A single membrane-embedded negative charge is critical for recognizing positively charged drugs by the Escherichia coli multidrug resistance protein MdfA

EMBO Journal

Volumn 18, Issue 4, 1999, Pages 822-832

  Edgar, Rotem ^a   Bibi, Eitan ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Escherichia coli; MdfA; Multidrug resistance; Negative charge; Transport

Indexed keywords

AMPICILLIN; BACTERIAL PROTEIN; CARRIER PROTEIN; CHLORAMPHENICOL; DOXORUBICIN; DRUG; KANAMYCIN; MEMBRANE PROTEIN; MULTIDRUG RESISTANCE PROTEIN; MUTANT PROTEIN;

ARTICLE; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG TRANSPORT; ESCHERICHIA COLI; HYDROPHOBICITY; MOLECULAR RECOGNITION; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ALKALINE PHOSPHATASE; AMINO ACID SEQUENCE; BACTERIAL PROTEINS; BIOLOGICAL TRANSPORT; BIOTINYLATION; CHLORAMPHENICOL; CONSERVED SEQUENCE; DRUG RESISTANCE, MULTIPLE; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; ETHIDIUM; GENE TARGETING; KANAMYCIN; KINETICS; MEMBRANE TRANSPORT PROTEINS; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MUTATION; P-GLYCOPROTEIN; RECOMBINANT FUSION PROTEINS; SEQUENCE ALIGNMENT;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; NEGIBACTERIA;

EID: 0033558105     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/18.4.822     Document Type: Article

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