
45. ARF links the tumour suppressors Rb and p53
46. The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNA methylation and down-regulated by wild-type p53
47. Increased p16 expression with first senescence arrest in human mammary epithelial cells and extended growth capacity with p16 inactivation
48. The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus
49. WAF1, a potential mediator of p53 tumor suppression
50. Subunit rearrangement of the cyclindependent kinases is associated with cellular transformation
51. The p21 cdk-interacting protein Cipl is a potent inhibitor of G1 cyclindependent kinases
52. Cipl
53. Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts
54. CDK inhibitors: Positive and negative regulators of G1-phase progression
55. Waf1/Cip1/Sdi1 induces permanent growth arrest with markers of replicative senescence in human tumor cells lacking functionnal p53
56. p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage
57. Expression of p21 is not required for senescence of human fibroblasts
58. Regulation of the CDK inhibitor p21 gene during cell cycle progression is under the control of the transcription factor E2F
59. INK4a
60. Interaction between the retinoblastoma protein and the oncoprotein MDM2
61. PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human gliobnastoma cells
62. PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5-triphosphate and Akt/protein kinase B signaling pathway
63. A phosphatidylinositol 3-kinase inhibitor induces a senescent-like growth arrest in human diploid fibroblasts
64. Extension of life-span by induction of telomerase into normal human cells
65. Absence of cancer-associated changes in human fibroblasts immortalized with telomerase
66. ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly (ADP-ribose) polymerase
67. Tankyrase, a poly (ADP-ribose) polymerase at human telomeres