Mutations in either nucleotide-binding site of P-glycoprotein (Mdr3) prevent vanadate trapping of nucleotide at both sites

Biochemistry

Volumn 37, Issue 13, 1998, Pages 4592-4602

  Urbatsch, Ina L ^a   Beaudet, Lucille ^a   Carrier, Isabelle ^a   Gros, Philippe ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; GLYCOPROTEIN P; VANADIC ACID;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING SITE; CANCER CHEMOTHERAPY; DRUG PROTEIN BINDING; DRUG TRANSPORT; ENDOMYCETALES; GENE MUTATION; GLYCOPROTEIN SYNTHESIS; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PURIFICATION; SACCHAROMYCES CEREVISIAE; TUMOR;

ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; AFFINITY LABELS; ATP-BINDING CASSETTE TRANSPORTERS; AZIDES; BASE SEQUENCE; BINDING SITES; ENZYME INHIBITORS; ESCHERICHIA COLI; HYDROLYSIS; LIPID METABOLISM; MUTAGENESIS, SITE-DIRECTED; NUCLEOTIDES; P-GLYCOPROTEIN; P-GLYCOPROTEINS; PICHIA; POINT MUTATION; VANADATES;

PICHIA PASTORIS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCETALES;

EID: 0032584289     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9728001     Document Type: Article

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